{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:57:48Z","timestamp":1760623068062,"version":"3.37.3"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0198920","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T17:28:57Z","timestamp":1529602137000},"page":"e0198920","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic profile and patient-reported outcomes in chronic obstructive pulmonary disease: A systematic review"],"prefix":"10.1371","volume":"13","author":[{"given":"H\u00e9lder","family":"Melro","sequence":"first","affiliation":[]},{"given":"Jorge","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Moura","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6200","authenticated-orcid":true,"given":"Alda","family":"Marques","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"journal-title":"Global Strategy for the Diagnosis, Management and Prevention of COPD","article-title":"Global Strategy for the Diagnosis, Management and Prevention of COPD","year":"2018","key":"ref1"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1183\/09031936.01.00268501","article-title":"Genetics of COPD: present and future","volume":"18","author":"J Hoidal","year":"2001","journal-title":"Eur Respir J"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/emmm.201100627","article-title":"Emerging genetics of COPD","volume":"4","author":"A Berndt","year":"2012","journal-title":"EMBO Mol Med"},{"issue":"4","key":"ref4","first-page":"541","article-title":"Genetics of chronic obstructive pulmonary disease","volume":"2","author":"C Seifart","year":"2007","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1586\/17476348.2016.1146595","article-title":"Patient reported outcome measures in chronic obstructive pulmonary disease: Which to use?","volume":"10","author":"M Ekstr\u00f6m","year":"2016","journal-title":"Expert Rev Respir Med"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2147\/COPD.S77368","article-title":"A review of the most common patient-reported outcomes in COPD\u2013revisiting current knowledge and estimating future challenges","volume":"10","author":"M Cazzola","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"14","key":"ref7","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1200\/JCO.2010.34.5629","article-title":"Genetic variations and patient-reported quality of life among patients with lung cancer","volume":"30","author":"JA Sloan","year":"2012","journal-title":"J Clin Oncol"},{"issue":"5","key":"ref8","first-page":"310","article-title":"Conceptual and analytical considerations toward the use of patient-reported outcomes in personalized medicine","volume":"5","author":"D Alemayehu","year":"2012","journal-title":"Am Health Drug Benefits"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"A12","DOI":"10.7326\/ACPJC-1995-123-3-A12","article-title":"The well-built clinical question: a key to evidence-based decisions","volume":"123","author":"WS Richardson","year":"1995","journal-title":"ACP J Clufb"},{"article-title":"Cochrane handbook for systematic reviews of interventions","year":"2011","author":"DL Patrick","key":"ref10"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"W-65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"A Liberati","year":"2009","journal-title":"Ann Intern Med"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12863-015-0211-2","article-title":"Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool","volume":"16","author":"ZN Sohani","year":"2015","journal-title":"BMC Genet"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"JR Landis","year":"1977","journal-title":"Biometrics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12931-015-0306-3","article-title":"Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study","volume":"16","author":"J Mandal","year":"2015","journal-title":"Respir Res"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1164\/rccm.201002-0151OC","article-title":"Loci Identified by Genome-wide Association Studies Influence Different Disease-related Phenotypes in Chronic Obstructive Pulmonary Disease","volume":"182","author":"SG Pillai","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1378\/chest.11-1655","article-title":"ADRB2 polymorphisms and budesonide\/formoterol responses in COPD","volume":"142","author":"ER Bleecker","year":"2012","journal-title":"Chest"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1440-1843.2008.01259.x","article-title":"Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD","volume":"13","author":"N Umeda","year":"2008","journal-title":"Respirology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.2147\/DDDT.S91823","article-title":"Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter","volume":"9","author":"JQ Zhang","year":"2015","journal-title":"Drug Des Devel Ther"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1164\/rccm.200603-443OC","article-title":"A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease","volume":"174","author":"N Takabatake","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/sj.gene.6363961","article-title":"Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections","volume":"4","author":"IA Yang","year":"2003","journal-title":"Genes Immun"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/jhg.2010.133","article-title":"Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms","volume":"56","author":"T Ishii","year":"2011","journal-title":"J Hum Genet"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1378\/chest.10-0375","article-title":"Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD","volume":"139","author":"CL Lin","year":"2011","journal-title":"Chest"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/thx.2010.152975","article-title":"SERPINA1 11478G -> A variant, serum alpha(1)-antitrypsin, exacerbation frequency and FEV1 decline in COPD","volume":"66","author":"JK Quint","year":"2011","journal-title":"Thorax"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2466-12-28","article-title":"25-hydroxyvitamin D deficiency, exacerbation frequency and human rhinovirus exacerbations in chronic obstructive pulmonary disease","volume":"12","author":"JK Quint","year":"2012","journal-title":"BMC Pulm Med"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/resp.12277","article-title":"Association of group component genetic variations in COPD and COPD exacerbation in a Japanese population","volume":"19","author":"T Ishii","year":"2014","journal-title":"Respirology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2147\/COPD.S79710","article-title":"Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes","volume":"10","author":"JQ Zhang","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2147\/COPD.S34186","article-title":"Exacerbation frequency and course of COPD","volume":"7","author":"DM Halpin","year":"2012","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1164\/ajrccm.157.5.9709032","article-title":"Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease","volume":"157","author":"TA Seemungal","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1001\/archinte.163.10.1180","article-title":"In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease","volume":"163","author":"SP Patil","year":"2003","journal-title":"Arch Intern Med"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/0971-6866.86170","article-title":"Are mannose-binding lectin gene 2 (MBL2) polymorphisms and MBL deficiency associated with infections?","volume":"17","author":"V Pradhan","year":"2011","journal-title":"Indian J Hum Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/B978-0-12-386960-9.00017-4","article-title":"Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle","volume":"86","author":"W Janssens","year":"2010","journal-title":"Vitam Horm"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/thx.2009.120659","article-title":"Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene","volume":"65","author":"W Janssens","year":"2010","journal-title":"Thorax"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.2147\/COPD.S91576","article-title":"Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD","volume":"10","author":"SW Kim","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.rmed.2003.09.001","article-title":"COPD exacerbations: the importance of a standard definition","volume":"98","author":"R Pauwels","year":"2004","journal-title":"Respir Med"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1524-4733.2010.00772.x","article-title":"Development of the EXAcerbations of Chronic Obstructive Pulmonary Disease Tool (EXACT): a patient-reported outcome (PRO) measure","volume":"13","author":"NK Leidy","year":"2010","journal-title":"Value Health"},{"issue":"2","key":"ref36","first-page":"146","article-title":"Interaction of Depression and Nicotine Addiction on the Severity of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study","volume":"45","author":"L Peian","year":"2016","journal-title":"Iran J Public Health"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1183\/09031936.00056908","article-title":"Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?","volume":"33","author":"M Quaak","year":"2009","journal-title":"Eur Respir J"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2156-15-78","article-title":"SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study","volume":"15","author":"MRP de Castro","year":"2014","journal-title":"BMC Genet"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jpsychores.2007.08.002","article-title":"Comprehensive pulmonary rehabilitation for anxiety and depression in adults with chronic obstructive pulmonary disease: systematic review and meta-analysis","volume":"63","author":"PA Coventry","year":"2007","journal-title":"J Psychosom Res"},{"key":"ref40","first-page":"379","article-title":"Cost-effectiveness of pulmonary rehabilitation","volume":"91","author":"RM Kaplan","year":"1996","journal-title":"Lung biology in health and disease"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1378\/chest.120.5.1493","article-title":"Polymorphism of the \u03b22-adrenoceptor in COPD in Chinese subjects","volume":"120","author":"L-I Ho","year":"2001","journal-title":"Chest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.rmed.2016.03.019","article-title":"Genetic effects on treatment response of umeclidinium\/vilanterol in chronic obstructive pulmonary disease","volume":"114","author":"L Condreay","year":"2016","journal-title":"Respir Med"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1465-9921-7-130","article-title":"The genetics of chronic obstructive pulmonary disease","volume":"7","author":"AM Wood","year":"2006","journal-title":"Respir Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2147\/COPD.S32675","article-title":"Beyond FEV1 in COPD: a review of patient-reported outcomes and their measurement","volume":"7","author":"P Jones","year":"2012","journal-title":"Int J Chron Obstruct Pulmon Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0198920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T03:44:21Z","timestamp":1661485461000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0198920"}},"subtitle":[],"editor":[{"given":"Anna","family":"Nolan","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0198920","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,6,21]]}}}