{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:27:43Z","timestamp":1778394463782,"version":"3.51.4"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:00:00Z","timestamp":1277078400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0011222","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T19:23:04Z","timestamp":1277148184000},"page":"e11222","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":156,"title":["Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis"],"prefix":"10.1371","volume":"5","author":[{"given":"In\u00eas","family":"Sofia Vala","sequence":"first","affiliation":[]},{"given":"Leila R.","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Natsuko","family":"Imaizumi","sequence":"additional","affiliation":[]},{"given":"Raquel J.","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Rino","sequence":"additional","affiliation":[]},{"given":"Fran\u00e7ois","family":"Kuonen","sequence":"additional","affiliation":[]},{"given":"Lara M.","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Curzio","family":"R\u00fcegg","sequence":"additional","affiliation":[]},{"given":"Isabel Monteiro","family":"Grillo","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Taborda","family":"Barata","sequence":"additional","affiliation":[]},{"given":"Marc","family":"Mareel","sequence":"additional","affiliation":[]},{"given":"Susana Constantino Rosa","family":"Santos","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2010,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nrc1735","article-title":"Radiation and the microenvironment - tumorigenesis and therapy.","volume":"5","author":"MH Barcellos-Hoff","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref2","first-page":"292","article-title":"Does ionizing radiation stimulate cancer invasion and metastasis?","volume":"95","author":"I Madani","year":"2008","journal-title":"Bull Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1158\/1078-0432.CCR-04-1223","article-title":"Inhibition of {alpha}v{beta}3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy.","volume":"11","author":"A Abdollahi","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1667\/RR3196","article-title":"A sense of danger from radiation.","volume":"162","author":"WH McBride","year":"2004","journal-title":"Radiat Res"},{"key":"ref5","first-page":"1247","article-title":"Over-expression of vascular endothelial growth factor after preoperative radiation therapy for rectal cancer.","volume":"8","author":"M Nozue","year":"2001","journal-title":"Oncol Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbrc.2006.04.121","article-title":"Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis.","volume":"345","author":"HK Sung","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/35050000","article-title":"A role for Saccharomyces cerevisiae histone H2A in DNA repair.","volume":"408","author":"JA Downs","year":"2000","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1074\/jbc.M002016200","article-title":"Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants.","volume":"276","author":"H Gille","year":"2001","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrc2397","article-title":"Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.","volume":"8","author":"MW Dewhirst","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrm2183","article-title":"Molecular regulation of angiogenesis and lymphangiogenesis.","volume":"8","author":"RH Adams","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nchembio778","article-title":"Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.","volume":"2","author":"PE Bayliss","year":"2006","journal-title":"Nat Chem Biol"},{"key":"ref12","first-page":"519","article-title":"A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.","volume":"67","author":"A Passaniti","year":"1992","journal-title":"Lab Invest"},{"key":"ref13","first-page":"1399","article-title":"Selective Events in the Metastatic Process Defined by Analysis of the Sequential Dissemination of Subpopulations of a Mouse Mammary Tumor.","volume":"52","author":"CJ Aslakson","year":"1992","journal-title":"Cancer Res"},{"key":"ref14","first-page":"3374","article-title":"Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation.","volume":"59","author":"DH Gorski","year":"1999","journal-title":"Cancer Res"},{"key":"ref15","first-page":"5565","article-title":"Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.","volume":"60","author":"CG Lee","year":"2000","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/28412","article-title":"Combined effects of angiostatin and ionizing radiation in antitumour therapy.","volume":"394","author":"HJ Mauceri","year":"1998","journal-title":"Nature"},{"key":"ref17","first-page":"269","article-title":"Anti-angiogenic agents can increase tumor oxygenation and response to radiation therapy.","volume":"2","author":"BA Teicher","year":"1995","journal-title":"Radiat OncolInvest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0002-9610(86)90324-7","article-title":"Neck dissection with and without radiotherapy: prognostic factors, patterns of recurrence, and survival.","volume":"152","author":"CJ O'Brien","year":"1986","journal-title":"Am J Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0360-3016(92)90025-D","article-title":"Local control and patient survival.","volume":"23","author":"HD Suit","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/cncr.11143","article-title":"Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy?","volume":"97","author":"FA Vicini","year":"2003","journal-title":"Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1126\/science.1060191","article-title":"Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.","volume":"293","author":"F Paris","year":"2001","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc2403","article-title":"VEGF-targeted therapy: mechanisms of anti-tumour activity.","volume":"8","author":"LM Ellis","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors.","volume":"9","author":"N Ferrara","year":"2003","journal-title":"Nat Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/sj.bjc.6600837","article-title":"Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection.","volume":"88","author":"S Zoula","year":"2003","journal-title":"Br J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/sj.onc.1204308","article-title":"Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase\/Akt dependent pathway.","volume":"20","author":"SC Santos","year":"2001","journal-title":"Oncogene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.yexcr.2007.02.020","article-title":"VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing.","volume":"313","author":"SC Santos","year":"2007","journal-title":"Exp Cell Res"},{"key":"ref27","article-title":"The Zebrafish Book.","author":"M Westerfield"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0011222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T13:11:39Z","timestamp":1540213899000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0011222"}},"subtitle":[],"editor":[{"given":"Andrei L.","family":"Gartel","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2010,6,21]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,6,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0011222","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,21]]}}}