{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:23:11Z","timestamp":1773667391211,"version":"3.50.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUI-BIQ\/117799\/2010"],"award-info":[{"award-number":["PTDC\/QUI-BIQ\/117799\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["Pest-OE\/EQB\/LA0004\/2011"],"award-info":[{"award-number":["Pest-OE\/EQB\/LA0004\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionaliza\u00e7\u00e3o (POCI) and Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["LISBOA-01-0145-FEDER-007660"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-007660"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/92537\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/92537\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ALFAMA Inc."}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0204624","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T13:49:14Z","timestamp":1538056154000},"page":"e0204624","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods"],"prefix":"10.1371","volume":"13","author":[{"given":"H\u00e9lia F.","family":"Jeremias","sequence":"first","affiliation":[]},{"given":"Diana","family":"Lousa","sequence":"additional","affiliation":[]},{"given":"Axel","family":"Hollmann","sequence":"additional","affiliation":[]},{"given":"Ana C.","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Carla S.","family":"Baltazar","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o D.","family":"Seixas","sequence":"additional","affiliation":[]},{"given":"Ana R.","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Nuno C.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Carlos C.","family":"Rom\u00e3o","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-556X","authenticated-orcid":true,"given":"Cl\u00e1udio M.","family":"Soares","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","article-title":"Carbon monoxide: endogenous production, physiological functions, and pharmacological applications","volume":"57","author":"L Wu","year":"2005","journal-title":"Pharmacol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.pharmtox.46.120604.141053","article-title":"CO as a cellular signaling molecule","volume":"46","author":"HP Kim","year":"2006","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.3000721","article-title":"Gaseotransmitters: New frontiers for translational science","volume":"2","author":"C Szabo","year":"2010","journal-title":"Sci Transl Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","article-title":"Mechanisms of cell protection by heme oxygenase-1","volume":"50","author":"R Gozzelino","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4187\/002013209793800394","article-title":"The evolution of carbon monoxide into medicine","volume":"54","author":"LE Otterbein","year":"2009","journal-title":"Respir Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/bies.20005","article-title":"Carbon monoxide in biology and medicine","volume":"26","author":"SW Ryter","year":"2004","journal-title":"Bioessays"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1039\/C3CC49196J","article-title":"Carbon monoxide-physiology, detection and controlled release","volume":"50","author":"SH Heinemann","year":"2014","journal-title":"Chem Commun (Cambridge, U K)"},{"key":"ref8","first-page":"1","article-title":"Localized delivery of carbon monoxide","volume":"118","author":"C Steiger","year":"2016","journal-title":"Eur J Pharm Biopharm"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1039\/c2cs15317c","article-title":"Developing drug molecules for therapy with carbon monoxide","volume":"41","author":"CC Rom\u00e3o","year":"2012","journal-title":"Chem Soc Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"R Motterlini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"9712","DOI":"10.1002\/anie.201311225","article-title":"Carbon-monoxide-releasing molecules for the delivery of therapeutic CO in vivo","volume":"53","author":"S Garcia-Gallego","year":"2014","journal-title":"Angew Chem, Int Ed"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"18045","DOI":"10.1039\/C6DT03515A","article-title":"CO-releasing molecule (CORM) conjugate systems","volume":"45","author":"AC Kautz","year":"2016","journal-title":"Dalton Trans"},{"key":"ref13","article-title":"All About Albumin: Biochemistry, Genetics, and Medical Applications","author":"T Peters Jr","year":"1995"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2174\/0929867023369673","article-title":"Reversible and covalent binding of drugs to human serum albumin: Methodological approaches and physiological relevance","volume":"9","author":"C Bertucci","year":"2002","journal-title":"Curr Med Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1016\/j.bbagen.2013.05.005","article-title":"Albumin-drug interaction and its clinical implication","volume":"1830","author":"K Yamasaki","year":"2013","journal-title":"Biochim Biophys Acta, Gen Subj"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.1039\/C2DT32174B","article-title":"Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics","volume":"42","author":"JD Seixas","year":"2013","journal-title":"Dalton Trans"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1021\/ja108820s","article-title":"CORM-3 reactivity toward proteins: The crystal structure of a Ru(II) dicarbonyl\u2013lysozyme complex","volume":"133","author":"T Santos-Silva","year":"2011","journal-title":"J Am Chem Soc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/anie.201409344","article-title":"Spontaneous CO release from Ru II(CO) 2-protein complexes in aqueous solution, cells, and mice","volume":"54","author":"M Chaves-Ferreira","year":"2015","journal-title":"Angew Chem, Int Ed"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1039\/B703887A","article-title":"Tricarbonylmanganese(I)-lysozyme complex: a structurally characterized organometallic protein","volume":"0","author":"M Razavet","year":"2007","journal-title":"Chem Commun (Cambridge, U K)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1039\/b923688k","article-title":"Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+)","volume":"46","author":"SL Binkley","year":"2010","journal-title":"Chem Commun (Cambridge, U K)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/cr040704h","article-title":"Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology","volume":"106","author":"AR Timerbaev","year":"2006","journal-title":"Chem Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/cbic.201200159","article-title":"Organometallic Compounds: An Opportunity for Chemical Biology?","volume":"13","author":"M Patra","year":"2012","journal-title":"ChemBioChem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1021\/om300360c","article-title":"Generation of carbon monoxide releasing molecules (CO-RMs) as drug candidates for the treatment of acute liver injury: Targeting of CO-RMs to the liver","volume":"31","author":"AR Marques","year":"2012","journal-title":"Organometallics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1039\/C1DT10649J","article-title":"17 e(-) rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application","volume":"41","author":"F Zobi","year":"2012","journal-title":"Dalton Trans"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1039\/J19690001309","article-title":"Evidence for near-Neighbour Interactions in Some Substituted Methyl Derivatives of Transition Metals Including Molecular Crystal Structure Determinations of (Pi-C5h5)Fe(CO)2CH2.CO2H and (Pi-C5h5)Mo(CO)3CH2.-CO2H","volume":"0","author":"JKP Ariyaratne","year":"1969","journal-title":"J Chem Soc A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1039\/b704832g","article-title":"[(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0\u20132), and CO2CH2CH2OH: a new group of CO-releasing molecules","volume":"0","author":"D Scapens","year":"2007","journal-title":"Dalton Trans"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1039\/b707377a","article-title":"Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation","author":"IJ Fairlamb","year":"2007","journal-title":"Dalton Trans"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1039\/c0dt00203h","article-title":"Iron indenyl carbonyl compounds: CO-releasing molecules","volume":"39","author":"L Hewison","year":"2010","journal-title":"Dalton Trans"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"13065","DOI":"10.1002\/chem.201501348","article-title":"Photoinduced Carbon Monoxide Release from Half-Sandwich Iron(II) Carbonyl Complexes by Visible Irradiation: Kinetic Analysis and Mechanistic Investigation","volume":"21","author":"X Jiang","year":"2015","journal-title":"Chemistry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1021\/om200495h","article-title":"Synthesis and Reactivity of Molybdenum Complexes Containing Functionalized Alkynyl Ligands: A Photochemically Activated CO-Releasing Molecule (PhotoCO-RM)","volume":"30","author":"WQ Zhang","year":"2011","journal-title":"Organometallics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbpa.2014.01.005","article-title":"Metal complexes as structural templates for targeting proteins","volume":"19","author":"M D\u00f6rr","year":"2014","journal-title":"Curr Opin Chem Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1021\/jm901241e","article-title":"Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success","volume":"52","author":"F Lovering","year":"2009","journal-title":"J Med Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molstruc.2005.04.032","article-title":"Studies of interaction between colchicine and bovine serum albumin by fluorescence quenching method","volume":"750","author":"YJ Hu","year":"2005","journal-title":"J Mol Struct"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/bi00793a015","article-title":"Solute perturbation of protein fluorescence. The quenching of the tryptophanyl fluorescence of model compounds and of lysozyme by iodide ions","volume":"10","author":"SS Lehrer","year":"1971","journal-title":"Biochemistry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1021\/acs.jpcb.5b00965","article-title":"Binding of Fatty Acid Amide Amphiphiles to Bovine Serum Albumin: Role of Amide Hydrogen Bonding","volume":"119","author":"S Ghosh","year":"2015","journal-title":"J Phys Chem B"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/1869","article-title":"Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites","volume":"5","author":"S Curry","year":"1998","journal-title":"Nat Struct Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.3390\/ijms15033580","article-title":"Interactive association of drugs binding to human serum albumin","volume":"15","author":"F Yang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1016\/j.ica.2006.03.017","article-title":"\u03b2-Cyclodextrin and permethylated \u03b2-cyclodextrin inclusion compounds of a cyclopentadienyl molybdenum tricarbonyl complex and their use as cyclooctene epoxidation catalyst precursors","volume":"359","author":"SS Braga","year":"2006","journal-title":"Inorg Chim Acta"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1039\/c0dt00203h","article-title":"Iron indenyl carbonyl compounds: CO-releasing molecules","volume":"39","author":"L Hewison","year":"2010","journal-title":"Dalton Trans"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.1021\/bi9803933","article-title":"Interaction of the major epitope region of HIV protein gp41 with membrane model systems. A fluorescence spectroscopy study","volume":"37","author":"NC Santos","year":"1998","journal-title":"Biochemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0076-6879(73)27030-1","article-title":"Circular dichroism and optical rotatory dispersion of proteins and polypeptides","author":"AJ Adler","year":"1973","journal-title":"Methods Enzymol: Academic Press"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"GM Morris","year":"2009","journal-title":"J Comp Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","article-title":"GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"S Pronk","year":"2013","journal-title":"Bioinformatics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00249-011-0700-9","article-title":"Definition and testing of the GROMOS force-field versions 54A7 and 54B7","volume":"40","author":"N Schmid","year":"2011","journal-title":"Eur Biophys J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/bip.360230807","article-title":"A consistent empirical potential for water-protein interactions","volume":"23","author":"J Hermans","year":"1984","journal-title":"Biopolymers"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular-dynamics with coupling to an external bath","volume":"81","author":"HJC Berendsen","year":"1984","journal-title":"J Chem Phys"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle Mesh Ewald\u2014an N.Log(N) Method for Ewald Sums in Large Systems","volume":"98","author":"T Darden","year":"1993","journal-title":"J Chem Phys"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: A linear constraint solver for molecular simulations","volume":"18","author":"B Hess","year":"1997","journal-title":"J Comput Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/jcc.540130805","article-title":"SETTLE: an analytical version of the SHAKE and RATTLE algorithm for rigid water models","volume":"13","author":"S Miyamoto","year":"1992","journal-title":"J Comput Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1016\/S0006-3495(99)77452-7","article-title":"Simulation of electron-proton coupling with a Monte Carlo method: Application to cytochrome c3 using continuum electrostatics","volume":"76","author":"AM Baptista","year":"1999","journal-title":"Biophys J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/jp002763e","article-title":"Some theoretical and computational aspects of the inclusion of proton isomerism in the protonation equilibrium of proteins","volume":"105","author":"AM Baptista","year":"2001","journal-title":"J Phys Chem B"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0204624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T02:45:33Z","timestamp":1540349133000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0204624"}},"subtitle":[],"editor":[{"given":"L. Michel","family":"Espinoza-Fonseca","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0204624","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]}}}