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Accessed 2012 September 5."},{"key":"ref6","first-page":"588","article-title":"Bacteremic pneumococcal pneumonia in 45 immunocompromised hospitalized adults","volume":"132","author":"ML Rioseco","year":"2004","journal-title":"Rev Med Chil"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s10067-005-0008-1","article-title":"Lethal acute respiratory distress syndrome during anti-TNF-alpha therapy for rheumatoid arthritis","volume":"25","author":"C Zimmer","year":"2006","journal-title":"Clin Rheumatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0194-5998(96)70243-7","article-title":"Cost-effectiveness considerations in otitis media treatment","volume":"114","author":"GA Gates","year":"1996","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/INF.0b013e318154b25d","article-title":"Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era","volume":"26","author":"ME Pichichero","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijporl.2009.09.006","article-title":"Epidemiology, natural history, and risk factors: Panel report from the Ninth International Research Conference on Otitis Media","volume":"74","author":"KA Daly","year":"2009","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Mitchell TJ (2004) Pneumolysin and Other Virulence Proteins. 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In: Snow JB, Wackym PA, editors. Otorhinolaryngology Head and Neck Surgery, 17th Edition. 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