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cell tryptase: a review of its physiology and clinical significance","volume":"59","author":"V Payne","year":"2004","journal-title":"Anaesthesia"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0041-0101(03)00225-3","article-title":"Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors","volume":"42","author":"I Katzir","year":"2003","journal-title":"Toxicon"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1432-1033.1972.tb02004.x","article-title":"The isolation and characterization of nerve-growth factor from the venom of Vipera russelli","volume":"29","author":"FL Pearce","year":"1972","journal-title":"Eur J Biochem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1113\/jphysiol.1986.sp016014","article-title":"Some characteristics of histamine secretion from rat peritoneal mast cells stimulated with nerve growth factor","volume":"372","author":"FL Pearce","year":"1986","journal-title":"J Physiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1146\/annurev.bi.41.070172.003325","article-title":"Glycoproteins","volume":"41","author":"RD Marshall","year":"1972","journal-title":"Annu Rev Biochem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/protein\/3.5.433","article-title":"Sequence differences between glycosylated and non-glycosylated Asn-X-Thr\/Ser acceptor sites: implications for protein engineering","volume":"3","author":"Y Gavel","year":"1990","journal-title":"Protein Eng"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev.bi.54.070185.003215","article-title":"Assembly of asparagine-linked oligosaccharides","volume":"54","author":"R Kornfeld","year":"1985","journal-title":"Annu Rev Biochem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/BJ20040569","article-title":"Sputa nerve growth factor forms a preferable substitute to mouse 7S-beta nerve growth factor","volume":"383","author":"DC Koh","year":"2004","journal-title":"Biochem J"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/ncomms2065","article-title":"Dynamic evolution of venom proteins in squamate reptiles","volume":"3","author":"NR Casewell","year":"2012","journal-title":"Nat Commun"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ympev.2011.07.008","article-title":"Phylogeny of iguanian lizards inferred from 29 nuclear loci, and a comparison of concatenated and species-tree approaches for an ancient, rapid radiation","volume":"61","author":"TM Townsend","year":"2011","journal-title":"Mol Phylogenet Evol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1098\/rsbl.2012.0703","article-title":"Resolving the phylogeny of lizards and snakes (Squamata) with extensive sampling of genes and species","volume":"8","author":"JJ Wiens","year":"2012","journal-title":"Biol Lett"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1080\/10635150802166053","article-title":"Branch lengths, support, and congruence: testing the phylogenomic approach with 20 nuclear loci in snakes","volume":"57","author":"JJ Wiens","year":"2008","journal-title":"Syst Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/sysbio\/syq048","article-title":"Combining phylogenomics and fossils in higher-level squamate reptile phylogeny: molecular data change the placement of fossil taxa","volume":"59","author":"JJ Wiens","year":"2010","journal-title":"Syst Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/molbev\/msq302","article-title":"Gene tree parsimony of multilocus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss","volume":"28","author":"NR Casewell","year":"2011","journal-title":"Mol Biol Evol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: Multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sysbio\/sys029","article-title":"MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space","volume":"61","author":"F Ronquist","year":"2012","journal-title":"Syst Biol"},{"key":"ref89","first-page":"59","article-title":"New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML","volume":"3","author":"S Guindon","year":"2010","journal-title":"Syst Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00239-001-0034-9","article-title":"The effect of recombination on the accuracy of phylogeny estimation","volume":"54","author":"D Posada","year":"2002","journal-title":"J Mol Evol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1093\/bioinformatics\/btq429","article-title":"Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology","volume":"26","author":"W Delport","year":"2010","journal-title":"Bioinformatics"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1093\/molbev\/msl051","article-title":"Automated phylogenetic detection of recombination using a genetic algorithm","volume":"23","author":"SL Kosakovsky Pond","year":"2006","journal-title":"Mol Biol Evol"},{"key":"ref93","first-page":"725","article-title":"A codon-based model of nucleotide substitution for protein-coding DNA sequences","volume":"11","author":"N Goldman","year":"1994","journal-title":"Mol Biol Evol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/oxfordjournals.molbev.a025957","article-title":"Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution","volume":"15","author":"Z Yang","year":"1998","journal-title":"Mol Biol Evol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/molbev\/msm088","article-title":"PAML 4: Phylogenetic analysis by maximum likelihood","volume":"24","author":"Z Yang","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/oxfordjournals.molbev.a004148","article-title":"Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages","volume":"19","author":"Z Yang","year":"2002","journal-title":"Mol Biol Evol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1093\/molbev\/msi237","article-title":"Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level","volume":"22","author":"J Zhang","year":"2005","journal-title":"Mol Biol Evol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/genetics\/148.3.929","article-title":"Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene","volume":"148","author":"R Nielsen","year":"1998","journal-title":"Genetics"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/molbev\/msi105","article-title":"Not so different after all: a comparison of methods for detecting amino acid sites under selection","volume":"22","author":"SL Kosakovsky Pond","year":"2005","journal-title":"Mol Biol Evol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/molbev\/mst030","article-title":"FUBAR: a fast, unconstrained bayesian approximation for inferring selection","volume":"30","author":"B Murrell","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/bioinformatics\/bti079","article-title":"HyPhy: hypothesis testing using phylogenies","volume":"21","author":"SLK Pond","year":"2005","journal-title":"Bioinformatics"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"e1002764","DOI":"10.1371\/journal.pgen.1002764","article-title":"Detecting individual sites subject to episodic diversifying selection","volume":"8","author":"B Murrell","year":"2012","journal-title":"PLoS Genet"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/bioinformatics\/btg043","article-title":"TreeSAAP: selection on amino acid properties using phylogenetic trees","volume":"19","author":"S Woolley","year":"2003","journal-title":"Bioinformatics"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00239-004-2597-8","article-title":"A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution","volume":"59","author":"JP Bielawski","year":"2004","journal-title":"J Mol Evol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1093\/bioinformatics\/bti320","article-title":"Datamonkey: rapid detection of selective pressure on individual sites of codon alignments","volume":"21","author":"SL Pond","year":"2005","journal-title":"Bioinformatics"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/molbev\/msp260","article-title":"Evolutionary fingerprinting of genes","volume":"27","author":"SLK Pond","year":"2010","journal-title":"Mol Biol Evol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","article-title":"Protein structure prediction on the Web: a case study using the Phyre server","volume":"4","author":"LA Kelley","year":"2009","journal-title":"Nat Protoc"},{"key":"ref108","article-title":"The PyMOL Molecular Graphics System. DeLano","author":"WL DeLano","year":"2002","journal-title":"Sci San Carlos, CA"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/jmbi.2000.4474","article-title":"ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information","volume":"307","author":"A Armon","year":"2001","journal-title":"J Mol Biol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1096-987X(199802)19:3<319::AID-JCC6>3.0.CO;2-W","article-title":"Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules","volume":"19","author":"R Fraczkiewicz","year":"1998","journal-title":"J Comput Chem"}],"updated-by":[{"DOI":"10.1371\/annotation\/accecc73-91b2-45d4-bb33-774b1f394ca1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0081827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T23:15:02Z","timestamp":1647558902000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0081827"}},"subtitle":[],"editor":[{"given":"Christine\u00a0A.","family":"Kozak","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":110,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0081827","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,29]]}}}