{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:42:41Z","timestamp":1767922961330,"version":"3.49.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0059265","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T05:57:48Z","timestamp":1363413468000},"page":"e59265","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Structural Properties of PAS Domains from the KCNH Potassium Channels"],"prefix":"10.1371","volume":"8","author":[{"given":"Ricardo","family":"Adaixo","sequence":"first","affiliation":[]},{"given":"Carol A.","family":"Harley","sequence":"additional","affiliation":[]},{"given":"Artur F.","family":"Castro-Rodrigues","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o H.","family":"Morais-Cabral","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1073\/pnas.91.8.3438","article-title":"A family of potassium channel genes related to eag in Drosophila and mammals","volume":"91","author":"JW Warmke","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature04710","article-title":"hERG potassium channels and cardiac arrhythmia","volume":"440","author":"MC Sanguinetti","year":"2006","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1460-9568.2002.02079.x","article-title":"The functional properties of the human ether-a-go-go-like (HELK2) K+ channel","volume":"16","author":"A Becchetti","year":"2002","journal-title":"Eur J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1517\/14728222.12.7.837","article-title":"Eag1 as a cancer target","volume":"12","author":"LA Pardo","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81635-9","article-title":"Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain","volume":"95","author":"JH Morais Cabral","year":"1998","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jmb.2012.06.025","article-title":"Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel","volume":"423","author":"MJ Marques-Carvalho","year":"2012","journal-title":"J Mol Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature10735","article-title":"Structure of the carboxy-terminal region of a KCNH channel","volume":"481","author":"TI Brelidze","year":"2012","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"27989","DOI":"10.1074\/jbc.M109.016337","article-title":"Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods","volume":"284","author":"TI Brelidze","year":"2009","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.physiol.68.040104.134728","article-title":"CNG and HCN channels: two peas, one pod","volume":"68","author":"KB Craven","year":"2006","journal-title":"Annu Rev Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.str.2009.08.011","article-title":"Structure and signaling mechanism of Per-ARNT-Sim domains","volume":"17","author":"A Moglich","year":"2009","journal-title":"Structure"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev-physiol-021909-135922","article-title":"Mammalian Per-Arnt-Sim proteins in environmental adaptation","volume":"72","author":"BE McIntosh","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-micro-121809-151631","article-title":"Ligand-binding PAS domains in a genomic, cellular, and structural context","volume":"65","author":"JT Henry","year":"2011","journal-title":"Annu Rev Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1113\/jphysiol.1996.sp021410","article-title":"Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel","volume":"3)","author":"R Schonherr","year":"1996","journal-title":"J Physiol 493 (Pt"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1469-7793.1997.537bj.x","article-title":"Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment","volume":"3)","author":"H Terlau","year":"1997","journal-title":"J Physiol 502 (Pt"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbrc.2010.10.132","article-title":"NMR solution structure of the N-terminal domain of hERG and its interaction with the S4\u2013S5 linker","volume":"403","author":"Q Li","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e16191","DOI":"10.1371\/journal.pone.0016191","article-title":"The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation","volume":"6","author":"CA Ng","year":"2011","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1074\/jbc.M110.199364","article-title":"Mechanistic insight into human ether-a-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain","volume":"286","author":"FW Muskett","year":"2011","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1085\/jgp.115.6.749","article-title":"Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels","volume":"115","author":"J Wang","year":"2000","journal-title":"J Gen Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13082","DOI":"10.1073\/pnas.0900180106","article-title":"A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels","volume":"106","author":"AS Gustina","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1107\/S1744309110027880","article-title":"Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels","volume":"66","author":"R Adaixo","year":"2010","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nsmb1269","article-title":"The multifunctional human p100 protein \u2018hooks\u2019 methylated ligands","volume":"14","author":"N Shaw","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e32654","DOI":"10.1371\/journal.pone.0032654","article-title":"Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel","volume":"7","author":"CA Harley","year":"2012","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1107\/S0907444905039107","article-title":"The integration of macromolecular diffraction data","volume":"62","author":"AG Leslie","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Xds","volume":"66","author":"W Kabsch","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"P Evans","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"AJ McCoy","year":"2007","journal-title":"J Appl Crystallogr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1107\/S0907444906005270","article-title":"Optimal description of a protein structure in terms of multiple groups undergoing TLS motion","volume":"62","author":"J Painter","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"GN Murshudov","year":"1997","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"PD Adams","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref31","unstructured":"Schrodinger LLC (2010) The PyMOL Molecular Graphics System, Version 1.3r1."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkl282","article-title":"CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues","volume":"34","author":"J Dundas","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000188","DOI":"10.1371\/journal.pcbi.1000188","article-title":"Cavities and atomic packing in protein structures and interfaces","volume":"4","author":"S Sonavane","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1126\/science.1137128","article-title":"Conformational switching in the fungal light sensor Vivid","volume":"316","author":"BD Zoltowski","year":"2007","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9449","DOI":"10.1073\/pnas.1100262108","article-title":"Structural basis of photosensitivity in a bacterial light-oxygen-voltage\/helix-turn-helix (LOV-HTH) DNA-binding protein","volume":"108","author":"AI Nash","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"14001","DOI":"10.1021\/bi701543e","article-title":"N- and C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa","volume":"46","author":"AS Halavaty","year":"2007","journal-title":"Biochemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jmb.2005.08.043","article-title":"Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization","volume":"353","author":"PB Card","year":"2005","journal-title":"J Mol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1073\/pnas.0808092106","article-title":"Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor","volume":"106","author":"TH Scheuermann","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"19065","DOI":"10.1074\/jbc.M111.238899","article-title":"Demonstration of physical proximity between the N terminus and the S4\u2013S5 linker of the human ether-a-go-go-related gene (hERG) potassium channel","volume":"286","author":"P de la Pena","year":"2011","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/S0006-3495(03)75052-8","article-title":"Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii","volume":"84","author":"R Fedorov","year":"2003","journal-title":"Biophys J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jmb.2008.08.010","article-title":"C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain","volume":"383","author":"YF Zhou","year":"2008","journal-title":"J Mol Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1021\/bi00019a004","article-title":"1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore","volume":"34","author":"GE Borgstahl","year":"1995","journal-title":"Biochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T21:42:14Z","timestamp":1540244534000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059265"}},"subtitle":[],"editor":[{"given":"Zhe","family":"Zhang","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,3,15]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059265","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,15]]}}}