{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:29:41Z","timestamp":1767176981032,"version":"build-2238731810"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0060672","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T17:09:34Z","timestamp":1365440974000},"page":"e60672","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Carbon Monoxide Abrogates Ischemic Insult to Neuronal Cells via the Soluble Guanylate Cyclase-cGMP Pathway"],"prefix":"10.1371","volume":"8","author":[{"given":"Nils","family":"Schallner","sequence":"first","affiliation":[]},{"given":"Carlos C.","family":"Rom\u00e3o","sequence":"additional","affiliation":[]},{"given":"Julia","family":"Biermann","sequence":"additional","affiliation":[]},{"given":"Wolf A.","family":"Lagr\u00e8ze","sequence":"additional","affiliation":[]},{"given":"Leo E.","family":"Otterbein","sequence":"additional","affiliation":[]},{"given":"Hartmut","family":"Buerkle","sequence":"additional","affiliation":[]},{"given":"Torsten","family":"Loop","sequence":"additional","affiliation":[]},{"given":"Ulrich","family":"Goebel","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1097\/ALN.0b013e318216e7f4","article-title":"Perioperative stroke and associated mortality after noncardiac, nonneurologic surgery","volume":"114","author":"GA Mashour","year":"2011","journal-title":"Anesthesiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1471-4159.2008.05610.x","article-title":"Pre-conditioning induced by carbon monoxide provides neuronal protection against apoptosis","volume":"107","author":"HL Vieira","year":"2008","journal-title":"J Neurochem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1167\/iovs.09-4894","article-title":"Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia\/reperfusion injury","volume":"51","author":"J Biermann","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1124\/jpet.106.104729","article-title":"Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3","volume":"318","author":"MG Bani-Hani","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/CCM.0b013e31822f0d64","article-title":"CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke","volume":"40","author":"A Yabluchanskiy","year":"2012","journal-title":"Crit Care Med"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Seixas JD, Mukhopadhyay A, Santos-Silva T, Otterbein LE, Gallo DJ, <etal>et al<\/etal>.. (2012) Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics. Dalton Trans 10.1039\/c2dt32174b.","DOI":"10.1039\/C2DT32174B"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.4049\/jimmunol.1002433","article-title":"An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis","volume":"186","author":"SZ Sheikh","year":"2011","journal-title":"J Immunol"},{"key":"ref8","unstructured":"Rodrigues S, Seixas JD, Guerreiro B, Pereira NMP, Romao CC, <etal>et al<\/etal>.. (2011) Prevention of Gastric Ulcer by Carbon Monoxide. US 2011\/0038955 A1. Feb. 17."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1161\/ATVBAHA.111.229039","article-title":"Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules","volume":"31","author":"A Marazioti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"R Motterlini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.bjp.0706241","article-title":"Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages","volume":"145","author":"P Sawle","year":"2005","journal-title":"Br J Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M503512200","article-title":"Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle","volume":"280","author":"C Taille","year":"2005","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1096\/fj.04-2169fje","article-title":"CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule","volume":"19","author":"R Motterlini","year":"2005","journal-title":"FASEB J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1152\/jn.1995.74.4.1498","article-title":"Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide","volume":"74","author":"T Leinders-Zufall","year":"1995","journal-title":"J Neurophysiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/sj.bjp.0705825","article-title":"Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule","volume":"142","author":"R Foresti","year":"2004","journal-title":"Br J Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000065431","article-title":"Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells","volume":"11","author":"RR Fiscus","year":"2002","journal-title":"Neurosignals"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejphar.2011.08.028","article-title":"p38beta-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro","volume":"670","author":"N Schallner","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1167\/iovs.07-1050","article-title":"Quantification of ischemic damage in the rat retina: a comparative study using evoked potentials, electroretinography, and histology","volume":"49","author":"T Jehle","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1523\/JNEUROSCI.08-01-00265.1988","article-title":"Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats","volume":"8","author":"MP Villegas-Perez","year":"1988","journal-title":"J Neurosci"},{"key":"ref20","first-page":"587","article-title":"Cytoarchitecture of the retinal ganglion cells in the rat","volume":"43","author":"J Danias","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/ALN.0b013e3181733115","article-title":"Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs","volume":"108","author":"U Goebel","year":"2008","journal-title":"Anesthesiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1164\/rccm.200708-1265OC","article-title":"Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1","volume":"177","author":"A Hoetzel","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"LE Otterbein","year":"2000","journal-title":"Nat Med"},{"key":"ref24","first-page":"L688","article-title":"Carbon monoxide provides protection against hyperoxic lung injury","volume":"276","author":"LE Otterbein","year":"1999","journal-title":"Am J Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm817","article-title":"Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury","volume":"9","author":"LE Otterbein","year":"2003","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0002-9440(10)63646-2","article-title":"Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects","volume":"163","author":"R Song","year":"2003","journal-title":"Am J Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1074\/jbc.M607610200","article-title":"Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation","volume":"282","author":"X Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1074\/jbc.M208419200","article-title":"Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3","volume":"278","author":"X Zhang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1074\/jbc.M111.306738","article-title":"Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of Bcl-2","volume":"287","author":"AS Almeida","year":"2012","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12640-009-9014-4","article-title":"Low doses of carbon monoxide protect against experimental focal brain ischemia","volume":"15","author":"E Zeynalov","year":"2009","journal-title":"Neurotox Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e41982","DOI":"10.1371\/journal.pone.0041982","article-title":"Inhaled carbon monoxide provides cerebral cytoprotection in pigs","volume":"7","author":"VL Mahan","year":"2012","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1039\/c2cs15317c","article-title":"Developing drug molecules for therapy with carbon monoxide","volume":"41","author":"CC Romao","year":"2012","journal-title":"Chem Soc Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.RES.0000084381.86567.08","article-title":"Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule","volume":"93","author":"JE Clark","year":"2003","journal-title":"Circ Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1124\/jpet.106.117218","article-title":"Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow","volume":"321","author":"P Urquhart","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.bjp.0707184","article-title":"The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells","volume":"150","author":"J Megias","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.2008.155481","article-title":"Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK\/HO-1 signalling and reduction of oxidative stress","volume":"58","author":"O De Backer","year":"2009","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1399-3089.2009.00521.x","article-title":"In vitro and in vivo effects of the carbon monoxide-releasing molecule, CORM-3, in the xenogeneic pig-to-primate context","volume":"16","author":"M Vadori","year":"2009","journal-title":"Xenotransplantation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/mol.109.055137","article-title":"Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo","volume":"76","author":"K Tsoyi","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"F789","DOI":"10.1152\/ajprenal.00363.2005","article-title":"Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule","volume":"290","author":"Y Tayem","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(02)00964-3","article-title":"Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells","volume":"333","author":"Y Kitamura","year":"2002","journal-title":"Neurosci Lett"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/toxsci\/kfh089","article-title":"Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells","volume":"79","author":"K Newhouse","year":"2004","journal-title":"Toxicol Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1046\/j.1471-4159.2002.01224.x","article-title":"Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells","volume":"83","author":"X Wang","year":"2002","journal-title":"J Neurochem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1124\/jpet.107.123505","article-title":"Chondroitin sulfate protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase\/Akt","volume":"323","author":"N Canas","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuroscience.2011.10.031","article-title":"Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y","volume":"199","author":"N Xiong","year":"2011","journal-title":"Neuroscience"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/mol.108.047985","article-title":"Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function","volume":"75","author":"LF Hu","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tox.2009.06.004","article-title":"Tranexamic acid protects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells","volume":"262","author":"HJ Kim","year":"2009","journal-title":"Toxicology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.neuro.2009.08.005","article-title":"Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis","volume":"30","author":"HJ Park","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuint.2010.05.008","article-title":"Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells","volume":"57","author":"Y Wu","year":"2010","journal-title":"Neurochem Int"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/SHK.0b013e3181e46f15","article-title":"Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-beta\/JAK2\/STAT-1\/INOS\/NO signaling but not COX-2 in TLR-activated macrophages","volume":"34","author":"K Tsoyi","year":"2010","journal-title":"Shock"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"C256","DOI":"10.1152\/ajpcell.00272.2010","article-title":"Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-alpha-induced apoptosis","volume":"300","author":"S Basuroy","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1096\/fj.06-6644com","article-title":"Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species","volume":"21","author":"BS Zuckerbraun","year":"2007","journal-title":"FASEB J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.immuni.2006.03.012","article-title":"Carbon monoxide orchestrates a protective response through PPARgamma","volume":"24","author":"M Bilban","year":"2006","journal-title":"Immunity"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.91.16.7583","article-title":"Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase","volume":"91","author":"SL Archer","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1167\/iovs.05-0417","article-title":"Inhaled carbon monoxide increases retinal and choroidal blood flow in healthy humans","volume":"46","author":"H Resch","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0006-291X(91)90527-E","article-title":"Expression of soluble guanylate cyclase activity requires both enzyme subunits","volume":"174","author":"WA Buechler","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/bj3350125","article-title":"Functional properties of a naturally occurring isoform of soluble guanylyl cyclase","volume":"1)","author":"M Russwurm","year":"1998","journal-title":"Biochem J 335 (Pt"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e16380","DOI":"10.1371\/journal.pone.0016380","article-title":"Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia\/reperfusion injury","volume":"6","author":"SY Li","year":"2011","journal-title":"PLoS One"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.exer.2011.11.013","article-title":"Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation","volume":"94","author":"Z Zhang","year":"2012","journal-title":"Exp Eye Res"}],"updated-by":[{"DOI":"10.1371\/annotation\/f047d50f-761b-4c99-9e13-d2526fde71b7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T04:35:24Z","timestamp":1644726924000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060672"}},"subtitle":[],"editor":[{"given":"Karl-Wilhelm","family":"Koch","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,4,8]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060672","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,8]]}}}