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Clin 61: 69\u201390. caac.20107 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.3322\/caac.20107\" xlink:type=\"simple\">10.3322\/caac.20107<\/ext-link> [doi]<\/comment>.","DOI":"10.3322\/caac.20107"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/jnci\/djj067","article-title":"Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention","volume":"98","author":"X Castellsague","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1155\/2007\/914823","article-title":"The epidemiology of human papillomavirus infection and cervical cancer","volume":"23","author":"FX Bosch","year":"2007","journal-title":"Dis Markers"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"HH zur","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00130404-200309000-00002","article-title":"Cervical cytology classification and the Bethesda System","volume":"9","author":"DD Davey","year":"2003","journal-title":"Cancer Journal"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Martin AG (2007) Molecular biology of cervical cancer. Clin Transl Oncol 9: 347\u2013354. <comment>DOI <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1007\/s12094-007-0066-8\" xlink:type=\"simple\">10.1007\/s12094-007-0066-8<\/ext-link><\/comment>.","DOI":"10.1007\/s12094-007-0066-8"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, et al.. (2003) Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem 278: 13061\u201313068. 10.1074\/jbc.M210015200 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/M210015200\" xlink:type=\"simple\">M210015200<\/ext-link> [pii]<\/comment>.","DOI":"10.1074\/jbc.M210015200"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Yeung K, Seitz T, Li S, Janosch P, McFerran B, et al.. (1999) Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401: 173\u2013177. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1038\/43686\" xlink:type=\"simple\">10.1038\/43686<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/43686"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1128\/MCB.20.9.3079-3085.2000","article-title":"Mechanism of suppression of the Raf\/MEK\/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein","volume":"20","author":"K Yeung","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref10","first-page":"4437","article-title":"Growth-suppressive function of phosphatidylethanolamine-binding protein in anaplastic thyroid cancer","volume":"26","author":"J Akaishi","year":"2006","journal-title":"Anticancer Res"},{"key":"ref11","unstructured":"Zhang L, Fu Z, Binkley C, Giordano T, Burant CF, et al.. (2004) Raf kinase inhibitory protein inhibits beta-cell proliferation. Surgery 136: 708\u2013715. 10.1016\/j.surg.2003.12.013 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/S0039606004000200\" xlink:type=\"simple\">S0039606004000200<\/ext-link> [pii]<\/comment>."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Al-Mulla F, Bitar MS, Taqi Z, Rath O, Kolch W (2010) RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility. Mol. Biosyst 7: 928\u201341. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1039\/c0mb00208a\" xlink:type=\"simple\">10.1039\/c0mb00208a<\/ext-link> [doi]<\/comment>.","DOI":"10.1039\/C0MB00208A"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Bement WM (2005) A role for RKIP in cell motility. Chem Biol 12: 953\u2013954. S1074\u20135521(05)00268\u20131 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/j.chembiol.2005.08.012\" xlink:type=\"simple\">10.1016\/j.chembiol.2005.08.012<\/ext-link> [doi]<\/comment>.","DOI":"10.1016\/j.chembiol.2005.08.012"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Baritaki S, Chapman A, Yeung K, Spandidos DA, Palladino M, et al.. (2009) Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene 28: 3573\u20133585. onc2009214 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1038\/onc.2009.214\" xlink:type=\"simple\">10.1038\/onc.2009.214<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/onc.2009.214"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hellmann J, Rommelspacher H, Muhlbauer E, Wernicke C (2010) Raf kinase inhibitor protein enhances neuronal differentiation in human SH-SY5Y cells. Dev Neurosci 32: 33\u201346. 000236595 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1159\/000236595\" xlink:type=\"simple\">10.1159\/000236595<\/ext-link> [doi]<\/comment>.","DOI":"10.1159\/000236595"},{"key":"ref16","unstructured":"Keller ET, Fu Z, Brennan M (2004) The role of Raf kinase inhibitor protein (RKIP) in health and disease. Biochem Pharmacol 68: 1049\u20131053. 10.1016\/j.bcp.2004.04.024 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/S0006295204003600\" xlink:type=\"simple\">S0006295204003600<\/ext-link> [pii]<\/comment>."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.canlet.2004.02.006","article-title":"Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene","volume":"207","author":"ET Keller","year":"2004","journal-title":"Cancer Lett"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Martinho O, Sim\u00f5es K, Longatto-Filho A, Jacob CE, Zilberstein B, et al.. (2013) Absence of RKIP expression is an independent prognostic biomarker in gastric cancer. Oncol Rep 29(2): 690\u20136. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.3892\/or.2012.2179\" xlink:type=\"simple\">10.3892\/or.2012.2179<\/ext-link> [doi]<\/comment>.","DOI":"10.3892\/or.2012.2179"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, et al.. (2009) Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J 28: 347\u2013358. emboj2008294 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1038\/emboj.2008.294\" xlink:type=\"simple\">10.1038\/emboj.2008.294<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/emboj.2008.294"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/jnci\/95.12.878","article-title":"Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis","volume":"95","author":"Z Fu","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Hagan S, Al-Mulla F, Mallon E, Oien K, Ferrier R, et al.. (2005) Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res 11: 7392\u20137397. 11\/20\/7392 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1158\/1078-0432.CCR-05-0283\" xlink:type=\"simple\">10.1158\/1078\u20130432.CCR-05\u20130283<\/ext-link> [doi]<\/comment>.","DOI":"10.1158\/1078-0432.CCR-05-0283"},{"key":"ref22","first-page":"5672","article-title":"Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol","volume":"24","author":"F Al-Mulla","year":"2006"},{"key":"ref23","first-page":"820","article-title":"Loss of Raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. Am J Clin Pathol","volume":"127","author":"P Minoo","year":"2007"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Kim HS, Kim GY, Lim SJ, Kim YW (2010) Raf-1 kinase inhibitory protein expression in thyroid carcinomas. Endocr Pathol 21: 253\u2013257. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1007\/s12022-010-9131-x\" xlink:type=\"simple\">10.1007\/s12022-010-9131-x<\/ext-link> [doi]<\/comment>.","DOI":"10.1007\/s12022-010-9131-x"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Martinho O, Gouveia A, Silva P, Pimenta A, Reis RM, et al.. (2009) Loss of RKIP expression is associated with poor survival in GISTs. Virchows Arch 455: 277\u2013284. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1007\/s00428-009-0821-z\" xlink:type=\"simple\">10.1007\/s00428-009-0821-z<\/ext-link> [doi]<\/comment>.","DOI":"10.1007\/s00428-009-0821-z"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Maresch J, Birner P, Zakharinov M, Toumangelova-Uzeir K, Natchev S, et al.. (2010) Additive effect on survival of Raf kinase inhibitor protein and signal transducer and activator of transcription 3 in high-grade glioma. Cancer. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/cncr.25799\" xlink:type=\"simple\">10.1002\/cncr.25799<\/ext-link> [doi]<\/comment>.","DOI":"10.1002\/cncr.25799"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Kim HS, Kim GY, Lim SJ, Kim YW (2010) Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma. Pathology 42: 655\u2013660. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.3109\/00313025.2010.522172\" xlink:type=\"simple\">10.3109\/00313025.2010.522172<\/ext-link> [doi]<\/comment>.","DOI":"10.3109\/00313025.2010.522172"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Xu YF, Yi Y, Qiu SJ, Gao Q, Li YW, et al.. (2010) PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection. J Hepatol 53: 872\u2013879. S0168\u20138278(10)00618\u20135 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/j.jhep.2010.05.019\" xlink:type=\"simple\">10.1016\/j.jhep.2010.05.019<\/ext-link> [doi]<\/comment>.","DOI":"10.1016\/j.jhep.2010.05.019"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Zaravinos A, Chatziioannou M, Lambrou GI, Boulalas I, Delakas D, et al.. (2010) Implication of RAF and RKIP Genes in Urinary Bladder Cancer. Pathol. Oncol. Res. 17: 181\u201390. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1007\/s12253-010-9295-1\" xlink:type=\"simple\">10.1007\/s12253\u2013010\u20139295\u20131<\/ext-link> [doi]<\/comment>.","DOI":"10.1007\/s12253-010-9295-1"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Chatterjee D, Sabo E, Tavares R, Resnick MB (2008) Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome. Clin Cancer Res 14: 2994\u20133001. 14\/10\/2994 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1158\/1078-0432.CCR-07-4496\" xlink:type=\"simple\">10.1158\/1078\u20130432.CCR-07\u20134496<\/ext-link> [doi]<\/comment>.","DOI":"10.1158\/1078-0432.CCR-07-4496"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Houben R, Michel B, Vetter-Kauczok CS, Pfohler C, Laetsch B, et al.. (2006) Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma. J Invest Dermatol 126: 1135\u20131142. 5700170 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1038\/sj.jid.5700170\" xlink:type=\"simple\">10.1038\/sj.jid.5700170<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/sj.jid.5700170"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1021\/pr800602c","article-title":"Identification of RKIP as an invasion suppressor protein in nasopharyngeal carcinoma by proteomic analysis","volume":"7","author":"Y Chen","year":"2008","journal-title":"J Proteome Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1158\/1078-0432.CCR-07-1380","article-title":"Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and raf-1 kinase inhibitor protein expression","volume":"14","author":"I Zlobec","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Fu Z, Kitagawa Y, Shen R, Shah R, Mehra R, et al.. (2006) Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer. Prostate 66: 248\u2013256. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/pros.20319\" xlink:type=\"simple\">10.1002\/pros.20319<\/ext-link> [doi].","DOI":"10.1002\/pros.20319"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Biewenga P, Buist MR, Moerland PD, van Thernaat EVL, van Kampen AHC, et al.. (2008) Gene expression in early stage cervical cancer. Gynecologic Oncology 108: 520\u2013526. <comment>DOI <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/j.ygyno.2007.11.024\" xlink:type=\"simple\">10.1016\/j.ygyno.2007.11.024<\/ext-link><\/comment>.","DOI":"10.1016\/j.ygyno.2007.11.024"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/147323001103900125","article-title":"Immunohistochemical detection of Raf kinase inhibitor protein in normal cervical tissue and cervical cancer tissue","volume":"39","author":"CJ Hu","year":"2011","journal-title":"J Int Med Res"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Eves EM, Shapiro P, Naik K, Klein UR, Trakul N, et al.. (2006) Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell 23: 561\u2013574. S1097\u20132765(06)00496\u20135 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/j.molcel.2006.07.015\" xlink:type=\"simple\">10.1016\/j.molcel.2006.07.015<\/ext-link> [doi]<\/comment>.","DOI":"10.1016\/j.molcel.2006.07.015"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Logarinho E, Maffini S, Barisic M, Marques A, Toso A, et al.. (2012) CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment. Nat Cell Biol 14: 295\u2013303. ncb2423 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1038\/ncb2423\" xlink:type=\"simple\">10.1038\/ncb2423<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/ncb2423"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Cardeal LB, Boccardo E, Termini L, Rabachini T, Andreoli MA, et al.. (2012) HPV16 oncoproteins induce MMPs\/RECK-TIMP-2 imbalance in primary keratinocytes: possible implications in cervical carcinogenesis. PLoS One 7: e33585. 10.1371\/journal.pone.0033585 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/PONE-D-12-01424\" xlink:type=\"simple\">PONE-D-12\u201301424<\/ext-link> [pii]<\/comment>.","DOI":"10.1371\/journal.pone.0033585"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Martinho O, Faloppa CC, Scapulatempo NC, Longatto-Filho A, Baiocchi G, et al.. (2012) Loss of RKIP expression during the carcinogenic evolution of endometrial cancer. J. Clin. Pathol. 65: 122\u20138. jclinpath-2011\u2013200358 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1136\/jclinpath-2011-200358\" xlink:type=\"simple\">10.1136\/jclinpath-2011\u2013200358<\/ext-link> [doi]<\/comment>.","DOI":"10.1136\/jclinpath-2011-200358"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Martinho O, Granja S, Jaraquemada T, Caeiro C, Miranda-Goncalves V, et al.. (2012) Downregulation of RKIP Is Associated with Poor Outcome and Malignant Progression in Gliomas. PLoS One 7: e30769. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0030769\" xlink:type=\"simple\">10.1371\/journal.pone.0030769<\/ext-link> [doi];<\/comment>PONE-D-11\u201315118 [pii].","DOI":"10.1371\/journal.pone.0030769"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR (2005) Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem 280: 24931\u201324940. M413929200 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1074\/jbc.M413929200\" xlink:type=\"simple\">10.1074\/jbc.M413929200<\/ext-link> [doi]<\/comment>.","DOI":"10.1074\/jbc.M413929200"},{"key":"ref43","first-page":"84","article-title":"Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness. Hum Mol Genet","volume":"22","author":"S Moniz","year":"2013"},{"key":"ref44","first-page":"235","article-title":"Risk Factors for High-Grade Cervical Intraepithelial Neoplasia in Patients with Atypical Squamous Cells of Undetermined Significance (ASC-US) Papanicolaou Smears","volume":"12","author":"Y Poomtavorn","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Li HZ, Wang Y, Gao Y, Shao J, Zhao XL, et al.. (2008) Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer. Mol Cancer Res 6: 917\u2013928. 6\/6\/917 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1158\/1541-7786.MCR-08-0093\" xlink:type=\"simple\">10.1158\/1541\u20137786.MCR-08\u20130093<\/ext-link> [doi]<\/comment>.","DOI":"10.1158\/1541-7786.MCR-08-0093"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Zaravinos A, Kanellou P, Baritaki S, Bonavida B, Spandidos DA (2009) BRAF and RKIP are significantly decreased in cutaneous squamous cell carcinoma. Cell Cycle 8: 1402\u20131408. 8308 [pii].","DOI":"10.4161\/cc.8.9.8308"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Lorenz K, Lohse MJ, Quitterer U (2003) Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature 426: 574\u2013579. 10.1038\/nature02158 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/nature02158\" xlink:type=\"simple\">nature02158<\/ext-link> [pii]<\/comment>.","DOI":"10.1038\/nature02158"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, et al.. (2001) Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol 21: 7207\u20137217. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1128\/MCB.21.21.7207-7217.2001\" xlink:type=\"simple\">10.1128\/MCB.21.21.7207\u20137217.2001<\/ext-link> [doi].","DOI":"10.1128\/MCB.21.21.7207-7217.2001"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Al-Mulla F, Bitar MS, Al-Maghrebi M, Behbehani AI, Al-Ali W, et al.. (2011) Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3{beta}. Cancer Res. 15: 1334\u201343. 0008\u20135472.CAN-10\u20133102 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1158\/0008-5472.CAN-10-3102\" xlink:type=\"simple\">10.1158\/0008\u20135472.CAN-10\u20133102<\/ext-link> [doi]<\/comment>.","DOI":"10.1158\/0008-5472.CAN-10-3102"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Shemon AN, Eves EM, Clark MC, Heil G, Granovsky A, et al.. (2009) Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One 4: e6028. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0006028\" xlink:type=\"simple\">10.1371\/journal.pone.0006028<\/ext-link> [doi]<\/comment>.","DOI":"10.1371\/journal.pone.0006028"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Lee HC, Tian B, Sedivy JM, Wands JR, Kim M (2006) Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology 131: 1208\u20131217. S0016\u20135085(06)01537-X <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1053\/j.gastro.2006.07.012\" xlink:type=\"simple\">10.1053\/j.gastro.2006.07.012<\/ext-link> [doi]<\/comment>.","DOI":"10.1053\/j.gastro.2006.07.012"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Schuierer MM, Bataille F, Hagan S, Kolch W, Bosserhoff AK (2004) Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines. Cancer Res 64: 5186\u20135192. 10.1158\/0008\u20135472.CAN-03\u20133861 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/64\/15\/5186\" xlink:type=\"simple\">64\/15\/5186<\/ext-link> [pii]<\/comment>.","DOI":"10.1158\/0008-5472.CAN-03-3861"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Ruan L, Wang GL, Yi H, Chen Y, Tang CE, et al.. (2010) Raf kinase inhibitor protein correlates with sensitivity of nasopharyngeal carcinoma to radiotherapy. J Cell Biochem 110: 975\u2013981. <comment><ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/jcb.22611\" xlink:type=\"simple\">10.1002\/jcb.22611<\/ext-link> [doi]<\/comment>.","DOI":"10.1002\/jcb.22611"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Li HZ, Gao Y, Zhao XL, Liu YX, Sun BC, et al.. (2009) Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer. Mol Cancer Res 7: 832\u2013840. 1541\u20137786.MCR-08\u20130403 <comment>[pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1158\/1541-7786.MCR-08-0403\" xlink:type=\"simple\">10.1158\/1541\u20137786.MCR-08\u20130403<\/ext-link> [doi]<\/comment>.","DOI":"10.1158\/1541-7786.MCR-08-0403"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"17515","DOI":"10.1074\/jbc.M313816200","article-title":"RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis","volume":"279","author":"D Chatterjee","year":"2004","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Wu K, Bonavida B (2009) The activated NF-kappaB-Snail-RKIP circuitry in cancer regulates both the metastatic cascade and resistance to apoptosis by cytotoxic drugs. Crit Rev Immunol 29: 241\u2013254. 18841dcb1a005a88,0d4f451d6774e29d [pii].","DOI":"10.1615\/CritRevImmunol.v29.i3.40"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Woods Ignatoski KM, Grewal NK, Markwart SM, Vellaichamy A, Chinnaiyan AM, et al.. (2008) Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. Int J Radiat Oncol Biol Phys 72: 153\u2013160. S0360\u20133016(08)00835\u20133 [pii];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/j.ijrobp.2008.04.072\" xlink:type=\"simple\">10.1016\/j.ijrobp.2008.04.072<\/ext-link> [doi].","DOI":"10.1016\/j.ijrobp.2008.04.072"},{"key":"ref58","unstructured":"Chatterjee D, Bai Y, Wang Z, Beach S, Mott S, et al.. (2004) RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem 279: 17515\u201317523. 10.1074\/jbc.M313816200 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/M313816200\" xlink:type=\"simple\">M313816200<\/ext-link> [pii]<\/comment>."},{"key":"ref59","unstructured":"Al-Mulla F, Bitar MS, Feng J, Park S, Yeung KC (2012) A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. PLoS One 7: e29532. 10.1371\/journal.pone.0029532 <comment>[doi];<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/PONE-D-11-09100\" xlink:type=\"simple\">PONE-D-11-09100<\/ext-link> [pii]<\/comment>."},{"key":"ref60","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.chembiol.2005.07.007","article-title":"A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration","volume":"12","author":"S Zhu","year":"2005","journal-title":"Chem Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.1158\/0008-5472.CAN-03-3500","article-title":"Inhibition of the Raf-MEK1\/2-ERK1\/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin\u2019s lymphoma B cells by Rituximab","volume":"64","author":"AR Jazirehi","year":"2004","journal-title":"Cancer Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.niox.2008.04.018","article-title":"Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases","volume":"19","author":"B Bonavida","year":"2008","journal-title":"Nitric Oxide"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:10:31Z","timestamp":1688123431000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059104"}},"subtitle":[],"editor":[{"given":"Rossella","family":"Rota","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,3,19]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059104","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,19]]}}}