{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:00:25Z","timestamp":1740146425332,"version":"3.37.3"},"reference-count":93,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/78835\/2011"],"award-info":[{"award-number":["SFRH\/BD\/78835\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["BPD\/UI51\/5388\/2017"],"award-info":[{"award-number":["BPD\/UI51\/5388\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/104165\/2014"],"award-info":[{"award-number":["SFRH\/BPD\/104165\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/79077\/2011"],"award-info":[{"award-number":["SFRH\/BD\/79077\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/111736\/2015"],"award-info":[{"award-number":["SFRH\/BPD\/111736\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00889\/2015"],"award-info":[{"award-number":["IF\/00889\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0202402","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T23:31:51Z","timestamp":1535412711000},"page":"e0202402","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast"],"prefix":"10.1371","volume":"13","author":[{"given":"Ana Rita D.","family":"Ara\u00fajo","sequence":"first","affiliation":[]},{"given":"T\u00e2nia","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Elisabete A.","family":"Maciel","sequence":"additional","affiliation":[]},{"given":"Clara","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Catarina M.","family":"Morais","sequence":"additional","affiliation":[]},{"given":"Deolinda R.","family":"Santinha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7083-6266","authenticated-orcid":true,"given":"Joana F.","family":"Tavares","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Am\u00e1lia S.","family":"Jurado","sequence":"additional","affiliation":[]},{"given":"V\u00edtor","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[]},{"given":"Maria Ros\u00e1rio M.","family":"Domingues","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-1146","authenticated-orcid":true,"given":"Manuel A. S.","family":"Santos","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg2662","article-title":"The evolutionary consequences of erroneous protein synthesis","volume":"10","author":"D Allan Drummond","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref2","article-title":"Protein mistranslation: friend or foe?","author":"LR de Pouplana","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molcel.2010.10.001","article-title":"Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms","volume":"40","author":"A Buchberger","year":"2010","journal-title":"Mol Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.tibs.2011.01.004","article-title":"Mitochondrial protein quality control during biogenesis and aging","volume":"36","author":"BM Baker","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0092-8674(90)90059-N","article-title":"Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation","volume":"61","author":"JM Shoffner","year":"1990","journal-title":"Cell"},{"key":"ref6","first-page":"1213","article-title":"A new mtDNA mutation in the tRNA(Lys) gene associated with myoclonic epilepsy and ragged-red fibers (MERRF)","volume":"51","author":"G Silvestri","year":"1992","journal-title":"Am J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng0595-47","article-title":"MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNALys and premature translation termination","volume":"10","author":"JA Enriquez","year":"1995","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-genet-110410-132531","article-title":"Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases","author":"T Suzuki","year":"2011","journal-title":"Annual Review of Genetics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/path.3028","article-title":"Mitochondrial DNA and disease","volume":"226","author":"LC Greaves","year":"2012","journal-title":"J Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"D611","DOI":"10.1093\/nar\/gki079","article-title":"MITOMAP: a human mitochondrial genome database\u20142004 update","volume":"33","author":"MC Brandon","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi0123s44","article-title":"MtDNA variation and analysis using Mitomap and Mitomaster","author":"MT Lott","year":"2013","journal-title":"Curr Protoc Bioinforma"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"11043","DOI":"10.1073\/pnas.0802862105","article-title":"Aminoacyl tRNA synthetases and their connections to disease","volume":"105","author":"SG Park","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ymgme.2013.01.010","article-title":"Mitochondrial aminoacyl-tRNA synthetases in human disease","volume":"108","author":"S Konovalova","year":"2013","journal-title":"Mol Genet Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ajhg.2011.04.006","article-title":"Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy","volume":"88","author":"A G\u00f6tz","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ajhg.2009.12.005","article-title":"A major determinant for binding and aminoacylation of tRNA(Ala) in cytoplasmic Alanyl-tRNA synthetase is mutated in dominant axonal Charcot-Marie-Tooth disease","volume":"86","author":"P Latour","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature05096","article-title":"Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration","volume":"443","author":"JW Lee","year":"2006","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1086\/421530","article-title":"Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathy and sideroblastic anemia (MLASA)","volume":"74","author":"Y Bykhovskaya","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref18","first-page":"481","article-title":"When ribosomes go bad: diseases of ribosome biogenesis. Mol Biosyst","volume":"6","author":"EF Freed","year":"2010","journal-title":"The Royal Society of Chemistry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1046\/j.1365-2958.1999.01233.x","article-title":"Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in <italic>Candida<\/italic> spp","volume":"31","author":"MAS Santos","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/j.1460-2075.1996.tb00886.x","article-title":"Transfer RNA structural change is a key element in the reassignment of the CUG codon in <italic>Candida albicans<\/italic>","volume":"15","author":"MAS Santos","year":"1996","journal-title":"Embo J"},{"year":"2011","author":"DD Mateus","key":"ref21"},{"key":"ref22","first-page":"969","article-title":"Molecular reconstruction of a fungal genetic code alteration","volume":"10","author":"DD Mateus","year":"2013","journal-title":"RNA Biol. Landes Bioscience"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fmicb.2016.00401","article-title":"The Fungus <italic>Candida albicans<\/italic> Tolerates Ambiguity at Multiple Codons","volume":"7","author":"J Sim\u00f5es","year":"2016","journal-title":"Front Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"11079","DOI":"10.1073\/pnas.1302094110","article-title":"Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification","volume":"110","author":"AR Bezerra","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1093\/nar\/gku1404","article-title":"Protein mistranslation protects bacteria against oxidative stress","volume":"43","author":"Y Fan","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-genet-111212-133522","article-title":"Adaptive Translation as a Mechanism of Stress Response and Adaptation","volume":"47","author":"T Pan","year":"2013","journal-title":"Annu Rev Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1038\/sj.emboj.7601876","article-title":"Critical roles for a genetic code alteration in the evolution of the genus <italic>Candida<\/italic>","volume":"26","author":"RM Silva","year":"2007","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000996","article-title":"A Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen <italic>Candida albicans<\/italic>","volume":"2","author":"I Miranda","year":"2007","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1741-7007-10-55","article-title":"Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast","volume":"10","author":"J Paredes","year":"2012","journal-title":"BMC Biol"},{"key":"ref30","unstructured":"Costa TLVM. Cellular responses to genome mistranslation. Aveiro. 2012."},{"year":"2013","author":"JMS Sim\u00f5es","key":"ref31"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1462-5822.2010.01550.x","article-title":"Lipid signalling in pathogenic fungi","author":"A Singh","year":"2011","journal-title":"Cellular Microbiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/BJ20111752","article-title":"Cell signalling by reactive lipid species: new concepts and molecular mechanisms","volume":"442","author":"A Higdon","year":"2012","journal-title":"Biochem J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/bies.201300064","article-title":"Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling","volume":"35","author":"KO Schink","year":"2013","journal-title":"BioEssays"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.plipres.2008.01.001","article-title":"Synthesis and turnover of non-polar lipids in yeast","volume":"47","author":"S Rajakumari","year":"2008","journal-title":"Prog Lipid Res"},{"key":"ref36","first-page":"241","article-title":"Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria","volume":"45","author":"MS Sharpley","year":"2006","journal-title":"Biochemistry. American Chemical Society"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10863-008-9168-4","article-title":"Supercomplex organization of the oxidative phosphorylation enzymes in yeast mitochondria","volume":"40","author":"RA Stuart","year":"2008","journal-title":"J Bioenerg Biomembr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.bbabio.2012.04.015","article-title":"The stability and activity of respiratory Complex II is cardiolipin-dependent","volume":"1817","author":"CT Schwall","year":"2012","journal-title":"Biochim Biophys Acta\u2014Bioenerg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1021\/bi990603r","article-title":"Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1","volume":"38","author":"B Gomez","year":"1999","journal-title":"Biochemistry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.bbabio.2009.02.012","article-title":"Role of phospholipids in respiratory cytochrome <italic>bc<\/italic>1 complex catalysis and supercomplex formation","volume":"1787","author":"T Wenz","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"14966","DOI":"10.1021\/bi9914053","article-title":"Phospholipase A2 digestion of cardiolipin bound to bovine cytochrome c oxidase alters both activity and quaternary structure","volume":"38","author":"E Sedl\u00e1k","year":"1999","journal-title":"Biochemistry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"43553","DOI":"10.1074\/jbc.C200551200","article-title":"Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane","volume":"277","author":"M Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"29403","DOI":"10.1074\/jbc.M504955200","article-title":"Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria","volume":"280","author":"M Zhang","year":"2005","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"52873","DOI":"10.1074\/jbc.M308366200","article-title":"Cardiolipin Stabilizes Respiratory Chain Supercomplexes","volume":"278","author":"K Pfeiffer","year":"2003","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1021\/ja310577u","article-title":"Evidence for cardiolipin binding sites on the membrane-exposed surface of the cytochrome <italic>bc<\/italic>1","volume":"135","author":"C Arnarez","year":"2013","journal-title":"J Am Chem Soc."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1091\/mbc.e08-09-0896","article-title":"The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome","volume":"19","author":"SM Claypool","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(02)03292-1","article-title":"Cardiolipin: a proton trap for oxidative phosphorylation","volume":"528","author":"TH Haines","year":"2002","journal-title":"FEBS Lett"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1083\/jcb.200907074","article-title":"Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response","volume":"187","author":"S Schuck","year":"2009","journal-title":"J Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/83817","article-title":"A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy","volume":"27","author":"K Zhang","year":"2001","journal-title":"Nat Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"12843","DOI":"10.1073\/pnas.0802607105","article-title":"Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids","volume":"105","author":"M-P Agbaga","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"32521","DOI":"10.1074\/jbc.M503411200","article-title":"Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4","volume":"280","author":"C Grayson","year":"2005","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ygeno.2003.10.004","article-title":"Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein","volume":"83","author":"R Ambasudhan","year":"2004","journal-title":"Genomics"},{"key":"ref53","first-page":"657","article-title":"Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants","volume":"11","author":"G Karan","year":"2005","journal-title":"Mol Vis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ajmg.a.20660","article-title":"X-linked cardioskeletal myopathy and neutropenia (Barth syndrome): An update","volume":"126A","author":"PG Barth","year":"2004","journal-title":"Am J Med Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1016\/j.febslet.2006.07.022","article-title":"Barth syndrome, a human disorder of cardiolipin metabolism","volume":"580","author":"M Schlame","year":"2006","journal-title":"FEBS Lett"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10545-012-9509-7","article-title":"Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: Toward a new category of inherited metabolic diseases","volume":"36","author":"F Lamari","year":"2013","journal-title":"J Inherit Metab Dis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0076-6879(02)50957-5","article-title":"Transformation of yeast by lithium acetate\/single-stranded carrier DNA\/polyethylene glycol method","author":"RD Gietz","year":"2002","journal-title":"Methods in Enzymology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1038\/nprot.2006.468","article-title":"In-gel digestion for mass spectrometric characterization of proteins and proteomes","volume":"1","author":"A Shevchenko","year":"2006","journal-title":"Nat Protoc"},{"key":"ref60","first-page":"911","article-title":"A rapid method of total lipid extracion and purification","volume":"37","author":"EG Bligh","year":"1959","journal-title":"Can J Physiol Pharmacol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0003-2697(70)90343-X","article-title":"Spectrophotometric determination of phosphate esters in the presence and absence of orthophosphate","volume":"36","author":"EM Bartlett","year":"1970","journal-title":"Anal Biochem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chroma.2004.07.090","article-title":"Evaluation of a methylation procedure to determine cyclopropenoids fatty acids from <italic>Sterculia striata<\/italic> St. Hil. Et Nauds seed oil","volume":"1054","author":"S Aued-Pimentel","year":"2004","journal-title":"J Chromatogr A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"[18] Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides","author":"SP Wolff","year":"1994","journal-title":"Methods in enzymology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0304-4157(78)90010-2","article-title":"Fluidity parameters of lipid regions determined by fluorescence polarization","volume":"515","author":"M Shinitzky","year":"1978","journal-title":"Biochim Biophys Acta\u2014Rev Biomembr"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"45e","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"MW Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/(SICI)1097-0061(199905)15:7<601::AID-YEA390>3.0.CO;2-N","article-title":"Systematic analysis of yeast strains with possible defects in lipid metabolism","volume":"15","author":"G Daum","year":"1999","journal-title":"Yeast"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbalip.2006.06.010","article-title":"Regulation of long chain unsaturated fatty acid synthesis in yeast","volume":"1771","author":"CE Martin","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1073\/pnas.0811700106","article-title":"Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry","volume":"106","author":"CS Ejsing","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e35063","DOI":"10.1371\/journal.pone.0035063","article-title":"Flexibility of a eukaryotic lipidome-insights from yeast lipidomics","volume":"7","author":"C Klose","year":"2012","journal-title":"PLoS One"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.chembiol.2015.02.007","article-title":"Quantitative analysis of proteome and lipidome dynamics reveals functional regulation of global lipid metabolism","volume":"22","author":"A Casanovas","year":"2015","journal-title":"Chem Biol"},{"key":"ref71","unstructured":"Gomes ACEO. The role of environmental stress on protein synthesis fidelity. Thesis. University of Aveiro. 2012."},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.4161\/rna.32199","article-title":"TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish","volume":"11","author":"M Reverendo","year":"2014","journal-title":"RNA Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1074\/jbc.273.12.6796","article-title":"Steric limitations in the interaction of the ATP binding domains of the ArsA ATPase","volume":"273","author":"J Li","year":"1998","journal-title":"J Biol Chem"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1021\/bi961296h","article-title":"Mutations at a Glycine Loop in Aminolevulinate Synthase Affect Pyridoxal Phosphate Cofactor Binding and Catalysis \u2020","volume":"35","author":"J Gong","year":"1996","journal-title":"Biochemistry"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/312071a0","article-title":"Biological properties of human c-Ha-ras1 genes mutated at codon 12","volume":"312","author":"PH Seeburg","year":"1984","journal-title":"Nature"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1016\/S0021-9258(17)36898-9","article-title":"Primary structural constraints of P-loop of mitochondrial F1-ATPase from yeast","volume":"269","author":"H Shen","year":"1994","journal-title":"J Biol Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"29389","DOI":"10.1074\/jbc.M115.695171","article-title":"Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein","volume":"290","author":"TW Loo","year":"2015","journal-title":"J Biol Chem"},{"key":"ref78","article-title":"Fatty Acylation of Proteins: The Long and the Short of it","author":"MD Resh","year":"2016","journal-title":"Prog Lipid Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"12494","DOI":"10.1073\/pnas.96.22.12494","article-title":"Measures of residue density in protein structures","volume":"96","author":"F Baud","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1093\/nar\/gkp1083","article-title":"Chimeric tRNAs as tools to induce proteome damage and identify components of stress responses","volume":"38","author":"R Geslain","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref81","first-page":"11","article-title":"The environmental stress response: a common yeast response to diverse environmental stresses","author":"AP Gasch","year":"2002","journal-title":"Top Curr Genet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"29011","DOI":"10.1074\/jbc.M601545200","article-title":"Global translational responses to oxidative stress impact upon multiple levels of protein synthesis","volume":"281","author":"D Shenton","year":"2006","journal-title":"J Biol Chem"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nrm1618","article-title":"Translational control in stress and apoptosis","volume":"6","author":"M Holcik","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbalip.2006.07.004","article-title":"Fatty acid synthesis and elongation in yeast","volume":"1771","author":"O Tehlivets","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1194\/jlr.R800043-JLR200","article-title":"Regulation of phospholipid synthesis in yeast","volume":"50","author":"GM Carman","year":"2009","journal-title":"J Lipid Res"},{"key":"ref86","article-title":"Features of the Phosphatidylinositol Cycle and its Role in Signal Transduction","author":"RM Epand","year":"2016","journal-title":"J Membr Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"35953","DOI":"10.1074\/jbc.M112.370155","article-title":"Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator","volume":"287","author":"V Shulga Y","year":"2012","journal-title":"J Biol Chem"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1093\/emboj\/20.18.5280","article-title":"Bacterial senescence: Protein oxidation in non-proliferating cells is dictated by the accuracy of the ribosomes","volume":"20","author":"M Ballesteros","year":"2001","journal-title":"EMBO J"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"VN Bochkov","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10529-010-0465-8","article-title":"Total fatty acid content of the plasma membrane of <italic>Saccharomyces cerevisiae<\/italic> is more responsible for ethanol tolerance than the degree of unsaturation","volume":"33","author":"HS Kim","year":"2011","journal-title":"Biotechnol Lett"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s002530051658","article-title":"Overexpression of the OLE1 gene enhances ethanol fermentation by <italic>Saccharomyces cerevisiae<\/italic>","volume":"53","author":"S Kajiwara","year":"2000","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1091\/mbc.e11-07-0624","article-title":"The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p","author":"CH De Smet","year":"2012","journal-title":"Molecular Biology of the Cell"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"G van Meer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0202402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T17:04:13Z","timestamp":1720544653000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0202402"}},"subtitle":[],"editor":[{"given":"Stephan N.","family":"Witt","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":93,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0202402","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,8,27]]}}}