{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:50:35Z","timestamp":1774468235759,"version":"3.50.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0073846","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T20:58:24Z","timestamp":1378414704000},"page":"e73846","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":141,"title":["Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset"],"prefix":"10.1371","volume":"8","author":[{"given":"Mariana C.","family":"Rocha","sequence":"first","affiliation":[]},{"given":"Paula A.","family":"Pousinha","sequence":"additional","affiliation":[]},{"given":"Alexandra M.","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Ana M.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[]},{"given":"Joaquim A.","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"S Boill\u00e9e","year":"2006","journal-title":"Neuron"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrneurol.2011.152","article-title":"Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis","volume":"7","author":"L Ferraiuolo","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1523\/JNEUROSCI.20-07-02534.2000","article-title":"Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases","volume":"20","author":"D Frey","year":"2000","journal-title":"J Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nbd.2007.07.003","article-title":"Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis","volume":"28","author":"J Hegedus","year":"2007","journal-title":"Neurobiol Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1113\/jphysiol.2007.149286","article-title":"Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis","volume":"586","author":"J Hegedus","year":"2008","journal-title":"J Physiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.expneurol.2011.05.007","article-title":"Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: a longitudinal MRI study","volume":"231","author":"S Marcuzzo","year":"2011","journal-title":"Exp Neurol"},{"key":"ref7","first-page":"6.2.8","article-title":"Neuromuscular transmission in a transgene animal model of motor neuron disease. In Proceedings of the 18th Annual International Conference","author":"YI Kim","year":"1996"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fncel.2011.00026","article-title":"Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS","volume":"5","author":"N Naumenko","year":"2011","journal-title":"Front Cell Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12015-011-9281-3","article-title":"Defective neuromuscular transmission in the SOD1 G93A transgenic mouse improves after administration of human umbilical cord blood cells","volume":"8","author":"N Souayah","year":"2012","journal-title":"Stem Cell Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"ME Gurney","year":"1994","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"DR Rosen","year":"1993","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1385-299X(97)00034-2","article-title":"An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism","volume":"2","author":"G Rozas","year":"1997","journal-title":"Brain Res Brain Res Protoc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ana.10476","article-title":"Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS","volume":"53","author":"W Zhang","year":"2003","journal-title":"Ann Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.neurobiolaging.2012.01.008","article-title":"Neuromuscular transmission modulation by adenosine upon aging","volume":"33","author":"PA Pousinha","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1113\/jphysiol.1987.sp016470","article-title":"On the role, inactivation and origin of endogenous adenosine at the frog neuromuscular junction","volume":"384","author":"JA Ribeiro","year":"1987","journal-title":"J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.1975.tb06931.x","article-title":"The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions","volume":"54","author":"JA Ribeiro","year":"1975","journal-title":"Br J Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1016\/S0021-9258(17)39364-X","article-title":"Conus geographus toxins that discriminate between neuronal and muscle sodium channels","volume":"260","author":"LJ Cruz","year":"1985","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1113\/jphysiol.2002.022343","article-title":"Age-dependent synapse withdrawal at axotomised neuromuscular junctions in Wld(s) mutant and Ube4b\/Nmnat transgenic mice","volume":"543","author":"TH Gillingwater","year":"2002","journal-title":"J Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1124\/jpet.106.108670","article-title":"Acetylcholine release at neuromuscular junctions of adult tottering mice is controlled by N-(cav2.2) and R-type (cav2.3) but not L-type (cav1.2) Ca2+ channels","volume":"319","author":"NE Pardo","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1523\/JNEUROSCI.2011-10.2011","article-title":"Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease","volume":"31","author":"JL Rozas","year":"2011","journal-title":"J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2006.03.055","article-title":"Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse","volume":"1089","author":"MS Sons","year":"2006","journal-title":"Brain Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1113\/jphysiol.1978.sp012133","article-title":"The effect of age on neuromuscular transmission","volume":"274","author":"SS Kelly","year":"1978","journal-title":"J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0301-0082(00)00055-1","article-title":"Safety factor at the neuromuscular junction","volume":"64","author":"SJ Wood","year":"2001","journal-title":"Prog Neurobiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF02207269","article-title":"On the possible origin of giant or slow-rising miniature end-plate potentials at the neuromuscular junction","volume":"431","author":"LC Sellin","year":"1996","journal-title":"Pflugers Arch"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1098\/rspb.1982.0028","article-title":"Discrepancies between spontaneous and evoked synaptic potentials at normal, regenerating and botulinum toxin poisoned mammalian neuromuscular junctions","volume":"215","author":"C Colm\u00e9us","year":"1982","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0006-8993(83)91123-X","article-title":"Botulinum toxin and 4-aminoquinoline induce a similar abnormal type of spontaneous quantal transmitter release at the rat neuromuscular junction","volume":"264","author":"S Thesleff","year":"1983","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn1583","article-title":"Synaptic vesicle pools","volume":"6","author":"SO Rizzoli","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2202-10-64","article-title":"Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease","volume":"10","author":"MK Jaiswal","year":"2009","journal-title":"BMC Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1523\/JNEUROSCI.18-09-03241.1998","article-title":"Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1","volume":"18","author":"J Kong","year":"1998","journal-title":"J Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1471-4159.2006.03619.x","article-title":"Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu\/Zn-superoxide dismutase mutant mice","volume":"96","author":"M Damiano","year":"2006","journal-title":"J Neurochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.0810934106","article-title":"The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals","volume":"106","author":"KT Nguyen","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1113\/jphysiol.2003.041905","article-title":"Stimulation-induced mitochondrial [Ca2+] elevations in mouse motor terminals: comparison of wild-type with SOD1-G93A","volume":"549","author":"L Vila","year":"2003","journal-title":"J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1074\/jbc.M109.041319","article-title":"Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis","volume":"285","author":"J Zhou","year":"2010","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1523\/JNEUROSCI.4394-05.2006","article-title":"Calcium signaling pathways mediating synaptic potentiation triggered by amyotrophic lateral sclerosis IgG in motor nerve terminals","volume":"26","author":"MR Pagani","year":"2006","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1113\/jphysiol.1990.sp018298","article-title":"Spontaneous activity at long-term silenced synapses in rat muscle","volume":"430","author":"K Gundersen","year":"1990","journal-title":"J Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1113\/jphysiol.1960.sp006573","article-title":"Properties of regenerating neuromuscular synapses in the frog","volume":"154","author":"R Miledi","year":"1960","journal-title":"J Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1113\/jphysiol.1960.sp006379","article-title":"Physiological and structural changes at the amphibian myoneural junction, in the course of nerve degeneration","volume":"150","author":"R Birks","year":"1960","journal-title":"J Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1113\/jphysiol.1980.sp013446","article-title":"A comparative electrophysiological study of motor end-plate diseased skeletal muscle in the mouse","volume":"307","author":"SP Weinstein","year":"1980","journal-title":"J Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"LR Fischer","year":"2004","journal-title":"Exp Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/hmg\/ddn422","article-title":"Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3","volume":"18","author":"M Tateno","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.4081\/ni.2009.e16","article-title":"Early detachment of neuromuscular junction proteins in ALS mice with SODG93A mutation","volume":"1","author":"H Narai","year":"2009","journal-title":"Neurol Int"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1523\/JNEUROSCI.4496-09.2010","article-title":"Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice","volume":"30","author":"R Ruiz","year":"2010","journal-title":"J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.nmd.2005.02.005","article-title":"Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis","volume":"15","author":"JD Atkin","year":"2005","journal-title":"Neuromuscul Disord"},{"key":"ref44","first-page":"519","article-title":"Muscle fibre growth in five different muscles in both sexes of mice","volume":"104","author":"RW Rowe","year":"1969","journal-title":"J Anat"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cne.20620","article-title":"A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis","volume":"490","author":"AM Schaefer","year":"2005","journal-title":"J Comp Neurol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e34640","DOI":"10.1371\/journal.pone.0034640","article-title":"Shared resistance to aging and ALS in neuromuscular junctions of specific muscles","volume":"7","author":"G Valdez","year":"2012","journal-title":"PLOS ONE"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"541","DOI":"10.33549\/physiolres.930521","article-title":"Characterization of neuromuscular transmission in mice with progressive motoneuronopathy","volume":"53","author":"K Kretschmannov\u00e1","year":"2004","journal-title":"Physiol Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1080\/14660820050515539","article-title":"Pathophysiological significance of fasciculations in the early diagnosis of ALS","volume":"1","author":"M de Carvalho","year":"2000","journal-title":"Amyotroph Lateral Scler Other Mot Neuron Disord"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1113\/jphysiol.1981.sp013960","article-title":"Age changes in neuromuscular junction morphology and acetylcholine receptor distribution on rat skeletal muscle fibres","volume":"320","author":"J Courtney","year":"1981","journal-title":"J Physiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.nmd.2006.01.002","article-title":"Variability and failure of neurotransmission in the diaphragm of mdx mice","volume":"16","author":"KE Personius","year":"2006","journal-title":"Neuromuscul Disord"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0073846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T10:26:58Z","timestamp":1688466418000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0073846"}},"subtitle":[],"editor":[{"given":"Cedric","family":"Raoul","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,9,5]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0073846","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,5]]}}}