{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:15:15Z","timestamp":1761513315541},"reference-count":136,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0067694","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T21:07:00Z","timestamp":1372712820000},"page":"e67694","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["GRG5\/AES Interacts with T-Cell Factor 4 (TCF4) and Downregulates Wnt Signaling in Human Cells and Zebrafish Embryos"],"prefix":"10.1371","volume":"8","author":[{"given":"\u00c2ngela M. Sousa","family":"Costa","sequence":"first","affiliation":[]},{"given":"Isabel","family":"Pereira-Castro","sequence":"additional","affiliation":[]},{"given":"Elisabete","family":"Ricardo","sequence":"additional","affiliation":[]},{"given":"Forrest","family":"Spencer","sequence":"additional","affiliation":[]},{"given":"Shannon","family":"Fisher","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds Teixeira da","family":"Costa","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,7,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/nar\/20.3.611","article-title":"A gene family of HMG-box transcription factors with homology to TCF-1","volume":"20","author":"J Castrop","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1101\/gad.5.12b.2567","article-title":"DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1","volume":"5","author":"K Giese","year":"1991","journal-title":"Genes Dev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(92)90129-Z","article-title":"The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures","volume":"69","author":"K Giese","year":"1992","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1002\/j.1460-2075.1992.tb05374.x","article-title":"Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix","volume":"11","author":"M van de Wetering","year":"1992","journal-title":"EMBO J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1101\/gad.5.5.880","article-title":"LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]","volume":"5","author":"A Travis","year":"1991","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/j.1460-2075.1991.tb07928.x","article-title":"Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box","volume":"10","author":"M van de Wetering","year":"1991","journal-title":"EMBO J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1101\/gad.5.4.656","article-title":"A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer","volume":"5","author":"ML Waterman","year":"1991","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1101\/gad.13.6.709","article-title":"Wnt3a-\/--like phenotype and limb deficiency in Lef1(-\/-)Tcf1(-\/-) mice","volume":"13","author":"J Galceran","year":"1999","journal-title":"Genes Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1242\/dev.127.3.469","article-title":"Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1","volume":"127","author":"J Galceran","year":"2000","journal-title":"Development"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/35038097","article-title":"Repressor activity of Headless\/Tcf3 is essential for vertebrate head formation","volume":"407","author":"CH Kim","year":"2000","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1128\/MCB.18.3.1248","article-title":"Two members of the Tcf family implicated in Wnt\/beta-catenin signaling during embryogenesis in the mouse","volume":"18","author":"V Korinek","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0092-8674(95)90100-0","article-title":"pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos","volume":"83","author":"R Lin","year":"1995","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80112-9","article-title":"XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos","volume":"86","author":"M Molenaar","year":"1996","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0925-4773(98)00132-4","article-title":"Function of zebrafish beta-catenin and TCF-3 in dorsoventral patterning","volume":"77","author":"F Pelegri","year":"1998","journal-title":"Mech Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0092-8674(00)81925-X","article-title":"Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF","volume":"88","author":"M van de Wetering","year":"1997","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0002-9440(10)65247-9","article-title":"Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium","volume":"154","author":"N Barker","year":"1999","journal-title":"Am J Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/1270","article-title":"Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4","volume":"19","author":"V Korinek","year":"1998","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-\/- colon carcinoma","volume":"275","author":"V Korinek","year":"1997","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/sj.embor.7401071","article-title":"T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine","volume":"8","author":"V Muncan","year":"2007","journal-title":"EMBO Rep"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/382638a0","article-title":"Functional interaction of beta-catenin with the transcription factor LEF-1","volume":"382","author":"J Behrens","year":"1996","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0925-4773(96)00597-7","article-title":"Nuclear localization of beta-catenin by interaction with transcription factor LEF-1","volume":"59","author":"O Huber","year":"1996","journal-title":"Mech Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1101\/gad.11.24.3286","article-title":"Wnt signaling: a common theme in animal development","volume":"11","author":"KM Cadigan","year":"1997","journal-title":"Genes Dev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1242\/jcs.00089","article-title":"The Wnt signalling pathway","volume":"115","author":"J Huelsken","year":"2002","journal-title":"J Cell Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"CY Logan","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1073\/pnas.92.7.3046","article-title":"Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein","volume":"92","author":"S Munemitsu","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.8259518","article-title":"Association of the APC gene product with beta-catenin","volume":"262","author":"B Rubinfeld","year":"1993","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.8259519","article-title":"Association of the APC tumor suppressor protein with catenins","volume":"262","author":"LK Su","year":"1993","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"PJ Morin","year":"1997","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(02)01014-0","article-title":"The beta-catenin\/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells","volume":"111","author":"M van de Wetering","year":"2002","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.280.5363.596","article-title":"Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta","volume":"280","author":"J Behrens","year":"1998","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0960-9822(98)70226-X","article-title":"Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta","volume":"8","author":"MJ Hart","year":"1998","journal-title":"Curr Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/emboj\/17.5.1371","article-title":"Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin","volume":"17","author":"S Ikeda","year":"1998","journal-title":"EMBO J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.272.5264.1023","article-title":"Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly","volume":"272","author":"B Rubinfeld","year":"1996","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1073\/pnas.95.6.3020","article-title":"Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription","volume":"95","author":"C Sakanaka","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1101\/gad.10.12.1443","article-title":"The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3","volume":"10","author":"C Yost","year":"1996","journal-title":"Genes Dev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(00)80324-4","article-title":"The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation","volume":"90","author":"L Zeng","year":"1997","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1006\/dbio.1994.1336","article-title":"Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase","volume":"166","author":"M Peifer","year":"1994","journal-title":"Dev Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/dev.120.2.369","article-title":"wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo","volume":"120","author":"M Peifer","year":"1994","journal-title":"Development"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0092-8674(05)80065-0","article-title":"wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate","volume":"71","author":"E Siegfried","year":"1992","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/367076a0","article-title":"Components of wingless signalling in Drosophila","volume":"367","author":"E Siegfried","year":"1994","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1093\/emboj\/16.13.3797","article-title":"beta-catenin is a target for the ubiquitin-proteasome pathway","volume":"16","author":"H Aberle","year":"1997","journal-title":"EMBO J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.1038\/sj.onc.1210055","article-title":"beta-catenin destruction complex: insights and questions from a structural perspective","volume":"25","author":"D Kimelman","year":"2006","journal-title":"Oncogene"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1101\/gad.11.18.2359","article-title":"A beta-catenin\/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus","volume":"11","author":"M Brannon","year":"1997","journal-title":"Genes Dev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)81924-8","article-title":"LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic","volume":"88","author":"J Riese","year":"1997","journal-title":"Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)80531-0","article-title":"Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos","volume":"90","author":"CE Rocheleau","year":"1997","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0092-8674(00)80530-9","article-title":"Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm","volume":"90","author":"CJ Thorpe","year":"1997","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/26982","article-title":"Drosophila Tcf and Groucho interact to repress Wingless signalling activity","volume":"395","author":"RA Cavallo","year":"1998","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1073\/pnas.95.20.11590","article-title":"Transcriptional repression by AML1 and LEF-1 is mediated by the TLE\/Groucho corepressors","volume":"95","author":"D Levanon","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/26989","article-title":"The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors","volume":"395","author":"J Roose","year":"1998","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1242\/dev.00935","article-title":"Tcf3: a transcriptional regulator of axis induction in the early embryo","volume":"131","author":"BJ Merrill","year":"2004","journal-title":"Development"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00427-005-0474-0","article-title":"Choice of either beta-catenin or Groucho\/TLE as a co-factor for Xtcf-3 determines dorsal-ventral cell fate of diencephalon during Xenopus development","volume":"215","author":"S Tsuji","year":"2005","journal-title":"Dev Genes Evol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/dbio.1995.0009","article-title":"beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning","volume":"172","author":"KA Guger","year":"1995","journal-title":"Dev Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/dbio.2001.0503","article-title":"Heads or tails? Amphioxus and the evolution of anterior-posterior patterning in deuterostomes","volume":"241","author":"LZ Holland","year":"2002","journal-title":"Dev Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0925-4773(95)00442-4","article-title":"Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin","volume":"53","author":"GM Kelly","year":"1995","journal-title":"Mech Dev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.136.5.1123","article-title":"Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway","volume":"136","author":"CA Larabell","year":"1997","journal-title":"J Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0925-4773(96)00546-1","article-title":"Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos","volume":"57","author":"S Schneider","year":"1996","journal-title":"Mech Dev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s004270050226","article-title":"Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish","volume":"209","author":"L Sumoy","year":"1999","journal-title":"Dev Genes Evol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.1999.9551","article-title":"TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis","volume":"217","author":"A Vonica","year":"2000","journal-title":"Dev Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1101\/gad.12.13.1931","article-title":"Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates","volume":"12","author":"AL Fisher","year":"1998","journal-title":"Genes Dev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1073\/pnas.94.12.6250","article-title":"Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis","volume":"94","author":"B Giebel","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/sj.emboj.7600907","article-title":"Huckebein-mediated autoregulation of Glide\/Gcm triggers glia specification","volume":"25","author":"R De Iaco","year":"2006","journal-title":"EMBO J"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/nar\/29.7.1410","article-title":"All Tcf HMG box transcription factors interact with Groucho-related co-repressors","volume":"29","author":"H Brantjes","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"47732","DOI":"10.1074\/jbc.M208154200","article-title":"Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation","volume":"277","author":"M Lepourcelet","year":"2002","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ydbio.2004.12.023","article-title":"LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo","volume":"279","author":"RC Range","year":"2005","journal-title":"Dev Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.7.3.491","article-title":"Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain","volume":"7","author":"K Han","year":"1993","journal-title":"Genes Dev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1128\/MCB.21.14.4614-4625.2001","article-title":"Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split","volume":"21","author":"X Yu","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1101\/gad.13.1.125","article-title":"PRDI-BF1\/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins","volume":"13","author":"B Ren","year":"1999","journal-title":"Genes Dev"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1074\/jbc.275.6.4383","article-title":"Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats","volume":"275","author":"T Tetsuka","year":"2000","journal-title":"J Biol Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2407-9-159","article-title":"Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression","volume":"9","author":"L Arce","year":"2009","journal-title":"BMC Cancer"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/33952","article-title":"Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3","volume":"392","author":"SE Rundlett","year":"1998","journal-title":"Nature"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"38989","DOI":"10.1074\/jbc.M111.297952","article-title":"Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability","volume":"286","author":"NJ Sarma","year":"2011","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/nar\/20.6.1425","article-title":"Improved method for high efficiency transformation of intact yeast cells","volume":"20","author":"D Gietz","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1242\/dev.121.2.347","article-title":"Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish","volume":"121","author":"MA Akimenko","year":"1995","journal-title":"Development"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/nprot.2006.230","article-title":"Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish","volume":"1","author":"S Fisher","year":"2006","journal-title":"Nat Protoc"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1006\/dbio.1997.8788","article-title":"Differential regulation of chordin expression domains in mutant zebrafish","volume":"192","author":"VE Miller-Bertoglio","year":"1997","journal-title":"Dev Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1073\/pnas.92.23.10713","article-title":"Intraembryonic hematopoietic cell migration during vertebrate development","volume":"92","author":"HW Detrich 3rd","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1093\/emboj\/cdg593","article-title":"An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction","volume":"22","author":"J Zhao","year":"2003","journal-title":"EMBO J"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"C Thisse","year":"2008","journal-title":"Nat Protoc"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1093\/nar\/gkp1197","article-title":"Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt\/beta-catenin targets","volume":"38","author":"A Weise","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/nar\/gkg346","article-title":"HMG box transcription factor TCF-4\u2019s interaction with CtBP1 controls the expression of the Wnt target Axin2\/Conduction in human embryonic kidney cells","volume":"31","author":"T Valenta","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.1074\/jbc.M007533200","article-title":"Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4","volume":"276","author":"T Pukrop","year":"2001","journal-title":"J Biol Chem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1038\/sj.onc.1210056","article-title":"Diversity of LEF\/TCF action in development and disease","volume":"25","author":"L Arce","year":"2006","journal-title":"Oncogene"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1242\/dev.126.14.3159","article-title":"XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development","volume":"126","author":"M Brannon","year":"1999","journal-title":"Development"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1242\/dev.126.17.3747","article-title":"Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho","volume":"126","author":"RE Goldstein","year":"1999","journal-title":"Development"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"14159","DOI":"10.1074\/jbc.M107055200","article-title":"Functional diversity of Xenopus lymphoid enhancer factor\/T-cell factor transcription factors relies on combinations of activating and repressing elements","volume":"277","author":"D Gradl","year":"2002","journal-title":"J Biol Chem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1002\/dvdy.22439","article-title":"AES\/GRG5: more than just a dominant-negative TLE\/GRG family member","volume":"239","author":"B Beagle","year":"2010","journal-title":"Dev Dyn"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1128\/MCB.16.6.2670","article-title":"The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein\u2013protein interaction domain","volume":"16","author":"AL Fisher","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.genet.37.110801.143752","article-title":"Molecular genetics of axis formation in zebrafish","volume":"39","author":"AF Schier","year":"2005","journal-title":"Annu Rev Genet"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1242\/dev.127.18.3899","article-title":"Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish","volume":"127","author":"C Kelly","year":"2000","journal-title":"Development"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0092-8674(89)90506-0","article-title":"Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis","volume":"58","author":"AP McMahon","year":"1989","journal-title":"Cell"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1083\/jcb.128.5.959","article-title":"Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling","volume":"128","author":"N Funayama","year":"1995","journal-title":"J Cell Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.123.2.477","article-title":"Induction of a secondary body axis in Xenopus by antibodies to beta-catenin","volume":"123","author":"PD McCrea","year":"1993","journal-title":"J Cell Biol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cub.2005.01.041","article-title":"The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt\/beta-catenin signaling in mesoderm and neuroectoderm patterning","volume":"15","author":"G Weidinger","year":"2005","journal-title":"Curr Biol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1242\/dev.01733","article-title":"Wnt\/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish","volume":"132","author":"CJ Thorpe","year":"2005","journal-title":"Development"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1242\/dev.068270","article-title":"Tcf\/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS","volume":"138","author":"H Wang","year":"2011","journal-title":"Development"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ydbio.2004.06.015","article-title":"Autoregulation of canonical Wnt signaling controls midbrain development","volume":"273","author":"M Kunz","year":"2004","journal-title":"Dev Biol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ng.431","article-title":"Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia","volume":"41","author":"H Nguyen","year":"2009","journal-title":"Nat Genet"},{"key":"ref98","first-page":"3465","article-title":"Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation","volume":"61","author":"JM Mariadason","year":"2001","journal-title":"Cancer Res"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2010.07.062","article-title":"The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner","volume":"399","author":"I Struewing","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1128\/MCB.02132-06","article-title":"A unique DNA binding domain converts T-cell factors into strong Wnt effectors","volume":"27","author":"FA Atcha","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref101","first-page":"3872","article-title":"The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines","volume":"60","author":"A Duval","year":"2000","journal-title":"Cancer Res"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1210\/me.2003-0225","article-title":"TCF and Groucho-related genes influence pituitary growth and development","volume":"17","author":"ML Brinkmeier","year":"2003","journal-title":"Mol Endocrinol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00335-001-2076-0","article-title":"Identification of members of the Wnt signaling pathway in the embryonic pituitary gland","volume":"12","author":"KR Douglas","year":"2001","journal-title":"Mamm Genome"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0925-4773(02)00180-6","article-title":"Expression and splice variant analysis of the zebrafish tcf4 transcription factor","volume":"117","author":"RM Young","year":"2002","journal-title":"Mech Dev"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0925-4773(98)00131-2","article-title":"TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs","volume":"77","author":"EA Cho","year":"1998","journal-title":"Mech Dev"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1002\/j.1460-2075.1993.tb06155.x","article-title":"LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites","volume":"12","author":"K Giese","year":"1993","journal-title":"EMBO J"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1101\/gad.7.12a.2418","article-title":"The hLEF\/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells","volume":"7","author":"P Carlsson","year":"1993","journal-title":"Genes Dev"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/jcb.20476","article-title":"Mammalian Groucho homologs: redundancy or specificity?","volume":"95","author":"M Gasperowicz","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1128\/MCB.12.6.2475","article-title":"Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains","volume":"12","author":"SM Wainwright","year":"1992","journal-title":"Mol Cell Biol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/MCB.17.9.5581","article-title":"Groucho-dependent and -independent repression activities of Runt domain proteins","volume":"17","author":"BD Aronson","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1128\/MCB.15.9.5007","article-title":"The transcriptional repressor even-skipped interacts directly with TATA-binding protein","volume":"15","author":"M Um","year":"1995","journal-title":"Mol Cell Biol"},{"key":"ref112","first-page":"1243","article-title":"WT1, the Wilms\u2019 tumor suppressor gene product, represses transcription through an interactive nuclear protein","volume":"10","author":"ZY Wang","year":"1995","journal-title":"Oncogene"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0168-9525(96)10022-6","article-title":"Active repression mechanisms of eukaryotic transcription repressors","volume":"12","author":"W Hanna-Rose","year":"1996","journal-title":"Trends Genet"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/gb-2008-9-1-205","article-title":"The Groucho\/TLE\/Grg family of transcriptional co-repressors","volume":"9","author":"BH Jennings","year":"2008","journal-title":"Genome Biol"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.molcel.2007.10.002","article-title":"Repression by Groucho\/TLE\/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo","volume":"28","author":"T Sekiya","year":"2007","journal-title":"Mol Cell"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1128\/MCB.24.10.4341-4350.2004","article-title":"Groucho oligomerization is required for repression in vivo","volume":"24","author":"H Song","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1128\/MCB.18.12.7259","article-title":"A role for Groucho tetramerization in transcriptional repression","volume":"18","author":"G Chen","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"33026","DOI":"10.1074\/jbc.271.51.33026","article-title":"Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain","volume":"271","author":"M Pinto","year":"1996","journal-title":"J Biol Chem"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(00)00161-X","article-title":"Groucho\/TLE family proteins and transcriptional repression","volume":"249","author":"G Chen","year":"2000","journal-title":"Gene"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1101\/gad.13.17.2218","article-title":"A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development","volume":"13","author":"G Chen","year":"1999","journal-title":"Genes Dev"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BJ20091631","article-title":"Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription","volume":"427","author":"Y Zhang","year":"2010","journal-title":"Biochem J"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1242\/dev.046219","article-title":"The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans","volume":"137","author":"EB Flowers","year":"2010","journal-title":"Development"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nsmb912","article-title":"Beta-catenin directly displaces Groucho\/TLE repressors from Tcf\/Lef in Wnt-mediated transcription activation","volume":"12","author":"DL Daniels","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"e11821","DOI":"10.1371\/journal.pone.0011821","article-title":"Differential modulation of TCF\/LEF-1 activity by the soluble LRP6-ICD","volume":"5","author":"B Beagle","year":"2010","journal-title":"PLOS ONE"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1126\/science.285.5435.1923","article-title":"Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1","volume":"285","author":"J Roose","year":"1999","journal-title":"Science"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.embor.7401122","article-title":"Differential in vivo requirements for oligomerization during Groucho-mediated repression","volume":"9","author":"BH Jennings","year":"2008","journal-title":"EMBO Rep"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ydbio.2011.10.016","article-title":"Huckebein is part of a combinatorial repression code in the anterior blastoderm","volume":"361","author":"LP Andrioli","year":"2012","journal-title":"Dev Biol"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0925-4773(99)00101-X","article-title":"Maternal and embryonic expression of zebrafish lef1","volume":"86","author":"RI Dorsky","year":"1999","journal-title":"Mech Dev"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1242\/dev.00150","article-title":"Beta-catenin\/Tcf-regulated transcription prior to the midblastula transition","volume":"129","author":"J Yang","year":"2002","journal-title":"Development"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-60327-469-2_17","article-title":"Wnt signaling mediates diverse developmental processes in zebrafish","volume":"469","author":"H Verkade","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"e1000548","DOI":"10.1371\/journal.pcbi.1000548","article-title":"Gene circuit analysis of the terminal gap gene huckebein","volume":"5","author":"M Ashyraliyev","year":"2009","journal-title":"PLOS Comput Biol"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00427-008-0248-6","article-title":"C2H2 zinc finger genes of the Gli, Zic, KLF, SP, Wilms&apos; tumour, Huckebein, Snail, Ovo, Spalt, Odd, Blimp-1, Fez and related gene families from Branchiostoma floridae","volume":"218","author":"SM Shimeld","year":"2008","journal-title":"Dev Genes Evol"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0925-4773(99)00259-2","article-title":"Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis","volume":"91","author":"M Molenaar","year":"2000","journal-title":"Mech Dev"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ydbio.2004.03.003","article-title":"Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice","volume":"270","author":"W Wang","year":"2004","journal-title":"Dev Biol"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ydbio.2005.10.012","article-title":"Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes","volume":"289","author":"HJ Standley","year":"2006","journal-title":"Dev Biol"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1242\/dev.02152","article-title":"Distinct roles for Xenopus Tcf\/Lef genes in mediating specific responses to Wnt\/beta-catenin signalling in mesoderm development","volume":"132","author":"F Liu","year":"2005","journal-title":"Development"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0067694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T23:58:35Z","timestamp":1645919915000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0067694"}},"subtitle":[],"editor":[{"given":"Michael","family":"Schubert","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,7,1]]},"references-count":136,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0067694","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,1]]}}}