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Magalh\u00e3es","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"issue":"11","key":"ref84","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1128\/AAC.46.11.3634-3636.2002","article-title":"In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies","volume":"46","author":"G Ramage","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"ref85","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1128\/AAC.01701-10","article-title":"Effects of fluconazole, amphotericin B, and caspofungin on Candida albicans biofilms under conditions of flow and on biofilm dispersion","volume":"55","author":"P Uppuluri","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: Survival mechanisms of clinically relevant microorganisms 1","volume":"15","author":"RM Donlan","year":"2002","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"ref87","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1128\/JCM.37.6.1771-1776.1999","article-title":"The Calgary Biofilm Device: New technology for rapid determination of antibiotic susceptibilities of bacterial biofilms","volume":"37","author":"H Ceri","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"9","key":"ref88","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1128\/AAC.00126-11","article-title":"Pharmacokinetics\/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms","volume":"55","author":"W Hengzhuang","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4248\/IJOS11026","article-title":"The clinical impact of bacterial biofilms","volume":"3","author":"N Hoiby","year":"2011","journal-title":"Int J Oral Sci"},{"issue":"5","key":"ref90","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1128\/AAC.06486-11","article-title":"In vivo pharmacokinetics\/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection","volume":"56","author":"W Hengzhuang","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"ref91","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jinf.2014.07.014","article-title":"New approaches to the treatment of biofilm-related infections","volume":"69","author":"M Wilkins","year":"2014","journal-title":"J Infect"},{"issue":"10","key":"ref92","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.2217\/fmb.13.101","article-title":"Mechanisms of Candida biofilm drug resistance","volume":"8","author":"HT Taff","year":"2013","journal-title":"Future Microbiol"},{"issue":"4","key":"ref93","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00294-013-0400-3","article-title":"Recent insights into <italic>Candida albicans<\/italic> biofilm resistance mechanisms","volume":"59","author":"L Math\u00e9","year":"2013","journal-title":"Curr Genet"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jbiotec.2014.09.003","article-title":"Antibiotic resistance in Pseudomonas aeruginosa biofilms: towards the development of novel anti-biofilm therapies","volume":"191","author":"PK Taylor","year":"2014","journal-title":"J Biotechnol"},{"issue":"13","key":"ref95","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.micinf.2003.08.009","article-title":"Antimicrobial resistance of Pseudomonas aeruginosa biofilms","volume":"5","author":"E Drenkard","year":"2003","journal-title":"Microbes Infect"},{"issue":"1","key":"ref96","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"TF Mah","year":"2001","journal-title":"Trends Microbiol"},{"issue":"2","key":"ref97","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrd1008","article-title":"Understanding biofilm resistance to antibacterial agents","volume":"2","author":"D Davies","year":"2003","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"ref98","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijantimicag.2009.12.011","article-title":"Antibiotic resistance of bacterial biofilms","volume":"35","author":"N Hoiby","year":"2010","journal-title":"Int J Antimicrob Agents"},{"issue":"3","key":"ref99","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00006-08","article-title":"Polymyxins revisited","volume":"21","author":"D Landman","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10096-004-1106-8","article-title":"Use of intravenous polymyxin B during continuous venovenous hemodialysis","volume":"23","author":"JC Sarria","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"ref101","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/1040841X.2013.794127","article-title":"Thirty years of viable but nonculturable state research: unsolved molecular mechanisms","volume":"41","author":"D Pinto","year":"2015","journal-title":"Crit Rev Microbiol"},{"issue":"3","key":"ref102","doi-asserted-by":"crossref","first-page":"e17585","DOI":"10.1371\/journal.pone.0017585","article-title":"Entry of Yersinia pestis into the viable but nonculturable state in a low-temperature tap water microcosm","volume":"6","author":"DR Pawlowski","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"ref103","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s10482-013-9877-5","article-title":"CadF expression in Campylobacter jejuni strains incubated under low-temperature water microcosm conditions which induce the viable but non-culturable (VBNC) state","volume":"103","author":"V Patrone","year":"2013","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"8","key":"ref104","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/jac\/dkt086","article-title":"Antibiotic pressure can induce the viable but non-culturable state in Staphylococcus aureus growing in biofilms","volume":"68","author":"S Pasquaroli","year":"2013","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"ref105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00248-013-0297-x","article-title":"Pseudomonas aeruginosa biofilms in disease","volume":"68","author":"LR Mulcahy","year":"2014","journal-title":"Microb Ecol"},{"issue":"1","key":"ref106","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/AEM.62.1.115-120.1996","article-title":"Potential virulence of viable but nonculturable Shigella dysenteriae type 1","volume":"62","author":"I Rahman","year":"1996","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"ref107","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijfoodmicro.2009.10.004","article-title":"Effect of high pressure CO2 and mild heat processing on natural microorganisms in apple juice","volume":"137","author":"H Liao","year":"2010","journal-title":"Int J Food Microbiol"},{"issue":"1\u20132","key":"ref108","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijfoodmicro.2010.07.022","article-title":"Sulphur dioxide affects culturability and volatile phenol production by Brettanomyces\/Dekkera bruxellensis","volume":"143","author":"M Agnolucci","year":"2010","journal-title":"Int J Food Microbiol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1039\/c2sm25100k","article-title":"Force microscopic and thermodynamic analysis of the adhesion between <italic>Pseudomonas aeruginosa<\/italic> and <italic>Candida albicans<\/italic>","volume":"8","author":"ES Ovchinnikova","year":"2012","journal-title":"Soft Matter"},{"issue":"7","key":"ref110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10295-005-0225-2","article-title":"Pseudomonas aeruginosa, Candida albicans, and device-related nosocomial infections: implications, trends, and potential approaches for control","volume":"32","author":"GE Pierce","year":"2005","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"Pt B","key":"ref111","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jprot.2015.06.006","article-title":"Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host-pathogen interaction","volume":"127","author":"A Gil-Bona","year":"2015","journal-title":"J Proteomics"},{"issue":"3","key":"ref112","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jac\/dkl521","article-title":"Biofilm formation by fluconazole-resistant Candida albicans strains is inhibited by fluconazole","volume":"59","author":"I Bruzual","year":"2007","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"ref113","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1128\/IAI.72.10.6023-6031.2004","article-title":"Development and characterization of an in vivo central venous catheter <italic>Candida albicans<\/italic> biofilm model","volume":"72","author":"D Andes","year":"2004","journal-title":"Infect Immun"},{"issue":"1","key":"ref114","doi-asserted-by":"crossref","first-page":"e86270","DOI":"10.1371\/journal.pone.0086270","article-title":"Participation of <italic>Candida albicans<\/italic> Transcription Factor RLM1 in Cell Wall Biogenesis and 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