{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:46:06Z","timestamp":1761108366735,"version":"3.37.3"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2019-108079GB-C22\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2019-108079GB-C22\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Excess of deaths is a technique used in epidemiology to assess the deaths caused by an unexpected event. For the present COVID\u201319 pandemic, we discuss the performance of some linear and nonlinear time series forecasting techniques widely used for modeling the actual pandemic and provide estimates for this metric from January 2020 to April 2021. We apply the results obtained to evaluate the evolution of the present pandemic in Brazil and Spain, which allows in particular to compare how well (or bad) these countries have managed the pandemic. For Brazil, our calculations refute the claim made by some officials that the present pandemic is \u201ca little flu\u201d. Some studies suggest that the virus could be lying dormant across the world before been detected for the first time. In that regard, our results show that there is no evidence of deaths by the virus in 2019.<\/jats:p>","DOI":"10.1371\/journal.pone.0255909","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T18:03:28Z","timestamp":1630605808000},"page":"e0255909","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["On the effect of COVID-19 pandemic in the excess of human mortality. The case of Brazil and Spain"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-2739","authenticated-orcid":true,"given":"Jorge A.","family":"Borrego\u2013Morell","sequence":"first","affiliation":[]},{"given":"Edmundo J.","family":"Huertas","sequence":"additional","affiliation":[]},{"given":"Nuria","family":"Torrado","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"pone.0255909.ref001","unstructured":"Ma J. Coronavirus: China\u2019s first confirmed Covid\u201319 case traced back to November 17. South China Morning Post. 2020 March 13 [Cited 2021 June 30]. 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Available from: https:\/\/pkg.robjhyndman.com\/forecast\/."},{"issue":"3","key":"pone.0255909.ref029","first-page":"1","article-title":"Automatic time series forecasting: The forecast package for R","volume":"26","author":"RJ Hyndman","year":"2008","journal-title":"J. Statist. Softw"},{"key":"pone.0255909.ref030","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-71918-2","volume-title":"Forecasting with exponential smoothing: the state space approach","author":"RJ Hyndman","year":"2008"},{"key":"pone.0255909.ref031","volume-title":"Forecasting: methods and applications","author":"S Makridakis","year":"1998","edition":"3"},{"key":"pone.0255909.ref032","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0169-2070(00)00065-0","article-title":"Out-of sample tests of forecasting accuracy: A tutorial and review","volume":"16","author":"LJ Tashman","year":"2000","journal-title":"Int. J. Forecast"},{"key":"pone.0255909.ref033","unstructured":"Borges A.\u2019A little flu\u2019: Brazil\u2019s Bolsonaro playing down coronavirus crisis. Euronews. 2020 April 10 [Cited 2021 June 30]. Available from: https:\/\/www.euronews.com\/2020\/04\/06\/a-little-flu-brazil-s-bolsonaro-playing-down-coronavirus-crisis"},{"issue":"5","key":"pone.0255909.ref034","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2666-5247(21)00095-1","article-title":"No end in sight for the Brazilian COVID-19 crisis","volume":"2","author":"T Burki","year":"2021","journal-title":"The Lancet Microbe"},{"key":"pone.0255909.ref035","unstructured":"Reuters Staff. TIMELINE\u2013How the coronavirus spread in Spain. Reuters Healthcare. 2020 April 2 [Cited 2021 June 30]. Available from: https:\/\/www.reuters.com\/article\/health-coronavirus-spain-factbox-idUSL8N2BO4TL"},{"key":"pone.0255909.ref036","unstructured":"Governo do Brasil, Brasil confirms the first case of the novel coronavirus (in brazilian language). Governo do Brasil. 2020 February 26 [Cited 2021 June 30]. Available from: https:\/\/www.gov.br\/pt-br\/noticias\/saude-e-vigilancia-sanitaria\/2020\/02\/brasil-confirma-primeiro-caso-do-novo-coronavirus"},{"key":"pone.0255909.ref037","unstructured":"Paraguassu L. Major Brazilian cities set lockdowns as virus spreads. Reuters World News. 2020 May 5 [Cited 2021 June 30]. Available from: https:\/\/www.reuters.com\/article\/instant-article\/idUKKBN22H2V5"},{"key":"pone.0255909.ref038","unstructured":"EUROEFE with EPA. Spain won\u2019t declare another national state of alarm, allows regions to lockdown if necessary. Euractiv. 2020 Aug 26 [Cited 2021 June 30]. 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Available from: https:\/\/www.nytimes.com\/2021\/02\/28\/opinion\/brazil-covid-vaccines.html"},{"key":"pone.0255909.ref040","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/biom.13188","article-title":"Multivariate hierarchical frameworks for modeling delayed reporting in count data","volume":"76","author":"O Stoner","year":"2020","journal-title":"Biometrics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T18:04:09Z","timestamp":1630605849000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0255909"}},"subtitle":[],"editor":[{"given":"Chi-Hua","family":"Chen","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0255909","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2021,9,2]]}}}