{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:57:52Z","timestamp":1775624272328,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0134969","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T18:11:20Z","timestamp":1438971080000},"page":"e0134969","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Endometrial Endometrioid Carcinoma Metastases Show Decreased ER-Alpha and PR-A Expression Compared to Matched Primary Tumors"],"prefix":"10.1371","volume":"10","author":[{"given":"Carla","family":"Bartosch","sequence":"first","affiliation":[]},{"given":"Sara","family":"Monteiro-Reis","sequence":"additional","affiliation":[]},{"given":"Renata","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Armindo","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Carmen","family":"Jer\u00f3nimo","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 M.","family":"Lopes","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1525-1438.2007.00996.x","article-title":"The incidence of pelvic lymph node metastasis by FIGO staging for patients with adequately surgically staged endometrial adenocarcinoma of endometrioid histology","volume":"18","author":"DS Chi","year":"2008","journal-title":"International journal of gynecological cancer: official journal of the International Gynecological Cancer Society"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/S1470-2045(12)70213-9","article-title":"Markers for individualised therapy in endometrial carcinoma","volume":"13","author":"HB Salvesen","year":"2012","journal-title":"The Lancet Oncology"},{"issue":"Suppl 1","key":"ref3","first-page":"S105","article-title":"Carcinoma of the corpus uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer","volume":"95","author":"WT Creasman","year":"2006","journal-title":"International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics"},{"key":"ref4","article-title":"SEER Cancer Statistics Review","author":"N Howlader","year":"1975"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1525-1438.2007.00897.x","article-title":"Hormone therapy in advanced and recurrent endometrial cancer: a systematic review","volume":"17","author":"SB Decruze","year":"2007","journal-title":"International journal of gynecological cancer: official journal of the International Gynecological Cancer Society"},{"issue":"16","key":"ref6","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1016\/j.ejca.2013.06.016","article-title":"Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial","volume":"49","author":"J Trovik","year":"2013","journal-title":"Eur J Cancer"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ygyno.2013.06.015","article-title":"Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma","volume":"130","author":"J Huvila","year":"2013","journal-title":"Gynecol Oncol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/gyno.1999.5662","article-title":"Assessment of hypermethylated DNA in two promoter regions of the estrogen receptor alpha gene in human endometrial diseases","volume":"76","author":"M Hori","year":"2000","journal-title":"Gynecol Oncol"},{"issue":"10","key":"ref9","first-page":"4026","article-title":"Loss of estrogen receptor (ER) expression in endometrial tumors is not associated with de novo methylation of the 5&apos; end of the ER gene","volume":"6","author":"JR Navari","year":"2000","journal-title":"Clin Cancer Res"},{"issue":"1","key":"ref10","first-page":"97","article-title":"Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer","volume":"61","author":"M Sasaki","year":"2001","journal-title":"Cancer Res"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ygyno.2005.05.035","article-title":"Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines","volume":"99","author":"Y Xiong","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cancergencyto.2007.02.002","article-title":"Down-regulation of the progesterone receptor by the methylation of progesterone receptor gene in endometrial cancer cells","volume":"175","author":"Y Ren","year":"2007","journal-title":"Cancer genetics and cytogenetics"},{"issue":"5485","key":"ref13","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1126\/science.289.5485.1751","article-title":"Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform","volume":"289","author":"B Mulac-Jericevic","year":"2000","journal-title":"Science"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jsbmb.2004.07.007","article-title":"Significance of progesterone receptor-A and -B expressions in endometrial adenocarcinoma","volume":"92","author":"T Miyamoto","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ygyno.2008.10.032","article-title":"Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer","volume":"112","author":"V Jongen","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.humpath.2012.09.007","article-title":"The expression ratios of estrogen receptor alpha (ERalpha) to estrogen receptor beta1 (ERbeta1) and ERalpha to ERbeta2 identify poor clinical outcome in endometrioid endometrial cancer","volume":"44","author":"GF Zannoni","year":"2013","journal-title":"Hum Pathol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1365-2559.2011.04106.x","article-title":"Immunohistochemical features of post-radiation vaginal recurrences of endometrioid carcinomas of the endometrium: role for proteins involved in resistance to apoptosis and hypoxia","volume":"60","author":"M Santacana","year":"2012","journal-title":"Histopathology"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1097\/PAS.0b013e318273591a","article-title":"Clinicopathologic analysis of matched primary and recurrent endometrial carcinoma","volume":"36","author":"RA Soslow","year":"2012","journal-title":"The American journal of surgical pathology"},{"issue":"17","key":"ref19","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1016\/j.ejca.2014.09.003","article-title":"Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions","volume":"50","author":"IL Tangen","year":"2014","journal-title":"Eur J Cancer"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10549-007-9620-x","article-title":"Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions","volume":"109","author":"C Jeronimo","year":"2008","journal-title":"Breast cancer research and treatment"},{"issue":"18","key":"ref21","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1038\/sj.onc.1209145","article-title":"Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors","volume":"25","author":"M Ehrlich","year":"2006","journal-title":"Oncogene"},{"issue":"8","key":"ref22","first-page":"3410","article-title":"Epigenetic patterns in the progression of esophageal adenocarcinoma","volume":"61","author":"CA Eads","year":"2001","journal-title":"Cancer Res"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2353\/jmoldx.2006.050135","article-title":"Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis","volume":"8","author":"S Ogino","year":"2006","journal-title":"The Journal of molecular diagnostics: JMD"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-pathol-020712-163923","article-title":"Cellular heterogeneity and molecular evolution in cancer","volume":"8","author":"V Almendro","year":"2013","journal-title":"Annual review of pathology"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/bcr1508","article-title":"Evaluation of Ki-67 proliferation and apoptotic index before, during and after neoadjuvant chemotherapy for primary breast cancer","volume":"8","author":"R Burcombe","year":"2006","journal-title":"Breast cancer research: BCR"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1634\/theoncologist.2008-0073","article-title":"Changes and predictive and prognostic value of the mitotic index, Ki-67, cyclin D1, and cyclo-oxygenase-2 in 710 operable breast cancer patients treated with neoadjuvant chemotherapy","volume":"13","author":"F Penault-Llorca","year":"2008","journal-title":"The oncologist"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"20130016","DOI":"10.1098\/rsfs.2013.0016","article-title":"Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance","volume":"3","author":"J Gallaher","year":"2013","journal-title":"Interface focus"},{"issue":"9\u201311","key":"ref28","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/15257770600894527","article-title":"Difference in Ki67 and thymidylate synthase expression in primary tumour compared with metastatic nodes in breast cancer patients","volume":"25","author":"A Calascibetta","year":"2006","journal-title":"Nucleosides, nucleotides & nucleic acids"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/(SICI)1096-9098(199708)65:4<274::AID-JSO9>3.0.CO;2-2","article-title":"Proliferative activity of esophageal carcinomas and their lymph node metastases: comparison using argyrophilic nucleolar organizer region staining","volume":"65","author":"K Yano","year":"1997","journal-title":"Journal of surgical oncology"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"e94476","DOI":"10.1371\/journal.pone.0094476","article-title":"Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease","volume":"9","author":"AS Brodsky","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2559.2006.02402.x","article-title":"Ki67 immunohistochemistry: a valuable marker in prognostication but with a risk of misclassification: proliferation subgroups formed based on Ki67 immunoreactivity and standardized mitotic index","volume":"48","author":"P Jalava","year":"2006","journal-title":"Histopathology"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/modpathol.3800620","article-title":"Immunophenotypic diversity of endometrial adenocarcinomas: implications for differential diagnosis","volume":"19","author":"M Reid-Nicholson","year":"2006","journal-title":"Mod Pathol"},{"issue":"5\u20136","key":"ref33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0960-0760(97)00057-5","article-title":"Clinical implication of expression of progesterone receptor form A and B mRNAs in secondary spreading of gynecologic cancers","volume":"62","author":"J Fujimoto","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000059575","article-title":"Clinical implications of the expression of estrogen receptor-alpha and -beta in primary and metastatic lesions of uterine endometrial cancers","volume":"62","author":"J Fujimoto","year":"2002","journal-title":"Oncology"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/annonc\/mds248","article-title":"Discordance in receptor status between primary and recurrent breast cancer has a prognostic impact: a single-institution analysis","volume":"24","author":"MV Dieci","year":"2013","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology \/ ESMO"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ctrv.2011.11.006","article-title":"Tissue confirmation of disease recurrence in breast cancer patients: pooled analysis of multi-centre, multi-disciplinary prospective studies","volume":"38","author":"E Amir","year":"2012","journal-title":"Cancer treatment reviews"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1186\/bcr2645","article-title":"Receptor conversion in distant breast cancer metastases","volume":"12","author":"LD Hoefnagel","year":"2010","journal-title":"Breast cancer research: BCR"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"M Esteller","year":"2008","journal-title":"N Engl J Med"},{"issue":"8","key":"ref39","first-page":"3262","article-title":"Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer","volume":"61","author":"M Sasaki","year":"2001","journal-title":"Cancer Res"},{"issue":"12","key":"ref40","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1128\/MCB.14.12.8356","article-title":"The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells","volume":"14","author":"DX Wen","year":"1994","journal-title":"Mol Cell Biol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10549-010-0908-x","article-title":"Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas","volume":"126","author":"V Wargon","year":"2011","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1071-5576(02)00217-4","article-title":"Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines","volume":"10","author":"E Smid-Koopman","year":"2003","journal-title":"J Soc Gynecol Investig"},{"issue":"3","key":"ref43","first-page":"881","article-title":"Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors","volume":"62","author":"D Dai","year":"2002","journal-title":"Cancer Res"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ygyno.2004.01.042","article-title":"Drastic decrease of progesterone receptor form B but not A mRNA reflects poor patient prognosis in endometrial cancers","volume":"93","author":"H Sakaguchi","year":"2004","journal-title":"Gynecol Oncol"},{"issue":"9","key":"ref45","first-page":"1860","article-title":"Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications for unopposed estrogen action","volume":"58","author":"NS Kumar","year":"1998","journal-title":"Cancer Res"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/path.1738","article-title":"Aberrations in the progesterone receptor gene and the risk of recurrent endometrial carcinoma","volume":"205","author":"JM Pijnenborg","year":"2005","journal-title":"J Pathol"},{"issue":"19","key":"ref47","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.1073\/pnas.192172299","article-title":"A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk","volume":"99","author":"I De Vivo","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00428-004-1059-4","article-title":"Correlation between the DNA global methylation status and progesterone receptor expression in normal endometrium, endometrioid adenocarcinoma and precursors","volume":"445","author":"L Ghabreau","year":"2004","journal-title":"Virchows Archiv: an international journal of pathology"},{"issue":"15","key":"ref49","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1158\/0008-5472.CAN-13-0930","article-title":"Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy","volume":"73","author":"DM Janzen","year":"2013","journal-title":"Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0134969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:32:48Z","timestamp":1588995168000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0134969"}},"subtitle":[],"editor":[{"given":"Jae-Wook","family":"Jeong","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,8,7]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0134969","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,7]]}}}