{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T13:08:36Z","timestamp":1720357716080},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0050123","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T22:59:46Z","timestamp":1353538786000},"page":"e50123","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Proteome Response to Amyloid Protein Expression In Vivo"],"prefix":"10.1371","volume":"7","author":[{"given":"Ricardo A.","family":"Gomes","sequence":"first","affiliation":[]},{"given":"Catarina","family":"Franco","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo","family":"Da Costa","sequence":"additional","affiliation":[]},{"given":"S\u00e9bastien","family":"Planchon","sequence":"additional","affiliation":[]},{"given":"Jenny","family":"Renaut","sequence":"additional","affiliation":[]},{"given":"Raquel M.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Marta Sousa","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Ana Varela","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Ana Ponces","family":"Freire","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Cordeiro","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02778007","article-title":"Unifying features of systemic and cerebral amyloidosis","volume":"8","author":"J Ghiso","year":"1994","journal-title":"Mol Neurobiol"},{"key":"ref2","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"CA Ross","year":"2004","journal-title":"Nat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/BJ20040833","article-title":"Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy","volume":"385","author":"R Gomes","year":"2005","journal-title":"Biochem J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cell.2006.04.014","article-title":"Molecular chaperones and protein quality control","volume":"125","author":"B Bukau","year":"2006","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrn1587","article-title":"Modulation of neurodegeneration by molecular chaperones","volume":"6","author":"PJ Muchowski","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.spen.2006.11.005","article-title":"Mechanisms of disease II: cellular protein quality control","volume":"14","author":"TF Outeiro","year":"2007","journal-title":"Semin Pediatr Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.1143780","article-title":"Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson&apos;s disease","volume":"317","author":"TF Outeiro","year":"2007","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1742-4658.2006.05181.x","article-title":"Protein-misfolding diseases and chaperone-based therapeutic approaches","volume":"273","author":"TK Chaudhuri","year":"2006","journal-title":"FEBS J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/13506120308998998","article-title":"Tabulation of human transthyretin (TTR) variants, 2003","volume":"10","author":"LH Connors","year":"2003","journal-title":"Amyloid"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/humu.1132","article-title":"Transthyretin mutations in hyperthyroxinemia and amyloid diseases","volume":"17","author":"MJ Saraiva","year":"2001","journal-title":"Hum Mutat"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1471-2350-11-130","article-title":"A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers","volume":"11","author":"M Olsson","year":"2010","journal-title":"BMC Med Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2169\/internalmedicine.32.920","article-title":"Transthyretin and familial amyloidotic polyneuropathy","volume":"32","author":"Y Ando","year":"1993","journal-title":"Intern Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1073\/pnas.87.7.2843","article-title":"Fibril in senile systemic amyloidosis is derived from normal transthyretin","volume":"87","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2169\/internalmedicine.34.703","article-title":"Anticipation of age-of-onset in familial amyloidotic polyneuropathy and its pathogenesis","volume":"34","author":"S Araki","year":"1995","journal-title":"Intern Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e24850","DOI":"10.1371\/journal.pone.0024850","article-title":"Beyond genetic factors in familial amyloidotic polyneuropathy: protein glycation and the loss of fibrinogen&apos;s chaperone activity","volume":"6","author":"G da Costa","year":"2011","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nature07341","article-title":"Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast","volume":"455","author":"LM de Godoy","year":"2008","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Nagaraj N, Kulak NA, Cox J, Neuhaus N, Mayr K, <etal>et al<\/etal>.. (2011) Systems-wide perturbation analysis with near complete coverage of the yeast proteome by single-shot UHPLC runs on a bench-top Orbitrap. Mol Cell Proteomics.","DOI":"10.1074\/mcp.M111.013722"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1073\/pnas.97.4.1589","article-title":"Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins","volume":"97","author":"S Krobitsch","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.1090439","article-title":"Yeast cells provide insight into alpha-synuclein biology and pathobiology","volume":"302","author":"TF Outeiro","year":"2003","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1073\/pnas.91.21.9906","article-title":"Characterization of three yeast copper-zinc superoxide dismutase mutants analogous to those coded for in familial amyotrophic lateral sclerosis","volume":"91","author":"CR Nishida","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00220559","article-title":"Transthyretin Pro55, a variant associated with early-onset, aggressive, diffuse amyloidosis with cardiac and neurologic involvement","volume":"89","author":"DR Jacobson","year":"1992","journal-title":"Hum Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2164-11-32","article-title":"Integrative analysis of the heat shock response in Aspergillus fumigatus","volume":"11","author":"D Albrecht","year":"2010","journal-title":"BMC Genomics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.1063522","article-title":"Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct","volume":"294","author":"KA Conway","year":"2001","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biocel.2004.05.016","article-title":"Effect of oxidative stress on in vivo ADP-ribosylation of eukaryotic elongation factor 2","volume":"37","author":"M Bektas","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"21209","DOI":"10.1074\/jbc.R110.113795","article-title":"eEF1A: thinking outside the ribosome","volume":"285","author":"MK Mateyak","year":"2010","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1128\/MCB.25.1.403-413.2005","article-title":"Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A","volume":"25","author":"SM Chuang","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.1073\/pnas.91.16.7648","article-title":"Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu","volume":"91","author":"H Gonen","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"18545","DOI":"10.1074\/jbc.M201022200","article-title":"Interaction of the eukaryotic elongation factor 1A with newly synthesized polypeptides","volume":"277","author":"Y Hotokezaka","year":"2002","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/PL00012492","article-title":"sHsps and their role in the chaperone network","volume":"59","author":"M Haslbeck","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e8626","DOI":"10.1371\/journal.pone.0008626","article-title":"Control of Alzheimer&apos;s amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila","volume":"5","author":"R Sanokawa-Akakura","year":"2010","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1598","DOI":"10.1371\/journal.pone.0001598","article-title":"Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis","volume":"3","author":"S Bandhakavi","year":"2008","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer&apos;s disease","volume":"14","author":"H Du","year":"2008","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1074\/jbc.M413209200","article-title":"Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae","volume":"280","author":"JT Hannich","year":"2005","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neurobiolaging.2008.04.001","article-title":"The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems","volume":"31","author":"SD Santos","year":"2010","journal-title":"Neurobiol Aging"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.bbamcr.2010.03.005","article-title":"The ribosome-bound Hsp70 homolog Ssb of Saccharomyces cerevisiae","volume":"1803","author":"K Peisker","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1126\/science.275.5298.387","article-title":"Functional specificity among Hsp70 molecular chaperones","volume":"275","author":"P James","year":"1997","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1038\/emboj.2008.194","article-title":"Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions","volume":"27","author":"J Shorter","year":"2008","journal-title":"EMBO J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"21998","DOI":"10.1074\/jbc.M602302200","article-title":"Endoplasmic reticulum stress associated with extracellular aggregates. Evidence from transthyretin deposition in familial amyloid polyneuropathy","volume":"281","author":"PF Teixeira","year":"2006","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1091\/mbc.E06-04-0338","article-title":"The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system","volume":"18","author":"SH Park","year":"2007","journal-title":"Mol Biol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/msb.2009.26","article-title":"An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell","volume":"5","author":"Y Gong","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1073\/pnas.0235361100","article-title":"Positive and negative regulation of APP amyloidogenesis by sumoylation","volume":"100","author":"Y Li","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of Huntingtin and Huntington&apos;s disease pathology","volume":"304","author":"JS Steffan","year":"2004","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/path.2224","article-title":"Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy","volume":"213","author":"SD Santos","year":"2007","journal-title":"J Pathol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/sj.embor.7400203","article-title":"Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation","volume":"5","author":"C Schuberth","year":"2004","journal-title":"EMBO Rep"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.1180823","article-title":"The genetic landscape of a cell","volume":"327","author":"M Costanzo","year":"2010","journal-title":"Science"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature04670","article-title":"Global landscape of protein complexes in the yeast Saccharomyces cerevisiae","volume":"440","author":"NJ Krogan","year":"2006","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10400","DOI":"10.1074\/jbc.M900377200","article-title":"The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization","volume":"284","author":"JH Kim","year":"2009","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1042\/BJ20031885","article-title":"Regulation of transcription by Saccharomyces cerevisiae 14-3-3 proteins","volume":"382","author":"A Bruckmann","year":"2004","journal-title":"Biochem J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.1021\/bi035421i","article-title":"Transcriptomic and proteomic analysis of a 14\u20133-3 gene-deficient yeast","volume":"43","author":"T Ichimura","year":"2004","journal-title":"Biochemistry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1091\/mbc.11.12.4241","article-title":"Genomic expression programs in the response of yeast cells to environmental changes","volume":"11","author":"AP Gasch","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"31079","DOI":"10.1074\/jbc.M202718200","article-title":"Genome-wide analysis of gene expression regulated by the calcineurin\/Crz1p signaling pathway in Saccharomyces cerevisiae","volume":"277","author":"H Yoshimoto","year":"2002","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bbrc.2008.09.146","article-title":"Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway in Saccharomyces cerevisiae","volume":"377","author":"ID Choi","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/315688a0","article-title":"Yeast heat-shock protein of Mr 48,000 is an isoprotein of enolase","volume":"315","author":"H Iida","year":"1985","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"15585","DOI":"10.1074\/jbc.270.26.15585","article-title":"Cloning and characterization of COX14, whose product is required for assembly of yeast cytochrome oxidase","volume":"270","author":"DM Glerum","year":"1995","journal-title":"J Biol Chem"},{"key":"ref55","unstructured":"Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, <etal>et al<\/etal>.. (1999) Current protocols in molecular biology. New York, NY: Wiley-Inter-science."},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1111\/j.1742-4658.2006.05520.x","article-title":"Yeast protein glycation in vivo by methylglyoxal. Molecular modification of glycolytic enzymes and heat shock proteins","volume":"273","author":"RA Gomes","year":"2006","journal-title":"FEBS J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.4564-06.2007","article-title":"Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies","volume":"27","author":"ML Kramer","year":"2007","journal-title":"J Neurosci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2144\/000112691","article-title":"Selective detection, quantification, and subcellular location of \u03b1-synuclein aggregates with a protein aggregate filtration assay","volume":"44","author":"ML Kramer","year":"2008","journal-title":"BioTechniques"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1096-9888(199902)34:2<105::AID-JMS768>3.0.CO;2-4","article-title":"Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption\/ionization mass spectrometry","volume":"34","author":"J Gobom","year":"1999","journal-title":"J Mass Spectrom"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"DW Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"DW Huang","year":"2009","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0050123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T21:37:04Z","timestamp":1562362624000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0050123"}},"subtitle":[],"editor":[{"given":"Mick F.","family":"Tuite","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":61,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0050123","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}