{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:15:33Z","timestamp":1777288533325,"version":"3.51.4"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T00:00:00Z","timestamp":1458259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0151847","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T23:06:50Z","timestamp":1458342410000},"page":"e0151847","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multiple Stressor Differential Tolerances: Possible Implications at the Population Level"],"prefix":"10.1371","volume":"11","author":[{"given":"C\u00e1tia","family":"Ven\u00e2ncio","sequence":"first","affiliation":[]},{"given":"Rui","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Amadeu","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Lopes","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.chemosphere.2006.12.024","article-title":"Micro-evolution due to pollution: possible consequences for ecosystem responses to toxic stress","volume":"67","author":"MH Medina","year":"2007","journal-title":"Chemosphere"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1897\/08-359.1","article-title":"Genetic erosion and population resilience in <italic>Daphnia longispina<\/italic> O.F.M\u00fcller under simulated predation and metal pressures","volume":"28","author":"I Lopes","year":"2009","journal-title":"Environ Toxicol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/etc.1802","article-title":"Contaminant driven genetic erosion: A case study with <italic>Daphnia longispina<\/italic>","volume":"31","author":"R Ribeiro","year":"2012","journal-title":"Environ ToxicolChem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1383-5742(01)00065-5","article-title":"Effects of contaminants on genetic patterns in aquatic organisms: a review","volume":"489","author":"NM Belfiore","year":"2001","journal-title":"Mut Res-Reviews Mut Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1080\/1080-700291905783","article-title":"Genetic variation in toxicant-stressed populations: an evaluation of the \u201cgenetic erosion\u201d hypothesis","volume":"8","author":"NM Van Straalen","year":"2002","journal-title":"Hum Ecol Risk Assess"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1021\/es061992x","article-title":"Microevolution and Ecotoxicology of Metals in Invertebrates","volume":"41","author":"AJ Morgan","year":"2007","journal-title":"Environ SciTechnol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aquatox.2007.10.003","article-title":"Evolutionary ecotoxicology of wild yellow perch (<italic>Perca flavescens<\/italic>) populations chronically exposed to a polymetallic gradient","volume":"86","author":"V Bourret","year":"2008","journal-title":"Aquat Toxicol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.envpol.2008.11.005","article-title":"Rapid genetic erosion in pollutant-exposed experimental chironomid populations","volume":"157","author":"C Nowak","year":"2009","journal-title":"Environ Pollut"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.envpol.2009.12.007","article-title":"Relationship between heavy metals pollution and genetic diversity in Mediterranean populations of the sandhopper <italic>Talitrus saltator<\/italic> (Montagu) (Crustacea, Amphipoda)","volume":"158","author":"G Ungherese","year":"2010","journal-title":"Environ Pollut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00244-003-2143-5","article-title":"Genetic determination of tolerance to lethal and sublethal copper concentrations in field populations of <italic>Daphnia longispina<\/italic>","volume":"46","author":"I Lopes","year":"2004","journal-title":"Arch Environ ContToxicol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/etc.97","article-title":"Genetic costs of tolerance to metals in <italic>Daphnia longispina<\/italic> populations historically exposed to a copper mine drainage","volume":"29","author":"AR Agra","year":"2010","journal-title":"Environ ToxicolChem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0166-445X(99)00020-X","article-title":"Long-term effects of copper on the structure of freshwater periphyton communities and their tolerance to copper, zinc, nickel and silver","volume":"47","author":"D Soldo","year":"2000","journal-title":"Aquatic toxicology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1034\/j.1399-3054.2001.1130409.x","article-title":"Nickel and copper tolerance and toxicity in three Tuscan populations of <italic>Silene paradoxa<\/italic>","volume":"113","author":"C Gonnelli","year":"2001","journal-title":"Physiologia Plantarum"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1897\/04-132R.1","article-title":"Genetically determined resistance to lethal levels of copper by <italic>Daphnia longispina<\/italic>: association with sublethal response and multiple\/coresistance","volume":"24","author":"I. Lopes","year":"2005","journal-title":"Environmental Toxicology and Chemistry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.0030-1299.2004.13255.x","article-title":"Impacts of multiple stressors on biodiversity and ecosystem functioning: The role of species co\u2010tolerance","volume":"104","author":"R Vinebrooke","year":"2004","journal-title":"Oikos"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10646-013-1070-0","article-title":"Contaminant driven genetic erosion and associated hypothesis on alleles loss, reduced population growth rate and increased susceptibility to future stressors\u2013an essay","volume":"22","author":"R Ribeiro","year":"2013","journal-title":"Ecotoxicology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/etc.1762","article-title":"Testing hypotheses on the resistance to metals by <italic>Daphnia longispina<\/italic>: differential acclimation, endpoints association, and fitness costs","volume":"31","author":"L Saro","year":"2012","journal-title":"Environ ToxicolChem"},{"key":"ref18","first-page":"1904","article-title":"Differential resistance to copper and mine drainage in <italic>Daphnia longispina<\/italic>: relationship with allozyme genotypes","volume":"26","author":"N Martins","year":"2007","journal-title":"Arch Environ ContToxicol"},{"key":"ref19","first-page":"213","article-title":"Interdisciplinary Studies on Environmental Chemistry\u2013Biological Responses to Contaminants","volume":"3","author":"RM Silva","year":"2010"},{"key":"ref20","first-page":"729","article-title":"Annual Book of ASTM Standards","volume":"1105","year":"2002"},{"key":"ref21","unstructured":"Baird DJ, Soares AMVM, Girling A, Barber MC, Calow P (1989)The long term maintenance of <italic>Daphnia magna<\/italic> Straus for use in ecotoxicity tests: problems and prospects. In: Lokke, H., Tyle, H., Bro-Rasmussen, F. (Eds.), Proceedings of the First European Conference on Ecotoxicology. Lyngby, Denmark, pp. 144\u2013148."},{"key":"ref22","unstructured":"OECD\u2014Organization for Economic Cooperation and Development (2004) <italic>Daphnia<\/italic> sp. Acute Immobilisation Test. OECD guidelines for the testing of chemicals 202. Paris, France."},{"key":"ref23","first-page":"339","article-title":"Probit analysis of preference data","volume":"33","author":"M Sakuma","year":"1998","journal-title":"ApplEntomolZool"},{"key":"ref24","article-title":"Extreme Environmental Change and Evolution","author":"AA Hoffman","year":"1997"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1897\/04-132R.1","article-title":"Genetically determined resistance to lethal levels of copper by <italic>Daphnia longispina<\/italic>: association with sublethal response and multiple\/coresistance","volume":"24","author":"I. Lopes","year":"2005","journal-title":"Environmental Toxicology and Chemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00244-003-2143-5","article-title":"Genetic determination of tolerance to lethal and sublethal copper concentrations in field populations of <italic>Daphnia longispina<\/italic>","volume":"46","author":"I Lopes","year":"2004","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1890\/14-1663.1","article-title":"Tainted resurrection: metal pollution is linked with reduced hatching and high juvenile mortality in <italic>Daphnia<\/italic> egg banks","volume":"96","author":"MA Rogalski","year":"2015","journal-title":"Ecology"},{"key":"ref28","first-page":"343","article-title":"Quantitative DNA-methylation in <italic>Daphnia magna<\/italic> and effects of multigeneration Zn exposure","volume":"150","author":"MB Vandegehuchte","year":"2009","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1016\/j.envpol.2010.07.023","article-title":"Gene transcription profiles, global DNA methylation and potential transgenerational epigenetic effects related to Zn exposure history in <italic>Daphniamagna<\/italic>","volume":"158","author":"MB Vandegehuchte","year":"2010","journal-title":"Environmental Pollution"},{"key":"ref30","article-title":"Daphnia as an emerging epigenetic model organism","author":"KD Harris","year":"2012","journal-title":"Genetics research international"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/etc.2887","article-title":"Global cytosine methylation in <italic>Daphnia magna<\/italic> depends on genotype, environment, and their interaction","volume":"34","author":"J Asselman","year":"2015","journal-title":"Environmental Toxicology and Chemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1098\/rspb.1997.0225","article-title":"Long-term genetic shifts in a microcrustacean egg bank associated with anthropogenic changes in the lake Constance ecosystem","volume":"264","author":"LJ Weider","year":"1997","journal-title":"Proc. R. Soc. Lond. B"},{"key":"ref33","first-page":"203","article-title":"Heavy metal co-tolerance in a chromium tolerant strain of <italic>Daphnia magna<\/italic>","volume":"23","author":"A M\u00fcnzinger","year":"1992","journal-title":"AquatToxicol"},{"key":"ref34","first-page":"47","article-title":"Plasmid mediated tolerance and removal of heavy metals by <italic>Enterbacter<\/italic> sp","volume":"5","author":"B El-Deeb","year":"2009","journal-title":"Am J BiochemBiotechnol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1469-8137.1980.tb04449.x","article-title":"Heavy metal co-tolerance in a copper tolerant population of the marine fouling alga <italic>Ectocarpus silisulosus<\/italic>","volume":"85","author":"A Hall","year":"1980","journal-title":"New Phytologist"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1128\/AEM.47.4.821-824.1984","article-title":"Uptake of metal ions by <italic>Rhizopus arrhizus<\/italic> biomass","volume":"47","author":"JM Tobin","year":"1984","journal-title":"Appl Environ Microbiol"},{"key":"ref37","first-page":"270","article-title":"Kinetics of uptake and intracellular location of cobalt, manganese and zinc in the estuarine green alga <italic>Chlorella salina<\/italic>","volume":"37","author":"GW Garnham","year":"1992","journal-title":"ApplMicrobiolBiotechnol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF01607543","article-title":"Heavy metal tolerance in a cadmium-resistant population of <italic>Euglena gracilis<\/italic>","volume":"32","author":"A Bariaud","year":"1984","journal-title":"Bull Environ ContToxicol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1021\/es040354g","article-title":"Internal metal sequestration and its ecotoxicological relevance: review","volume":"38","author":"MG Vijver","year":"2004","journal-title":"Environ SciTechnol"},{"key":"ref40","first-page":"173","article-title":"Metal fluxes across the membranes of aquatic organisms","volume":"1","author":"K Simkiss","year":"1989","journal-title":"CRC Crit. Rev. Aquatic Sci."},{"key":"ref41","first-page":"197","article-title":"Chemical and biological regulation of aquatic systems","author":"A Tessier","year":"1994"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1469-8137.1993.tb03902.x","article-title":"Nickel and zinc tolerance and co-tolerance in populations of <italic>Deschampsia cespitosa<\/italic> (L.) Beauv. subject to artificial selection","volume":"125","author":"BAK Von Frenckell-Insam","year":"1993","journal-title":"New Phytologist"},{"key":"ref43","first-page":"7279","article-title":"Copper-Adapted <italic>Suillus luteus<\/italic>, a Symbiotic Solution for Pine Colonizing Cu Mine Spoils","volume":"71","author":"K Adriaensen","year":"2005","journal-title":"ApplEnvironMicrobiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0168-6445(03)00045-7","article-title":"<italic>Ralstonia metallidurans<\/italic>, a bacterium specifically adapted to toxic metals: towards a catalogue of metal-responsive genes","volume":"27","author":"M Mergeay","year":"2003","journal-title":"FEMS Microbiol Rev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1104\/pp.108.115782","article-title":"Examining the specific contributions of individual <italic>Arabidopsis<\/italic> metallothioneins to copper distribution and metal tolerance","volume":"146","author":"WJ Guo","year":"2008","journal-title":"Plant Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1023\/A:1004234604143","article-title":"Nickel tolerance and copper-nickel co-tolerance in <italic>Mimulus guttatus<\/italic> from copper mine and serpentine habitats","volume":"191","author":"GH Tilstone","year":"1997","journal-title":"Plant and Soil"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/hdy.1997.183","article-title":"Does copper tolerance give cadmium tolerance in <italic>Mimulus guttatus<\/italic>","volume":"79","author":"GH Tilstone","year":"1997","journal-title":"Heredity"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0151847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T11:00:55Z","timestamp":1600340455000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0151847"}},"subtitle":[],"editor":[{"given":"Elena","family":"Gorokhova","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,3,18]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0151847","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,18]]}}}