{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T18:28:31Z","timestamp":1655490511083},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0095888","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T22:39:14Z","timestamp":1398292754000},"page":"e95888","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Specific Activation of K-RasG12D Allele in the Bladder Urothelium Results in Lung Alveolar and Vascular Defects"],"prefix":"10.1371","volume":"9","author":[{"given":"Francisco","family":"Ayala de la Pe\u00f1a","sequence":"first","affiliation":[]},{"given":"Keizo","family":"Kanasaki","sequence":"additional","affiliation":[]},{"given":"Megumi","family":"Kanasaki","sequence":"additional","affiliation":[]},{"given":"Sylvia","family":"Vong","sequence":"additional","affiliation":[]},{"given":"Carlota","family":"Rovira","sequence":"additional","affiliation":[]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrc2109","article-title":"Hyperactive Ras in developmental disorders and cancer","volume":"7","author":"S Schubbert","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"ref2","first-page":"145","article-title":"Mouse models of K-ras-initiated carcinogenesis","volume":"1756","author":"KP Janssen","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/jmg.2007.055772","article-title":"Clinical and molecular aspects of RAS related disorders","volume":"45","author":"E Denayer","year":"2008","journal-title":"J Med Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1128\/MCB.21.5.1444-1452.2001","article-title":"Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development","volume":"21","author":"LM Esteban","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1101\/gad.11.19.2468","article-title":"K-ras is an essential gene in the mouse with partial functional overlap with N-ras","volume":"11","author":"L Johnson","year":"1997","journal-title":"Genes Dev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1535-6108(03)00191-0","article-title":"Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context","volume":"4","author":"C Guerra","year":"2003","journal-title":"Cancer Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1128\/MCB.00965-07","article-title":"Biochemical and functional characterization of germ line KRAS mutations","volume":"27","author":"S Schubbert","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1101\/gad.1526207","article-title":"Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis","volume":"21","author":"AT Shaw","year":"2007","journal-title":"Genes Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1535-6108(04)00085-6","article-title":"Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects","volume":"5","author":"DA Tuveson","year":"2004","journal-title":"Cancer Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1038\/sj.onc.1204315","article-title":"Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation","volume":"20","author":"ZT Zhang","year":"2001","journal-title":"Oncogene"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Cordon-Cardo C (2008) Molecular alterations associated with bladder cancer initiation and progression. Scand J Urol Nephrol Suppl: 154\u2013165.","DOI":"10.1080\/03008880802291915"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1097\/01.ju.0000088670.02905.78","article-title":"Review Article: The Role of Ras Superfamily Proteins in Bladder Cancer Progression","volume":"170","author":"G Oxford","year":"2003","journal-title":"J Urol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e74809","DOI":"10.1371\/journal.pone.0074809","article-title":"Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia","volume":"8","author":"X Yang","year":"2013","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e65189","DOI":"10.1371\/journal.pone.0065189","article-title":"Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection","volume":"8","author":"J Steinestel","year":"2013","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.semperi.2006.05.004","article-title":"Pathology of Bronchopulmonary Dysplasia","volume":"30","author":"JJ Coalson","year":"2006","journal-title":"Semin Perinatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1056\/NEJMra067279","article-title":"Chronic lung disease after premature birth","volume":"357","author":"E Baraldi","year":"2007","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"20778","DOI":"10.1074\/jbc.M110.198069","article-title":"Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma","volume":"286","author":"F Ayala de la Pena","year":"2011","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ymgme.2006.03.014","article-title":"Mouth cell collection device for newborn mice","volume":"89","author":"YH Zhang","year":"2006","journal-title":"Mol Genet Metab"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Birkedal-Hansen H, Yamada S, Windsor J, Pollard AH, Lyons G, et al. (2008) Matrix metalloproteinases. Curr Protoc Cell Biol Chapter 10: Unit 10 8.","DOI":"10.1002\/0471143030.cb1008s40"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"F562","DOI":"10.1152\/ajprenal.00368.2004","article-title":"Gene deletion in urothelium by specific expression of Cre recombinase","volume":"289","author":"L Mo","year":"2005","journal-title":"Am J Physiol Ren Physiol"},{"key":"ref21","unstructured":"Schittny PH. J B (2003) Morphogenesis of the mammalian lung: aspects of structure and extracellular matrix components. In: Massaro D Chambon P, editors MGD, editor. Lung development and regeneration. New York: Marcel Dekker Inc. pp. 275\u2013317."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ppul.20252","article-title":"Similarities and dissimilarities of branching and septation during lung development","volume":"40","author":"M Roth-Kleiner","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1053\/jpsu.2000.18305","article-title":"Early fetal obstructive uropathy produces Potter's syndrome in the lamb","volume":"35","author":"H Kitagawa","year":"2000","journal-title":"J Pediatr Surg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1046\/j.1469-0705.2000.00252.x","article-title":"The fetal lung. 2: Pulmonary hypoplasia","volume":"16","author":"JA Laudy","year":"2000","journal-title":"Ultrasound Obs Gynecol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1158\/0008-5472.CAN-05-0074","article-title":"K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts","volume":"65","author":"P Vizan","year":"2005","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1203\/PDR.0b013e3181b3b0fa","article-title":"Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk","volume":"66","author":"EC McGowan","year":"2009","journal-title":"Pediatr Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1091\/mbc.E08-07-0732","article-title":"Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9","volume":"20","author":"XQ Wang","year":"2009","journal-title":"Mol Biol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.jp.7211290","article-title":"Amniotic Fluid: Not Just Fetal Urine Anymore","volume":"25","author":"MA Underwood","year":"2005","journal-title":"J Perinatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1073\/pnas.92.3.679","article-title":"A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice","volume":"92","author":"JH Lin","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1158\/1078-0432.CCR-08-1136","article-title":"Tumor-specific urinary matrix metalloproteinase fingerprinting: identification of high molecular weight urinary matrix metalloproteinase species","volume":"14","author":"R Roy","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1152\/jappl.1986.61.1.68","article-title":"Influence of upper respiratory tract on liquid flow to and from fetal lungs","volume":"61","author":"R Harding","year":"1986","journal-title":"J Appl Physiol"},{"key":"ref32","first-page":"1562","article-title":"Pitfalls, Problems, and Progress in Bronchopulmonary Dysplasia 10.1542\/peds.2008-1962","volume":"123","author":"A Bhandari","year":"2009","journal-title":"Pediatrics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1203\/PDR.0b013e31820bcb2a","article-title":"Developmental stage is a major determinant of lung injury in a murine model of bronchopulmonary dysplasia","volume":"69","author":"E Backstrom","year":"2011","journal-title":"Pediatr Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"8724","DOI":"10.1074\/jbc.M511798200","article-title":"Loss of PECAM-1 function impairs alveolarization","volume":"281","author":"HM DeLisser","year":"2006","journal-title":"J Biol Chem"},{"key":"ref35","first-page":"702","article-title":"Loss of HIF-2[alpha] and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice","volume":"8","author":"V Compernolle","year":"2002"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1164\/rccm.200611-1660PP","article-title":"Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease","volume":"175","author":"B Thebaud","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000047179","article-title":"Basement membrane biomarkers in very low birth weight premature infants. Association with length of NICU stay and bronchopulmonary dysplasia","volume":"81","author":"ZH Aghai","year":"2002","journal-title":"Biol Neonate"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1542\/peds.113.6.1709","article-title":"Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9\/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung disease","volume":"113","author":"II Ekekezie","year":"2004","journal-title":"Pediatrics"},{"key":"ref39","first-page":"84","article-title":"Complex Integration of Matrix, Oxidative Stress, and Apoptosis in Genetic Emphysema 10.2353\/ajpath.2009.080870","volume":"175","author":"M Podowski","year":"2009","journal-title":"Am J Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"15571","DOI":"10.1073\/pnas.1007625107","article-title":"Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM","volume":"107","author":"H Yao","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0002-9440(10)64318-0","article-title":"Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium","volume":"162","author":"JK McGuire","year":"2003","journal-title":"Am J Pathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1164\/rccm.200506-927OC","article-title":"Growth of pulmonary microvasculature in ventilated preterm infants","volume":"173","author":"ME De Paepe","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1161\/CIRCULATIONAHA.105.541524","article-title":"Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization","volume":"112","author":"B Thebaud","year":"2005","journal-title":"Circulation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1158\/0008-5472.CAN-08-4382","article-title":"Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis","volume":"69","author":"Y Huang","year":"2009","journal-title":"Cancer Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1073\/pnas.98.1.154","article-title":"Urothelial function reconsidered: a role in urinary protein secretion","volume":"98","author":"FM Deng","year":"2001","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0095888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T21:03:13Z","timestamp":1565384593000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0095888"}},"subtitle":[],"editor":[{"given":"Rory Edward","family":"Morty","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,4,23]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0095888","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,23]]}}}