{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:33:37Z","timestamp":1776087217912,"version":"3.50.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0050619","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T23:02:10Z","timestamp":1353538930000},"page":"e50619","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":185,"title":["Chlorogenic Acid and Rutin Play a Major Role in the In Vivo Anti-Diabetic Activity of Morus alba Leaf Extract on Type II Diabetic Rats"],"prefix":"10.1371","volume":"7","author":[{"given":"Attila","family":"Hunyadi","sequence":"first","affiliation":[]},{"given":"Ana","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Tusty-Jiuan","family":"Hsieh","sequence":"additional","affiliation":[]},{"given":"Adrienn","family":"Seres","sequence":"additional","affiliation":[]},{"given":"Istv\u00e1n","family":"Zupk\u00f3","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global Prevalence of Diabetes. Estimates for the year 2000 and projections for 2030","volume":"27","author":"SH Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"JE Shaw","year":"2009","journal-title":"Diabetes Res Clin Pr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7326\/0003-4819-157-1-201207030-00019","article-title":"Oral Pharmacological Treatment of Type 2 Diabetes Mellitus","volume":"157(1)","author":"A Quaseem","year":"2012","journal-title":"Ann Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-2007-969435","article-title":"Isolation and hypoglycemic activity of Moran A, a glycoprotein of Morus alba root barks","volume":"2","author":"H Hikino","year":"1985","journal-title":"Planta Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1248\/yakushi1947.115.6_476","article-title":"Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice","volume":"115","author":"F Chen","year":"1995","journal-title":"Yakugaku Zasshi"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1055\/s-2007-978957","article-title":"Potentiation of glucose-induced insuline secretion by fagomine, a pseudo-sugar isolated from mulberry leaves","volume":"30","author":"S Taniguchi","year":"1998","journal-title":"Horm Metab Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02976428","article-title":"Purification and characterization of Moran 20K from Morus alba","volume":"22","author":"ES Kim","year":"1999","journal-title":"Arch Pharm Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1099-1573(199903)13:2<91::AID-PTR350>3.0.CO;2-8","article-title":"Hypoglycaemic activity of four plants used in Chilean popular medicine","volume":"13","author":"I Lemus","year":"1999","journal-title":"Phytother Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3177\/jnsv.50.161","article-title":"Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats","volume":"50","author":"C Miyahara","year":"2004","journal-title":"J Nutr Sci Vitaminol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0009-8981(01)00632-5","article-title":"Effect of mulberry (Morus alba L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes","volume":"314","author":"B Andallu","year":"2001","journal-title":"Clin Chim Acta"},{"key":"ref11","first-page":"4524","article-title":"Effects of propolis and mulberry leaf extract on type 2 diabetes","volume":"8","author":"K Murata","year":"2003","journal-title":"Focus Alternat Complement Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.2337\/dc06-2120","article-title":"Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects","volume":"30","author":"M Mudra","year":"2007","journal-title":"Diabetes Care"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1021\/jf062680g","article-title":"Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans","volume":"55","author":"T Kimura","year":"2007","journal-title":"J Agric Food Chem"},{"key":"ref14","first-page":"571","article-title":"Structure of moranoline, a piperidine alkaloid from Morus species","volume":"50(11)","author":"M Yagi","year":"1976","journal-title":"J Agric Chem Soc Japan"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0008-6215(94)84060-1","article-title":"N-containing sugars from Morus alba and their glycosidase inhibitory activities","volume":"17","author":"N Asano","year":"1994","journal-title":"Carbohydr Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1021\/jf010567e","article-title":"Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.)","volume":"49","author":"N Asano","year":"2001","journal-title":"J Agric Food Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jep.2005.03.013","article-title":"Hypoglycemic effect of Egyptian Morus alba root bark extract: Effect in diabetes and lipid peroxidation of streptozocin-induced diabetic rats","volume":"100","author":"AN Singab","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1248\/cpb.41.1238","article-title":"Two new arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis","volume":"41(7)","author":"P Basnet","year":"1993","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"ref19","first-page":"515791","article-title":"Studies on inhibitor effects and activator of a-glucosidase in mulberry leaves. Shipin Kexue (Beijing, China) 27(2): 108\u2013111","volume":"2007","author":"M Qingyi","year":"2006","journal-title":"Chem Abstr"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Hunyadi A, Veres K, Danko B, Kele Z, Weber E, <etal>et al<\/etal>. (2012) <italic>In vitro<\/italic> anti-diabetic activity and chemical composition of an apolar fraction of <italic>Morus alba<\/italic> leaf water extract. Phytother Res DOI: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/ptr.4803\" xlink:type=\"simple\">10.1002\/ptr.4803<\/ext-link>.","DOI":"10.1002\/ptr.4803"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1248\/yakushi1947.87.6_748","article-title":"Isolation of the insect-moulting hormones from mulberry leaves","volume":"87","author":"T Takemoto","year":"1967","journal-title":"Yakugaku Zasshi"},{"key":"ref22","unstructured":"Lafont R, Dinan L (2003) Practical uses for ecdysteroids in mammals including humans: an update. J Insect Sci 3:7; online: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/insectscience.org\/3.7\" xlink:type=\"simple\">http:\/\/insectscience.org\/3.7<\/ext-link>."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00216-011-5639-2","article-title":"Determination of D-fagomine in buckwheat and mulberry by cation exchange HPLC\/ESI-Q-MS","volume":"402(5)","author":"S Am\u00e9zqueta","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.lwt.2011.09.008","article-title":"Development of high1-deoxynojirimycin (DNJ) contentmulberrytea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction","volume":"45(2)","author":"C Vichasilpa","year":"2012","journal-title":"LWT-Food Sci Technol"},{"key":"ref25","first-page":"1217","article-title":"Investigation of the antidiabetic activity of <italic>Morus alba<\/italic> leaf extract <italic>in vitro<\/italic> and <italic>in vivo<\/italic>","volume":"76(12)","author":"A Hunyadi","year":"2010","journal-title":"Planta Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-8741(01)00335-X","article-title":"Hypoglycemic effect of <italic>Cecropia obtusifolia<\/italic> on streptozotocin diabetic rats","volume":"78","author":"A Andrade-Cetto","year":"2001","journal-title":"J Ethnopharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1742-7843.2006.pto_241.x","article-title":"Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats","volume":"98(1)","author":"N Kamalakkannan","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1440-1681.2009.05162.x","article-title":"Effects of experimentally induced diabetes mellitus on pharmacologically and electrically elicited myometrial contractility","volume":"36","author":"G Spiegl","year":"2009","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2337\/diab.23.11.889","article-title":"Diabetogenic effect of streptozotocin in the rat during the perinatal period","volume":"23","author":"B Portha","year":"1974","journal-title":"Diabetes"},{"key":"ref30","unstructured":"Vogel HG ed. (2002) Drug Discovery and Evaluation. Pharmacological Assays. Springer Verlag: Berlin."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.930111","article-title":"The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas","volume":"50","author":"T Szkudelski","year":"2001","journal-title":"Physiol Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0050619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T09:34:47Z","timestamp":1745228087000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0050619"}},"subtitle":[],"editor":[{"given":"Bridget","family":"Wagner","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0050619","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}