{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:24:58Z","timestamp":1771503898900,"version":"3.50.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053424","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T15:01:26Z","timestamp":1357657286000},"page":"e53424","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Self-Interaction of Human Pex11p\u03b2 during Peroxisomal Growth and Division"],"prefix":"10.1371","volume":"8","author":[{"given":"Nina A.","family":"Bonekamp","sequence":"first","affiliation":[]},{"given":"Sandra","family":"Grille","sequence":"additional","affiliation":[]},{"given":"Maria Joao","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Monica","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Aroso","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Ana Cristina","family":"Magalhaes","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Islinger","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schrader","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2006.08.010","article-title":"Peroxisomal disorders: the single peroxisomal enzyme deficiencies","volume":"1763","author":"RJ Wanders","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cell.2010.04.018","article-title":"Peroxisomes are signaling platforms for antiviral innate immunity","volume":"141","author":"E Dixit","year":"2010","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1091\/mbc.E10-11-0919","article-title":"Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk","volume":"22","author":"O Ivashchenko","year":"2011","journal-title":"Mol Biol Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00418-012-0941-4","article-title":"The peroxisome: an update on mysteries","volume":"137","author":"M Islinger","year":"2012","journal-title":"Histochem Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JAD-2011-111163","article-title":"Potential Roles of Peroxisomes in Alzheimer's Disease and in Dementia of the Alzheimer's Type","volume":"29","author":"G Lizard","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.bbadis.2011.12.014","article-title":"Fission and proliferation of peroxisomes","volume":"822","author":"M Schrader","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1083\/jcb.200702167","article-title":"Yeast peroxisomes multiply by growth and division","volume":"178","author":"AM Motley","year":"2007","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ceb.2011.05.005","article-title":"Peroxisome biogenesis: recent advances","volume":"23","author":"JM Nuttall","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2012.01.054","article-title":"Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes","volume":"149","author":"A van der Zand","year":"2012","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.bbamcr.2006.09.010","article-title":"Peroxisome biogenesis disorders","volume":"1763","author":"SJ Steinberg","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.bbadis.2012.04.006","article-title":"Genetics and molecular basis of human peroxisome biogenesis disorders","volume":"1822","author":"HR Waterham","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1749-6632.1996.tb18660.x","article-title":"The importance of microtubules in determination of shape and intracellular distribution of peroxisomes","volume":"804","author":"M Schrader","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0074-7696(06)55005-3","article-title":"Growth and division of peroxisomes","volume":"255","author":"M Schrader","year":"2006","journal-title":"Int Rev Cytol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1242\/jcs.062109","article-title":"Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway","volume":"123","author":"HK Delille","year":"2010","journal-title":"J Cell Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1242\/jcs.064907","article-title":"PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance","volume":"123","author":"J Koch","year":"2010","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1111\/j.1742-4658.2005.04939.x","article-title":"Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation","volume":"272","author":"S Thoms","year":"2005","journal-title":"Febs J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A lethal defect of mitochondrial and peroxisomal fission","volume":"356","author":"HR Waterham","year":"2007","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/jmedgenet-2012-100778","article-title":"A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11beta gene","volume":"49","author":"MS Ebberink","year":"2012","journal-title":"J Med Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/emboj.2010.299","article-title":"Membrane curvature during peroxisome fission requires Pex11","volume":"30","author":"L Opalinski","year":"2011","journal-title":"EMBO J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1242\/jcs.102178","article-title":"PEX11 proteins attract Mff and hFis1 to coordinate peroxisomal fission","volume":"125","author":"J Koch","year":"2012","journal-title":"J Cell Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"29607","DOI":"10.1074\/jbc.273.45.29607","article-title":"Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli","volume":"273","author":"M Schrader","year":"1998","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1600-0854.2011.01198.x","article-title":"Peroxisome fission is associated with reorganization of specific membrane proteins","volume":"12","author":"MN Cepinska","year":"2011","journal-title":"Traffic"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/cib.13647","article-title":"Pex11pbeta-mediated maturation of peroxisomes","volume":"4","author":"HK Delille","year":"2011","journal-title":"Commun Integr Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"17012","DOI":"10.1074\/jbc.M212031200","article-title":"The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11","volume":"278","author":"X Li","year":"2003","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.yexcr.2007.02.028","article-title":"Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis","volume":"313","author":"S Kobayashi","year":"2007","journal-title":"Exp Cell Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1074\/jbc.M211761200","article-title":"Dynamin-like protein 1 is involved in peroxisomal fission","volume":"278","author":"A Koch","year":"2003","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1242\/jcs.01268","article-title":"Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1","volume":"117","author":"A Koch","year":"2004","journal-title":"J Cell Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1091\/mbc.E05-02-0159","article-title":"A role for fis1 in both mitochondrial and peroxisomal fission in Mammalian cells","volume":"16","author":"A Koch","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1091\/mbc.E07-12-1287","article-title":"The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells","volume":"19","author":"S Gandre-Babbe","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/bies.20659","article-title":"Mitochondria and peroxisomes: Are the \u2018Big Brother\u2019 and the 'Little Sister' closer than assumed?","volume":"29","author":"M Schrader","year":"2007","journal-title":"Bioessays"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10545-008-1018-3","article-title":"Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria","volume":"32","author":"F Camoes","year":"2009","journal-title":"J Inherit Metab Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.1128\/MCB.22.23.8226-8240.2002","article-title":"PEX11alpha Is Required for Peroxisome Proliferation in Response to 4-Phenylbutyrate but Is Dispensable for Peroxisome Proliferator-Activated Receptor Alpha-Mediated Peroxisome Proliferation","volume":"22","author":"X Li","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1128\/MCB.22.12.4358-4365.2002","article-title":"PEX11 beta deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function","volume":"22","author":"X Li","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00418-012-1010-8","article-title":"Postfixation detergent treatment liberates the membrane modelling protein Pex11beta from peroxisomal membranes","volume":"138","author":"M Schrader","year":"2012","journal-title":"Histochem Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1083\/jcb.121.6.1271","article-title":"Biogenesis of peroxisomes: isolation and characterization of two distinct peroxisomal populations from normal and regenerating rat liver","volume":"121","author":"G Luers","year":"1993","journal-title":"J Cell Biol"},{"key":"ref36","first-page":"24","article-title":"Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs","volume":"69","author":"M Schrader","year":"1996","journal-title":"Eur J Cell Biol"},{"key":"ref37","first-page":"281","article-title":"Heterogeneity of peroxisomes in human hepatoblastoma cell line HepG2. Evidence of distinct subpopulations","volume":"64","author":"M Schrader","year":"1994","journal-title":"Eur J Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.135.1.123","article-title":"Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division","volume":"135","author":"PA Marshall","year":"1996","journal-title":"J Cell Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1242\/jcs.02904","article-title":"Five Arabidopsis peroxin 11 homologs individually promote peroxisome elongation, division without elongation, or aggregation","volume":"119","author":"MJ Lingard","year":"2006","journal-title":"J Cell Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0014-5793(98)00815-1","article-title":"Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11","volume":"431","author":"I Abe","year":"1998","journal-title":"FEBS Lett"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0006-291X(02)02936-4","article-title":"cDNA cloning and characterization of the third isoform of human peroxin Pex11p","volume":"300","author":"A Tanaka","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1074\/jbc.M109.094805","article-title":"Phosphorylation-dependent activation of peroxisome proliferator protein PEX11 controls peroxisome abundance","volume":"285","author":"B Knoblach","year":"2010","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1091\/mbc.E11-09-0782","article-title":"Phosphorylation-dependent Pex11p and Fis1p interaction regulates peroxisome division","volume":"23","author":"S Joshi","year":"2012","journal-title":"Mol Biol Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1242\/jcs.087452","article-title":"Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division","volume":"125","author":"A Itoyama","year":"2012","journal-title":"J Cell Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/humu.20535","article-title":"Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency","volume":"28","author":"S Ferdinandusse","year":"2007","journal-title":"Hum Mutat"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1937-6448(10)79003-1","article-title":"Molecular basis of peroxisome division and proliferation in plants","volume":"279","author":"J Hu","year":"2010","journal-title":"Int Rev Cell Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1515\/BMC.2011.031","article-title":"Membrane elongation factors in organelle maintenance: the case of peroxisome proliferation","volume":"2","author":"J Koch","year":"2011","journal-title":"BioMol Concepts"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1006\/bbrc.1998.9684","article-title":"cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p","volume":"252","author":"I Abe","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1600-0854.2007.00661.x","article-title":"A bioinformatics approach to identifying tail-anchored proteins in the human genome","volume":"8","author":"T Kalbfleisch","year":"2007","journal-title":"Traffic"},{"key":"ref50","first-page":"661","article-title":"Peroxisome morphology in pathology","volume":"27","author":"D Ribeiro","year":"2012","journal-title":"Histol Histopathol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0022-2275(20)31527-3","article-title":"Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid","volume":"42","author":"S Ferdinandusse","year":"2001","journal-title":"J Lipid Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/jmg.2009.074302","article-title":"Identification of an unusual variant peroxisome biogenesis disorder caused by mutations in the PEX16 gene","volume":"47","author":"MS Ebberink","year":"2010","journal-title":"J Med Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1016\/j.yexcr.2008.09.009","article-title":"The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction","volume":"314","author":"MN Serasinghe","year":"2008","journal-title":"Exp Cell Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T14:11:42Z","timestamp":1644070302000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053424"}},"subtitle":[],"editor":[{"given":"Henrik","family":"Einwaechter","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053424","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]}}}