{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:04:56Z","timestamp":1776866696768,"version":"3.51.2"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0122308","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T13:08:58Z","timestamp":1427807338000},"page":"e0122308","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":165,"title":["Mitochondrial Dynamics Protein Drp1 Is Overexpressed in Oncocytic Thyroid Tumors and Regulates Cancer Cell Migration"],"prefix":"10.1371","volume":"10","author":[{"given":"Andr\u00e9","family":"Ferreira-da-Silva","sequence":"first","affiliation":[]},{"given":"Cristina","family":"Valacca","sequence":"additional","affiliation":[]},{"given":"Elisabete","family":"Rios","sequence":"additional","affiliation":[]},{"given":"Helena","family":"P\u00f3pulo","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Sobrinho-Sim\u00f5es","sequence":"additional","affiliation":[]},{"given":"Luca","family":"Scorrano","sequence":"additional","affiliation":[]},{"given":"Valdemar","family":"M\u00e1ximo","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Campello","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the Origin of Cancer Cells","volume":"123","author":"O Warburg","year":"1956","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/sj.bjc.6602547","article-title":"Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid","volume":"92","author":"V Maximo","year":"2005","journal-title":"Br J Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00428-009-0766-2","article-title":"Mitochondria and cancer","volume":"454","author":"V Maximo","year":"2009","journal-title":"Virchows Arch"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"729290","DOI":"10.1155\/2012\/729290","article-title":"Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases","volume":"2012","author":"M Corrado","year":"2012","journal-title":"Int J Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1530\/ERC-11-0354","article-title":"The biology and the genetics of Hurthle cell tumors of the thyroid","volume":"19","author":"V Maximo","year":"2012","journal-title":"Endocr Relat Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s004280000219","article-title":"Hurthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance","volume":"437","author":"V Maximo","year":"2000","journal-title":"Virchows Arch"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s004280050209","article-title":"Oncocytic tumours","volume":"433","author":"G Tallini","year":"1998","journal-title":"Virchows Arch"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000027766","article-title":"Benign and malignant oncocytoma of the salivary glands with an immunohistochemical evaluation of Ki-67","volume":"62","author":"K Ito","year":"2000","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1464-410X.2005.05827.x","article-title":"Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases","volume":"96","author":"T Gudbjartsson","year":"2005","journal-title":"BJU Int"},{"key":"ref10","article-title":"Mitochondria and cancer","author":"J Lima","year":"2009"},{"key":"ref11","first-page":"933","article-title":"The eosinophilic cells of the parathyroid (oxyphil cells), salivary (oncocytes), and thyroid (Huerthle cells) glands. Light and electron microscopic observations","volume":"11","author":"SI Roth","year":"1962","journal-title":"Lab Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/01913128509142147","article-title":"Hurthle cell and mitochondrion-rich papillary carcinomas of the thyroid gland: an ultrastructural and immunocytochemical study","volume":"8","author":"MA Sobrinho-Simoes","year":"1985","journal-title":"Ultrastruct Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/01913128509141518","article-title":"Hurthle-cell lesions of the thyroid: a combined study using transmission electron microscopy, scanning electron microscopy, and immunocytochemistry","volume":"8","author":"JM Nesland","year":"1985","journal-title":"Ultrastruct Pathol"},{"key":"ref14","first-page":"878","article-title":"Molecular basis off hurthle cell papillary thyroid carcinoma","volume":"85","author":"CC Cheung","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/path.1511","article-title":"BRAF mutations are associated with some histological types of papillary thyroid carcinoma","volume":"202","author":"V Trovisco","year":"2004","journal-title":"J Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0002-9440(10)64361-1","article-title":"Clinical significance of molecular expression profiles of Hurthle cell tumors of the thyroid gland analyzed via tissue microarrays","volume":"160","author":"A Hoos","year":"2002","journal-title":"Am J Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ecl.2008.02.004","article-title":"Intragenic mutations in thyroid cancer","volume":"37","author":"M Sobrinho-Simoes","year":"2008","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1365-2559.2012.04276.x","article-title":"RET\/PTC rearrangement is prevalent in follicular Hurthle cell carcinomas","volume":"61","author":"MM de Vries","journal-title":"Histopathology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1097\/00000478-199812000-00008","article-title":"Follicular and Hurthle cell carcinomas of the thyroid: a comparative study","volume":"22","author":"HL Evans","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0002-9440(10)61132-7","article-title":"Mitochondrial DNA Somatic Mutations (Point Mutations and Large Deletions) and Mitochondrial DNA Variants in Human Thyroid Pathology: A Study with Emphasis on Hurthle Cell Tumors","volume":"160","author":"V Maximo","year":"2002","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2407-12-53","article-title":"Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors","volume":"12","author":"L Pereira","year":"2012","journal-title":"BMC Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0925-4439(95)00034-2","article-title":"Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems","volume":"1271","author":"G Attardi","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0925-4439(96)00026-9","article-title":"Coordinate expression of nuclear and mitochondrial genes involved in energy production in carcinoma and oncocytoma","volume":"1316","author":"A Heddi","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/1096-9896(200012)192:4<561::AID-PATH790>3.0.CO;2-3","article-title":"Mitochondrial DNA &apos;common&apos; deletion in Hurthle cell lesions of the thyroid","volume":"192","author":"V Maximo","year":"2000","journal-title":"J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1073\/pnas.0703056104","article-title":"Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors","volume":"104","author":"G Gasparre","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/sj.bjc.6603455","article-title":"Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas","volume":"95","author":"E Bonora","year":"2006","journal-title":"Br J Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"C Frezza","year":"2006","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"OM de Brito","year":"2008","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1096\/fj.11-196543","article-title":"Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer","volume":"26","author":"J Rehman","journal-title":"FASEB J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1084\/jem.20061877","article-title":"Orchestration of lymphocyte chemotaxis by mitochondrial dynamics","volume":"203","author":"S Campello","year":"2006","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/onc.2012.494","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","volume":"32","author":"J Zhao","journal-title":"Oncogene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"B Westermann","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"S Cipolat","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","article-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Glands","author":"RA LR DeLellis","year":"2004"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/mp.56.4.198","article-title":"Demystified\u2026tissue microarray technology","volume":"56","author":"J Packeisen","year":"2003","journal-title":"Mol Pathol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/thy.2007.0097","article-title":"Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines","volume":"17","author":"AM Meireles","year":"2007","journal-title":"Thyroid"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1158\/0008-5472.CAN-09-0727","article-title":"Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1","volume":"69","author":"JC Ricarte-Filho","year":"2009","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts","volume":"2","author":"C Frezza","year":"2007","journal-title":"Nat Protoc"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-207-6_2","article-title":"Scratch-wound assay","volume":"769","author":"G Cory","journal-title":"Methods Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2007.11.019","article-title":"Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax\/Bak-dependent mitochondrial outer membrane permeabilization","volume":"14","author":"A Cassidy-Stone","year":"2008","journal-title":"Dev Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.1074\/jbc.M112.359174","article-title":"Loss of mitofusin 2 promotes endoplasmic reticulum stress","volume":"287","author":"GA Ngoh","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1242\/jcs.093609","article-title":"Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle\u2014pivotal roles in Ca(2)(+) and reactive oxygen species signaling","volume":"126","author":"V Eisner","journal-title":"J Cell Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"S Cogliati","journal-title":"Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"H167","DOI":"10.1152\/ajpheart.00833.2011","article-title":"Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death","volume":"302","author":"KN Papanicolaou","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1038\/sj.emboj.7601253","article-title":"Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons","volume":"25","author":"MJ Barsoum","year":"2006","journal-title":"EMBO J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"N Taguchi","year":"2007","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"GM Cereghetti","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/embor.2009.86","article-title":"MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission","volume":"10","author":"E Braschi","year":"2009","journal-title":"EMBO Rep"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12038-011-9100-7","article-title":"Synergistic growth inhibition of cancer cells harboring the RET\/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death","volume":"36","author":"AP Goncalves","journal-title":"J Biosci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0122308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:51:14Z","timestamp":1588974674000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0122308"}},"subtitle":[],"editor":[{"given":"Marc","family":"Liesa","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,3,30]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0122308","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,30]]}}}