{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:43:45Z","timestamp":1769813025430,"version":"3.49.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0048783","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T22:54:23Z","timestamp":1352415263000},"page":"e48783","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson\u2019s Disease Dementia"],"prefix":"10.1371","volume":"7","author":[{"given":"Sarah","family":"Jesse","sequence":"first","affiliation":[]},{"given":"Stefan","family":"Lehnert","sequence":"additional","affiliation":[]},{"given":"Olaf","family":"Jahn","sequence":"additional","affiliation":[]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[]},{"given":"Petra","family":"Steinacker","sequence":"additional","affiliation":[]},{"given":"Saskia","family":"Tawfik","sequence":"additional","affiliation":[]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[]},{"given":"Christine A. F.","family":"von Arnim","sequence":"additional","affiliation":[]},{"given":"Manuela","family":"Neumann","sequence":"additional","affiliation":[]},{"given":"Hans A.","family":"Kretzschmar","sequence":"additional","affiliation":[]},{"given":"Hasan","family":"Kulaksiz","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Lenter","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Boris","family":"Ferger","sequence":"additional","affiliation":[]},{"given":"Bastian","family":"Hengerer","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1586\/14737175.7.12.1693","article-title":"Molecular pathways and genetic aspects of Parkinson&apos;s disease: from bench to bedside","volume":"7","author":"M Di Napoli","year":"2007","journal-title":"Expert Rev Neurother"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2165\/00002512-200623100-00004","article-title":"Management of Parkinson&apos;s disease dementia:practical considerations","volume":"23","author":"A Rongve","year":"2006","journal-title":"Drugs Aging"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/archneur.60.3.387","article-title":"Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study","volume":"60","author":"D Aarsland","year":"2003","journal-title":"Arch Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/mds.24893","article-title":"Diagnostic criteria for mild cognitive impairment in Parkinson&apos;s disease: Movement Disorder Society Task Force guidelines","volume":"27","author":"I Litvan","year":"2012","journal-title":"Mov Disord"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z","article-title":"Mental symptoms in Parkinson&apos;s disease are important contributors to caregiver distress","volume":"14","author":"D Aarsland","year":"1999","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/mds.21677","article-title":"Cognitive dysfunction and dementia in Parkinson disease","volume":"22","author":"N Caballol","year":"2007","journal-title":"Mov Disord"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1001\/archneur.1997.00550150024011","article-title":"Mortality from Parkinson disease","volume":"54","author":"ED Louis","year":"1997","journal-title":"Arch Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.maturitas.2008.12.022","article-title":"When should drug treatment be started for people with dementia?","volume":"62","author":"B Singh","year":"2009","journal-title":"Maturitas"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/sj.mp.4000458","article-title":"Lewy body diseases and multiple system atrophy as alpha-synucleinopathies","volume":"3","author":"M Goedert","year":"1998","journal-title":"Mol Psychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbadis.2008.07.006","article-title":"A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders","volume":"1792","author":"KA Jellinger","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00401-008-0347-5","article-title":"Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease","volume":"115","author":"KA Jellinger","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.mad.2005.09.014","article-title":"Pathophysiology of synuclein aggregation in Lewy body disease","volume":"127","author":"EB Mukaetova-Ladinska","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/mds.20535","article-title":"How to diagnose dementia with Lewy bodies: state of the art","volume":"20","author":"F Geser","year":"2005","journal-title":"Mov Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/gps.2496","article-title":"The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson\u2019s disease dementia","volume":"26","author":"M Andersson","year":"2011","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.4564-06.2007","article-title":"Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies","volume":"27","author":"ML Kramer","year":"2007","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1074\/jbc.M310994200","article-title":"Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective","volume":"279","author":"M Tanaka","year":"2004","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"II3","DOI":"10.1007\/PL00007758","article-title":"Pathoanatomy of Parkinson&apos;s disease","volume":"247","author":"H Braak","year":"2000","journal-title":"J Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s004010051150","article-title":"Parkinson&apos;s disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system","volume":"99","author":"H Braak","year":"2000","journal-title":"Acta Neuropathol"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Wolters ECh, Braak H (2006) Parkinson&apos;s disease: premotor clinico-pathological correlations. J Neural Transm Suppl: 309\u2013319.","DOI":"10.1007\/978-3-211-45295-0_47"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1523\/JNEUROSCI.2617-07.2007","article-title":"Different species of alpha-synuclein oligomers induce calcium influx and seeding","volume":"27","author":"KM Danzer","year":"2007","journal-title":"J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.neuroscience.2008.02.049","article-title":"Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins","volume":"154","author":"C Schnack","year":"2008","journal-title":"Neuroscience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1755-5949.2008.00064.x","article-title":"Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a review","volume":"(2)","author":"S Jesse","year":"2009","journal-title":"CNS Neurosci Ther 15"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.biopsych.2008.02.016","article-title":"Cerebrospinal fluid biomarkers in Parkinson&apos;s disease with dementia and dementia with Lewy bodies","volume":"64","author":"L Parnetti","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1474-4422(11)70014-X","article-title":"\u03b1-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study","volume":"10","author":"B Mollenhauer","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.expneurol.2012.01.024","article-title":"iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson&apos;s disease dementia","volume":"234","author":"S Lehnert","year":"2012","journal-title":"Exp Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1002\/pmic.200800375","article-title":"Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease","volume":"8","author":"P Brechlin","year":"2008","journal-title":"Proteomics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/PL00007725","article-title":"Cognitive deficits in Parkinson&apos;s disease","volume":"244","author":"B Dubois","year":"1997","journal-title":"J Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00702-010-0370-2","article-title":"Sharpening the boundaries of Parkinson-associated dementia: recommendation for a neuropsychological diagnostic procedure","volume":"117","author":"M Bothe","year":"2010","journal-title":"Journal of Neural Transmission"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1742-1241.2008.01869.x","article-title":"Diagnosis and management of Parkinson&apos;s disease dementia","volume":"62","author":"W Poewe","year":"2008","journal-title":"Int J Clin Pract"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1212\/01.wnl.0000271077.82508.a0","article-title":"Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies","volume":"69","author":"HM Nielsen","year":"2007","journal-title":"Neurology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"15957","DOI":"10.1016\/S0021-9258(17)33954-6","article-title":"The serpin superfamily of proteinase inhibitors: structure, function, and regulation","volume":"269","author":"J Potempa","year":"1994","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BST0330321","article-title":"Molecular mousetraps and the serpinopathies","volume":"33","author":"DA Lomas","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1432-1033.1982.tb07054.x","article-title":"Biosynthesis and secretion of alpha 1-antitrypsin in primary cultures of rat hepatocytes. Characterization of differently glycosylated intracellular and extracellular forms","volume":"129","author":"V Gross","year":"1982","journal-title":"Eur J Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrn1349","article-title":"Glycans and neural cell interactions","volume":"5","author":"R Kleene","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-5793(02)03487-7","article-title":"Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta","volume":"530","author":"F Liu","year":"2002","journal-title":"FEBS Lett"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-5793(02)02228-7","article-title":"Role of glycosylation in hyperphosphorylation of tau in Alzheimer&apos;s disease","volume":"512","author":"F Liu","year":"2002","journal-title":"FEBS Lett"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/mas.20221","article-title":"Glycoproteomics in neurodegenerative diseases","volume":"29","author":"H Hwang","year":"2009","journal-title":"Mass Spectrom Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.1060627","article-title":"Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson&apos;s disease","volume":"293","author":"H Shimura","year":"2001","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"121ra20","DOI":"10.1126\/scitranslmed.3002566","article-title":"Phosphorylated a-Synuclein in Parkinson&apos;s Disease","volume":"4","author":"Y Wang","year":"2012","journal-title":"Sci Transl Med"},{"key":"ref40","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"CA Ross","year":"2004","journal-title":"Nat Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-5793(98)01146-6","article-title":"Synthetic filaments assembled from C-terminally truncated alpha-synuclein","volume":"436","author":"RA Crowther","year":"1998","journal-title":"FEBS Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2119\/2007-00100.Irvine","article-title":"Protein aggregation in the brain: the molecular basis for Alzheimer&apos;s and Parkinson&apos;s diseases","volume":"14","author":"GB Irvine","year":"2008","journal-title":"Mol Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson&apos;s disease and dementia with lewy bodies","volume":"95","author":"MG Spillantini","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0022-2836(02)01088-4","article-title":"Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization","volume":"324","author":"GL Devlin","year":"2002","journal-title":"J Mol Biol"},{"key":"ref45","first-page":"160","article-title":"Heterozygous alpha-I antitrypsin deficiency as a co-factor in the development of chronic liver disease: a review","volume":"65","author":"KF Kok","year":"2007","journal-title":"Neth J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/nature07394","article-title":"Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization","volume":"455","author":"M Yamasaki","year":"2008","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/humu.10100","article-title":"Familial conformational diseases and dementias","volume":"20","author":"DC Crowther","year":"2002","journal-title":"Hum Mutat"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/S0002-9440(10)65510-1","article-title":"Familial encephalopathy with neuroserpin inclusion bodies","volume":"155","author":"RL Davis","year":"1999","journal-title":"Am J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease:report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"G McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1001\/archneur.58.11.1803","article-title":"Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick&apos;s Disease","volume":"58","author":"GM McKhann","year":"2001","journal-title":"Arch Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria","volume":"51","author":"D Neary","year":"1998","journal-title":"Neurology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/pmic.200390006","article-title":"A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard","volume":"3","author":"A Alban","year":"2003","journal-title":"Proteomics"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/elps.200305400","article-title":"A versatile electrophoresis system for the analysis of high- and low-molecular-weight proteins","volume":"24","author":"C Tastet","year":"2003","journal-title":"Electrophoresis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00216-006-0592-1","article-title":"Technical innovations for the automated identification of gel-separated proteins by MALDI-TOF mass spectrometry","volume":"386","author":"O Jahn","year":"2006","journal-title":"Anal Bioanal Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e10079","DOI":"10.1371\/journal.pone.0010079","article-title":"A proteomic approach for the diagnosis of bacterial meningitis","volume":"5","author":"S Jesse","year":"2010","journal-title":"PLoS One"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1523\/JNEUROSCI.1254-07.2007","article-title":"Proteolipid protein is required for transport of sirtuin 2 into CNS myelin","volume":"27","author":"H Werner","year":"2007","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1105\/tpc.107.050989","article-title":"Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms","volume":"19","author":"S Reumann","year":"2007","journal-title":"Plant Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1136\/bmj.308.6943.1552","article-title":"Diagnostic tests. 1: Sensitivity and specificity","volume":"308","author":"DG Altman","year":"1994","journal-title":"BMJ"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0048783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T02:01:21Z","timestamp":1643594481000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0048783"}},"subtitle":[],"editor":[{"given":"Owen A.","family":"Ross","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,11,8]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0048783","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,8]]}}}