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Cambridge, MA: MIT Press. pp. 45\u201380.","DOI":"10.7551\/mitpress\/9780262513678.003.0003"},{"key":"ref20","unstructured":"Gould SJ (1989) Wonderful Life: The Burgess Shale and the Nature of History. W. W. 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Singapure: World Scientific Publishing.","DOI":"10.1142\/9789812567222"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1086\/285356","article-title":"Acquisition and allocation of resources: genetic (co) variances, selection, and life histories","volume":"139","author":"de Jong G","year":"1992","journal-title":"Am Nat"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2307\/2406513","article-title":"The relationship between mating speed and wing length in <italic>Drosophila subobscura<\/italic>","volume":"25","author":"M Monclus","year":"1971","journal-title":"Evolution"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2148-5-7","article-title":"Genetics and geometry of canalization and developmental stability in <italic>Drosophila subobscura<\/italic>","volume":"5","author":"M Santos","year":"2005","journal-title":"BMC Evol Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Y Benjamini","year":"2001","journal-title":"Ann Stat"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1558-5646.2009.00649.x","article-title":"A general framework for the analysis of phenotypic trajectories in evolutionary studies","volume":"63","author":"DC Adams","year":"2009","journal-title":"Evolution"},{"key":"ref54","unstructured":"R CDT (2008) R: a language and environment for statistical computing. Version 2.70. R Found Stat Comput."},{"key":"ref55","unstructured":"Adler D, D.Murdoch (2012) rgl: 3D visualization device system (OpenGL). R Package version 092894."},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Chippindale AK (2006) Experimental Evolution. In: Fox C, Wolf J, editors. Evolutionary genetics: concepts and case studies. London. pp. 482\u2013501.","DOI":"10.1093\/oso\/9780195168174.003.0031"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00114-008-0372-1","article-title":"Roles of adaptation, chance and history in the evolution of the dinoflagellate <italic>Prorocentrum triestinum<\/italic>","volume":"95","author":"A Flores-Moya","year":"2008","journal-title":"Naturwissenschaften"},{"key":"ref58","unstructured":"Spor A, Kvitek DJ, Nidelet T, Martin J, Legrand J, <etal>et al<\/etal>.. (2013) Phenotypic and Genotypic Convergences Are Influenced By Historical Contingency and Environment in Yeast. Evolution 1\u201319."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1073\/pnas.0803151105","article-title":"Historical contingency and the evolution of a key innovation in an experimental population of <italic>Escherichia coli<\/italic>","volume":"105","author":"ZD Blount","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1214449","article-title":"Repeatability and Contingency in the Evolution of a Key Innovation in Phage Lambda","volume":"335","author":"JR Meyer","year":"2012","journal-title":"Science"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1098\/rsbl.2013.0215","article-title":"The incidental response to uniform natural selection","volume":"9","author":"G Bell","year":"2013","journal-title":"Biol Lett"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.0014-3820.2003.tb00262.x","article-title":"Genetic architecture of differences between populations of cowpea weevil (<italic>Callosobruchus maculatus<\/italic>) evolved in the same environment","volume":"57","author":"J Bieri","year":"2003","journal-title":"Evolution"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2311.2003.00526.x","article-title":"Evolutionary conservatism of geographic variation in host preference in <italic>Callosobruchus maculatus<\/italic>","volume":"28","author":"TJ Kawecki","year":"2003","journal-title":"Ecol Entomol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1420-9101.2005.01071.x","article-title":"Genetically idiosyncratic responses of <italic>Drosophila melanogaster<\/italic> populations to selection for improved learning ability","volume":"19","author":"TJ Kawecki","year":"2006","journal-title":"J Evol Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1420-9101.2004.00782.x","article-title":"Clinal variation and laboratory adaptation in the rainforest species <italic>Drosophila birchii<\/italic> for stress resistance, wing size, wing shape and development time","volume":"18","author":"J Griffiths","year":"2005","journal-title":"J Evol Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.hdy.6801095","article-title":"Experimental evolution: experimental evolution and evolvability","volume":"100","author":"N Colegrave","year":"2008","journal-title":"Heredity (Edinb)"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2307\/2408694","article-title":"Genetic Covariation Among Life-History Components: The Effect of Novel Environments","volume":"39","author":"PM Service","year":"1985","journal-title":"Evolution"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature09352","article-title":"Genome-wide analysis of a long-term evolution experiment with <italic>Drosophila<\/italic>","volume":"467","author":"MK Burke","year":"2010","journal-title":"Nature"},{"key":"ref69","first-page":"1503","article-title":"Convergence to a Novel Environment: Comparative Method versus Experimental Evolution","volume":"58","author":"M Matos","year":"2004","journal-title":"Evolution"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12064-010-0086-8","article-title":"Playing Darwin. 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