{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:12:53Z","timestamp":1771035173510,"version":"3.50.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0114197","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T20:26:52Z","timestamp":1417552012000},"page":"e114197","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":136,"title":["Phage Therapy as an Approach to Prevent Vibrio anguillarum Infections in Fish Larvae Production"],"prefix":"10.1371","volume":"9","author":[{"given":"Yolanda J.","family":"Silva","sequence":"first","affiliation":[]},{"given":"Liliana","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Cristiana","family":"Mateus","sequence":"additional","affiliation":[]},{"given":"\u00c2ngela","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Calado","sequence":"additional","affiliation":[]},{"given":"Newton C. M.","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Miguel A.","family":"Pardo","sequence":"additional","affiliation":[]},{"given":"Igor","family":"Hernandez","sequence":"additional","affiliation":[]},{"given":"Adelaide","family":"Almeida","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/md7030268","article-title":"Phage therapy and photodynamic therapy: Low environmental impact approaches to inactivate microorganisms in fish farming plants","volume":"7","author":"A Almeida","year":"2009","journal-title":"Marine Drugs"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0169-409X(01)00159-4","article-title":"Aquaculture pharmaceuticals and biologicals: current perspectives and future possibilities","volume":"50","author":"ZJ Shao","year":"2001","journal-title":"Adv Drug Deliver Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2761.2002.00401.x","article-title":"Proliferative kidney disease in Switzerland: current state of knowledge","volume":"25","author":"T Wahli","year":"2002","journal-title":"J Fish Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.aquaculture.2013.02.013","article-title":"Recently discovered <italic>Vibrio anguillarum<\/italic> phages can protect against experimentally induced vibriosis in Atlantic salmon, <italic>Salmo salar<\/italic>","volume":"392\u2013395","author":"G Higuera","year":"2013","journal-title":"Aquaculture"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.aquaculture.2013.03.007","article-title":"Efficacy of phage therapy to prevent mortality during the vibriosis of brine shrimp","volume":"400","author":"SF Mart\u00ednez-D\u00edaz","year":"2013","journal-title":"Aquaculture"},{"key":"ref6","first-page":"689","article-title":"Prevalence and quantification of <italic>Vibrio<\/italic> species and <italic>Vibrio parahaemolyticus<\/italic> in freshwater fish at hypermarket level","volume":"18","author":"A Noorlis","year":"2011","journal-title":"Int Food Res J"},{"key":"ref7","unstructured":"Noya M, Magarinos B, Lamas J (1995) La administracion intraperitoneal y oral de glucano afecta al sistema immune no especifico y a la resistencia de la dorada, <italic>Sparus aurata<\/italic>, a la pasteurelosis. In Proceedings of the Fifth National Congress of Aquaculture, Sant Carles de la Rapita, Spain. pp. 734\u2013738."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0044-8486(91)90284-E","article-title":"Pasteurellosis in gilthead seabream, <italic>Sparus aurata<\/italic>: first report in Spain","volume":"99","author":"AE Toranzo","year":"1991","journal-title":"Aquaculture"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.aquaculture.2007.05.023","article-title":"Furunculosis in Atlantic salmon (<italic>Salmo salar<\/italic> L.) is not readily controllable by bacteriophage therapy","volume":"270","author":"DW Verner-Jeffreys","year":"2007","journal-title":"Aquaculture"},{"key":"ref10","unstructured":"Martinez JL (2003) Recent Advances in Marine Biotechnology. Molecular Genetics of Marine Organisms; Fingerman, N.Eds.; Science Publishers, Inc: Enfield, New Hampshire, USA. Vol. 10."},{"key":"ref11","first-page":"53","article-title":"Susceptibility to antibiotics of <italic>Vibrio<\/italic> spp. and <italic>Photobacterium damselae<\/italic> ssp. piscicida strains isolated from Italian aquaculture farms","volume":"34","author":"L Pasqualina","year":"2011","journal-title":"New Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0044-8486(97)00114-2","article-title":"The use of immunostimulation in marine larviculture: possibilities and challenges","volume":"155","author":"O Vadstein","year":"1997","journal-title":"Aquaculture"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2165\/00063030-200216010-00006","article-title":"Bacteriophages: potential treatment for bacterial infections","volume":"16","author":"DH Duckworth","year":"2002","journal-title":"BioDrugs"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.aquaculture.2007.04.049","article-title":"Biocontrol of pathogens in shrimp hatcheries using bacteriophages","volume":"268","author":"I Karunasagar","year":"2007","journal-title":"Aquaculture"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3354\/dao037033","article-title":"Protective effects of bacteriophage on experimental <italic>Lactococcus garvieae<\/italic> infection in yellowtail","volume":"37","author":"T Nakai","year":"1999","journal-title":"Dis Aquat Org"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0923-2508(01)01280-3","article-title":"Bacteriophage therapy of infectious diseases in aquaculture","volume":"153","author":"T Nakai","year":"2002","journal-title":"Res Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/AEM.66.4.1416-1422.2000","article-title":"Isolation of bacteriophages specific to a fish pathogen, <italic>Pseudomonas plecoglossicida<\/italic>, as a candidate for disease control","volume":"66","author":"SC Park","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3354\/dao053033","article-title":"Bacteriophage control of <italic>Pseudomonas plecoglossicida<\/italic> infection in ayu Plecoglossus altivelis","volume":"53","author":"S Park","year":"2003","journal-title":"Dis Aquat Org"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1462-2920.2006.01140.x","article-title":"Molecular characterization of <italic>Vibrio harveyi<\/italic> bacteriophages isolated from aquaculture environments along the coast of India","volume":"9","author":"MM Shivu","year":"2007","journal-title":"Environ Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.aquaculture.2005.12.003","article-title":"Isolation of <italic>Vibrio harveyi<\/italic> bacteriophage with a potential for biocontrol of luminous vibriosis in hatchery environments","volume":"255","author":"MG Vinod","year":"2006","journal-title":"Aquaculture"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/j.1365-2672.2009.04578.x","article-title":"Isolation of lytic bacteriophage against <italic>Vibrio harveyi<\/italic>","volume":"108","author":"C Crothers-Stomps","year":"2010","journal-title":"J Appl Microbiol"},{"key":"ref22","first-page":"239","article-title":"Isolation and characterization of bacteriophage PM2 from <italic>Aeromonas hydrophila<\/italic>","volume":"68","author":"S Merino","year":"1990","journal-title":"FEMS Microbiol Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3354\/dao054187","article-title":"Experimental bacteriophage-mediated virulence in strains of <italic>Vibrio harveyi<\/italic>","volume":"54","author":"J Munro","year":"2003","journal-title":"Dis Aquat Org"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1128\/AEM.47.6.1201-1205.1984","article-title":"Isolation of <italic>Yersinia ruckeri<\/italic> bacteriophages","volume":"47","author":"RMW Stevenson","year":"1984","journal-title":"Appl Environ Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3147\/jsfp.15.271","article-title":"Biological control of fish pathogen, <italic>Aeromonas hydrophila<\/italic>, by bacteriophage AH1","volume":"15","author":"JL Wu","year":"1981","journal-title":"Fish Pathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1128\/AEM.67.9.4233-4241.2001","article-title":"Bacteriophage latent-period evolution as a response to resource availability","volume":"13","author":"ST Abedon","year":"2001","journal-title":"Appl Env Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0044-8486(01)00702-5","article-title":"Interactions between fish larvae and bacteria in marine aquaculture","volume":"200","author":"JA Olafsen","year":"2001","journal-title":"Aquaculture"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1128\/AEM.55.6.1435-1446.1989","article-title":"Bacterial colonization of cod (<italic>Gadus morhua<\/italic> L.) and halibut (<italic>Hippoglossus hippoglossus<\/italic>) eggs in marine aquaculture","volume":"55","author":"GH Hansen","year":"1989","journal-title":"Appl Environ Microbiol"},{"key":"ref29","first-page":"825","article-title":"The ingestion of bacteria in suspension by the common carp <italic>Cyprinus carpio<\/italic> L. J Fish Biol","volume":"39","author":"MCM Beveridge","year":"1991"},{"key":"ref30","unstructured":"Olafsen JA (1984) Ingestion of bacteria by cod <italic>Gadus morhua<\/italic> L. larvae. In:The Propagation of Cod, <italic>Gadus morhua<\/italic> L. Institute of Marine Research, Bergen. pp. 627\u2013643."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1095-8649.1992.tb02562.x","article-title":"Intact antigen uptake by intestinal epithelial cells of marine fish larvae","volume":"40","author":"JA Olafsen","year":"1992","journal-title":"J Fish Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e53157","DOI":"10.1371\/journal.pone.0053157","article-title":"Phage-driven loss of virulence in a fish pathogenic bacterium","volume":"7","author":"E Laanto","year":"2012","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3354\/meps089165","article-title":"Bacterial colonization of seston particles in brackish waters (Ria de Aveiro, Portugal)","volume":"89","author":"A Almeida","year":"1992","journal-title":"Mar Ecol Prog Ser"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.3390\/md9112236","article-title":"Bacteriophages with potential for inactivation of fish pathogenic bacteria: survival, host specificity and effect on bacterial community structure","volume":"9","author":"C Pereira","year":"2011","journal-title":"Marine Drugs"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4014\/jmb.1110.10041","article-title":"Isolation of surfactant-resistant pseudomonads from the estuarine surface microlayer","volume":"22","author":"A Louvado","year":"2012","journal-title":"J Microbiol Biotech"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s10096-012-1691-x","article-title":"Phage therapy to control multidrug-resistant <italic>Pseudomonas aeruginosa<\/italic> skin infections: <italic>in vitro<\/italic> and <italic>ex vivo<\/italic> experiments","volume":"31","author":"A Vieira","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.aquaculture.2014.01.001","article-title":"Efficiency of phage cocktails in the inactivation of Vibrio in aquaculture","volume":"424","author":"C Mateus","year":"2014","journal-title":"Aquaculture"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1128\/AEM.66.12.5488-5491.2000","article-title":"Rapid method for coextraction of DNA and RNA from natural environments for analysis of ribosomal DNA and rRNA-based microbial community composition","volume":"66","author":"RI Griffiths","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"ref39","unstructured":"Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory Press."},{"key":"ref40","article-title":"Morfologia e Infec\u00e7\u00e3o Bacteriof\u00e1gica. Relat\u00f3rio de uma Aula Pr\u00e1tica para Presta\u00e7\u00e3o de Provas de Apid\u00e3o Pedag\u00f3gica e Capacidade Cient\u00edfica","author":"A Almeida","year":"1994","journal-title":"Universidade de Aveiro"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"e25486","DOI":"10.1371\/journal.pone.0025486","article-title":"Bacteriophage-Resistant Mutants in Yersinia pestis: Identification of Phage Receptors and Attenuation for Mice","volume":"6","author":"AA Filippov","year":"2011","journal-title":"PLoS ONE"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1089\/zeb.2011.0724","article-title":"Zebrafish (<italic>Danio rerio<\/italic>) Larvae as a system to test the efficacy of polysaccharides as immunostimulants","volume":"9","author":"U Oyarbide","year":"2012","journal-title":"Zebrafish"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1128\/CDLI.5.3.294-298.1998","article-title":"Use of lytic bacteriophage for control of experimental <italic>Escherichia coli<\/italic> septicemia and meningitis in chickens and calves","volume":"5","author":"P Barrow","year":"1998","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/1751-7915.12090","article-title":"Influence of environmental variables in the efficiency of phage therapy in aquaculture","volume":"7","author":"YJ Silva","year":"2014","journal-title":"Microb Biotechnol"},{"key":"ref45","first-page":"1287","article-title":"Phage therapy","volume":"2","year":"1983","journal-title":"Lancet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e11720","DOI":"10.1371\/journal.pone.0011720","article-title":"Bacteriophage-resistant <italic>Staphylococcus aureus<\/italic> mutant confers broad immunity against staphylococcal infection in mice","volume":"5","author":"R Capparelli","year":"2010","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e25486","DOI":"10.1371\/journal.pone.0025486","article-title":"Bacteriophage-resistant mutants in <italic>Yersinia pestis<\/italic>: identification of phage receptors and attenuation for mice","volume":"6","author":"AA Filippov","year":"2011","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1128\/IAI.70.8.3985-3993.2002","article-title":"Bacteriophage control of bacterial virulence","volume":"70","author":"PL Wagner","year":"2002","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrmicro822","article-title":"Population and evolutionary dynamics of phage therapy","volume":"2","author":"BR Levin","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref50","first-page":"26","article-title":"Colonization of fish skin is vital for <italic>Vibrio anguillarum<\/italic> to cause disease. Environ Microbiol Rep 2: 133\u2013139.Cantas L, S\u00f8rby JR, Alestr\u00f6m P, S\u00f8rum H (2012) Culturable gut microbiota diversity in zebrafish","volume":"9","author":"B Weber","year":"2010","journal-title":"Zebrafish"},{"key":"ref51","first-page":"590385","article-title":"Molecular Characterisation of Bacterial Community Structure along the Intestinal Tract of Zebrafish (Danio rerio): A Pilot Study","volume":"14","author":"CC Lan","year":"2012","journal-title":"ISRN Microbiol"},{"key":"ref52","first-page":"1","article-title":"Bacterial Community Assembly and Turnover within the Intestines of Developing Zebrafish","volume":"7","author":"Q Yan","year":"2012","journal-title":"Plos One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0114197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T13:23:54Z","timestamp":1598534634000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0114197"}},"subtitle":[],"editor":[{"given":"Krystyna","family":"Da\u02dbbrowska","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,12,2]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0114197","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,2]]}}}