{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:25:23Z","timestamp":1757456723886,"version":"3.40.5"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n General de la Universidad de Salamanca","award":["0348_CIE_6_E"],"award-info":[{"award-number":["0348_CIE_6_E"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The progressive aging of the population represents a challenge for society. In particular, a strong increase in the number of people over 90 is expected in the next two decades. As this phenomenon will lead to an increase in illness and age-related dependency, the study of long-lived people represents an opportunity to explore which lifestyle factors are associated with healthy aging and which with the emergence of age-related diseases, especially Alzheimer\u2019s type dementia. The project \u201cFactors associated with healthy and pathologically aging in a sample of elderly people over 90 in the city of Madrid\u201d (MADRID+90) brings together a multidisciplinary research team in neurodegenerative diseases that includes experts in epidemiology, neurology, neuropsychology, neuroimaging and computational neuroscience. In the first phase of the project, a stratified random sampling was carried out according to the census of the city of Madrid followed by a survey conducted on 191 people aged 90 and over. This survey gathered information on demographics, clinical data, lifestyles and cognitive status. Here, the main results of that survey are showed. The second phase of the project aims to characterize individual trajectories in the course of either healthy and pathological aging, from a group of 50 subjects over 90 who will undergo a comprehensive clinical examination comprised of neurological and cognitive testing, MRI and EEG. The ultimate goal of the project is to characterize the biophysical and clinical profiles of a population that tends to receive little attention in the literature. A better understanding of the rapidly increasing group of nonagenarians will also help to design new policies that minimize the impact and future social and economic consequences of rapidly aging societies.<\/jats:p>","DOI":"10.1371\/journal.pone.0251796","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T17:27:41Z","timestamp":1621272461000},"page":"e0251796","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["MADRID+90 study on factors associated with longevity: Study design and preliminary data"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-8699","authenticated-orcid":true,"given":"Miguel A.","family":"Fern\u00e1ndez-Bl\u00e1zquez","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-7083","authenticated-orcid":true,"given":"Teodoro","family":"del Ser","sequence":"additional","affiliation":[]},{"given":"Bel\u00e9n","family":"Frades-Payo","sequence":"additional","affiliation":[]},{"given":"Marina","family":"\u00c1vila-Villanueva","sequence":"additional","affiliation":[]},{"given":"Meritxell","family":"Valent\u00ed-Soler","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda T.","family":"Ben\u00edtez-Robredo","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Bermejo-Agu\u00f1a","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3940-5609","authenticated-orcid":true,"given":"Eduardo J.","family":"Pedrero-P\u00e9rez","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Quilis-Sancho","sequence":"additional","affiliation":[]},{"given":"Ana B.","family":"Pastor","sequence":"additional","affiliation":[]},{"given":"Concepci\u00f3n","family":"Fern\u00e1ndez-Garrido","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Morales-Alonso","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 M.","family":"Diaz-Olalla","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-7173","authenticated-orcid":true,"given":"Nadine Correia","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Maest\u00fa","sequence":"additional","affiliation":[]},{"given":"Jaime","family":"G\u00f3mez-Ram\u00edrez","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"pone.0251796.ref001","article-title":"General management of nonagenarian patients: A review of the literature","author":"R Rivoirard","year":"2014","journal-title":"Swiss Medical Weekly"},{"key":"pone.0251796.ref002","article-title":"Probabilistic Population Projections based on the World Population Prospects: The 2012 Revision","author":"U Nations","year":"2014","journal-title":"Popul Div Dep Econ Soc Aff"},{"key":"pone.0251796.ref003","article-title":"Prevalence of dementia after age 90: Results from the 90+ study","author":"MM Corrada","year":"2008","journal-title":"Neurology"},{"key":"pone.0251796.ref004","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mad.2018.06.002","article-title":"Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity","author":"M Revelas","year":"2018","journal-title":"Mechanisms of Ageing and Development. 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