{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:01:46Z","timestamp":1771707706866,"version":"3.50.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0074798","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T22:44:16Z","timestamp":1380667456000},"page":"e74798","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Association between Inflammatory Infiltrates and Isolated Monosomy 22\/del(22q) in Meningiomas"],"prefix":"10.1371","volume":"8","author":[{"given":"Patr\u00edcia Henriques","family":"Domingues","sequence":"first","affiliation":[]},{"given":"Cristina","family":"Teod\u00f3sio","sequence":"additional","affiliation":[]},{"given":"\u00c1lvaro","family":"Otero","sequence":"additional","affiliation":[]},{"given":"Pablo","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Ortiz","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda del Carmen Garc\u00eda","family":"Macias","sequence":"additional","affiliation":[]},{"given":"Jes\u00fas Mar\u00eda","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Ana Bel\u00e9n","family":"Nieto","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda Celeste","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"de Oliveira","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[]},{"given":"Maria Dolores","family":"Tabernero","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"ref1","unstructured":"Louis DN, Ohgaki H, Wiestler OT, Cavenee WK (2007) Meningeal Tumours. WHO Classification of Tumors of the Central Nervous System. 4 ed. Lyon, France: IARC press. 163\u2013172."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(06)70625-1","article-title":"Histological classification and molecular genetics of meningiomas","volume":"5","author":"MJ Riemenschneider","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1158\/1078-0432.CCR-05-1480","article-title":"The cytogenetic relationship between primary and recurrent meningiomas points to the need for new treatment strategies in cases at high risk of relapse","volume":"12","author":"AB Espinosa","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref4","first-page":"411","article-title":"Primary resected meningiomas: relapses and proliferation markers","volume":"18","author":"JP Kalala","year":"2004","journal-title":"In Vivo"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1215\/15228517-2007-026","article-title":"Early recurrences in histologically benign\/grade I meningiomas are associated with large tumors and coexistence of monosomy 14 and del(1p36) in the ancestral tumor cell clone","volume":"9","author":"A Maillo","year":"2007","journal-title":"Neuro Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1750-3639.2008.00191.x","article-title":"Gene expression profiles of meningiomas are associated with tumor cytogenetics and patient outcome","volume":"19","author":"MD Tabernero","year":"2009","journal-title":"Brain Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1525-1578(10)60527-2","article-title":"Intratumoral patterns of clonal evolution in meningiomas as defined by multicolor interphase fluorescence in situ hybridization (FISH): is there a relationship between histopathologically benign and atypical\/anaplastic lesions?","volume":"6","author":"JM Sayagues","year":"2004","journal-title":"J Mol Diagn"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1158\/0008-5472.CAN-12-0122","article-title":"Tumor microenvironment complexity: emerging roles in cancer therapy","volume":"72","author":"MA Swartz","year":"2012","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2990.2008.00960.x","article-title":"The microglial\/macrophagic response at the tumour-brain border of invasive meningiomas","volume":"35","author":"S Grund","year":"2009","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.ajpath.2012.07.033","article-title":"Immunophenotypic identification and characterization of tumor cells and infiltrating cell populations in meningiomas","volume":"181","author":"PH Domingues","year":"2012","journal-title":"Am J Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1258\/ebm.2011.011007","article-title":"Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity","volume":"236","author":"C Jochems","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1158\/0008-5472.CAN-11-3218","article-title":"Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma","volume":"72","author":"G Erdag","year":"2012","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jcp.41.3.314","article-title":"Immunocytochemical study of the cellular immune response in meningiomas","volume":"41","author":"ML Rossi","year":"1988","journal-title":"J Clin Pathol"},{"key":"ref14","first-page":"16","article-title":"Correlaci\u00f3n clinico-biol\u00f3gica y caracter\u00edsticas del ADN en 74 pacientes con c\u00e1ncer colorrectal (citometr\u00eda de flujo de piezas en fresco) Cir Esp","volume":"51","author":"J Garc\u00eda Garc\u00eda","year":"1992"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0344-0338(11)80747-8","article-title":"Transrectal fine needle aspiration biopsy of the prostate combining cytomorphologic, DNA ploidy status and cell cycle distribution studies","volume":"190","author":"JI Paz-Bouza","year":"1994","journal-title":"Pathol Res Pract"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1309\/WP3QWKVJFYDHHXQD","article-title":"Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samples","volume":"123","author":"I Cruz","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cyto.b.20605","article-title":"Cell-cycle distribution of different cell compartments in normal versus reactive bone marrow: a frame of reference for the study of dysplastic hematopoiesis","volume":"80","author":"S Matarraz","year":"2011","journal-title":"Cytometry B Clin Cytom"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1634\/theoncologist.12-10-1225","article-title":"Patient gender is associated with distinct patterns of chromosomal abnormalities and sex chromosome linked gene-expression profiles in meningiomas","volume":"12","author":"MD Tabernero","year":"2007","journal-title":"Oncologist"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"VG Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1233009","article-title":"Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO","volume":"339","author":"VE Clark","year":"2013","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/187152411794961095","article-title":"Genetic and modifying factors that determine the risk of brain tumors","volume":"11","author":"C Montelli Tde","year":"2011","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.lfs.2012.03.018","article-title":"Role of CD69 in acute lung injury","volume":"90","author":"S Ishizaki","year":"2012","journal-title":"Life Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.4049\/jimmunol.173.10.6000","article-title":"CD63 as an activation-linked T cell costimulatory element","volume":"173","author":"K Pfistershammer","year":"2004","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1165\/ajrcmb.23.3.4182","article-title":"Immunologic characterization of normal human pleural macrophages","volume":"23","author":"M Frankenberger","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jlb.47.6.490","article-title":"Surface phenotype analysis of human monocyte to macrophage maturation","volume":"47","author":"R Andreesen","year":"1990","journal-title":"J Leukoc Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1365-2567.2001.01171.x","article-title":"Interleukin-10 induces macrophage apoptosis and expression of CD16 (FcgammaRIII) whose engagement blocks the cell death programme and facilitates differentiation","volume":"102","author":"ZQ Wang","year":"2001","journal-title":"Immunology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1471-4914(01)01963-3","article-title":"A crucial role for CD44 in inflammation","volume":"7","author":"E Pure","year":"2001","journal-title":"Trends Mol Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood-2005-05-1902","article-title":"The intracellular domain of CD44 promotes the fusion of macrophages","volume":"107","author":"W Cui","year":"2006","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jss.2006.12.542","article-title":"Analysis of gene expression in the tumor-associated macrophage","volume":"142","author":"MD Duff","year":"2007","journal-title":"J Surg Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.166.5.3256","article-title":"Functional association of CD9 with the Fc gamma receptors in macrophages","volume":"166","author":"K Kaji","year":"2001","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1038\/onc.2008.267","article-title":"NK cells and cancer immunosurveillance","volume":"27","author":"I Waldhauer","year":"2008","journal-title":"Oncogene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","author":"SK Biswas","year":"2010","journal-title":"Nat Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1182\/blood-2001-11-0106","article-title":"Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation","volume":"100","author":"AB Geldhof","year":"2002","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"T Krausgruber","year":"2011","journal-title":"Nat Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ni1010-879","article-title":"Regulation of alternative macrophage activation by chromatin remodeling","volume":"11","author":"S Bowdridge","year":"2010","journal-title":"Nat Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"T Calandra","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cellsig.2003.07.002","article-title":"Mechanisms and effectors of MIF-dependent promotion of tumourigenesis","volume":"16","author":"RA Mitchell","year":"2004","journal-title":"Cell Signal"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.yexmp.2009.01.001","article-title":"Mechanisms of macrophage migration inhibitory factor (MIF)-dependent tumor microenvironmental adaptation","volume":"86","author":"BE Rendon","year":"2009","journal-title":"Exp Mol Pathol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/1097-0142(20000715)89:2<334::AID-CNCR18>3.0.CO;2-N","article-title":"Intracellular distribution of macrophage migration inhibitory factor predicts the prognosis of patients with adenocarcinoma of the lung","volume":"89","author":"A Kamimura","year":"2000","journal-title":"Cancer"},{"key":"ref40","first-page":"253","article-title":"Clinical utility of serum macrophage migration inhibitory factor in men with prostate cancer as a novel biomarker of detection and disease progression","volume":"15","author":"M Muramaki","year":"2006","journal-title":"Oncol Rep"},{"key":"ref41","first-page":"2047","article-title":"Apoptosis-related biomarkers sFAS, MIF, ICAM-1 and PAI-1 in serum of breast cancer patients undergoing neoadjuvant chemotherapy","volume":"32","author":"DM Fersching","year":"2012","journal-title":"Anticancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3748\/wjg.v18.i18.2253","article-title":"CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer","volume":"18","author":"YX Zheng","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11060-011-0640-3","article-title":"Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas","volume":"106","author":"XB Wang","year":"2012","journal-title":"J Neurooncol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0074798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T03:31:20Z","timestamp":1564284680000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0074798"}},"subtitle":[],"editor":[{"given":"Isaac","family":"Yang","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0074798","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}