{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:26:50Z","timestamp":1773221210037,"version":"3.50.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T00:00:00Z","timestamp":1324944000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0029583","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T21:54:31Z","timestamp":1325022871000},"page":"e29583","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat"],"prefix":"10.1371","volume":"6","author":[{"given":"Jo\u00e3o","family":"Martins","sequence":"first","affiliation":[]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Batista","sequence":"additional","affiliation":[]},{"given":"B\u00e1rbara","family":"Oliveiros","sequence":"additional","affiliation":[]},{"given":"Ana Raquel","family":"Santiago","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Galv\u00e3o","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udia","family":"Cavadas","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio F.","family":"Ambr\u00f3sio","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,12,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12035-009-8064-1","article-title":"Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview.","volume":"39","author":"JP Capela","year":"2009","journal-title":"Mol Neurobiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.55.3.3","article-title":"The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").","volume":"55","author":"AR Green","year":"2003","journal-title":"Pharmacol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2174\/138920110791591535","article-title":"Mechanisms underlying the hepatotoxic effects of ecstasy.","volume":"11","author":"M Carvalho","year":"2010","journal-title":"Curr Pharm Biotechnol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0140-6736(92)91469-O","article-title":"Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy").","volume":"340","author":"JA Henry","year":"1992","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/138920110791591526","article-title":"The cardiovascular and cardiac actions of ecstasy and its metabolites.","volume":"11","author":"SK Shenouda","year":"2010","journal-title":"Curr Pharm Biotechnol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.3310\/hta13060","article-title":"The harmful health effects of recreational ecstasy: a systematic review of observational evidence.","volume":"13","author":"G Rogers","year":"2009","journal-title":"Health Technol Assess"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00213-006-0322-6","article-title":"3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings.","volume":"189","author":"MH Baumann","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1471-4159.1996.66010243.x","article-title":"Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions.","volume":"66","author":"GA Gudelsky","year":"1996","journal-title":"J Neurochem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2005.07.002","article-title":"Effect of 3,4-methylendioxymethamphetamine (MDMA, "ecstasy") on dopamine transmission in the nucleus accumbens shell and core.","volume":"1055","author":"C Cadoni","year":"2005","journal-title":"Brain Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1097\/00001756-199911260-00039","article-title":"Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.","volume":"10","author":"N Aguirre","year":"1999","journal-title":"Neuroreport"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/sj.bjp.0706783","article-title":"MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature.","volume":"148","author":"E O'Shea","year":"2006","journal-title":"Br J Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/sj.npp.1300808","article-title":"Pharmacokinetic profile of single and repeated oral doses of MDMA in squirrel monkeys: relationship to lasting effects on brain serotonin neurons.","volume":"31","author":"A Mechan","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/09595230600657758","article-title":"Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues.","volume":"25","author":"M Lyvers","year":"2006","journal-title":"Drug Alcohol Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1196\/annals.1369.037","article-title":"MDMA induces caspase-3 activation in the limbic system but not in striatum.","volume":"1074","author":"I Tamburini","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.taap.2003.12.017","article-title":"Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells.","volume":"196","author":"A Jimenez","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.neuro.2007.04.005","article-title":"Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons.","volume":"28","author":"JP Capela","year":"2007","journal-title":"Neurotoxicology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1192\/bjp.159.5.713","article-title":"\u2018Ecstasy\u2019 psychosis and flashbacks.","volume":"159","author":"FJ Creighton","year":"1991","journal-title":"Br J Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00213-004-1789-7","article-title":"Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics.","volume":"173","author":"M Farre","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1440-1614.2002.t01-1-01016.x","article-title":"Persisting continuous visual perception disorder in a chronic MDMA (\u2018ecstasy\u2019) user.","volume":"36","author":"T Passie","year":"2002","journal-title":"Aust N Z J Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jat\/26.2.113","article-title":"Distribution study of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine in a fatal overdose.","volume":"26","author":"EA De Letter","year":"2002","journal-title":"J Anal Toxicol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/138920110791591553","article-title":"Post-mortem (re)distribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): human and animal data.","volume":"11","author":"EA De Letter","year":"2010","journal-title":"Curr Pharm Biotechnol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.forsciint.2003.12.015","article-title":"Interpretation of a 3,4-methylenedioxymethamphetamine (MDMA) blood level: discussion by means of a distribution study in two fatalities.","volume":"141","author":"EA De Letter","year":"2004","journal-title":"Forensic Sci Int"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00006982-200110000-00030","article-title":"Central serous chorioretinopathy in a patient using methylenedioxymethamphetamine (MDMA) or "ecstasy".","volume":"21","author":"L Hassan","year":"2001","journal-title":"Retina"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0002-9394(03)00076-X","article-title":"Central serous chorioretinopathy associated with administration of sympathomimetic agents.","volume":"136","author":"JC Michael","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s11064-007-9285-1","article-title":"Oxidative stress in rat retina and hippocampus after chronic MDMA (\u2018ecstasy\u2019) administration.","volume":"32","author":"M Miranda","year":"2007","journal-title":"Neurochem Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuroscience.2007.12.027","article-title":"Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy.","volume":"152","author":"AR Alvaro","year":"2008","journal-title":"Neuroscience"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02582979","article-title":"Electroretinographic evaluation in adult diabetics.","volume":"94","author":"SH Kim","year":"1997","journal-title":"Doc Ophthalmol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1002691917441","article-title":"The a- and b-wave latencies as a prognostic indicator of neovascularisation in central retinal vein occlusion.","volume":"99","author":"M Moschos","year":"1999","journal-title":"Doc Ophthalmol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/bjo.85.4.403","article-title":"The b-wave of the dark adapted flash electroretinogram in patients with advanced asymmetrical glaucoma and normal subjects.","volume":"85","author":"IM Velten","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"ref30","first-page":"3754","article-title":"Effect of body temperature on electroretinogram of mice.","volume":"43","author":"A Mizota","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3109\/02656738909140492","article-title":"Effect of elevation of body temperature on the electroretinogram of the rat.","volume":"5","author":"B Ahmed","year":"1989","journal-title":"Int J Hyperthermia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1113\/jphysiol.2005.090662","article-title":"Light responses and light adaptation in rat retinal rods at different temperatures.","volume":"567","author":"S Nymark","year":"2005","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1978.sp012372","article-title":"Changes in pigeon cone photocurrent caused by reduction in extracellular calcium activity.","volume":"280","author":"GB Arden","year":"1978","journal-title":"J Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1113\/jphysiol.2002.030304","article-title":"Rod and cone contributions to the a-wave of the electroretinogram of the macaque.","volume":"547","author":"JG Robson","year":"2003","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0006-8993(02)03478-9","article-title":"MDMA alters the response of the circadian clock to a photic and non-photic stimulus.","volume":"956","author":"S Colbron","year":"2002","journal-title":"Brain Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.07-02-00319.1987","article-title":"An indoleamine system in photoreceptor cell terminals of the Long-Evans rat retina.","volume":"7","author":"DA Redburn","year":"1987","journal-title":"J Neurosci"},{"key":"ref37","first-page":"1040","article-title":"Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR.","volume":"12","author":"NA Sharif","year":"2006","journal-title":"Mol Vis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00247483","article-title":"Dopamine and serotonin in cat retina: electroretinography and histology.","volume":"71","author":"W Skrandies","year":"1988","journal-title":"Exp Brain Res"},{"key":"ref39","first-page":"1109","article-title":"Destruction of the indoleamine-accumulating amacrine cells alters the ERG of rabbits.","volume":"26","author":"K Nakatsuka","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1523\/JNEUROSCI.18-16-06395.1998","article-title":"Synchronization of visual responses between the cortex, lateral geniculate nucleus, and retina in the anesthetized cat.","volume":"18","author":"M Castelo-Branco","year":"1998","journal-title":"J Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0042-6989(99)00042-5","article-title":"Synchronous oscillations in the cat retina.","volume":"39","author":"S Neuenschwander","year":"1999","journal-title":"Vision Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00213-004-1787-9","article-title":"Effects of a single dose of 3,4-methylenedioxymethamphetamine on circadian patterns, motor activity and sleep in drug-naive rats and rats previously exposed to MDMA.","volume":"173","author":"B Balogh","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s002130000578","article-title":"Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine.","volume":"153","author":"TL Wallace","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1080\/00207450601050147","article-title":"Functional consequences of retinopetal fibers originating in the dorsal raphe nucleus.","volume":"118","author":"ML Lorincz","year":"2008","journal-title":"Int J Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/0748730402238235","article-title":"Circadian rhythm of iguana electroretinogram: the role of dopamine and melatonin.","volume":"17","author":"M Miranda-Anaya","year":"2002","journal-title":"J Biol Rhythms"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cbpa.2008.01.040","article-title":"Melatonin modulates the ERG circadian rhythm in crayfish.","volume":"149","author":"H Solis-Chagoyan","year":"2008","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:DOOP.0000019487.88486.0a","article-title":"Dopamine and retinal function.","volume":"108","author":"P Witkovsky","year":"2004","journal-title":"Doc Ophthalmol"},{"key":"ref48","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2010.08.014","article-title":"Nitric oxide amplifies the rat electroretinogram.","author":"A Vielma","year":"2010"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.brainresbull.2007.04.002","article-title":"Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ.","volume":"73","author":"RJ Fawcett","year":"2007","journal-title":"Brain Res Bull"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1167\/iovs.02-0471","article-title":"Retinal neuronal death induced by intraocular administration of a nitric oxide donor and its rescue by neurotrophic factors in rats.","volume":"44","author":"K Takahata","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-8993(98)00313-8","article-title":"Role of brain nitric oxide in (+\/-)3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats.","volume":"795","author":"Y Zheng","year":"1998","journal-title":"Brain Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1124\/jpet.104.074849","article-title":"Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.","volume":"312","author":"AS Darvesh","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0006-2952(99)00104-5","article-title":"Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide.","volume":"58","author":"C Montoliu","year":"1999","journal-title":"Biochem Pharmacol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0029583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T11:50:14Z","timestamp":1593431414000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0029583"}},"subtitle":[],"editor":[{"given":"Alain","family":"Ch\u00e9dotal","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,12,27]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0029583","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,27]]}}}