{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:30:56Z","timestamp":1759743056276},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0158801","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T17:35:16Z","timestamp":1469640916000},"page":"e0158801","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers"],"prefix":"10.1371","volume":"11","author":[{"given":"Elena","family":"Vigorito","sequence":"first","affiliation":[]},{"given":"Karoline B.","family":"Kuchenbaecker","sequence":"additional","affiliation":[]},{"given":"Jonathan","family":"Beesley","sequence":"additional","affiliation":[]},{"given":"Julian","family":"Adlard","sequence":"additional","affiliation":[]},{"given":"Bjarni A.","family":"Agnarsson","sequence":"additional","affiliation":[]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[]},{"given":"Banu K.","family":"Arun","sequence":"additional","affiliation":[]},{"given":"Laure","family":"Barjhoux","sequence":"additional","affiliation":[]},{"given":"Muriel","family":"Belotti","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Benitez","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Berger","sequence":"additional","affiliation":[]},{"given":"Anders","family":"Bojesen","sequence":"additional","affiliation":[]},{"given":"Bernardo","family":"Bonanni","sequence":"additional","affiliation":[]},{"given":"Carole","family":"Brewer","sequence":"additional","affiliation":[]},{"given":"Trinidad","family":"Caldes","sequence":"additional","affiliation":[]},{"given":"Maria A.","family":"Caligo","sequence":"additional","affiliation":[]},{"given":"Ian","family":"Campbell","sequence":"additional","affiliation":[]},{"given":"Salina B.","family":"Chan","sequence":"additional","affiliation":[]},{"given":"Kathleen B. M.","family":"Claes","sequence":"additional","affiliation":[]},{"given":"David E.","family":"Cohn","sequence":"additional","affiliation":[]},{"given":"Jackie","family":"Cook","sequence":"additional","affiliation":[]},{"given":"Mary B.","family":"Daly","sequence":"additional","affiliation":[]},{"given":"Francesca","family":"Damiola","sequence":"additional","affiliation":[]},{"given":"Rosemarie","family":"Davidson","sequence":"additional","affiliation":[]},{"given":"Antoine de","family":"Pauw","sequence":"additional","affiliation":[]},{"given":"Capucine","family":"Delnatte","sequence":"additional","affiliation":[]},{"given":"Orland","family":"Diez","sequence":"additional","affiliation":[]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[]},{"given":"Martine","family":"Dumont","sequence":"additional","affiliation":[]},{"given":"Katarzyna","family":"Durda","sequence":"additional","affiliation":[]},{"given":"Bernd","family":"Dworniczak","sequence":"additional","affiliation":[]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[]},{"given":"Diana","family":"Eccles","sequence":"additional","affiliation":[]},{"given":"Christina","family":"Edwinsdotter Ardnor","sequence":"additional","affiliation":[]},{"given":"Ros","family":"Eeles","sequence":"additional","affiliation":[]},{"given":"Bent","family":"Ejlertsen","sequence":"additional","affiliation":[]},{"given":"Steve","family":"Ellis","sequence":"additional","affiliation":[]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[]},{"given":"Lidia","family":"Feliubadalo","sequence":"additional","affiliation":[]},{"given":"Florentia","family":"Fostira","sequence":"additional","affiliation":[]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[]},{"given":"Eitan","family":"Friedman","sequence":"additional","affiliation":[]},{"given":"Debra","family":"Frost","sequence":"additional","affiliation":[]},{"given":"Pragna","family":"Gaddam","sequence":"additional","affiliation":[]},{"given":"Patricia A.","family":"Ganz","sequence":"additional","affiliation":[]},{"given":"Judy","family":"Garber","sequence":"additional","affiliation":[]},{"given":"Vanesa","family":"Garcia-Barberan","sequence":"additional","affiliation":[]},{"given":"Marion","family":"Gauthier-Villars","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Gehrig","sequence":"additional","affiliation":[]},{"given":"Anne-Marie","family":"Gerdes","sequence":"additional","affiliation":[]},{"given":"Sophie","family":"Giraud","sequence":"additional","affiliation":[]},{"given":"Andrew K.","family":"Godwin","sequence":"additional","affiliation":[]},{"given":"David E.","family":"Goldgar","sequence":"additional","affiliation":[]},{"given":"Christopher R.","family":"Hake","sequence":"additional","affiliation":[]},{"given":"Thomas V. O.","family":"Hansen","sequence":"additional","affiliation":[]},{"given":"Sue","family":"Healey","sequence":"additional","affiliation":[]},{"given":"Shirley","family":"Hodgson","sequence":"additional","affiliation":[]},{"given":"Frans B. L.","family":"Hogervorst","sequence":"additional","affiliation":[]},{"given":"Claude","family":"Houdayer","sequence":"additional","affiliation":[]},{"given":"Peter J.","family":"Hulick","sequence":"additional","affiliation":[]},{"given":"Evgeny N.","family":"Imyanitov","sequence":"additional","affiliation":[]},{"given":"Claudine","family":"Isaacs","sequence":"additional","affiliation":[]},{"given":"Louise","family":"Izatt","sequence":"additional","affiliation":[]},{"given":"Angel","family":"Izquierdo","sequence":"additional","affiliation":[]},{"given":"Lauren","family":"Jacobs","sequence":"additional","affiliation":[]},{"given":"Anna","family":"Jakubowska","sequence":"additional","affiliation":[]},{"given":"Ramunas","family":"Janavicius","sequence":"additional","affiliation":[]},{"given":"Katarzyna","family":"Jaworska-Bieniek","sequence":"additional","affiliation":[]},{"given":"Uffe Birk","family":"Jensen","sequence":"additional","affiliation":[]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[]},{"given":"Joseph","family":"Vijai","sequence":"additional","affiliation":[]},{"given":"Beth Y.","family":"Karlan","sequence":"additional","affiliation":[]},{"given":"Karin","family":"Kast","sequence":"additional","affiliation":[]},{"name":"KConFab Investigators","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Khan","sequence":"additional","affiliation":[]},{"given":"Ava","family":"Kwong","sequence":"additional","affiliation":[]},{"given":"Yael","family":"Laitman","sequence":"additional","affiliation":[]},{"given":"Jenny","family":"Lester","sequence":"additional","affiliation":[]},{"given":"Fabienne","family":"Lesueur","sequence":"additional","affiliation":[]},{"given":"Annelie","family":"Liljegren","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[]},{"given":"Phuong L.","family":"Mai","sequence":"additional","affiliation":[]},{"given":"Siranoush","family":"Manoukian","sequence":"additional","affiliation":[]},{"given":"Sylvie","family":"Mazoyer","sequence":"additional","affiliation":[]},{"given":"Alfons","family":"Meindl","sequence":"additional","affiliation":[]},{"given":"Arjen R.","family":"Mensenkamp","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Montagna","sequence":"additional","affiliation":[]},{"given":"Katherine L.","family":"Nathanson","sequence":"additional","affiliation":[]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[]},{"given":"Heli","family":"Nevanlinna","sequence":"additional","affiliation":[]},{"given":"Dieter","family":"Niederacher","sequence":"additional","affiliation":[]},{"given":"Edith","family":"Olah","sequence":"additional","affiliation":[]},{"given":"Olufunmilayo I.","family":"Olopade","sequence":"additional","affiliation":[]},{"given":"Kai-ren","family":"Ong","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Osorio","sequence":"additional","affiliation":[]},{"given":"Sue Kyung","family":"Park","sequence":"additional","affiliation":[]},{"given":"Ylva","family":"Paulsson-Karlsson","sequence":"additional","affiliation":[]},{"given":"Inge Sokilde","family":"Pedersen","sequence":"additional","affiliation":[]},{"given":"Bernard","family":"Peissel","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Peterlongo","sequence":"additional","affiliation":[]},{"given":"Georg","family":"Pfeiler","sequence":"additional","affiliation":[]},{"given":"Catherine M.","family":"Phelan","sequence":"additional","affiliation":[]},{"given":"Marion","family":"Piedmonte","sequence":"additional","affiliation":[]},{"given":"Bruce","family":"Poppe","sequence":"additional","affiliation":[]},{"given":"Miquel Angel","family":"Pujana","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Radice","sequence":"additional","affiliation":[]},{"given":"Gad","family":"Rennert","sequence":"additional","affiliation":[]},{"given":"Gustavo C.","family":"Rodriguez","sequence":"additional","affiliation":[]},{"given":"Matti A.","family":"Rookus","sequence":"additional","affiliation":[]},{"given":"Eric A.","family":"Ross","sequence":"additional","affiliation":[]},{"given":"Rita Katharina","family":"Schmutzler","sequence":"additional","affiliation":[]},{"given":"Jacques","family":"Simard","sequence":"additional","affiliation":[]},{"given":"Christian F.","family":"Singer","sequence":"additional","affiliation":[]},{"given":"Thomas P.","family":"Slavin","sequence":"additional","affiliation":[]},{"given":"Penny","family":"Soucy","sequence":"additional","affiliation":[]},{"given":"Melissa","family":"Southey","sequence":"additional","affiliation":[]},{"given":"Doris","family":"Steinemann","sequence":"additional","affiliation":[]},{"given":"Dominique","family":"Stoppa-Lyonnet","sequence":"additional","affiliation":[]},{"given":"Grzegorz","family":"Sukiennicki","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Sutter","sequence":"additional","affiliation":[]},{"given":"Csilla I.","family":"Szabo","sequence":"additional","affiliation":[]},{"given":"Muy-Kheng","family":"Tea","sequence":"additional","affiliation":[]},{"given":"Manuel R.","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Soo-Hwang","family":"Teo","sequence":"additional","affiliation":[]},{"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[]},{"given":"Mads","family":"Thomassen","sequence":"additional","affiliation":[]},{"given":"Maria Grazia","family":"Tibiletti","sequence":"additional","affiliation":[]},{"given":"Laima","family":"Tihomirova","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Tognazzo","sequence":"additional","affiliation":[]},{"given":"Elizabeth J.","family":"van Rensburg","sequence":"additional","affiliation":[]},{"given":"Liliana","family":"Varesco","sequence":"additional","affiliation":[]},{"given":"Raymonda","family":"Varon-Mateeva","sequence":"additional","affiliation":[]},{"given":"Athanassios","family":"Vratimos","sequence":"additional","affiliation":[]},{"given":"Jeffrey N.","family":"Weitzel","sequence":"additional","affiliation":[]},{"given":"Lesley","family":"McGuffog","sequence":"additional","affiliation":[]},{"given":"Judy","family":"Kirk","sequence":"additional","affiliation":[]},{"given":"Amanda Ewart","family":"Toland","sequence":"additional","affiliation":[]},{"given":"Ute","family":"Hamann","sequence":"additional","affiliation":[]},{"given":"Noralane","family":"Lindor","sequence":"additional","affiliation":[]},{"given":"Susan J.","family":"Ramus","sequence":"additional","affiliation":[]},{"given":"Mark H.","family":"Greene","sequence":"additional","affiliation":[]},{"given":"Fergus J.","family":"Couch","sequence":"additional","affiliation":[]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[]},{"given":"Paul D. P.","family":"Pharoah","sequence":"additional","affiliation":[]},{"given":"Georgia","family":"Chenevix-Trench","sequence":"additional","affiliation":[]},{"given":"Antonis C.","family":"Antoniou","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"pone.0158801.ref001","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/jmedgenet-2013-102015","article-title":"Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants","volume":"51","author":"S Jervis","year":"2014","journal-title":"J Med Genet"},{"key":"pone.0158801.ref002","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"A Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"key":"pone.0158801.ref003","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ygyno.2011.12.415","article-title":"Hereditary ovarian cancer: beyond the usual suspects","volume":"124","author":"KP Pennington","year":"2012","journal-title":"Gynecol Oncol"},{"key":"pone.0158801.ref004","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/jnci\/djq494","article-title":"Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers","volume":"103","author":"SJ Ramus","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"pone.0158801.ref005","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ng.424","article-title":"A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2","volume":"41","author":"H Song","year":"2009","journal-title":"Nat Genet"},{"key":"pone.0158801.ref006","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1242\/dev.112888","article-title":"The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells","volume":"141","author":"A Vanhoutteghem","year":"2014","journal-title":"Development"},{"key":"pone.0158801.ref007","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/jcs.139451","article-title":"Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion","volume":"127","author":"G Fang","year":"2014","journal-title":"J Cell Sci"},{"key":"pone.0158801.ref008","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbrc.2007.12.050","article-title":"Identification and characterization of the novel centrosomal protein centlein","volume":"366","author":"K Makino","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0158801.ref009","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/bcr1670","article-title":"An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)","volume":"9","author":"G Chenevix-Trench","year":"2007","journal-title":"Breast Cancer Res"},{"key":"pone.0158801.ref010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ng.2592","article-title":"iCOGS collection provides a collaborative model","volume":"45","author":"OG Bahcall","year":"2013","journal-title":"Nat Genet"},{"key":"pone.0158801.ref011","doi-asserted-by":"crossref","first-page":"e1003212","DOI":"10.1371\/journal.pgen.1003212","article-title":"Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk","volume":"9","author":"FJ Couch","year":"2013","journal-title":"PLoS Genet. Public Library of Science"},{"key":"pone.0158801.ref012","doi-asserted-by":"crossref","first-page":"e1003173","DOI":"10.1371\/journal.pgen.1003173","article-title":"Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk","volume":"9","author":"MM Gaudet","year":"2013","journal-title":"PLoS Genet"},{"key":"pone.0158801.ref013","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng2088","article-title":"A new multipoint method for genome-wide association studies by imputation of genotypes","volume":"39","author":"J Marchini","year":"2007","journal-title":"Nat Genet"},{"key":"pone.0158801.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gepi.20074","article-title":"A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes","volume":"29","author":"AC Antoniou","year":"2005","journal-title":"Genet Epidemiol"},{"key":"pone.0158801.ref015","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/ng.669","article-title":"A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population","volume":"42","author":"AC Antoniou","year":"2010","journal-title":"Nat Genet"},{"key":"pone.0158801.ref016","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/gepi.21620","article-title":"Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations","volume":"36","author":"DR Barnes","year":"2012","journal-title":"Genet Epidemiol"},{"key":"pone.0158801.ref017","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/gepi.20504","article-title":"Evaluating the power to discriminate between highly correlated SNPs in genetic association studies","volume":"34","author":"MS Udler","year":"2010","journal-title":"Genet Epidemiol"},{"key":"pone.0158801.ref018","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1093\/hmg\/ddv101","article-title":"Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci","volume":"24","author":"SG Coetzee","year":"2015","journal-title":"Hum Mol Genet"},{"key":"pone.0158801.ref019","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1158\/1078-0432.CCR-1029-3","article-title":"Pathology of ovarian cancers in BRCA1 and BRCA2 carriers","volume":"10","author":"SR Lakhani","year":"2004","journal-title":"Clin Cancer Res"},{"key":"pone.0158801.ref020","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1093\/hmg\/ddv101","article-title":"Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci","volume":"24","author":"SG Coetzee","year":"2015","journal-title":"Hum Mol Genet"},{"key":"pone.0158801.ref021","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng.3185","article-title":"Identification of six new susceptibility loci for invasive epithelial ovarian cancer","volume":"47","author":"KB Kuchenbaecker","year":"2015","journal-title":"Nat Genet"},{"key":"pone.0158801.ref022","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1158\/1055-9965.EPI-11-0775","article-title":"Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1\/2 (CIMBA)","volume":"21","author":"N Mavaddat","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T17:59:56Z","timestamp":1576259996000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158801"}},"subtitle":[],"editor":[{"given":"Ludmila","family":"Prokunina-Olsson","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,7,27]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0158801","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,7,27]]}}}