{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:01:50Z","timestamp":1772762510394,"version":"3.50.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T00:00:00Z","timestamp":1273449600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0010558","type":"journal-article","created":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T20:50:30Z","timestamp":1273524630000},"page":"e10558","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Modulation of IL-17 and Foxp3 Expression in the Prevention of Autoimmune Arthritis in Mice"],"prefix":"10.1371","volume":"5","author":[{"given":"Joana","family":"Duarte","sequence":"first","affiliation":[]},{"given":"Ana","family":"Agua-Doce","sequence":"additional","affiliation":[]},{"given":"Vanessa G.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Eurico","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Graca","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2010,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/rheumatology\/40.4.447","article-title":"Mortality in rheumatoid arthritis: relationship to single and composite measures of disease activity.","volume":"40","author":"JC Chehata","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/art.10705","article-title":"Survival in rheumatoid arthritis: a population-based analysis of trends over 40 years.","volume":"48","author":"SE Gabriel","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis.","volume":"423","author":"GS Firestein","year":"2003","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0008-8749(92)90250-S","article-title":"The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells.","volume":"144","author":"S Banerjee","year":"1992","journal-title":"Cell Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0008-8749(89)90001-4","article-title":"Collagen arthritis in the rat is initiated by CD4+ T cells and can be amplified by iron.","volume":"121","author":"FC Breedveld","year":"1989","journal-title":"Cell Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM197509112931101","article-title":"Predominantly T-cell infiltrate in rheumatoid synovial membranes.","volume":"293","author":"JA Van Boxel","year":"1975","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E","article-title":"Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium.","volume":"42","author":"M Chabaud","year":"1999","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.","volume":"103","author":"S Kotake","year":"1999","journal-title":"J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.4049\/jimmunol.164.5.2832","article-title":"High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism.","volume":"164","author":"M Ziolkowska","year":"2000","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/rheumatology\/39.10.1139","article-title":"Pharmacokinetic, pharmacodynamic and clinical effects of a humanized IgG1 anti-CD4 monoclonal antibody in the peripheral blood and synovial fluid of rheumatoid arthritis patients.","volume":"39","author":"EH Choy","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"ref11","first-page":"247","article-title":"Reprogramming the immune system using antibodies.","volume":"333","author":"L Graca","year":"2006","journal-title":"Methods Mol Biol"},{"key":"ref12","first-page":"220","article-title":"CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis.","volume":"29","author":"U Mason","year":"2002","journal-title":"J Rheumatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1358\/dot.1999.35.4-5.552208","article-title":"What we have learned from trials of immunomodulatory agents in rheumatoid arthritis: Future directions.","volume":"35","author":"H Schulze-Koops","year":"1999","journal-title":"Drugs Today (Barc)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.coph.2007.05.001","article-title":"T cell immunomodulation\u2013the Holy Grail of therapeutic tolerance.","volume":"7","author":"JD Isaacs","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.4049\/jimmunol.165.9.4783","article-title":"Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.","volume":"165","author":"L Graca","year":"2000","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1385\/IR:28:3:181","article-title":"Antibody-induced transplantation tolerance: the role of dominant regulation.","volume":"28","author":"L Graca","year":"2003","journal-title":"Immunol Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0952-7915(02)00379-5","article-title":"Regulatory T cells in transplantation.","volume":"14","author":"M Karim","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature02119","article-title":"Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.","volume":"426","author":"N Sakaguchi","year":"2003","journal-title":"Nature"},{"key":"ref19","first-page":"475","article-title":"Chronic arthritis directly induces quantitative and qualitative bone disturbances leading to compromised biomechanical properties.","volume":"27","author":"J Caetano-Lopes","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3.","volume":"299","author":"S Hori","year":"2003","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.micinf.2006.10.012","article-title":"IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.","volume":"9","author":"Q Wu","year":"2007","journal-title":"Microbes Infect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.4049\/jimmunol.172.10.6003","article-title":"Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.","volume":"172","author":"SP Cobbold","year":"2004","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1084\/jem.20041758","article-title":"A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.","volume":"201","author":"H Yoshitomi","year":"2005","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","article-title":"Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.","volume":"204","author":"K Hirota","year":"2007","journal-title":"J Exp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI200421795","article-title":"Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice.","volume":"114","author":"H Hata","year":"2004","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1084\/jem.169.3.779","article-title":"Induction of classical transplantation tolerance in the adult.","volume":"169","author":"SX Qin","year":"1989","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.4049\/jimmunol.168.11.5558","article-title":"Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance.","volume":"168","author":"L Graca","year":"2002","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.20012097","article-title":"Identification of regulatory T cells in tolerated allografts.","volume":"195","author":"L Graca","year":"2002","journal-title":"J Exp Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.168.3.1080","article-title":"CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses.","volume":"168","author":"CI Kingsley","year":"2002","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.","volume":"24","author":"M Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ni1552","article-title":"Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.","volume":"9","author":"HC Hsu","year":"2008","journal-title":"Nat Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"21789","DOI":"10.1073\/pnas.0912152106","article-title":"IL-17-producing T cells can augment autoantibody-induced arthritis.","volume":"106","author":"JP Jacobs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/rheumatology\/kel437","article-title":"NKT cells: manipulable managers of joint inflammation.","volume":"46","author":"K Coppieters","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1172\/JCI8082","article-title":"Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.","volume":"104","author":"J Trambley","year":"1999","journal-title":"J Clin Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"10122","DOI":"10.1073\/pnas.0400084101","article-title":"Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.","volume":"101","author":"L Graca","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20062259","article-title":"T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.","volume":"204","author":"K Hirota","year":"2007","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.4049\/jimmunol.0903566","article-title":"Mast cells express IL-17A in rheumatoid arthritis synovium","volume":"184","author":"AJ Hueber","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/rheumatology\/ken163","article-title":"Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future.","volume":"47","author":"JD Isaacs","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.4049\/jimmunol.157.6.2685","article-title":"Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs.","volume":"157","author":"CQ Chu","year":"1996","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.4049\/jimmunol.159.10.5032","article-title":"Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody.","volume":"159","author":"C Mauri","year":"1997","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/08830188809044772","article-title":"In vivo modulation of murine collagen induced arthritis.","volume":"4","author":"GE Ranges","year":"1988","journal-title":"Int Rev Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.162.3.1105","article-title":"Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.","volume":"162","author":"GE Ranges","year":"1985","journal-title":"J Exp Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(87)91158-5","article-title":"Monoclonal anti-CD4 in arthritis.","volume":"2","author":"C Herzog","year":"1987","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/art.1780340202","article-title":"Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody.","volume":"34","author":"G Horneff","year":"1991","journal-title":"Arthritis Rheum"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/art.1780340504","article-title":"Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151. Clinical results and immunopharmacologic effects in an open study, including repeated administration.","volume":"34","author":"C Reiter","year":"1991","journal-title":"Arthritis Rheum"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0090-1229(91)90084-N","article-title":"Human anti-mouse antibody response induced by anti-CD4 monoclonal antibody therapy in patients with rheumatoid arthritis.","volume":"59","author":"G Horneff","year":"1991","journal-title":"Clin Immunol Immunopathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0010558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T03:31:29Z","timestamp":1685590289000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0010558"}},"subtitle":[],"editor":[{"given":"Derya","family":"Unutmaz","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2010,5,10]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0010558","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,10]]}}}