{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T10:40:31Z","timestamp":1653129631979},"reference-count":100,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136866","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T17:59:47Z","timestamp":1441303187000},"page":"e0136866","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["A G\u03b2 protein and the TupA Co-Regulator Bind to Protein Kinase A Tpk2 to Act as Antagonistic Molecular Switches of Fungal Morphological Changes"],"prefix":"10.1371","volume":"10","author":[{"given":"Thamarai K.","family":"Janganan","sequence":"first","affiliation":[]},{"given":"Gongyou","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Daliang","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o F.","family":"Menino","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Maria I.","family":"Borges-Walmsley","sequence":"additional","affiliation":[]},{"given":"Adrian R.","family":"Walmsley","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0966-842X(01)02292-2","article-title":"The pathobiology of <italic>Paracoccidioides brasiliensis<\/italic>","volume":"10","author":"MI Borges-Walmsley","year":"2002","journal-title":"Trends Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/mmy.40.3.225.242","article-title":"<italic>Paracoccidioides brasiliensis<\/italic> and paracoccidioidomycosis: molecular approaches to morphogenesis, diagnosis, epidemiology, taxonomy and genetics","volume":"40","author":"G San-Blas","year":"2002","journal-title":"Med. Mycol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.mib.2007.04.002","article-title":"Dimorphism and virulence in fungi","volume":"10","author":"BS Klein","year":"2007","journal-title":"Curr Opin Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1046\/j.1439-0507.2002.00752.x","article-title":"<italic>Paracoccidioides brasiliensis<\/italic>: virulence and an attempt to induce the dimorphic process with fetal calf serum","volume":"45","author":"C De Moraes Borba","year":"2002","journal-title":"Mycoses"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.phyto.41.052002.095728","article-title":"Of smuts, blasts, mildews, and blights: cAMP signaling in phytopathogenic fungi","volume":"41","author":"N Lee","year":"2003","journal-title":"Annu Rev Phytopathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1101\/gad.8.23.2805","article-title":"cAMP regulates morphogenesis in the fungal pathogen <italic>Ustilago maydis<\/italic>","volume":"8","author":"S Gold","year":"1994","journal-title":"Genes Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2660(06)57001-4","article-title":"Genetics of morphogenesis and pathogenic development of Ustilago maydis","volume":"57","author":"SJ Klosterman","year":"2007","journal-title":"Adv Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1105\/tpc.9.11.1973","article-title":"The adenylate cyclase gene <italic>MAC1<\/italic> of <italic>Magnaporthe grisea<\/italic> controls appressorium formation and other aspects of growth and development","volume":"9","author":"W Choi","year":"1997","journal-title":"Plant Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/sj.emboj.7601536","article-title":"Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism","volume":"26","author":"H Liu","year":"2007","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1128\/IAI.72.9.5193-5203.2004","article-title":"The cyclic AMP-dependent protein kinase a network regulates development and virulence in <italic>Aspergillus fumigatus<\/italic>","volume":"72","author":"B Liebmann","year":"2004","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1128\/IAI.00565-06","article-title":"Deletion of the regulatory subunit of protein kinase A in <italic>Aspergillus fumigatus<\/italic> alters morphology, sensitivity to oxidative damage, and virulence","volume":"74","author":"W Zhao","year":"2006","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1091\/mbc.12.11.3631","article-title":"Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus <italic>Candida albicans<\/italic>","volume":"12","author":"CR Rocha","year":"2001","journal-title":"Mol Biol Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1128\/EC.00318-07","article-title":"Genome-wide transcriptional profiling of the cyclic AMP-dependent signaling pathway during morphogenic transitions of <italic>Candida albicans<\/italic>","volume":"6","author":"YS Bahn","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/EC.1.1.75-84.2002","article-title":"Adenylyl cyclase functions down-stream of the Galpha protein Gpa1 and controls mating and pathogenicity of <italic>Cryptococcus neoformans<\/italic>","volume":"1","author":"JA Alspaugh","year":"2002","journal-title":"Eukaryot Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/emboj\/17.7.1996","article-title":"GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway","volume":"17","author":"Y Xue","year":"1998","journal-title":"EMBO J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1128\/JB.145.3.1452-1455.1981","article-title":"Regulation of dimorphism in <italic>Histoplasma capsulatum<\/italic> by cyclic adenosine 3&apos;,5&apos;-monophosphate","volume":"145","author":"J Medoff","year":"1981","journal-title":"J Bacteriol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/mcbr.1999.0169","article-title":"cAMP is involved in transcriptional regulation of delta9-desaturase during <italic>Histoplasma capsulatum<\/italic> morphogenesis","volume":"2","author":"A Storlazzi","year":"1999","journal-title":"Mol Cell Biol Res Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00444093","article-title":"Cyclic adenosine 3&apos;,5&apos; monophosphate (cAMP) and dimorphism in the pathogenic fungus <italic>Paracoccidioides brasiliensis<\/italic>","volume":"92","author":"S Paris","year":"1985","journal-title":"Mycopathologia"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1365-2958.2007.05824.x","article-title":"The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of <italic>Paracoccidioides brasiliensis<\/italic>","volume":"65","author":"D Chen","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1128\/MCB.19.7.4874","article-title":"Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in <italic>Saccharomyces cerevisiae<\/italic>","volume":"19","author":"X Pan","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S1369-5274(00)00142-9","article-title":"Signal transduction cascades regulating pseudohyphal differentiation of <italic>Saccharomyces cerevisiae<\/italic>","volume":"3","author":"X Pan","year":"2000","journal-title":"Curr. Opin. Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1073\/pnas.79.7.2355","article-title":"Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase","volume":"79","author":"K Matsumoto","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1073\/pnas.83.24.9303","article-title":"Cloning and characterization of the high-affinity cAMP phosphodiesterase of <italic>Saccharomyces cerevisiae<\/italic>","volume":"8","author":"P Sass","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1128\/MCB.8.1.505","article-title":"SRA5 encodes the low-Km cyclic AMP phosphodiesterase of <italic>Saccharomyces cerevisiae<\/italic>","volume":"8","author":"R. B. Wilson","year":"1988","journal-title":"Mol. Cell. Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1046\/j.1365-2958.1999.01413.x","article-title":"A <italic>Saccharomyces cerevisiae<\/italic> G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose","volume":"32","author":"L Kraakman","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.molcel.2004.10.004","article-title":"Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast <italic>Saccharomyces cerevisiae<\/italic>","volume":"16","author":"K Lemaire","year":"2004","journal-title":"Mol. Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7008","DOI":"10.1093\/emboj\/16.23.7008","article-title":"Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog","volume":"16","author":"MC Lorenz","year":"1997","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1093\/emboj\/18.20.5577","article-title":"A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2","volume":"18","author":"M Versele","year":"1999","journal-title":"EMBO J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/embo-reports\/kve132","article-title":"Sex and sugar in yeast: two distinct GPCR systems","volume":"2","author":"M Versele","year":"2001","journal-title":"EMBO Rep"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/EC.4.3.495-503.2005","article-title":"Except in every detail: comparing and contrasting G-protein signaling in <italic>Saccharomyces cerevisiae<\/italic> and <italic>Schizosaccharomyces pombe<\/italic>","volume":"4","author":"CS Hoffman","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1097-2765(02)00569-5","article-title":"The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits","volume":"10","author":"T Harashima","year":"2002","journal-title":"Mol Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1242\/jcs.00266","article-title":"Krh1p and Krh2p act down-stream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth","volume":"116","author":"M Batlle","year":"2003","journal-title":"J Cell Sci"},{"key":"ref33","first-page":"3199","article-title":"Cyclic AMP and the stimulation of trehalase activity in the yeast <italic>Saccharomyces cerevisiae<\/italic> by carbon sources, nitrogen sources and inhibitors of protein synthesis","volume":"131","author":"J M Thevelein","year":"1985","journal-title":"J. Gen. Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9142","DOI":"10.1016\/S0021-9258(19)76518-1","article-title":"Purification and characterization of C1, the catalytic subunit of <italic>Saccharomyces cerevisiae<\/italic> cAMP-dependent protein kinase encoded by <italic>TPK1<\/italic>","volume":"263","author":"M J Zoller","year":"1988","journal-title":"J. Biol. Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1128\/MCB.7.4.1371","article-title":"Cloning and characterization of <italic>BCY1<\/italic>, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in <italic>Saccharomyces cerevisiae<\/italic>","volume":"7","author":"T Toda","year":"1987","journal-title":"Mol. Cell. Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0092-8674(87)90223-6","article-title":"Three different genes in <italic>S<\/italic>. <italic>cerevisiae<\/italic> encode the catalytic subunits of the cAMP-dependent protein kinase","volume":"50","author":"T Toda","year":"1987","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"13034","DOI":"10.1073\/pnas.0509644103","article-title":"Kelch-repeat proteins interacting with the G\u03b1 protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast","volume":"103","author":"T Peeters","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tibs.2007.09.011","article-title":"Directly from Galpha to protein kinase A: the kelch repeat protein bypass of adenylate cyclase","volume":"32","author":"T Peeters","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(88)90572-7","article-title":"cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in <italic>S<\/italic>. <italic>cerevisiae<\/italic>","volume":"53","author":"S Cameron","year":"1988","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"13783","DOI":"10.1073\/pnas.95.23.13783","article-title":"The three yeast A kinases have specific signaling functions in pseudohyphal growth","volume":"95","author":"LS Robertson","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/emboj\/18.5.1257","article-title":"MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast <italic>FLO11<\/italic> gene","volume":"18","author":"S Rupp","year":"1999","journal-title":"EMBO J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1091\/mbc.9.1.161","article-title":"The cell surface flocculin Flo11 is required for pseudohyphae formation and invasion by <italic>Saccharomyces cerevisiae<\/italic>","volume":"9","author":"WS Lo","year":"1998","journal-title":"Mol Biol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1074\/jbc.274.1.205","article-title":"The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator","volume":"274","author":"RS Conlan","year":"1999","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1128\/MCB.22.12.3981-3993.2002","article-title":"Protein Kinase A operates as a molecular switch that governs pseudohyphal differentiation","volume":"22","author":"X Pan","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1091\/mbc.E05-06-0502","article-title":"The Flo8 transcription factor is essential for hyphal development and virulence in <italic>Candida albicans<\/italic>","volume":"17","author":"F Cao","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1128\/EC.00199-07","article-title":"Roles of <italic>Candida albicans<\/italic> Sfl1 in hyphal development","volume":"6","author":"Y Li","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1128\/EC.00236-07","article-title":"<italic>Candida albicans<\/italic> Sfl1 suppresses flocculation and filamentation","volume":"6","author":"J Bauer","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.277.5322.105","article-title":"Control of filament formation in <italic>Candida albicans<\/italic> by the transcriptional repressor TUPA","volume":"277","author":"BR Braun","year":"1997","journal-title":"Science"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/genetics\/156.1.31","article-title":"Identification and characterization of TUPA-regulated genes in <italic>Candida albicans<\/italic>","volume":"156","author":"BR Braun","year":"2000","journal-title":"Genetics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1046\/j.1365-2958.2003.03353.x","article-title":"Ssn6, an important factor of morphological conversion and virulence in <italic>Candida albicans<\/italic>","volume":"47","author":"CS Hwang","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1091\/mbc.E05-01-0071","article-title":"Global roles of Ssn6 in TupA- and Nrg1-dependent gene regulation in the fungal pathogen, <italic>Candida albicans<\/italic>","volume":"16","author":"S Garc\u00eda-S\u00e1nchez","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1093\/emboj\/20.17.4753","article-title":"NRG1, a repressor of filamentous growth in <italic>C<\/italic>. <italic>albicans<\/italic>, is down-regulated during filament induction","volume":"20","author":"BR Braun","year":"2001","journal-title":"EMBO J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1093\/emboj\/20.17.4742","article-title":"NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in <italic>Candida albicans<\/italic>","volume":"20","author":"AM Murad","year":"2001","journal-title":"EMBO J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1128\/MCB.21.7.2496-2505.2001","article-title":"Rfg1, a protein related to the <italic>Saccharomyces cerevisiae<\/italic> hypoxic regulator Rox1, controls filamentous growth and virulence in <italic>Candida albicans<\/italic>","volume":"21","author":"D Kadosh","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/genetics\/157.4.1503","article-title":"The DNA binding protein Rfg1 is a repressor of filamentation in <italic>Candida albicans<\/italic>","volume":"157","author":"RA Khalaf","year":"2001","journal-title":"Genetics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-2958.2003.03426.x","article-title":"TupA, the <italic>Penicillium marneffei<\/italic> Tup1p homologue, represses both yeast and spore development","volume":"48","author":"RB Todd","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"25168","DOI":"10.1074\/jbc.M702569200","article-title":"The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast","volume":"282","author":"CE Zeller","year":"2007","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1074\/mcp.M700184-MCP200","article-title":"The Saccharomyces homolog of mammalian RACK1, Cpc2\/Asc1p, is required for FLO11-dependent adhesive growth and dimorphism","volume":"6","author":"O Valerius","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-61779-539-8_12","article-title":"Gene knockdown in <italic>Paracoccidioides brasiliensis<\/italic> using antisense RNA","volume":"845","author":"JF Menino","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/1567-1364.12099","article-title":"<italic>Paracoccidioides brasiliensis<\/italic> PbP27 gene: knockdown procedures and functional characterization","volume":"14","author":"I Torres","year":"2014","journal-title":"FEMS Yeast Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e3173","DOI":"10.1371\/journal.pntd.0003173","article-title":"New developments of RNAi in Paracoccidioides brasiliensis: prospects for high-throughput, genome-wide, functional genomics","volume":"8","author":"T Goes","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref62","first-page":"5767","article-title":"Regulatable promoters of <italic>Saccharomyces cerevisiae<\/italic>: comparison of transcriptional activity and their use for heterologous expression","volume":"22","author":"D Mumberg","year":"1994"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1093\/emboj\/17.13.3556","article-title":"Yeast PKA represses Msn2p\/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation","volume":"17","author":"A Smith","year":"1998","journal-title":"EMBO J"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1128\/AEM.00470-08","article-title":"Protein kinase A regulates growth, sporulation and pigment formation in <italic>Aspergillus fumigatus<\/italic>","volume":"74","author":"C Grosse","year":"2008","journal-title":"Appl. Environ. Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nature04332","article-title":"Genomic sequence of the pathogenic and allergenic filamentous fungus <italic>Aspergillus fumigatus<\/italic>","volume":"438","author":"WC Nierman","year":"2005","journal-title":"Nature"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1101\/gad.1.9.931","article-title":"Rigorous feedback control of cAMP levels in <italic>Saccharomyces cerevisiae<\/italic>","volume":"1","author":"J Nikawa","year":"1987","journal-title":"Genes Dev"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1128\/MCB.10.9.4518","article-title":"Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase","volume":"10","author":"K Mbonyi","year":"1990","journal-title":"Mol Cell Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1128\/MCB.21.9.3179-3191.2001","article-title":"Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"21","author":"CA D'Souza","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1073\/pnas.0502270102","article-title":"Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway","volume":"102","author":"FD Ivey","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejcb.2009.08.005","article-title":"Differential localization to cytoplasm, nucleus or P-bodies of yeast PKA subunits under different growth conditions","volume":"89","author":"V Tudisca","year":"2009","journal-title":"Eur J Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/369758a0","article-title":"Functional dissection of the yeast Cyc8-Tup1 transcriptional co-repressor complex","volume":"369","author":"D Tzamarias","year":"1994","journal-title":"Nature"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1534\/genetics.107.081315","article-title":"Identification of novel activation mechanisms for <italic>FLO11<\/italic> regulation in <italic>Saccharomyces cerevisiae<\/italic>","volume":"178","author":"RR Barrales","year":"2008","journal-title":"Genetics"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1128\/JB.180.15.3992-3996.1998","article-title":"Multicellular stalk-like structures in <italic>Saccharomyces cerevisiae<\/italic>","volume":"180","author":"D Engelberg","year":"1998","journal-title":"J Bacteriol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1128\/JB.183.18.5402-5413.2001","article-title":"Anatomical analysis of <italic>Saccharomyces cerevisiae<\/italic> stalk-like structures reveals spatial organization and cell specialization","volume":"183","author":"R Scherz","year":"2001","journal-title":"J Bacteriol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/emboj\/21.1.135","article-title":"Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor","volume":"21","author":"W G\u00f6rner","year":"2002","journal-title":"EMBO J"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1128\/EC.3.5.1147-1153.2004","article-title":"Integration of stress responses: modulation of calcineurin signaling in Saccharomyces cerevisiae by protein kinase A","volume":"3","author":"KA Kafadar","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1073\/pnas.0607129103","article-title":"Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1","volume":"103","author":"RD Moir","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1128\/MCB.19.11.7705","article-title":"Dual lipid modification of the yeast G\u03b3 subunit Ste18p determines membrane localization of G\u03b2\u03b3","volume":"19","author":"JE Hirschman","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.1134041","article-title":"G protein signaling in yeast: new components, new connections, new compartments","volume":"314","author":"JE Slessareva","year":"2006","journal-title":"Science"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cell.2006.04.045","article-title":"Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein \u03b1 subunit at the endosome","volume":"126","author":"JE Slessareva","year":"2006","journal-title":"Cell"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1042\/bj20031962","article-title":"Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes","volume":"380","author":"S Baum","year":"2004","journal-title":"Biochem J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1128\/MCB.24.18.8276-8287.2004","article-title":"Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression","volume":"24","author":"VR Gerbasi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.embor.7400291","article-title":"Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome","volume":"5","author":"J Nilsson","year":"2004","journal-title":"EMBO Rep"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/MCB.01718-08","article-title":"Direct link between RACK1 function and localization at the ribosome <italic>in vivo<\/italic>","volume":"29","author":"SM Coyle","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1101\/gad.524209","article-title":"The SESA network links duplication of the yeast centrosome with the protein translation machinery","volume":"23","author":"B Sezen","year":"2009","journal-title":"Genes Dev"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0955-0674(99)00085-X","article-title":"A-kinase anchoring proteins: protein kinase A and beyond","volume":"12","author":"AS Edwards","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/jmbi.2001.4585","article-title":"The biological functions of A-kinase anchor proteins","volume":"308","author":"A Feliciello","year":"2001","journal-title":"J Mol Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1073\/pnas.0408608102","article-title":"A-kinase-interacting protein localizes protein kinase A in the nucleus","volume":"102","author":"M Sastri","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1124\/mol.109.059345","article-title":"Adenylyl Cyclase-AKAP Complexes: The Next Dimension in cAMP Signaling","volume":"76","author":"CW Dessauer","year":"2009","journal-title":"Mol Pharmacol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"7855","DOI":"10.1073\/pnas.82.23.7855","article-title":"Reconstitution of the GTP-dependent adenylate cyclase from products of the yeast CYR1 and RAS2 genes in <italic>Escherichia coli<\/italic>","volume":"82","author":"I Uno","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1074\/jbc.M109526200","article-title":"Critical function of the Ras-associating domain as a primary Ras-binding site for regulation of <italic>Saccharomyces cerevisiae<\/italic> adenylyl cyclase","volume":"277","author":"M Kido","year":"2002","journal-title":"J Biol Chem"},{"key":"ref92","first-page":"1248","article-title":"CAP is a bifunctional component of the <italic>Saccharomyces cerevisiae<\/italic> adenylyl cyclase complex","volume":"11","author":"J E Gerst","year":"1991"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0968-0004(00)01592-9","article-title":"Turning genes off by Ssn6\u2013Tup1: a conserved system of transcriptional repression in eukaryotes","volume":"25","author":"RL Smith","year":"2000","journal-title":"Trends Biochem. Sci"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1127677","article-title":"Activated signal transduction kinases frequently occupy target genes","volume":"313","author":"DK Pokholok","year":"2006","journal-title":"Science"},{"key":"ref95","first-page":"437","article-title":"Transcriptional repression by Tup1-Ssn6","volume":"84","author":"TM Malav\u00e9","year":"2006","journal-title":"Biochem Cell Biol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1093\/emboj\/17.19.5757","article-title":"Srb\/mediator proteins interact functionally and physically with transcriptional repressor Sfl1","volume":"17","author":"W Song","year":"1998","journal-title":"EMBO J"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1074\/jbc.274.1.205","article-title":"The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator","volume":"274","author":"RS Conlan","year":"1999","journal-title":"J Biol Chem"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature04187","article-title":"Global analysis of protein phosphorylation in yeast","volume":"438","author":"J Ptacek","year":"2005","journal-title":"Nature"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1074\/jbc.M704028200","article-title":"Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2","volume":"283","author":"EJ Kennedy","year":"2008","journal-title":"J Biol Chem"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1046\/j.1365-2958.2001.02688.x","article-title":"Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of <italic>Candida albicans<\/italic>","volume":"42","author":"DP Bockm\u00fchl","year":"2001","journal-title":"Mol Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T10:17:00Z","timestamp":1653128220000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136866"}},"subtitle":[],"editor":[{"given":"Gustavo Henrique","family":"Goldman","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,9,3]]},"references-count":100,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136866","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,3]]}}}