{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T13:29:48Z","timestamp":1720963788445},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0103258","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T17:52:58Z","timestamp":1429897978000},"page":"e0103258","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221\/222 Expression"],"prefix":"10.1371","volume":"10","author":[{"given":"Ana L.","family":"Teixeira","sequence":"first","affiliation":[]},{"given":"Francisca","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"M\u00f3nica","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Juliana I.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Lobo","sequence":"additional","affiliation":[]},{"given":"Joaquina","family":"Maur\u00edcio","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Carlos","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.eururo.2010.08.029","article-title":"Integrating surgery with targeted therapies for renal cell carcinoma: current evidence and ongoing trials","volume":"58","author":"A Bex","year":"2010","journal-title":"Eur Urol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.eururo.2011.06.049","article-title":"The epidemiology of renal cell carcinoma","volume":"60","author":"B Ljungberg","year":"2011","journal-title":"Eur Urol"},{"key":"ref3","first-page":"999","article-title":"Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR\/MMP-9 signaling pathway","volume":"28","author":"L Liang","year":"2012","journal-title":"Oncol Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.urolonc.2007.12.001","article-title":"Clinical implications of hypoxia inducible factor in renal cell carcinoma","volume":"27","author":"MC Smaldone","year":"2009","journal-title":"Urol Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.ctrv.2012.01.003","article-title":"Overcoming resistance to tyrosine kinase inhibitors in renal cell carcinoma","volume":"38","author":"A Ravaud","year":"2012","journal-title":"Cancer Treat Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.eururo.2008.04.056","article-title":"Update on the medical treatment of metastatic renal cell carcinoma","volume":"54","author":"A Ravaud","year":"2008","journal-title":"Eur Urol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jdermsci.2009.10.002","article-title":"EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments","volume":"56","author":"H Kataoka","year":"2009","journal-title":"J Dermatol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/sj.bjc.6605490","article-title":"Epidermal growth factor signalling and bone metastasis","volume":"102","author":"X Lu","year":"2010","journal-title":"Br J Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/HYPERTENSIONAHA.108.113860","article-title":"Epidermal growth factor receptor signaling in the kidney: key roles in physiology and disease","volume":"52","author":"WB Melenhorst","year":"2008","journal-title":"Hypertension"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1186\/1750-2187-7-14","article-title":"Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR\/ERK signalling pathway","volume":"7","author":"VM Villaamil","year":"2012","journal-title":"J Mol Signal"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e23936","DOI":"10.1371\/journal.pone.0023936","article-title":"The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR","volume":"6","author":"L Zhou","year":"2011","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/jhg.2010.12","article-title":"A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population","volume":"55","author":"J Zhu","year":"2010","journal-title":"J Hum Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1158\/1078-0432.CCR-07-5119","article-title":"Genetic polymorphism in EGF is associated with prostate cancer aggressiveness and progression-free interval in androgen blockade-treated patients","volume":"14","author":"AL Teixeira","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1158\/1078-0432.CCR-07-4932","article-title":"A Functional Epidermal Growth Factor (EGF) Polymorphism, EGF Serum Levels, and Esophageal Adenocarcinoma Risk and Outcome","volume":"14","author":"M Lanuti","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(02)07600-6","article-title":"Association between functional polymorphism in EGF gene and malignant melanoma","volume":"359","author":"M Shahbazi","year":"2002","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1479-5876-10-183","article-title":"TGF-beta\u2014an excellent servant but a bad master","volume":"10","author":"L Kubiczkova","year":"2012","journal-title":"J Transl Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1359\/jbmr.061005","article-title":"TGF-beta promotes the establishment of renal cell carcinoma bone metastasis","volume":"22","author":"SL Kominsky","year":"2007","journal-title":"J Bone Miner Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00240-003-0360-z","article-title":"Expression of transforming growth factor beta in renal cell carcinoma and matched non-involved renal tissue","volume":"32","author":"D Mitropoulos","year":"2004","journal-title":"Urol Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00240-002-0245-6","article-title":"TGF-beta1 in patients with renal cell carcinoma","volume":"30","author":"A Hegele","year":"2002","journal-title":"Urol Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1161\/01.CIR.101.24.2783","article-title":"Association of a T29\u2014>C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese","volume":"101","author":"M Yokota","year":"2000","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1042\/BST20110623","article-title":"Regulation of signalling by microRNAs","volume":"40","author":"R Avraham","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2000876","DOI":"10.1126\/scisignal.2000876","article-title":"EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors","volume":"3","author":"R Avraham","year":"2010","journal-title":"Sci Signal"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.2217\/pgs.13.184","article-title":"Renal cell carcinoma development and miRNAs: a possible link to the EGFR pathway","volume":"14","author":"F Dias","year":"2013","journal-title":"Pharmacogenomics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8822","DOI":"10.1158\/0008-5472.CAN-10-0638","article-title":"EGFR promotes lung tumorigenesis by activating miR-7 through a Ras\/ERK\/Myc pathway that targets the Ets2 transcriptional repressor ERF","volume":"70","author":"YT Chou","year":"2010","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/gm272","article-title":"MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer","volume":"3","author":"MY Shah","year":"2011","journal-title":"Genome Med"},{"key":"ref26","first-page":"21","article-title":"Identification of miR-7 as an oncogene in renal cell carcinoma","volume":"21","author":"Z Yu","year":"2013","journal-title":"J Mol Histol"},{"key":"ref27","first-page":"31","article-title":"Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients","volume":"31","author":"AL Teixeira","year":"2013","journal-title":"Tumour Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1158\/1541-7786.MCR-11-0035","article-title":"MicroRNAs associated with mitogen-activated protein kinase in human pancreatic cancer","volume":"10","author":"Y Ikeda","year":"2012","journal-title":"Mol Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"EA Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"ref30","first-page":"035","article-title":"ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma","volume":"25","author":"SA Brooks","year":"2014","journal-title":"Eur Urol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"12710","DOI":"10.3390\/ijms131012710","article-title":"Crossing Paths in Human Renal Cell Carcinoma (hRCC)","volume":"13","author":"GA Gallego","year":"2012","journal-title":"Int J Mol Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1947601909359929","article-title":"Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns","volume":"1","author":"AR Brannon","year":"2010","journal-title":"Genes Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.eururo.2011.10.007","article-title":"Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology","volume":"61","author":"AR Brannon","year":"2012","journal-title":"Eur Urol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature12222","article-title":"Comprehensive molecular characterization of clear cell renal cell carcinoma","volume":"499","year":"2013","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.canlet.2013.08.006","article-title":"Genomics and epigenomics of clear cell renal cell carcinoma: recent developments and potential applications","volume":"341","author":"M Rydzanicz","year":"2013","journal-title":"Cancer Lett"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/ijc.25164","article-title":"Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma","volume":"127","author":"H Fukasawa","year":"2010","journal-title":"Int J Cancer"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e72419","DOI":"10.1371\/journal.pone.0072419","article-title":"Improvement of a predictive model of castration-resistant prostate cancer: functional genetic variants in TGFbeta1 signaling pathway modulation","volume":"8","author":"AL Teixeira","year":"2013","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/onc.2011.266","article-title":"The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C","volume":"31","author":"X Niu","year":"2012","journal-title":"Oncogene"},{"key":"ref40","first-page":"1714","article-title":"ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion","volume":"40","author":"LJ Xiao","year":"2012","journal-title":"Int J Oncol"},{"key":"ref41","first-page":"1121","article-title":"Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells","volume":"60","author":"P O-charoenrat","year":"2000","journal-title":"Cancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"29897","DOI":"10.1074\/jbc.M804612200","article-title":"MicroRNA-221\/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1","volume":"283","author":"TE Miller","year":"2008","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fgene.2012.00286","article-title":"EGFR signaling pathway and related-miRNAs in age-related diseases: the example of miR-221 and miR-222","volume":"3","author":"AL Teixeira","year":"2012","journal-title":"Front Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1186\/1476-4598-9-229","article-title":"MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma","volume":"9","author":"CZ Zhang","year":"2010","journal-title":"Mol Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"29261","DOI":"10.1074\/jbc.M112.366518","article-title":"Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer","volume":"287","author":"HM Jung","year":"2012","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1349-7006.2012.02265.x","article-title":"Low expression of RECK indicates a shorter survival for patients with invasive breast cancer","volume":"103","author":"Y Zhang","year":"2012","journal-title":"Cancer Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2490-12-18","article-title":"Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer","volume":"12","author":"ST Reis","year":"2012","journal-title":"BMC Urol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1479-5876-10-119","article-title":"High level of miR-221\/222 confers increased cell invasion and poor prognosis in glioma","volume":"10","author":"C Zhang","year":"2012","journal-title":"J Transl Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0103258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T12:05:44Z","timestamp":1540037144000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0103258"}},"subtitle":[],"editor":[{"given":"Andrew","family":"Dewan","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0103258","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}