{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:46:11Z","timestamp":1778654771637,"version":"3.51.4"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0135110","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T18:18:18Z","timestamp":1439403498000},"page":"e0135110","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["New Mechanisms of Flucytosine Resistance in C. glabrata Unveiled by a Chemogenomics Analysis in S. cerevisiae"],"prefix":"10.1371","volume":"10","author":[{"given":"Catarina","family":"Costa","sequence":"first","affiliation":[]},{"given":"Andreia","family":"Ponte","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Pais","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Mafalda","family":"Cavalheiro","sequence":"additional","affiliation":[]},{"given":"Takashi","family":"Yaguchi","sequence":"additional","affiliation":[]},{"given":"Hiroji","family":"Chibana","sequence":"additional","affiliation":[]},{"given":"Miguel Cacho","family":"Teixeira","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.12.1.80","article-title":"<italic>Candida glabrata<\/italic>: review of epidemiology, pathogenesis, and clinical disease with comparison to <italic>C<\/italic>. <italic>albicans<\/italic>","volume":"12","author":"PL Fidel Jr.","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1556\/AMicr.54.2007.3.1","article-title":"Pathogenicity and drug resistance in <italic>Candida albicans<\/italic> and other yeast species. A review","volume":"54","author":"NN Mishra","year":"2007","journal-title":"Acta Microbiol Immunol Hung"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance","volume":"12","author":"MA Ghannoum","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1128\/AAC.00605-10","article-title":"Mutational analysis of flucytosine resistance in <italic>Candida glabrata<\/italic>","volume":"54","author":"TD Edlind","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1128\/AAC.48.11.4377-4386.2004","article-title":"Molecular mechanisms of primary resistance to flucytosine in <italic>Candida albicans<\/italic>","volume":"48","author":"WW Hope","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref6","first-page":"101","article-title":"Mechanisms of resistance to antifungal agents: yeasts and filamentous fungi","volume":"25","author":"A Espinel-Ingroff","year":"2008","journal-title":"Rev Iberoam Micol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jac\/46.2.171","article-title":"Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions","volume":"46","author":"A Vermes","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1473-3099(02)00181-0","article-title":"Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences","volume":"2","author":"D Sanglard","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0140-6736(02)08162-X","article-title":"Antifungal drug resistance of pathogenic fungi","volume":"359","author":"DP Kontoyiannis","year":"2002","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/AAC.00824-06","article-title":"Molecular mechanism of flucytosine resistance in <italic>Candida lusitaniae<\/italic>: contribution of the <italic>FCY2<\/italic>, <italic>FCY1<\/italic>, and <italic>FUR1<\/italic> genes to 5-fluorouracil and fluconazole cross-resistance","volume":"51","author":"N Papon","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0924-8579(02)00201-7","article-title":"Expression profiling of the response of <italic>Saccharomyces cerevisiae<\/italic> to 5-fluorocytosine using a DNA microarray","volume":"20","author":"L Zhang","year":"2002","journal-title":"Int J Antimicrob Agents"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1004211","DOI":"10.1371\/journal.ppat.1004211","article-title":"Systematic phenotyping of a large-scale <italic>Candida glabrata<\/italic> deletion collection reveals novel antifungal tolerance genes","volume":"10","author":"T Schwarzmuller","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1046\/j.1365-2958.1999.01248.x","article-title":"Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation","volume":"31","author":"MJ T\u00e1mas","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1046\/j.1365-2958.2001.02485.x","article-title":"The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in <italic>Saccharomyces cerevisiae<\/italic>","volume":"40","author":"R Wysocki","year":"2001","journal-title":"Mol Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6446","DOI":"10.1128\/MCB.02205-06","article-title":"Hog1 mitogen-activated protein kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid","volume":"27","author":"M Mollapour","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1574-6968.2006.00395.x","article-title":"Roles of <italic>BOR1<\/italic>, <italic>DUR3<\/italic>, and <italic>FPS1<\/italic> in boron transport and tolerance in <italic>Saccharomyces cerevisiae<\/italic>","volume":"262","author":"A Nozawa","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1128\/AEM.00845-09","article-title":"Genome-wide identification of <italic>Saccharomyces cerevisiae<\/italic> genes required for maximal tolerance to ethanol","volume":"75","author":"MC Teixeira","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e55439","DOI":"10.1371\/journal.pone.0055439","article-title":"Quantitative 1H-NMR-metabolomics reveals extensive metabolic reprogramming and the effect of the aquaglyceroporin Fps1 in ethanol-stressed yeast cells","volume":"8","author":"AB Louren\u00e7o","year":"2013","journal-title":"PLoS One"},{"key":"ref19","first-page":"205","article-title":"Implications of <italic>FPS1<\/italic> deletion and membrane ergosterol content for glycerol efflux from <italic>Saccharomyces cerevisiae<\/italic>","volume":"1","author":"TH Toh","year":"2001","journal-title":"FEMS Yeast Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/EC.00231-12","article-title":"Mutants in the <italic>Candida glabrata<\/italic> glycerol channels are sensitized to cell wall stress","volume":"11","author":"SE Beese-Sims","year":"2012","journal-title":"Eukaryot Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1128\/EC.00414-06","article-title":"Development of a highly efficient gene targeting system induced by transient repression of <italic>YKU80<\/italic> expression in <italic>Candida glabrata<\/italic>","volume":"6","author":"K Ueno","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1128\/AAC.48.10.3773-3781.2004","article-title":"Azole resistance in <italic>Candida glabrata<\/italic>: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor","volume":"48","author":"JP Vermitsky","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1128\/AEM.69.7.4019-4028.2003","article-title":"Adaptation of <italic>Saccharomyces cerevisiae<\/italic> to the herbicide 2,4-dichlorophenoxyacetic acid, mediated by Msn2p- and Msn4p-regulated genes: important role of <italic>SPI1<\/italic>","volume":"69","author":"T Sim\u00f5es","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e24759","DOI":"10.1371\/journal.pone.0024759","article-title":"Intestinal resident yeast <italic>Candida glabrata<\/italic> requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine","volume":"6","author":"K Ueno","year":"2011","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2004.10.016","article-title":"Drag&amp;Drop cloning in yeast","volume":"344","author":"G Jansen","year":"2005","journal-title":"Gene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fmicb.2013.00170","article-title":"The dual role of <italic>Candida glabrata<\/italic> drug:H+ antiporter CgAqr1 (ORF <italic>CAGL0J09944g<\/italic>) in antifungal drug and acetic acid resistance","volume":"4","author":"C Costa","year":"2013","journal-title":"Front Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/jac\/dku044","article-title":"<italic>Candida glabrata<\/italic> drug:H+ antiporter CgTpo3 (ORF <italic>CAGL0I10384g<\/italic>): role in azole drug resistance and polyamine homeostasis","volume":"69","author":"C Costa","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1128\/AAC.00811-12","article-title":"<italic>Candida glabrata<\/italic> Drug:H+ Antiporter CgQdr2 Confers Imidazole Drug Resistance, Being Activated by Transcription Factor CgPdr1","volume":"57","author":"C Costa","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1574-6968.1996.tb08000.x","article-title":"Intracellular acidification does not account for inhibition of <italic>Saccharomyces cerevisiae<\/italic> growth in the presence of ethanol","volume":"135","author":"MF Rosa","year":"1996","journal-title":"FEMS Microbiology Letters"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1128\/AAC.49.6.2226-2236.2005","article-title":"Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in <italic>Candida albicans<\/italic>","volume":"49","author":"TT Liu","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1150021","article-title":"The chemical genomic portrait of yeast: uncovering a phenotype for all genes","volume":"320","author":"ME Hillenmeyer","year":"2008","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1371\/journal.ppat.0030092","article-title":"Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in <italic>Candida albicans<\/italic>","volume":"3","author":"D Xu","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/01.WCB.0000080651.64357.C6","article-title":"L-arginine levels in blood as a marker of nitric oxide-mediated brain damage in acute stroke: a clinical and experimental study","volume":"23","author":"A Armengou","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1749-6632.1960.tb40891.x","article-title":"The qualitative identification of free amino acids in human vaginal fluid","volume":"83","author":"AT Gregoire","year":"1959","journal-title":"Ann N Y Acad Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/AAC.12.2.255","article-title":"Morphological changes in yeasts as a result of the action of 5-fluorocytosine","volume":"12","author":"T Arai","year":"1977","journal-title":"Antimicrob Agents Chemother"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0135110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T08:55:07Z","timestamp":1567068907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0135110"}},"subtitle":[],"editor":[{"given":"Robert Alan","family":"Arkowitz","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,8,12]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0135110","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,12]]}}}