{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:24:48Z","timestamp":1767900288359,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0082874","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T21:41:30Z","timestamp":1386625290000},"page":"e82874","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mycobacterium avium Infection Induces H-Ferritin Expression in Mouse Primary Macrophages by Activating Toll-Like Receptor 2"],"prefix":"10.1371","volume":"8","author":[{"given":"Sandro","family":"Silva-Gomes","sequence":"first","affiliation":[]},{"given":"C\u00e9cile","family":"Bouton","sequence":"additional","affiliation":[]},{"given":"T\u00e2nia","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Santambrogio","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Appelberg","sequence":"additional","affiliation":[]},{"given":"Maria Salom\u00e9","family":"Gomes","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1353\/pbm.1993.0063","article-title":"The development of awareness of iron-withholding defense","volume":"36","author":"ED Weinberg","year":"1993","journal-title":"Perspect Biol Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1386-6532(00)00135-9","article-title":"Role of iron in experimental Mycobacterium avium infection","volume":"20","author":"MS Gomes","year":"2001","journal-title":"J Clin Virol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1386-6532(00)00136-0","article-title":"Iron and Mycobacterium tuberculosis infection","volume":"20","author":"N Lounis","year":"2001","journal-title":"J Clin Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20020897","article-title":"Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis","volume":"196","author":"UE Schaible","year":"2002","journal-title":"J Exp Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/IAI.00612-08","article-title":"Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice","volume":"76","author":"S Gomes-Pereira","year":"2008","journal-title":"Infect Immun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","article-title":"The ferritins: molecular properties, iron storage function and cellular regulation","volume":"1275","author":"PM Harrison","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bbagen.2010.02.005","article-title":"Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage","volume":"1800","author":"P Arosio","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1074\/jbc.275.5.3021","article-title":"Early embryonic lethality of H ferritin gene deletion in mice","volume":"275","author":"C Ferreira","year":"2000","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"FM Torti","year":"2002","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.nutr.28.061807.155521","article-title":"Systemic iron homeostasis and the iron-responsive element\/iron-regulatory protein (IRE\/IRP) regulatory network","volume":"28","author":"MU Muckenthaler","year":"2008","journal-title":"Annu Rev Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","volume":"11","author":"O Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90085-3","article-title":"Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase","volume":"81","author":"JD MacMicking","year":"1995","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/prep.2000.1212","article-title":"Functional and immunological analysis of recombinant mouse H- and L-ferritins from Escherichia coli","volume":"19","author":"P Santambrogio","year":"2000","journal-title":"Protein Expr Purif"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"MW Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1073\/pnas.85.7.2171","article-title":"Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5&apos; untranslated region of ferritin heavy- and light-subunit mRNAs","volume":"85","author":"EA Leibold","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0092-8674(89)90851-9","article-title":"A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA","volume":"58","author":"EW M\u00fcllner","year":"1989","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1128\/IAI.63.10.3759-3764.1995","article-title":"Relationship between virulence of Mycobacterium avium strains and induction of tumor necrosis factor alpha production in infected mice and in in vitro-cultured mouse macrophages","volume":"63","author":"AM Sarmento","year":"1995","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15285","DOI":"10.1074\/jbc.270.25.15285","article-title":"Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha","volume":"270","author":"EL Kwak","year":"1995","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1128\/IAI.70.6.3040-3052.2002","article-title":"Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria","volume":"70","author":"SK Roach","year":"2002","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"22846","DOI":"10.1074\/jbc.M111.231902","article-title":"Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide","volume":"286","author":"A Sty\u015b","year":"2011","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.163.7.3920","article-title":"Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis","volume":"163","author":"TK Means","year":"1999","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1574-695X.2007.00218.x","article-title":"The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through a Toll-like receptor 2-mediated signalling pathway","volume":"49","author":"M Mae","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tube.2007.09.002","article-title":"Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig","volume":"88","author":"RJ Basaraba","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1365-2249.2004.02490.x","article-title":"Differential gene expression in mononuclear phagocytes infected with pathogenic and non-pathogenic mycobacteria","volume":"136","author":"JA McGarvey","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1128\/IAI.73.11.7629-7636.2005","article-title":"Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels","volume":"73","author":"JA Carlyon","year":"2005","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/j.1462-5822.2007.00942.x","article-title":"The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium","volume":"9","author":"M Nairz","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2180-10-64","article-title":"Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens","volume":"10","author":"X Pan","year":"2010","journal-title":"BMC Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1126\/science.291.5508.1544","article-title":"Induction of direct antimicrobial activity through mammalian toll-like receptors","volume":"291","author":"S Thoma-Uszynski","year":"2001","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/eji.200737954","article-title":"Engagement of Toll-like receptor 2 in mouse macrophages infected with Mycobacterium avium induces non-oxidative and TNF-independent anti-mycobacterial activity","volume":"38","author":"MS Gomes","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"15382","DOI":"10.1074\/jbc.273.25.15382","article-title":"Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells","volume":"273","author":"V Picard","year":"1998","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1189\/jlb.0206079","article-title":"Macrophage nutriprive antimicrobial mechanisms","volume":"79","author":"R Appelberg","year":"2006","journal-title":"J Leukoc Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1182\/blood-2003-06-1842","article-title":"Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin","volume":"103","author":"A Cozzi","year":"2004","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1182\/blood.V97.9.2863","article-title":"Repression of ferritin expression increases the labile iron pool, oxidative stress, and short-term growth of human erythroleukemia cells","volume":"97","author":"O Kakhlon","year":"2001","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cell.2004.10.017","article-title":"Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species","volume":"119","author":"CG Pham","year":"2004","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbagen.2008.08.006","article-title":"Iron metabolism in the anemia of chronic disease","volume":"1790","author":"G Weiss","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.beha.2004.09.001","article-title":"Modification of iron regulation by the inflammatory response","volume":"18","author":"G Weiss","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1172\/JCI21441","article-title":"Anemia of inflammation: the cytokine-hepcidin link","volume":"113","author":"NC Andrews","year":"2004","journal-title":"J Clin Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"12214","DOI":"10.1073\/pnas.192316099","article-title":"Nitrogen monoxide-mediated control of ferritin synthesis: implications for macrophage iron homeostasis","volume":"99","author":"S Kim","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","first-page":"319","article-title":"Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor","volume":"61","author":"X Alvarez-Hern\u00e1ndez","year":"1989","journal-title":"Lab Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BJ20060215","article-title":"Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice","volume":"397","author":"AH Laftah","year":"2006","journal-title":"Biochem J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.imbio.2011.04.004","article-title":"Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin","volume":"216","author":"PN Rodrigues","year":"2011","journal-title":"Immunobiology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0082874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T21:44:45Z","timestamp":1688852685000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0082874"}},"subtitle":[],"editor":[{"given":"Fanis","family":"Missirlis","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,12,9]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0082874","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,9]]}}}