{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:03:18Z","timestamp":1767909798528,"version":"3.49.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058277","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T22:29:22Z","timestamp":1362522562000},"page":"e58277","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["Effect of Oxygen on Glucose Metabolism: Utilization of Lactate in Staphylococcus Aureus as Revealed by In Vivo NMR Studies"],"prefix":"10.1371","volume":"8","author":[{"given":"Maria Teresa","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Ana S.","family":"Manso","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Gaspar","sequence":"additional","affiliation":[]},{"given":"Mariana G.","family":"Pinho","sequence":"additional","affiliation":[]},{"given":"Ana Rute","family":"Neves","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"ref1","first-page":"505","article-title":"Nasal carriage of <italic>Staphylococcus aureus<\/italic>: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev","volume":"10","author":"J Kluytmans","year":"1997"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0924-8579(09)70542-4","article-title":"Antibiotics, skin and soft tissue infection and meticillin-resistant <italic>Staphylococcus aureus<\/italic>: cause and effect. Int. J. Antimicrob","volume":"34","author":"IM Gould","year":"2009","journal-title":"Agents"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"12312","DOI":"10.1073\/pnas.0404728101","article-title":"<italic>Staphylococcus aureus<\/italic> virulence genes identified by <italic>bursa aurealis<\/italic> mutagenesis and nematode killing. Proc. Natl. Acad. Sci","volume":"101","author":"T Bae","year":"2004","journal-title":"U. S. A"},{"key":"ref4","first-page":"872","article-title":"<italic>Staphylococcus aureus<\/italic> virulence factors identified by using a high-throughput <italic>Caenorhabditis elegans<\/italic>-killing model. Infect. Immun","volume":"73","author":"J Begun","year":"2005"},{"key":"ref5","first-page":"6686","article-title":"Synthesis and deformylation of <italic>Staphylococcus aureus<\/italic> delta-toxin are linked to tricarboxylic acid cycle activity. J. Bacteriol","volume":"185","author":"GA Somerville","year":"2003"},{"key":"ref6","first-page":"399","article-title":"Identification of <italic>Staphylococcus aureus<\/italic> virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis. Mol. Microbiol","volume":"26","author":"JM Mei","year":"1997"},{"key":"ref7","first-page":"76","article-title":"A proteomic view of cell physiology and virulence of <italic>Staphylococcus aureus<\/italic>. Int. J. Med. Microbiol","volume":"300","author":"M Hecker","year":"2010"},{"key":"ref8","first-page":"213","article-title":"Carbohydrate metabolism of <italic>Staphylococcus aureus<\/italic>. J. Gen. Microbiol","volume":"33","author":"KC Strasters","year":"1963"},{"key":"ref9","first-page":"531","article-title":"The effect of growth conditions on oxidative and dehydrogenase activity in <italic>Staphylococcus aureus<\/italic>. J. Gen. Microbiol","volume":"29","author":"FM Collins","year":"1962"},{"key":"ref10","first-page":"4275","article-title":"Anaerobic gene expression in <italic>Staphylococcus aureus<\/italic>. J. Bacteriol","volume":"189","author":"S Fuchs","year":"2007"},{"key":"ref11","first-page":"e87","article-title":"<italic>Staphylococcus aureus<\/italic> redirects central metabolism to increase iron availability. PLoS. Pathog","volume":"2","author":"DB Friedman","year":"2006"},{"key":"ref12","first-page":"1915","article-title":"<italic>Staphylococcus aureus<\/italic> physiological growth limitations: insights from flux calculations built on proteomics and external metabolite data. Proteomics","volume":"11","author":"C Liang","year":"2011"},{"key":"ref13","first-page":"1142","article-title":"Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in <italic>Staphylococcus aureus<\/italic>. Mol. Microbiol","volume":"76","author":"M Pagels","year":"2010"},{"key":"ref14","first-page":"157","article-title":"The requirement for acetate of a streptomycin-resistant strain of <italic>Staphylococcus aureus<\/italic>. J. Gen. Microbiol","volume":"29","author":"JF Gardner","year":"1962"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.1155207","article-title":"A nitric oxide-inducible lactate dehydrogenase enables <italic>Staphylococcus aureus<\/italic> to resist innate immunity","volume":"319","author":"AR Richardson","year":"2008","journal-title":"Science"},{"key":"ref16","first-page":"2385","article-title":"Advantage of upregulation of succinate dehydrogenase in <italic>Staphylococcus aureus<\/italic> biofilms. J. Bacteriol","volume":"192","author":"R Gaupp","year":"2010"},{"key":"ref17","first-page":"1241","article-title":"A metabolomics and proteomics study of the adaptation of <italic>Staphylococcus aureus<\/italic> to glucose starvation. Mol. Biosyst","volume":"7","author":"M Liebeke","year":"2011"},{"key":"ref18","first-page":"531","article-title":"Overview on sugar metabolism and its control in <italic>Lactococcus lactis<\/italic> - the input from <italic>in vivo<\/italic> NMR. FEMS Microbiol. Rev","volume":"29","author":"AR Neves","year":"2005"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1021\/bi00285a020","article-title":"Phosphorus-31 and carbon-13 nuclear magnetic resonance studies of anaerobic glucose metabolism and lactate transport in <italic>Staphylococcus aureus<\/italic> cells","volume":"22","author":"FS Ezra","year":"1983","journal-title":"Biochemistry"},{"key":"ref20","first-page":"795","article-title":"Characterization of the individual glucose uptake systems of <italic>Lactococcus lactis<\/italic>: mannose-PTS, cellobiose-PTS and the novel GlcU permease. Mol. Microbiol","volume":"71","author":"R Castro","year":"2009"},{"key":"ref21","first-page":"558","article-title":"Regulation of sigmaB-dependent transcription of sigB and asp23 in two different <italic>Staphylococcus aureus<\/italic> strains. Mol. Gen. Genet","volume":"261","author":"S Gertz","year":"1999"},{"key":"ref22","first-page":"250","article-title":"A protocol for the investigation of the intracellular <italic>Staphylococcus aureus<\/italic> metabolome. Anal. Biochem","volume":"401","author":"H Meyer","year":"2010"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1128\/JB.146.3.1020-1029.1981","article-title":"Intracellular mannitol, a product of glucose metabolism in staphylococci","volume":"146","author":"KG Edwards","year":"1981","journal-title":"J Bacteriol"},{"key":"ref24","first-page":"7311","article-title":"<sup>13<\/sup>C nuclear magnetic resonance analysis of glucose and citrate end products in an <italic>ldhL<\/italic>-<italic>ldhD<\/italic> double-knockout strain of <italic>Lactobacillus plantarum<\/italic>. J. Bacteriol","volume":"178","author":"T Ferain","year":"1996"},{"key":"ref25","first-page":"3859","article-title":"Metabolic characterization of <italic>Lactococcus lactis<\/italic> deficient in lactate dehydrogenase using <italic>in vivo<\/italic> <sup>13<\/sup>C-NMR. Eur. J. Biochem","volume":"267","author":"AR Neves","year":"2000"},{"key":"ref26","first-page":"3159","article-title":"Multiple enzyme forms of glyceraldehyde-3-phosphate dehydrogenase in <italic>Pseudomonas aeruginosa<\/italic> PAO. J. Gen. Microbiol","volume":"133","author":"DB Rivers","year":"1987"},{"key":"ref27","first-page":"28088","article-title":"Is the glycolytic flux in <italic>Lactococcus lactis<\/italic> primarily controlled by the redox charge? Kinetics of NAD(+) and NADH pools determined <italic>in vivo<\/italic> by <sup>13<\/sup>C NMR. J. Biol. Chem","volume":"277","author":"AR Neves","year":"2002"},{"key":"ref28","first-page":"159","article-title":"Engineering of sugar metabolism of <italic>Corynebacterium glutamicum<\/italic> for production of amino acid L-alanine under oxygen deprivation. Appl. Microbiol. Biotechnol","volume":"87","author":"T Jojima","year":"2010"},{"key":"ref29","first-page":"106","article-title":"Bacterial lactate dehydrogenases. Microbiol. Rev","volume":"44","author":"EI Garvie","year":"1980"},{"key":"ref30","first-page":"5924","article-title":"The lactate dehydrogenases encoded by the <italic>ldh<\/italic> and <italic>ldhB<\/italic> genes in <italic>Lactococcus lactis<\/italic> exhibit distinct regulation and catalytic properties: comparative modelling to probe the molecular basis. FEBS J","volume":"274","author":"P Gaspar","year":"2007"},{"key":"ref31","first-page":"152","article-title":"Regulation of <italic>Staphylococcus aureus<\/italic> lactate dehydrogenase. J. Bacteriol","volume":"95","author":"W Garrard","year":"1968"},{"key":"ref32","first-page":"824","article-title":"Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of <italic>Escherichia coli<\/italic>. Biochem. Biophys. Res. Commun","volume":"290","author":"MF Nu\u00f1ez","year":"2002"},{"key":"ref33","first-page":"5920","article-title":"Characterization of a <italic>Corynebacterium glutamicum<\/italic> lactate utilization operon induced during temperature-triggered glutamate production. Appl. Environ. Microbiol","volume":"71","author":"C Stansen","year":"2005"},{"key":"ref34","first-page":"6661","article-title":"Major role of NAD-dependent lactate dehydrogenases in aerobic lactate utilization in <italic>Lactobacillus plantarum<\/italic> during early stationary phase. J. Bacteriol","volume":"186","author":"P Goffin","year":"2004"},{"key":"ref35","first-page":"5820","article-title":"Inducible membrane-bound L-lactate dehydrogenase from <italic>Escherichia coli<\/italic>. Purification and properties. J. Biol. Chem","volume":"252","author":"M Futai","year":"1977"},{"key":"ref36","first-page":"555","article-title":"Energy conservation in aerobically grown <italic>Staphylococcus aureus<\/italic>. Res. Microbiol","volume":"150","author":"Z Tynecka","year":"1999"},{"key":"ref37","first-page":"1183","article-title":"<italic>Staphylococcus aureus<\/italic> CcpA affects virulence determinant production and antibiotic resistance. Antimicrob. Agents Chemother","volume":"50","author":"K Seidl","year":"2006"},{"key":"ref38","first-page":"1318","article-title":"Lactate acquisition promotes successful colonization of the murine genital tract by <italic>Neisseria gonorrhoeae<\/italic>. Infect. Immun","volume":"75","author":"RM Exley","year":"2007"},{"key":"ref39","first-page":"3525","article-title":"Role of PBP1 in cell division of <italic>Staphylococcus aureus<\/italic>. J. Bacteriol","volume":"189","author":"SF Pereira","year":"2007"},{"key":"ref40","first-page":"1466","article-title":"Engineering <italic>Lactococcus lactis<\/italic> for production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system. Appl. Environ. Microbiol","volume":"70","author":"P Gaspar","year":"2004"},{"key":"ref41","first-page":"345","article-title":"Characterization of the improved sensitivity obtained using a flow method for oxygenating and mixing cell suspensions in NMR","volume":"68","author":"H Santos","year":"1986","journal-title":"J Magn Reson"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/(SICI)1097-0290(19990720)64:2<200::AID-BIT9>3.0.CO;2-K","article-title":"<italic>In vivo<\/italic> nuclear magnetic resonance studies of glycolytic kinetics in <italic>Lactococcus lactis<\/italic>","volume":"64","author":"AR Neves","year":"1999","journal-title":"Biotechnol Bioeng"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T04:52:19Z","timestamp":1644468739000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058277"}},"subtitle":[],"editor":[{"given":"Malcolm James","family":"Horsburgh","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,3,5]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058277","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,5]]}}}