{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:48:57Z","timestamp":1773168537152,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GEDII - Portuguese Study Group for Inflammatory Bowel Disease"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0169102","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T22:02:31Z","timestamp":1483999351000},"page":"e0169102","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease"],"prefix":"10.1371","volume":"12","author":[{"given":"Cristiana","family":"Costa Pereira","sequence":"first","affiliation":[]},{"given":"Cec\u00edlia","family":"Dur\u00e3es","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Gr\u00e1cio","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Armando","family":"Peixoto","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Lago","sequence":"additional","affiliation":[]},{"given":"M\u00e1rcia","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Telmo","family":"Catarino","sequence":"additional","affiliation":[]},{"given":"Salom\u00e9","family":"Pinho","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Paulo","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[]},{"given":"Vito","family":"Annese","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9668","authenticated-orcid":false,"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"issue":"21","key":"ref1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory Bowel Disease","volume":"361","author":"C Abraham","year":"2009","journal-title":"New England Journal of Medicine"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory Bowel Disease","volume":"347","author":"DK Podolsky","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.0105-2896.2005.00293.x","article-title":"Defects in mucosal immunity leading to Crohn&apos;s disease","volume":"206","author":"GM Cobrin","year":"2005","journal-title":"Immunological reviews"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.0105-2896.2005.00286.x","article-title":"Defects in mucosal immunity leading to ulcerative colitis","volume":"206","author":"SR Targan","year":"2005","journal-title":"Immunological reviews"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0031-3955(05)70405-3","article-title":"Crohn&apos;s disease in children","volume":"43","author":"JS Hyams","year":"1996","journal-title":"Pediatric clinics of North America"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-3476(96)70193-2","article-title":"Clinical outcome of ulcerative colitis in children","volume":"129","author":"JS Hyams","year":"1996","journal-title":"The Journal of pediatrics"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejogrb.2013.08.011","article-title":"Surgical repair of rectovaginal fistulas in patients with Crohn&apos;s disease","volume":"171","author":"PA Nosti","year":"2013","journal-title":"European journal of obstetrics, gynecology, and reproductive biology"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ncpgasthep1340","article-title":"Diagnosis and management of fistulizing Crohn&apos;s disease","volume":"6","author":"OH Nielsen","year":"2009","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbacli.2015.11.002","article-title":"Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links","volume":"5","author":"A Jurjus","year":"2016","journal-title":"BBA clinical"},{"issue":"39","key":"ref10","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.3748\/wjg.v19.i39.6540","article-title":"Concepts of oxidative stress and antioxidant defense in Crohn&apos;s disease","volume":"19","author":"MA Alzoghaibi","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"10","key":"ref11","first-page":"2403","article-title":"Oxidative Stress and DNA Damage: Implications in Inflammatory Bowel Disease","volume":"21","author":"C Pereira","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"26","key":"ref12","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.2174\/138161212802083707","article-title":"Molecular link mechanisms between inflammation and cancer","volume":"18","author":"DB Vendramini-Costa","year":"2012","journal-title":"Current pharmaceutical design"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/ecco-jcc\/jjv141","article-title":"European Evidence-based Consensus: Inflammatory Bowel Disease and Malignancies","volume":"9","author":"V Annese","year":"2015","journal-title":"J Crohns Colitis"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"IN Zelko","year":"2002","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1053\/gast.2001.24051","article-title":"Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease","volume":"120","author":"F Degoul","year":"2001","journal-title":"Gastroenterology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.gene.2012.04.011","article-title":"Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease","volume":"501","author":"A Crawford","year":"2012","journal-title":"Gene"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"e107299","DOI":"10.1371\/journal.pone.0107299","article-title":"Methotrexate-Related Response on Human Peripheral Blood Mononuclear Cells May Be Modulated by the Ala16Val-SOD2 Gene Polymorphism","volume":"9","author":"F Barbisan","year":"2014","journal-title":"PLoS ONE"},{"issue":"7422","key":"ref18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"L Jostins","year":"2012","journal-title":"Nature"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"JZ Liu","year":"2015","journal-title":"Nat Genet"},{"issue":"10014","key":"ref20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(15)00465-1","article-title":"Inherited determinants of Crohn&apos;s disease and ulcerative colitis phenotypes: a genetic association study","volume":"387","author":"I Cleynen","year":"2016","journal-title":"Lancet (London, England)"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1053\/j.gastro.2014.12.030","article-title":"Identification of risk loci for Crohn&apos;s disease phenotypes using a genome-wide association study","volume":"148","author":"A Alonso","year":"2015","journal-title":"Gastroenterology"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn&apos;s disease and ulcerative colitis","volume":"3","author":"RB Sartor","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Ladislava B, Michal K, Katerina W, Milan B. Gene Polymorphisms and Inflammatory Bowel Diseases. In: (Ed.) DIS, editor. Inflammatory Bowel Disease. InTech2012.","DOI":"10.5772\/53465"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/ajg.2009.179","article-title":"Gene-gene interactions in inflammatory bowel disease: biological and clinical implications","volume":"104","author":"JP Achkar","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.annepidem.2003.09.013","article-title":"Investigating the Effect of Nonparticipation Using a Population-Based Case\u2014Control Study on Myocardial Infarction","volume":"14","author":"E Ramos","year":"2004","journal-title":"Ann Epidemiol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.crohns.2009.12.003","article-title":"The second European evidence-based Consensus on the diagnosis and management of Crohn&apos;s disease: Definitions and diagnosis","volume":"4","author":"G Van Assche","year":"2010","journal-title":"J Crohns Colitis"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.crohns.2012.09.003","article-title":"Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis","volume":"6","author":"A Dignass","year":"2012","journal-title":"J Crohns Colitis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/00365528909091339","article-title":"Classification of inflammatory bowel disease","volume":"170","author":"JE Lennard-Jones","year":"1989","journal-title":"Scandinavian journal of gastroenterology Supplement"},{"issue":"Suppl A","key":"ref29","doi-asserted-by":"crossref","first-page":"5a","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"MS Silverberg","year":"2005","journal-title":"Canadian journal of gastroenterology = Journal canadien de gastroenterologie"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.crohns.2009.12.002","article-title":"The second European evidence-based Consensus on the diagnosis and management of Crohn&apos;s disease: Current management","volume":"4","author":"A Dignass","year":"2010","journal-title":"J Crohns Colitis"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/pds.1930","article-title":"Estimating the prevalence of inflammatory bowel disease in Portugal using a pharmaco-epidemiological approach","volume":"19","author":"LF Azevedo","year":"2010","journal-title":"Pharmacoepidemiology and drug safety"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/gene.2015.35","article-title":"Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene?","volume":"16","author":"F Hauser","year":"2015","journal-title":"Genes Immun"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s11033-012-2234-3","article-title":"GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk","volume":"40","author":"Z Hong","year":"2013","journal-title":"Mol Biol Rep"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.3390\/nu7053621","article-title":"Selenium and chronic diseases: a nutritional genomics perspective","volume":"7","author":"C Meplan","year":"2015","journal-title":"Nutrients"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/carcin\/bgi267","article-title":"Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study","volume":"27","author":"G Ravn-Haren","year":"2006","journal-title":"Carcinogenesis"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1155\/2010\/354189","article-title":"The antioxidant enzyme GPX1 gene polymorphisms are associated with low BMD and increased bone turnover markers","volume":"29","author":"SJ Mlakar","year":"2010","journal-title":"Dis Markers"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.joca.2010.02.004","article-title":"Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease","volume":"18","author":"YM Xiong","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.freeradbiomed.2004.04.010","article-title":"Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer","volume":"36","author":"FF Chu","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2350-14-110","article-title":"SOD2 gene Val16ALa polymorphism is associated with macroalbuminuria in Mexican Type 2 Diabetes patients: a comparative study and meta-analysis","volume":"14","author":"I Ascencio-Montiel","year":"2013","journal-title":"BMC Medical Genetics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/apm.12192","article-title":"Manganese superoxide dismutase plays an important role in the inflammatory process and predicts disease severity and activity in patients with ulcerative colitis","volume":"122","author":"T Ikumoto","year":"2014","journal-title":"Acta Pathologica, Microbiologica et immunologica Scandinavica"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00008571-200303000-00004","article-title":"The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria","volume":"13","author":"A Sutton","year":"2003","journal-title":"Pharmacogenetics"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/01213011-200505000-00006","article-title":"The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability","volume":"15","author":"A Sutton","year":"2005","journal-title":"Pharmacogenetics and genomics"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2012.05.022","article-title":"Inflammatory cytokines in vitro production are associated with Ala16Val superoxide dismutase gene polymorphism of peripheral blood mononuclear cells","volume":"60","author":"MA Montano","year":"2012","journal-title":"Cytokine"},{"key":"ref44","first-page":"387176","article-title":"The role of manganese superoxide dismutase in inflammation defense","volume":"2011","author":"C Li","year":"2011","journal-title":"Enzyme Res"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"3190s","DOI":"10.1093\/jn\/134.11.3190S","article-title":"Manganese superoxide dismutase: genetic variation and regulation","volume":"134","author":"D St Clair","year":"2004","journal-title":"J Nutr"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0169102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T19:33:16Z","timestamp":1601321596000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0169102"}},"subtitle":[],"editor":[{"given":"John","family":"Green","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,1,4]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0169102","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,4]]}}}