{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:37:49Z","timestamp":1770071869728,"version":"3.49.0"},"reference-count":96,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The pathological interaction between oak trees and <jats:italic>Phytophthora cinnamomi<\/jats:italic> has implications in the cork oak decline observed over the last decades in the Iberian Peninsula. During host colonization, the phytopathogen secretes effector molecules like elicitins to increase disease effectiveness. The objective of this study was to unravel the proteome changes associated with the cork oak immune response triggered by <jats:italic>P<\/jats:italic>. <jats:italic>cinnamomi<\/jats:italic> inoculation in a long-term assay, through SWATH-MS quantitative proteomics performed in the oak leaves. Using the <jats:italic>Arabidopis<\/jats:italic> proteome database as a reference, 424 proteins were confidently quantified in cork oak leaves, of which 80 proteins showed a p-value below 0.05 or a fold-change greater than 2 or less than 0.5 in their levels between inoculated and control samples being considered as altered. The inoculation of cork oak roots with <jats:italic>P<\/jats:italic>. <jats:italic>cinnamomi<\/jats:italic> increased the levels of proteins associated with protein-DNA complex assembly, lipid oxidation, response to endoplasmic reticulum stress, and pyridine-containing compound metabolic process in the leaves. In opposition, several proteins associated with cellular metabolic compound salvage and monosaccharide catabolic process had significantly decreased abundances. The most significant abundance variations were observed for the Ribulose 1,5-Bisphosphate Carboxylase small subunit (RBCS1A), Heat Shock protein 90\u20131 (Hsp90-1), Lipoxygenase 2 (LOX2) and Histone superfamily protein H3.3 (A8MRLO\/At4G40030) revealing a pertinent role for these proteins in the host-pathogen interaction mechanism. This work represents the first SWATH-MS analysis performed in cork oak plants inoculated with <jats:italic>P<\/jats:italic>. <jats:italic>cinnamomi<\/jats:italic> and highlights host proteins that have a relevant action in the homeostatic states that emerge from the interaction between the oomycete and the host in the long term and in a distal organ.<\/jats:p>","DOI":"10.1371\/journal.pone.0245148","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T22:21:02Z","timestamp":1611354062000},"page":"e0245148","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Disclosing proteins in the leaves of cork oak plants associated with the immune response to Phytophthora cinnamomi inoculation in the roots: A long-term proteomics approach"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-5468","authenticated-orcid":true,"given":"Ana Cristina","family":"Coelho","sequence":"first","affiliation":[]},{"given":"Rosa","family":"Pires","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Sch\u00fctz","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia","family":"Santa","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Manadas","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia","family":"Pinto","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"pone.0245148.ref001","first-page":"461","article-title":"Experimental minimum threshold for Phytophthora cinnamomi root disease expression on Quercus suber","author":"MS Serrano","year":"2015","journal-title":"Phytopathol Mediterr"},{"issue":"3","key":"pone.0245148.ref002","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10342-013-0688-z","article-title":"Decline of Mediterranean oak trees and its association with Phytophthora cinnamomi: a review","volume":"132","author":"CDEP Camilo-Alves","year":"2013","journal-title":"Eur J Forest Res"},{"issue":"3","key":"pone.0245148.ref003","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10342-017-1055-2","article-title":"A tree species range in the face of climate change: cork oak as a study case for the Mediterranean biome","volume":"136","author":"F Vessella","year":"2017","journal-title":"Eur J For Res"},{"issue":"6","key":"pone.0245148.ref004","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11056-017-9595-3","article-title":"Chronic cork oak decline and water status: new insights","volume":"48","author":"CS Camilo-Alves","year":"2017","journal-title":"New For"},{"issue":"4","key":"pone.0245148.ref005","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10342-017-1064-1","article-title":"Across-scale patterning of plant\u2013soil\u2013pathogen interactions in Quercus suber decline","volume":"136","author":"J Avila","year":"2017","journal-title":"Eur J For Res"},{"key":"pone.0245148.ref006","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.foreco.2016.07.024","article-title":"How dependent are cork oak (Quercus suber L.) woodlands on groundwater? 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