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CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J [Internet]. 2004 Nov 15 [cited 2013 Feb 12]; <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fasebj.org\/cgi\/doi\/10.1096\/fj.04-2169fje\" xlink:type=\"simple\">http:\/\/www.fasebj.org\/cgi\/doi\/10.1096\/fj.04-2169fje<\/ext-link>"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.phrs.2006.01.012","article-title":"Renal vascular responses to CORM-A1 in the mouse","volume":"54","author":"M Ryan","year":"2006","journal-title":"Pharmacol Res"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"H2501","DOI":"10.1152\/ajpheart.00354.2007","article-title":"Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury","volume":"293","author":"A Zimmermann","year":"2007","journal-title":"AJP Heart Circ 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Protein","volume":"285","author":"YK Choi","year":"2010","journal-title":"J Biol Chem"},{"issue":"5","key":"ref76","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1074\/jbc.M110.168831","article-title":"Heme Oxygenase-1\/Carbon Monoxide Induces Vascular Endothelial Growth Factor Expression via p38 Kinase-dependent Activation of Sp1","volume":"286","author":"H Lin","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2011.03.013","article-title":"Beneficial effects of carbon monoxide-releasing molecule-2 (CORM-2) on acute doxorubicin cardiotoxicity in mice: Role of oxidative stress and apoptosis","volume":"253","author":"H Soni","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: A convergence point for many signalling 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Endod"},{"issue":"39","key":"ref82","doi-asserted-by":"crossref","first-page":"36993","DOI":"10.1074\/jbc.M302942200","article-title":"Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1","volume":"278","author":"D Morse","year":"2003","journal-title":"J Biol Chem"},{"issue":"5","key":"ref83","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/glia.20628","article-title":"Interleukin 15 expression in the CNS: Blockade of its activity prevents glial activation after an inflammatory injury","volume":"56","author":"D G\u00f3mez-Nicola","year":"2008","journal-title":"Glia"},{"issue":"12","key":"ref84","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1091\/mbc.E11-01-0053","article-title":"Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells","volume":"22","author":"D G\u00f3mez-Nicola","year":"2011","journal-title":"Mol Biol Cell"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2009.09.009","article-title":"Effects of interleukin-15 on neuronal differentiation of neural stem cells","volume":"1304","author":"Y-S Huang","year":"2009","journal-title":"Brain Res"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.neuroscience.2006.02.080","article-title":"Genes associated with neuronal differentiation of precursors from human brain","volume":"141","author":"S Yu","year":"2006","journal-title":"Neuroscience"},{"issue":"1","key":"ref87","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2202-14-132","article-title":"Temporal expression patterns of insulin-like growth factor binding protein-4 in the embryonic and postnatal rat brain","volume":"14","author":"X Jiang","year":"2013","journal-title":"BMC Neurosci"},{"issue":"19","key":"ref88","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1523\/JNEUROSCI.20-19-07377.2000","article-title":"Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen","volume":"20","author":"L Studer","year":"2000","journal-title":"J Neurosci"},{"issue":"5","key":"ref89","doi-asserted-by":"crossref","first-page":"e96465","DOI":"10.1371\/journal.pone.0096465","article-title":"Influence of Oxygen Tension on Dopaminergic Differentiation of Human Fetal Stem Cells of Midbrain and Forebrain Origin","volume":"9","author":"C Krabbe","year":"2014","journal-title":"PLoS ONE"},{"issue":"3","key":"ref90","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0034-5687(01)00306-1","article-title":"Tissue oxygen tension and brain sensitivity to hypoxia","volume":"128","author":"M Ereci\u0144ska","year":"2001","journal-title":"Respir Physiol"},{"issue":"9","key":"ref91","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"JA Forsythe","year":"1996","journal-title":"Mol Cell Biol"},{"issue":"18","key":"ref92","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1073\/pnas.97.18.10242","article-title":"Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia","volume":"97","author":"KL Jin","year":"2000","journal-title":"Proc Natl Acad Sci"},{"issue":"35","key":"ref93","doi-asserted-by":"crossref","first-page":"25875","DOI":"10.1074\/jbc.M701988200","article-title":"Endogenous Erythropoietin Signaling Is Required for Normal Neural Progenitor Cell Proliferation","volume":"282","author":"Z-Y Chen","year":"2007","journal-title":"J Biol Chem"},{"issue":"4","key":"ref94","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/sj.cdd.4402307","article-title":"Mitochondrial complex III regulates hypoxic activation of HIF","volume":"15","author":"T Klimova","year":"2008","journal-title":"Cell Death Differ"},{"issue":"1","key":"ref95","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00421-008-0776-9","article-title":"HIF-1\u03b1 subunit and vasoactive HIF-1-dependent genes are involved in carbon monoxide-induced cerebral hypoxic stress response","volume":"104","author":"S Bani Hashemi","year":"2008","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"ref96","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2007.01.047","article-title":"HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells","volume":"129","author":"R 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