{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:01:24Z","timestamp":1770274884159,"version":"3.49.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T00:00:00Z","timestamp":1255564800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0007429","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T21:03:56Z","timestamp":1255554236000},"page":"e7429","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Dynamic 3D Cell Rearrangements Guided by a Fibronectin Matrix Underlie Somitogenesis"],"prefix":"10.1371","volume":"4","author":[{"given":"Gabriel G.","family":"Martins","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Rifes","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Am\u00e2ndio","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Palmeirim","sequence":"additional","affiliation":[]},{"given":"S\u00f3lveig","family":"Thorsteinsd\u00f3ttir","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1126\/science.1075544","article-title":"Cell dynamics during somite boundary formation revealed by time-lapse analysis.","volume":"298","author":"PM Kulesa","year":"2002","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.cub.2004.11.056","article-title":"Genetic control of cell intercalation during tracheal morphogenesis in Drosophila.","volume":"14","author":"C Ribeiro","year":"2004","journal-title":"Curr Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.devcel.2006.02.019","article-title":"Chemokine signaling mediates self-organizing tissue migration in the zebrafish lateral line.","volume":"10","author":"P Haas","year":"2006","journal-title":"Dev Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1242\/jcs.03079","article-title":"Cell and fibronectin dynamics during branching morphogenesis.","volume":"119","author":"M Larsen","year":"2006","journal-title":"J Cell Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/nature06211","article-title":"The amniote primitive streak is defined by epithelial cell intercalation before gastrulation.","volume":"449","author":"O Voiculescu","year":"2007","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/dvdy.20345","article-title":"The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it.","volume":"233","author":"ED Hay","year":"2005","journal-title":"Dev Dyn"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1387\/ijdb.052044di","article-title":"Mechanical control of tissue morphogenesis during embryological development.","volume":"50","author":"DE Ingber","year":"2006","journal-title":"Int J Dev Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/jez.b.21198","article-title":"Epithelial type, ingression, blastopore architecture and the evolution of chordate mesoderm morphogenesis.","volume":"310","author":"DR Shook","year":"2008","journal-title":"J Exp Zoolog B Mol Dev Evol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1126\/science.1164073","article-title":"Morphogenetic cell movements: diversity from modular mechanical properties.","volume":"322","author":"DJ Montell","year":"2008","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/path.1472","article-title":"Integrins in regulation of tissue development and function.","volume":"201","author":"EH Danen","year":"2003","journal-title":"J Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/jcs.006064","article-title":"Extracellular matrix dynamics in development and regenerative medicine.","volume":"121","author":"WP Daley","year":"2008","journal-title":"J Cell Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00418-008-0537-1","article-title":"Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging.","volume":"130","author":"CM Ghajar","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ceb.2006.08.009","article-title":"The matrix reorganized: extracellular matrix remodeling and integrin signaling.","volume":"18","author":"M Larsen","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1242\/jcs.018093","article-title":"Integrin signalling at a glance.","volume":"122","author":"DS Harburger","year":"2009","journal-title":"J Cell Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/jcs.018564","article-title":"Integrins in cell migration\u2013the actin connection.","volume":"122","author":"M Vicente-Manzanares","year":"2009","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ceb.2006.07.002","article-title":"Crosstalk between different adhesion molecules.","volume":"18","author":"X Chen","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0070-2153(08)60248-3","article-title":"Somitogenesis.","volume":"38","author":"A Gossler","year":"1998","journal-title":"Curr Top Dev Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1057>3.0.CO;2-5","article-title":"Molecular and cellular biology of avian somite development.","volume":"219","author":"FE Stockdale","year":"2000","journal-title":"Dev Dyn"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/aja.1000110103","article-title":"The Somites of the chick.","volume":"2","author":"LW Williams","year":"1910","journal-title":"The American Journal of Anatomy"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0012-1606(74)90260-7","article-title":"Analysis of Normal Somite Development.","volume":"38","author":"BH Lipton","year":"1974","journal-title":"Developmental Biology"},{"key":"ref21","first-page":"227","article-title":"The mechanism of somite segmentation in the chick embryo.","volume":"51","author":"R Bellairs","year":"1979","journal-title":"J Embryol Exp Morphol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/dvdy.21143","article-title":"Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity.","volume":"236","author":"Y Saga","year":"2007","journal-title":"Dev Dyn"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/bdrc.20094","article-title":"Molecular clocks underlying vertebrate embryo segmentation: A 10-year-old hairy-go-round.","volume":"81","author":"RP Andrade","year":"2007","journal-title":"Birth Defects Res C Embryo Today"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrg2320","article-title":"Segmental patterning of the vertebrate embryonic axis.","volume":"9","author":"ML Dequeant","year":"2008","journal-title":"Nat Rev Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0045-6039(83)90092-1","article-title":"Fibronectin distribution during somitogenesis in the chick embryo.","volume":"13","author":"D Ostrovsky","year":"1983","journal-title":"Cell Differ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1083\/jcb.104.5.1361","article-title":"Adhesion molecules during somitogenesis in the avian embryo.","volume":"104","author":"JL Duband","year":"1987","journal-title":"J Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/dev.119.4.1079","article-title":"Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.","volume":"119","author":"EL George","year":"1993","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1097-0177(199610)207:2<145::AID-AJA3>3.0.CO;2-H","article-title":"Mesodermal development in mouse embryos mutant for fibronectin.","volume":"207","author":"EN Georges-Labouesse","year":"1996","journal-title":"Dev Dyn"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.devcel.2005.03.006","article-title":"Integrinalpha5-dependent Fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos.","volume":"8","author":"S Koshida","year":"2005","journal-title":"Dev Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.devcel.2005.01.016","article-title":"Integrinalpha5 and delta\/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis.","volume":"8","author":"D Julich","year":"2005","journal-title":"Dev Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1242\/dev.02230","article-title":"Regulation of somitogenesis by Ena\/VASP proteins and FAK during Xenopus development.","volume":"133","author":"KA Kragtorp","year":"2006","journal-title":"Development"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1002\/dvdy.21280","article-title":"Integrin alpha5 is required for somite rotation and boundary formation in Xenopus.","volume":"236","author":"KA Kragtorp","year":"2007","journal-title":"Dev Dyn"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1242\/dev.003665","article-title":"Redefining the role of ectoderm in somitogenesis: a player in the formation of the fibronectin matrix of presomitic mesoderm.","volume":"134","author":"P Rifes","year":"2007","journal-title":"Development"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0012-1606(76)90207-4","article-title":"Influence of Axial Structures on Chick Somite Formation.","volume":"53","author":"DS Packard","year":"1976","journal-title":"Developmental Biology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1520-6408(1998)23:1<77::AID-DVG8>3.0.CO;2-3","article-title":"Uncoupling segmentation and somitogenesis in the chick presomitic mesoderm.","volume":"23","author":"I Palmeirim","year":"1998","journal-title":"Dev Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1534-5807(01)00082-X","article-title":"A nomenclature for prospective somites and phases of cyclic gene expression in the presomitic mesoderm.","volume":"1","author":"O Pourquie","year":"2001","journal-title":"Dev Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jmor.1050880104","article-title":"A Series of Normal Stages in the Development of the Chick Embryo.","volume":"88","author":"V Hamburger","year":"1951","journal-title":"Journal of Morphology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1440-169X.1999.413437.x","article-title":"Efficient targeting of gene expression in chick embryos by microelectroporation.","volume":"41","author":"T Momose","year":"1999","journal-title":"Dev Growth Differ"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1242\/dev.122.5.1523","article-title":"Fates and migratory routes of primitive streak cells in the chick embryo.","volume":"122","author":"D Psychoyos","year":"1996","journal-title":"Development"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)80451-1","article-title":"Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis.","volume":"91","author":"I Palmeirim","year":"1997","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1083\/jcb.100.2.364","article-title":"Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.","volume":"100","author":"PJ McKeown-Longo","year":"1985","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0012-1606(82)90122-1","article-title":"Synthesis of type IV collagen and laminin in cultures of skeletal muscle cells and their assembly on the surface of myotubes.","volume":"93","author":"U Kuhl","year":"1982","journal-title":"Dev Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ar.1092320116","article-title":"Basement membrane and fibronectin matrix are distinct entities in the developing mouse blastocyst.","volume":"232","author":"S Thorsteinsdottir","year":"1992","journal-title":"Anat Rec"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.matbio.2003.10.006","article-title":"Basement membrane assembly, stability and activities observed through a developmental lens.","volume":"22","author":"PD Yurchenco","year":"2004","journal-title":"Matrix Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2004.08.003","article-title":"Mesenchymal-Epithelial Transition during Somitic Segmentation Is Regulated by Differential Roles of Cdc42 and Rac1.","volume":"7","author":"Y Nakaya","year":"2004","journal-title":"Dev Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/35098552","article-title":"The making of the somite: molecular events in vertebrate segmentation.","volume":"2","author":"Y Saga","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1242\/dev.01519","article-title":"Coupling segmentation to axis formation.","volume":"131","author":"J Dubrulle","year":"2004","journal-title":"Development"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1242\/dev.128.24.5139","article-title":"Evidence for medial\/lateral specification and positional information within the presomitic mesoderm.","volume":"128","author":"C Freitas","year":"2001","journal-title":"Development"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ar.1092370107","article-title":"Cell Behaviors Underlying Notochord Formation and Extension in Avian Embryos - Quantitative and Immunocytochemical Studies.","volume":"237","author":"RA Sausedo","year":"1993","journal-title":"Anatomical Record"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ar.1092390112","article-title":"Quantitative-Analyses of Cell Behaviors Underlying Notochord Formation and Extension in Mouse Embryos.","volume":"239","author":"RA Sausedo","year":"1994","journal-title":"Anatomical Record"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1432-0436.2005.00049.x","article-title":"How is the mouse germ-cell lineage established?","volume":"73","author":"A McLaren","year":"2005","journal-title":"Differentiation"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1098\/rstb.2000.0626","article-title":"Mechanisms of convergence and extension by cell intercalation.","volume":"355","author":"R Keller","year":"2000","journal-title":"Philosophical Transactions of the Royal Society B-Biological Sciences"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.18.022602.131838","article-title":"Molecular mechanisms of epithelial morphogenesis.","volume":"18","author":"F Schock","year":"2002","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1242\/jcs.00670","article-title":"The ins and outs of fibronectin matrix assembly.","volume":"116","author":"I Wierzbicka-Patynowski","year":"2003","journal-title":"J Cell Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.matbio.2005.06.008","article-title":"Fibronectin fibrillogenesis, a cell-mediated matrix assembly process.","volume":"24","author":"Y Mao","year":"2005","journal-title":"Matrix Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1091\/mbc.E02-01-0048","article-title":"Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions.","volume":"13","author":"J Sottile","year":"2002","journal-title":"Mol Biol Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nature01712","article-title":"Fibronectin requirement in branching morphogenesis.","volume":"423","author":"T Sakai","year":"2003","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1534-5807(04)00063-2","article-title":"Fibronectin regulates epithelial organization during myocardial migration in zebrafish.","volume":"6","author":"LA Trinh","year":"2004","journal-title":"Dev Cell"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1101\/gad.1643308","article-title":"Fibronectin fibrillogenesis regulates three-dimensional neovessel formation.","volume":"22","author":"X Zhou","year":"2008","journal-title":"Genes Dev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cub.2006.03.038","article-title":"Integrin alpha5beta1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension.","volume":"16","author":"LA Davidson","year":"2006","journal-title":"Curr Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0960-9822(03)00433-0","article-title":"Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus.","volume":"13","author":"M Marsden","year":"2003","journal-title":"Curr Biol"},{"key":"ref62","first-page":"207","article-title":"Cell Adhesiveness and Embryonic Differentiation.","volume":"46","author":"R Bellairs","year":"1978","journal-title":"Journal of Embryology and Experimental Morphology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jez.1402320207","article-title":"On the role of fibronectin during the compaction stage of somitogenesis in the chick embryo.","volume":"232","author":"JW Lash","year":"1984","journal-title":"J Exp Zool"},{"key":"ref64","first-page":"201","article-title":"The adhesion recognition signal of fibronectin: a possible trigger mechanism for compaction during somitogenesis.","author":"JW Lash","year":"1986"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1242\/jcs.115.6.1221","article-title":"Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.","volume":"115","author":"T Ohashi","year":"2002","journal-title":"J Cell Sci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1002\/dvdy.21600","article-title":"Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis.","volume":"237","author":"LA Davidson","year":"2008","journal-title":"Dev Dyn"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e247","DOI":"10.1371\/journal.pbio.0060247","article-title":"The ECM moves during primitive streak formation\u2013computation of ECM versus cellular motion.","volume":"6","author":"EA Zamir","year":"2008","journal-title":"PLoS Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1242\/dev.129.15.3633","article-title":"Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation.","volume":"129","author":"Y Sato","year":"2002","journal-title":"Development"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1073\/pnas.0902859106","article-title":"EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation.","volume":"106","author":"T Watanabe","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1242\/jcs.115.15.3073","article-title":"Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis.","volume":"115","author":"U Huynh-Do","year":"2002","journal-title":"J Cell Sci"},{"key":"ref71","first-page":"1197","article-title":"Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells.","volume":"27","author":"S Meyer","year":"2005","journal-title":"Int J Oncol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0007429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T08:49:12Z","timestamp":1634028552000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0007429"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Callaerts","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,10,15]]},"references-count":71,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2009,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0007429","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,15]]}}}