{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:24:16Z","timestamp":1777523056867,"version":"3.51.4"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T00:00:00Z","timestamp":1308614400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0020661","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T20:53:49Z","timestamp":1308689629000},"page":"e20661","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Excess Mortality Associated with Influenza Epidemics in Portugal, 1980 to 2004"],"prefix":"10.1371","volume":"6","author":[{"given":"Baltazar","family":"Nunes","sequence":"first","affiliation":[]},{"given":"Cecile","family":"Viboud","sequence":"additional","affiliation":[]},{"given":"Ausenda","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Corinne","family":"Ringholz","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Rebelo-de-Andrade","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Nogueira","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Miller","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/aje\/kwh227","article-title":"Influenza and the winter increase in mortality in the United States, 1959\u20131999.","volume":"160","author":"TA Reichert","year":"2004","journal-title":"American Journal of Epidemiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1086\/315320","article-title":"The impact of influenza epidemics on hospitalizations.","volume":"181","author":"L Simonsen","year":"2000","journal-title":"Journal of Infectious Diseases"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0950268898008966","article-title":"Estimating influenza-related hospitalization in the Netherlands.","volume":"121","author":"R Baltussen","year":"1998","journal-title":"Epidemiology and Infection"},{"key":"ref4","first-page":"75","article-title":"Impact of influenza vaccination on mortality by respiratory diseases among Brazilian elderly persons.","volume":"39","author":"P Francisco","year":"2005","journal-title":"Revista De Saude Publica"},{"key":"ref5","first-page":"355","article-title":"The impact of influenza vaccination in the reduction of morbidity and in the exacerbation in asthmatic patients.","volume":"1263","author":"S Oropesa","year":"2004","journal-title":"Options for the Control of Influenza V"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/archinte.165.3.265","article-title":"Impact of influenza vaccination on seasonal mortality in the US elderly population.","volume":"165","author":"L Simonsen","year":"2005","journal-title":"Archives of Internal Medicine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10654-005-1067-y","article-title":"A study of excess mortality during influenza epidemics in the Czech Republic, 1982\u20132000.","volume":"20","author":"J Kyncl","year":"2005","journal-title":"European Journal of Epidemiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.289.2.179","article-title":"Mortality associated with influenza and respiratory syncytial virus in the United States.","volume":"289","author":"WW Thompson","year":"2003","journal-title":"Jama-Journal of the American Medical Association"},{"key":"ref9","article-title":"Time series methods for obtaining excess mortality attributable to influenza epidemics.","author":"B Nunes","year":"2010","journal-title":"Statistical Methods in Medical Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1086\/507558","article-title":"Epidemiology of seasonal influenza: Use of surveillance data and statistical models to estimate the burden of disease.","volume":"194","author":"WW Thompson","year":"2006","journal-title":"Journal of Infectious Diseases"},{"key":"ref11","first-page":"302","article-title":"Influenza-attributable mortality among the elderly in Switzerland.","volume":"136","author":"MWG Brinkhof","year":"2006","journal-title":"Swiss Medical Weekly"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1017\/S0950268801005076","article-title":"Excess hospital admissions for pneumonia and influenza in persons\u219065 years associated with influenza epidemics in three English health districts: 1987\u201395.","volume":"126","author":"JS Nguyen-Van-Tam","year":"2001","journal-title":"Epidemiology and Infection"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"433-&","DOI":"10.1093\/oxfordjournals.aje.a120753","article-title":"Excess pneumonia-influenza mortality by age and sex in three major influenza A2 epidemics Unites States 1957\u201358 1960 and 1963.","volume":"86","author":"RE Serfling","year":"1967","journal-title":"American Journal of Epidemiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s100960000376","article-title":"Population-based study on incidence, risk factors, clinical complications and drug utilisation associated with influenza in the United Kingdom.","volume":"19","author":"CR Meier","year":"2000","journal-title":"European Journal of Clinical Microbiology & Infectious Diseases"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/jama.292.11.1333","article-title":"Influenza-associated hospitalizations in the United States.","volume":"292","author":"WW Thompson","year":"2004","journal-title":"Jama-Journal of the American Medical Association"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1017\/S0950268807007923","article-title":"Influenza-attributable deaths, Canada 1990\u20131999.","volume":"135","author":"DL Schanzer","year":"2007","journal-title":"Epidemiology and Infection"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/jmv.20135","article-title":"Excess hospital admissions for pneumonia, chronic obstructive pulmonary disease, and heart failure during influenza seasons in Hong Kong.","volume":"73","author":"FHY Yap","year":"2004","journal-title":"Journal of Medical Virology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1016\/j.vaccine.2006.06.052","article-title":"Influenza-related mortality in the Italian elderly: No decline associated with increasing vaccination coverage.","volume":"24","author":"C Rizzo","year":"2006","journal-title":"Vaccine"},{"key":"ref19","article-title":"Infoline. Instituto Nacional de Estat\u00edstica.","year":"2008"},{"key":"ref20","article-title":"Classifica\u00e7\u00e3o Internacional de Cuidados Prim\u00e1rios: Associa\u00e7\u00e3o Portuguesa de M\u00e9dicos de Cl\u00ednica Geral.","year":"1999"},{"key":"ref21","article-title":"M\u00e9dicos\u2013Sentinela. O que se fez em 2007. [Portuguese GP Network. What was done in 2007]","year":"2009"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.2105\/AJPH.72.11.1280","article-title":"Mortality during influenza epidemics in the United-States, 1967\u20131978.","volume":"72","author":"K Choi","year":"1982","journal-title":"American Journal of Public Health"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jech.49.4.419","article-title":"Influenza mortality among the elderly in France, 1980\u201390: how many deaths may have been avoided through vaccination?","volume":"49","author":"F Carrat","year":"1995","journal-title":"J Epidemiol Community Health"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/oxfordjournals.aje.a120753","article-title":"Excess pneumonia-influenza mortality by age and sex in three major influenza A2 epidemics, United States, 1957\u201358, 1960 and 1963.","volume":"86","author":"R Serfling","year":"1967","journal-title":"Am J Epidemiol"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v027.i03","article-title":"Automatic time series forecasting: The forecast package for R.","volume":"27","author":"RJ Hyndman","year":"2008","journal-title":"Journal of Statistical Software"},{"key":"ref26","article-title":"World Population Prospects: the 2008 revision","year":"2008"},{"key":"ref27","article-title":"The sum of log-normal probability distributions in scatter transmission systems.","volume":"8","author":"LF Fenton","year":"1960","journal-title":"IRE Trans Commun"},{"key":"ref28","article-title":"R: A Language and Environment for Statistical Computing","year":"2008"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-7622-2-6","article-title":"Influenza associated excess mortality in Germany, 1985\u20132001.","volume":"2","author":"P Zucs","year":"2005","journal-title":"Emerg Themes Epidemiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.2105\/AJPH.87.12.1944","article-title":"The impact of influenza epidemics on mortality: Introducing a severity index.","volume":"87","author":"L Simonsen","year":"1997","journal-title":"American Journal of Public Health"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1097\/CCM.0b013e318180b039","article-title":"Influenza.","volume":"36","author":"J Beigel","year":"2008","journal-title":"Crit Care Med"},{"key":"ref32","article-title":"De que mais se morre em Portugal [Main causes of death in Porugal]","author":"MJ Branco","year":"2003"},{"key":"ref33","year":"2006"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.med.51.1.407","article-title":"Global epidemiology of influenza: past and present.","volume":"51","author":"N Cox","year":"2000","journal-title":"Annu Rev Med"},{"key":"ref35","first-page":"4","article-title":"Influenza and cardiovascular disease: is there a causal relationship?","volume":"31","author":"M Madjid","year":"2004","journal-title":"Tex Heart Inst J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/ije\/22.2.334","article-title":"Impact of influenza on mortality in relation to age and underlying disease, 1967\u20131989.","volume":"22","author":"M Sprenger","year":"1993","journal-title":"Int J Epidemiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1183\/09031936.00034407","article-title":"Influenza- and respiratory syncytial virus-associated mortality and hospitalisations.","volume":"30","author":"A Jansen","year":"2007","journal-title":"European Respiratory Journal"},{"key":"ref38","article-title":"Vacina antigripal: cobertura da popula\u00e7\u00e3o portuguesa entre 1998\/1999 a 2007\/2008. [Influenza vaccine: coverage of the portugese population from 1998\/1999 to 2007\/2008]","author":"B Nunes","year":"2008"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/S0140-6736(01)06528-X","article-title":"Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study.","volume":"358","author":"MC Zambon","year":"2001","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1542\/peds.113.6.1758","article-title":"Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children.","volume":"113","author":"MK Iwane","year":"2004","journal-title":"Pediatrics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","article-title":"Bronchiolitis-associated hospitalizations among US children, 1980\u20131996.","volume":"282","author":"DK Shay","year":"1999","journal-title":"Jama-Journal of the American Medical Association"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.2807\/ese.14.18.19194-en","article-title":"Early estimates of the excess mortality associated with the 2008\u20139 influenza season in Portugal.","volume":"14","author":"P Nogueira","year":"2009","journal-title":"Euro Surveill"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.13.19529-en","article-title":"The new automated daily mortality surveillance system in Portugal.","volume":"15","author":"P Nogueira","year":"2010","journal-title":"Euro Surveill"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.05.19480-en","article-title":"Higher all-cause mortality in children during autumn 2009 compared with the three previous years: pooled results from eight European countries.","volume":"15","author":"A Mazick","year":"2010","journal-title":"Euro Surveill"},{"key":"ref45","first-page":"E070104.070101","article-title":"Monitoring excess mortality for public health action: potential for a future European network.","volume":"12","author":"A Mazick","year":"2007","journal-title":"Euro Surveill"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1017\/S0950268809002088","article-title":"A comparative study of the 1918\u20131920 influenza pandemic in Japan, USA and UK: mortality impact and implications for pandemic planning.","volume":"137","author":"SA Richard","year":"2009","journal-title":"Epidemiology and Infection"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0020661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T02:58:52Z","timestamp":1637895532000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0020661"}},"subtitle":[],"editor":[{"given":"Benjamin J.","family":"Cowling","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,6,21]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0020661","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,21]]}}}