{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:29:33Z","timestamp":1774506573663,"version":"3.50.1"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0024992","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T05:38:29Z","timestamp":1317188309000},"page":"e24992","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Intravascular Food Reward"],"prefix":"10.1371","volume":"6","author":[{"given":"Albino J.","family":"Oliveira-Maia","sequence":"first","affiliation":[]},{"given":"Craig D.","family":"Roberts","sequence":"additional","affiliation":[]},{"given":"Q. David","family":"Walker","sequence":"additional","affiliation":[]},{"given":"Brooke","family":"Luo","sequence":"additional","affiliation":[]},{"given":"Cynthia","family":"Kuhn","sequence":"additional","affiliation":[]},{"given":"Sidney A.","family":"Simon","sequence":"additional","affiliation":[]},{"given":"Miguel A. L.","family":"Nicolelis","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.physbeh.2004.04.031","article-title":"Oral and postoral determinants of food reward.","volume":"81","author":"A Sclafani","year":"2004","journal-title":"Physiol Behav"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.neuron.2008.01.032","article-title":"Food reward in the absence of taste receptor signaling.","volume":"57","author":"IE de Araujo","year":"2008","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.neuroimage.2007.10.061","article-title":"Sucrose activates human taste pathways differently from artificial sweetener.","volume":"39","author":"GK Frank","year":"2008","journal-title":"Neuroimage"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1460-9568.2008.06127.x","article-title":"Activation of dopamine D1-like receptors in nucleus accumbens is critical for the acquisition, but not the expression, of nutrient-conditioned flavor preferences in rats.","volume":"27","author":"K Touzani","year":"2008","journal-title":"Eur J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.physbeh.2009.12.012","article-title":"Post-oral infusion sites that support glucose-conditioned flavor preferences in rats.","volume":"99","author":"K Ackroff","year":"2010","journal-title":"Physiol Behav"},{"key":"ref6","first-page":"R192","article-title":"Hepatic portal glucose infusions decrease food intake and increase food preference.","volume":"251","author":"MG Tordoff","year":"1986","journal-title":"Am J Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/273461a0","article-title":"Compensatory and conditioned feeding responses to scheduled glucose infusions in the rat.","volume":"273","author":"P Mather","year":"1978","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1523\/JNEUROSCI.5749-09.2010","article-title":"Nutrient selection in the absence of taste receptor signaling.","volume":"30","author":"X Ren","year":"2010","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1037\/h0030813","article-title":"Intravascular taste in rats as demonstrated by conditioned aversion to sodium saccharin.","volume":"75","author":"RM Bradley","year":"1971","journal-title":"J Comp Physiol Psychol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1113\/expphysiol.1981.sp002588","article-title":"The influence of intravenous glucose on body temperature.","volume":"66","author":"JH Green","year":"1981","journal-title":"Q J Exp Physiol"},{"key":"ref11","first-page":"12","article-title":"Sweet taste signaling functions as a hypothalamic glucose sensor.","volume":"3","author":"X Ren","year":"2009","journal-title":"Front Integr Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1073\/pnas.0504657102","article-title":"Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats.","volume":"102","author":"ML Heien","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1039\/b307024g","article-title":"Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity.","volume":"128","author":"ML Heien","year":"2003","journal-title":"Analyst"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.1523\/JNEUROSCI.22-23-10477.2002","article-title":"Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics.","volume":"22","author":"DL Robinson","year":"2002","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1471-4159.2004.02559.x","article-title":"Nomifensine amplifies subsecond dopamine signals in the ventral striatum of freely-moving rats.","volume":"90","author":"DL Robinson","year":"2004","journal-title":"J Neurochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0031-9384(77)90342-0","article-title":"Blood glucose levels in portal and peripheral circulation and their relation to food intake in the rat.","volume":"19","author":"JH Strubbe","year":"1977","journal-title":"Physiol Behav"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/appe.2000.0370","article-title":"Post-ingestive positive controls of ingestive behavior.","volume":"36","author":"A Sclafani","year":"2001","journal-title":"Appetite"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1037\/h0060113","article-title":"Reward effects of food via stomach fistula compared with those of food via mouth.","volume":"45","author":"NE Miller","year":"1952","journal-title":"J Comp Physiol Psychol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1037\/h0040455","article-title":"Regulation of food intake in the absence of taste, smell, and other oropharyngeal sensations.","volume":"55","author":"AN Epstein","year":"1962","journal-title":"J Comp Physiol Psychol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1037\/h0028233","article-title":"Intragastric Reinforcement Effect.","volume":"69","author":"GL Holman","year":"1969","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/appe.1999.0251","article-title":"Effects of postprandial administration of insulin on food intake by the white rat and the mechanism of appetite for energy (first published in French in 1956).","volume":"33","author":"J Le Magnen","year":"1999","journal-title":"Appetite"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1126\/science.1257784","article-title":"Rapid discrimination of rewarding nutrient by the upper gastrointestinal tract.","volume":"192","author":"A Puerto","year":"1976","journal-title":"Science"},{"key":"ref23","first-page":"R672","article-title":"Robust conditioned flavor preference produced by intragastric starch infusions in rats.","volume":"255","author":"A Sclafani","year":"1988","journal-title":"Am J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3758\/BF03212315","article-title":"Preferences and Aversions for Stimuli Paired with Ethanol in Hungry Rats.","volume":"11","author":"JE Sherman","year":"1983","journal-title":"Animal Learning & Behavior"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn1344","article-title":"Molecular mechanisms of taste-recognition memory.","volume":"5","author":"F Bermudez-Rattoni","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1037\/h0061319","article-title":"Reinforcement of Position Preference by Automatic Intravenous Injections of Glucose.","volume":"47","author":"HW Coppock","year":"1954","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1037\/h0047138","article-title":"Effects of Intravenous Glucose Injections on Learning, General Activity, and Hunger Drive.","volume":"49","author":"RM Chambers","year":"1956","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/appe.1997.0101","article-title":"Role of gustatory and postingestive actions of sweeteners in the generation of positive affect as evaluated by place preference conditioning.","volume":"29","author":"A Agmo","year":"1997","journal-title":"Appetite"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0091-3057(85)90127-3","article-title":"The conditioned place preference is affected by two independent reinforcement processes.","volume":"23","author":"NM White","year":"1985","journal-title":"Pharmacol Biochem Behav"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/appe.1999.0252","article-title":"Effects of postprandial administration of glucose on the acquisition of appetites (first published in French in 1959).","volume":"33","author":"J Le Magnen","year":"1999","journal-title":"Appetite"},{"key":"ref31","first-page":"R1409","article-title":"Elevations of plasma glucose do not support taste-to-postingestive consequence learning.","volume":"261","author":"SE Gowans","year":"1991","journal-title":"Am J Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0031-9384(71)90165-X","article-title":"Flavor preference: effects of ingestion-contingent intravenous saline or glucose.","volume":"6","author":"SH Revusky","year":"1971","journal-title":"Physiol Behav"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0031-9384(82)90010-5","article-title":"Meal related effects of IV glucose, glucagon and insulin on blood glucose level: role in glucoregulation exhibited by self-injecting rats.","volume":"29","author":"J Jouhaneau","year":"1982","journal-title":"Physiol Behav"},{"key":"ref34","first-page":"R1136","article-title":"Effect of hepatic glucose infusion on glucose intake and licking microstructure in deprived and nondeprived rats.","volume":"277","author":"JP Baird","year":"1999","journal-title":"Am J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1098\/rstb.2006.1854","article-title":"Role of brain dopamine in food reward and reinforcement.","volume":"361","author":"RA Wise","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0006-8993(01)02451-9","article-title":"Accumbens dopamine mechanisms in sucrose intake.","volume":"904","author":"A Hajnal","year":"2001","journal-title":"Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/nn.2219","article-title":"Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.","volume":"11","author":"MF Roitman","year":"2008","journal-title":"Nat Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1152\/ajpregu.00282.2003","article-title":"Oral sucrose stimulation increases accumbens dopamine in the rat.","volume":"286","author":"A Hajnal","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.biopsych.2011.02.014","article-title":"Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state.","volume":"69","author":"RA Wheeler","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1172\/JCI29867","article-title":"Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.","volume":"116","author":"A Abizaid","year":"2006","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.physbeh.2006.03.027","article-title":"Alterations in blood glucose levels under hyperinsulinemia affect accumbens dopamine.","volume":"88","author":"NT Bello","year":"2006","journal-title":"Physiol Behav"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/syn.20418","article-title":"Effects of intravenous glucose on dopaminergic function in the human brain in vivo.","volume":"61","author":"LT Haltia","year":"2007","journal-title":"Synapse"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0006-8993(00)02573-7","article-title":"Glucose-regulated dopamine release from substantia nigra neurons.","volume":"874","author":"BE Levin","year":"2000","journal-title":"Brain Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1111\/j.1460-9568.2007.05772.x","article-title":"Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens.","volume":"26","author":"RM Wightman","year":"2007","journal-title":"European Journal of Neuroscience"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/syn.20343","article-title":"Pharmacologically induced, subsecond dopamine transients in the caudate-putamen of the anesthetized rat.","volume":"61","author":"BJ Venton","year":"2007","journal-title":"Synapse"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.npp.1300619","article-title":"Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration.","volume":"30","author":"GD Stuber","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1523\/JNEUROSCI.0529-04.2004","article-title":"Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats.","volume":"24","author":"JF Cheer","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/nn.2219","article-title":"Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.","volume":"11","author":"MF Roitman","year":"2008","journal-title":"Nature Neuroscience"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1111\/j.1460-9568.2009.07027.x","article-title":"Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats.","volume":"30","author":"BJ Aragona","year":"2009","journal-title":"Eur J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1523\/JNEUROSCI.22-11-04709.2002","article-title":"Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex.","volume":"22","author":"V Bassareo","year":"2002","journal-title":"J Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8821","DOI":"10.1523\/JNEUROSCI.2225-08.2008","article-title":"Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events.","volume":"28","author":"BJ Aragona","year":"2008","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"15075","DOI":"10.1073\/pnas.0706678104","article-title":"T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.","volume":"104","author":"RF Margolskee","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"R1643","DOI":"10.1152\/ajpregu.00495.2010","article-title":"Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice.","volume":"299","author":"A Sclafani","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1172\/JCI115100","article-title":"Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration.","volume":"87","author":"SR Myers","year":"1991","journal-title":"J Clin Invest"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI112847","article-title":"Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog.","volume":"79","author":"BA Adkins","year":"1987","journal-title":"J Clin Invest"},{"key":"ref56","first-page":"R112","article-title":"Hepatic phosphate trapping, decreased ATP, and increased feeding after 2,5-anhydro-D-mannitol.","volume":"266","author":"NE Rawson","year":"1994","journal-title":"Am J Physiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1982.sp014415","article-title":"Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig.","volume":"332","author":"A Niijima","year":"1982","journal-title":"J Physiol"},{"key":"ref58","first-page":"R1059","article-title":"Capsaicin attenuates feeding suppression but not reinforcement by intestinal nutrients.","volume":"270","author":"F Lucas","year":"1996","journal-title":"Am J Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0031-9384(02)00968-X","article-title":"Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients.","volume":"78","author":"A Sclafani","year":"2003","journal-title":"Physiol Behav"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0031-9384(96)80018-7","article-title":"Abdominal vagotomy does not block carbohydrate-conditioned flavor preferences in rats.","volume":"60","author":"A Sclafani","year":"1996","journal-title":"Physiol Behav"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"i182","DOI":"10.1093\/chemse\/bjh174","article-title":"Peripheral signals in the control of feeding behavior.","volume":"30","author":"MI Friedman","year":"2005","journal-title":"Chem Senses"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2008.10.011","article-title":"Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.","volume":"8","author":"KG Kumar","year":"2008","journal-title":"Cell Metab"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3945\/ajcn.2009.29007","article-title":"Hedonic hunger is increased in severely obese patients and is reduced after gastric bypass surgery.","volume":"92","author":"B Schultes","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/MOG.0b013e328333e94a","article-title":"Bariatric surgery and taste: novel mechanisms of weight loss.","volume":"26","author":"AD Miras","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1073\/pnas.0810184106","article-title":"Nicotine activates TRPM5-dependent and independent taste pathways.","volume":"106","author":"AJ Oliveira-Maia","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1213\/01.ane.0000297299.91527.74","article-title":"Anesthesia&apos;s effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats.","volume":"106","author":"CJ Zuurbier","year":"2008","journal-title":"Anesth Analg"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1021\/ac960347d","article-title":"Microelectrodes for the measurement of catecholamines in biological systems.","volume":"68","author":"PS Cahill","year":"1996","journal-title":"Anal Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1523\/JNEUROSCI.5562-08.2009","article-title":"Synaptic overflow of dopamine in the nucleus accumbens arises from neuronal activity in the ventral tegmental area.","volume":"29","author":"LA Sombers","year":"2009","journal-title":"J Neurosci"},{"key":"ref69","first-page":"65","article-title":"A simple sequential rejective multiple test procedure.","volume":"6","author":"S Holm","year":"1979","journal-title":"Scand J Statistics"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1039\/b307024g","article-title":"Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity.","volume":"128","author":"MLAV Heien","year":"2003","journal-title":"Analyst"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1073\/pnas.0504657102","article-title":"Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats.","volume":"102","author":"ML Heien","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0024992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:45:21Z","timestamp":1589042721000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0024992"}},"subtitle":[],"editor":[{"given":"Xiaoxi","family":"Zhuang","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,9,27]]},"references-count":71,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0024992","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,27]]}}}