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Cochrane Handbook for Systematic Reviews of Interventions Version 510 (updated March 2011) 2011."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1741-7015-9-39","article-title":"Using framework-based synthesis for conducting reviews of qualitative studies","volume":"9","author":"M Dixon-Woods","year":"2011","journal-title":"BMC medicine"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1369-7625.2007.00476.x","article-title":"A multidimensional conceptual framework for analysing public involvement in health services research","volume":"11","author":"SR Oliver","year":"2008","journal-title":"Health expectations: an international journal of public participation in health care and health policy"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.jclinepi.2012.05.005","article-title":"Cumulative complexity: a functional, patient-centered model of patient complexity can improve research and practice","volume":"65","author":"ND Shippee","year":"2012","journal-title":"Journal of clinical epidemiology"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1191\/1478088706qp063oa","article-title":"Using thematic analysis in psychology","volume":"3","author":"V Braun","year":"2006","journal-title":"Qualitative Research in Psychology"},{"issue":"9488","key":"ref21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(05)67030-4","article-title":"Patients&apos; help-seeking experiences and delay in cancer presentation: a qualitative synthesis","volume":"366","author":"LK Smith","year":"2005","journal-title":"The Lancet"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.2307\/j.ctvjnrv7n","article-title":"The Idea of Justice","author":"A Sen","year":"2009"},{"key":"ref23","unstructured":"CASP. Critical Appraisal Skills Programme\u2014Making sense of evidence: CASP Checklists 2013 [29\/05\/2014]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.casp-uk.net\/#!casp-tools-checklists\/c18f8\" xlink:type=\"simple\">http:\/\/www.casp-uk.net\/#!casp-tools-checklists\/c18f8<\/ext-link>."},{"issue":"9\u201310","key":"ref24","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1365-2702.2011.04001.x","article-title":"Factors influencing patients with stage 5 chronic kidney disease to opt for conservative management: a practitioner research study","volume":"21","author":"S Johnston","year":"2012","journal-title":"Journal of clinical nursing"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jcf.2010.08.016","article-title":"Perceptions of barriers and facilitators: self-management decisions by older adolescents and adults with CF","volume":"9","author":"M George","year":"2010","journal-title":"Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/09593985.2013.845863","article-title":"Growing up with Primary Ciliary Dyskinesia in Bradford, UK: exploring patients experiences as a physiotherapist","volume":"30","author":"LM Schofield","year":"2014","journal-title":"Physiotherapy theory and practice"},{"issue":"6","key":"ref27","first-page":"665","article-title":"&apos;You say treatment, I say hard work&apos;: treatment burden among people with chronic illness and their carers in Australia","volume":"21","author":"A Sav","year":"2013","journal-title":"Health & social care in the community"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1177\/1359105313475898","article-title":"A qualitative study of treatment burden among haemodialysis recipients","volume":"19","author":"C Karamanidou","year":"2013","journal-title":"Journal of Health Psychology"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1089\/109662103764978489","article-title":"What matters to seriously ill older persons making end-of-life treatment decisions?: A qualitative study","volume":"6","author":"TR Fried","year":"2003","journal-title":"Journal of Palliative Medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1471-2458-9-190","article-title":"Improving tuberculosis care in low income countries\u2014a qualitative study of patients&apos; understanding of &quot;patient support&quot; in Nepal","volume":"9","author":"CP Lewis","year":"2009","journal-title":"BMC public health"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/1467-9566.ep11339939","article-title":"Chronic illness as biographical disruption","volume":"4","author":"M Bury","year":"1982","journal-title":"Sociology of Health and IUness"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1258\/135581907779497486","article-title":"Appraising qualitative research for inclusion in systematic reviews: a quantitative and qualitative comparison of three methods","volume":"12","author":"M Dixon-Woods","year":"2007","journal-title":"Journal of Health Services Research & Policy"},{"issue":"281","key":"ref33","first-page":"1","article-title":"Rethinking the patient: using Burden of Treatment Theory to understand the changing dynamics of illness","volume":"14","author":"CR May","year":"2014","journal-title":"BMC Health Services Research"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0059723","article-title":"Social Networks, the \u2018Work\u2019 and Work Force of Chronic Illness Self-Management: A Survey Analysis of Personal Communities","volume":"8","author":"I Vassilev","year":"2013","journal-title":"Plos one"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/jme.19.2.108","article-title":"What is wrong with compliance?","volume":"19","author":"S Holm","year":"1993","journal-title":"Journal of medical ethics"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2648.2003.02711.x","article-title":"Nurses and \u2018difficult\u2019 patients: negotiating non-compliance","volume":"43","author":"S Russell","year":"2003","journal-title":"Journal of advanced nursing"},{"key":"ref37","unstructured":"GMC. Consent guidance: patients and doctors making decisions together 2008. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.gmc-uk.org\/static\/documents\/content\/Consent_-_English_0414.pdf\" xlink:type=\"simple\">http:\/\/www.gmc-uk.org\/static\/documents\/content\/Consent_-_English_0414.pdf<\/ext-link>."},{"key":"ref38","unstructured":"GMC. Treatment and care towards the end of life: good practice in decision making 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.gmc-uk.org\/static\/documents\/content\/Treatment_and_care_towards_the_end_of_life_-_English_0414.pdf\" xlink:type=\"simple\">http:\/\/www.gmc-uk.org\/static\/documents\/content\/Treatment_and_care_towards_the_end_of_life_-_English_0414.pdf<\/ext-link>."},{"key":"ref39","unstructured":"DH. 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