{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:10Z","timestamp":1770834130672,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T00:00:00Z","timestamp":1299801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0017660","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T18:56:49Z","timestamp":1300301809000},"page":"e17660","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["FGF Signaling Pathway in the Developing Chick Lung: Expression and Inhibition Studies"],"prefix":"10.1371","volume":"6","author":[{"given":"Rute S.","family":"Moura","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 P.","family":"Coutinho-Borges","sequence":"additional","affiliation":[]},{"given":"Ana P.","family":"Pacheco","sequence":"additional","affiliation":[]},{"given":"Paulo O.","family":"daMota","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Correia-Pinto","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1242\/dev.02310","article-title":"Regulation of early lung morphogenesis: questions, facts and controversies.","volume":"133","author":"WV Cardoso","year":"2006","journal-title":"Development"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCRESAHA.108.181818","article-title":"Branching Morphogenesis.","volume":"103","author":"A Horowitz","year":"2008","journal-title":"Circ Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","article-title":"Mechanisms underlying differential responses to FGF signaling.","volume":"16","author":"L Dailey","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ydbio.2005.09.011","article-title":"Functions and regulations of fibroblast growth factor signaling during embryonic development.","volume":"287","author":"B Thisse","year":"2005","journal-title":"Dev Biol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cytogfr.2005.01.001","article-title":"Cellular signaling by fibroblast growth factor receptors.","volume":"16","author":"VP Eswarakumar","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/humu.21067","article-title":"Molecular pathology of the fibroblast growth factor family.","volume":"30","author":"P Krejci","year":"2009","journal-title":"Hum Mutat"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10456-008-9089-1","article-title":"Sprouty proteins, masterminds of receptor tyrosine kinase signaling.","volume":"11","author":"MA Cabrita","year":"2008","journal-title":"Angiogenesis"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.devcel.2009.12.010","article-title":"Preparing for the first breath: genetic and cellular mechanisms in lung development.","volume":"18","author":"EE Morrisey","year":"2010","journal-title":"Dev Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/5096","article-title":"Fgf10 is essential for limb and lung formation.","volume":"21","author":"K Sekine","year":"1999","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1242\/dev.124.23.4867","article-title":"Fibroblast growth factor 10 (Fgf10) and branching morphogenesis in the embryonic mouse lung.","volume":"124","author":"S Bellusci","year":"1997","journal-title":"Development"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/dbio.1998.8994","article-title":"FGF-10 is a chemotactic factor for distal epithelial buds during lung development.","volume":"201","author":"WY Park","year":"1998","journal-title":"Dev Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1242\/dev.128.11.2095","article-title":"Lung hypoplasia and neonatal death in <italic>Fgf9<\/italic>-null mice identify this gene as an essential regulator of lung mesenchyme.","volume":"128","author":"JS Colvin","year":"2001","journal-title":"Development"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0925-4773(01)00286-6","article-title":"Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.","volume":"102","author":"AA Mailleux","year":"2001","journal-title":"Mech Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0960-9822(99)80094-3","article-title":"Conserved function of <italic>mSpry-2<\/italic>, a murine homolog of <italic>Drosophila sprouty<\/italic>, which negatively modulates respiratory organogenesis.","volume":"9","author":"JD Tefft","year":"1999","journal-title":"Curr Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1017\/S1464793106007111","article-title":"Development, structure, and function of a novel respiratory organ, the lung-air sac system of birds: to go where no other vertebrate has gone.","volume":"81","author":"JN Maina","year":"2006","journal-title":"Biol Rev Camb Philos Soc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1242\/dev.00345","article-title":"<italic>Tbx4-Fgf10<\/italic> system controls lung bud formation during chicken embryonic development.","volume":"130","author":"JI Sakiyama","year":"2003","journal-title":"Development"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/dbio.2000.9880","article-title":"Coordinated expression of <italic>Hoxb<\/italic> genes and signaling molecules during development of the chick respiratory tract.","volume":"227","author":"JI Sakiyama","year":"2000","journal-title":"Dev Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.mod.2008.11.006","article-title":"The cyst-branch difference in developing chick lung results from a different morphogen diffusion coefficient.","volume":"126","author":"T Miura","year":"2009","journal-title":"Mech Dev"},{"issue":"5314","key":"ref19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1126\/science.276.5314.955","article-title":"Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.","volume":"276","author":"M Mohammadi","year":"1997","journal-title":"Science"},{"issue":"7196","key":"ref20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature07005","article-title":"The branching programme of mouse lung development.","volume":"453","author":"RJ Metzger","year":"2008","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0040-8166(03)00058-2","article-title":"A systematic study of the development of the airway (bronchial) system of the avian lung from days 3 to 26 of embryogenesis: a transmission electron microscopic study on the domestic fowl, <italic>Gallus gallus<\/italic> variant <italic>domesticus<\/italic>.","volume":"35","author":"JN Maina","year":"2003","journal-title":"Tissue & Cell"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1242\/dev.114.1.233","article-title":"Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse.","volume":"114","author":"KG Peters","year":"1992","journal-title":"Development"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1165\/ajrcmb.19.4.2994","article-title":"Differential expression of fibroblast growth factor receptors 1 to 4 and ligand genes in late fetal and early postnatal rat lung.","volume":"19","author":"PP Powell","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.127.3.483","article-title":"An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.","volume":"127","author":"L De Moerlooze","year":"2000","journal-title":"Development"},{"issue":"25","key":"ref25","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","article-title":"Receptor Specificity of the Fibroblast Growth Factor Family.","volume":"271","author":"DM Ornitz","year":"1996","journal-title":"J Biol Chem"},{"issue":"19","key":"ref26","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/dev.128.19.3867","article-title":"Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains.","volume":"128","author":"Q Wang","year":"2001","journal-title":"Development"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1242\/dev.125.18.3615","article-title":"FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung.","volume":"125","author":"M Weinstein","year":"1998","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0925-4773(01)00526-3","article-title":"Expression of <italic>Sprouty<\/italic> genes <italic>1<\/italic>, <italic>2<\/italic> and <italic>4<\/italic> during mouse organogenesis.","volume":"109","author":"S Zhang","year":"2001","journal-title":"Mech Dev"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ydbio.2005.11.022","article-title":"VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis.","volume":"290","author":"PM Del Moral","year":"2006","journal-title":"Dev Biol"},{"issue":"14","key":"ref30","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1021\/jm980123i","article-title":"Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.","volume":"41","author":"L Sun","year":"1998","journal-title":"J Med Chem"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"L110","DOI":"10.1152\/ajplung.00407.2007","article-title":"Impaired VEGF and nitric oxide signaling after nitrofen exposure in rat fetal lung explants.","volume":"294","author":"V Muehlethaler","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1\u20132","key":"ref32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0925-4773(02)00132-6","article-title":"Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro.","volume":"116","author":"T Miura","year":"2002","journal-title":"Mech Dev"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1165\/rcmb.2007-0290OC","article-title":"Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung.","volume":"39","author":"S Gonzaga","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/375787a0","article-title":"Expression of a <italic>Delta<\/italic> homologue in prospective neurons in the chick.","volume":"375","author":"D Henrique","year":"1995","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1182\/blood-2006-05-021386","article-title":"Negative regulation of primitive hematopoiesis by the FGF signaling pathway.","volume":"108","author":"F Nakazawa","year":"2006","journal-title":"Blood"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/dvdy.21946","article-title":"Fgf signaling components are associated with muscles and tendons during limb development.","volume":"238","author":"S Eloy-Trinquet","year":"2009","journal-title":"Dev Dyn"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0017660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T11:27:40Z","timestamp":1637407660000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0017660"}},"subtitle":[],"editor":[{"given":"Bruce","family":"Riley","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,3,11]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0017660","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,11]]}}}