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Informe del registre del conjunt m\u00ednim basic de dades (CMBD)."},{"key":"ref16","unstructured":"European public assessment report (EPAR), 2013. Prevenar 13: EPAR-Summary for the public. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/medicines\/human\/medicines\/001104\/human_med_001220.jsp&mid=WC0b01ac058001d124\" xlink:type=\"simple\">http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/medicines\/human\/medicines\/001104\/human_med_001220.jsp&amp;mid=WC0b01ac058001d124<\/ext-link>."},{"key":"ref17","unstructured":"Anon, Manual de vacunas en l\u00ednea de la AEP. Comit\u00e9 Asesor de Vacunas. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/vacunasaep.org\/documentos\/manual\/manual-de-vacunas\" xlink:type=\"simple\">http:\/\/vacunasaep.org\/documentos\/manual\/manual-de-vacunas<\/ext-link>. Accessed 2014 Jun 8."},{"key":"ref18","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2013. Clinical breakpoints. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eucast.org\/clinical_breakpoints\/\" xlink:type=\"simple\">http:\/\/www.eucast.org\/clinical_breakpoints\/<\/ext-link>"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"AP Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1128\/JCM.01368-12","article-title":"Rapid and easy identification of capsular serotypes of <italic>Streptococcus pneumoniae<\/italic> by use of fragment analysis by automated fluorescence-based capillary electrophoresis","volume":"50","author":"L Selva","year":"2012","journal-title":"J Clin Microbiol"},{"key":"ref21","first-page":"699","article-title":"The quellung reaction, a neglected microbiologic technique","volume":"43","author":"R Austrian","year":"1976","journal-title":"Mt Sinai J Med"},{"issue":"Pt 11","key":"ref22","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1099\/00221287-144-11-3049","article-title":"A multilocus sequence typing scheme for <italic>Streptococcus pneumoniae<\/italic>: identification of clones associated with serious invasive disease","volume":"144","author":"MC Enright","year":"1998","journal-title":"Microbiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","article-title":"eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data","volume":"186","author":"EJ Feil","year":"2004","journal-title":"J 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