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Thus, the impact of different stressful experiences needs to be explored. This study aims to examine if the association between being victimized (adverse childhood experiences\u2014ACEs and bullying) and (hs-) C-Reactive Protein (CRP) is explained by the influence of adversity on the body mass index (BMI) of the child. We included children from the Portuguese birth cohort Generation XXI (n = 3712) that at 10 years of age completed a questionnaire on the exposure to ACEs and bullying victimization, assessed by an adaptation from the original ACEs study and an adaptation of The Bully Scale Survey, respectively. Following an overnight fast, a venous blood sample was collected by trained nurses and hs-CRP was assayed in fresh blood samples. Weight and height were measured with the child in underwear and bare feet. Weight was measured to the nearest one-tenth of a kilogram with the use of a digital scale (Tanita), and height was measured to the nearest one-tenth of a centimetre with the use of a wall stadiometer (seca\u00ae). BMI was calculated as the value of weight (kg) over squared height (m), and computed as an age- and sex-specific BMI standard deviation (SD) score (z-score), according to the World Health Organization Child Growth Standards (5\u201319 years). Regression coefficients and respective 95% Confidence Interval [\u03b2(95%CI)] were computed using path analysis. We observed that ACEs had a positive total effect on hs-CRP at the age of 10 years (\u03b2 = 0.06; 95%CI: -0.02; 0.15). A direct effect (\u03b2 = 0.02; 95%CI: -0.01; 0.06) accounted for 66.1% of the association between ACEs and hs-CRP. A positive total effect of bullying victimization on hs-CRP (\u03b2 = 0.20; 95%CI: 0.06; 0.34) was observed. A direct effect (\u03b2 = 0.08; 95%CI: -0.05; 0.21) accounted for 40.0% of the association, while an indirect effect through BMI (\u03b2 = 0.12; 95%CI: 0.06; 0.18) explained 60.0% of the pathway between bullying victimization and hs-CRP. Results suggest that there might be different mechanisms involved in the biological embedding of childhood experiences. BMI seems to explain a great part of the association between exposure to bullying victimization and hs-CRP at 10 years of age. Further research is still needed to better understand the mechanisms explaining the emergence and persistence of health poorer outcomes later in life for victims of abuse.<\/jats:p>","DOI":"10.1371\/journal.pone.0273329","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T17:28:37Z","timestamp":1660930117000},"page":"e0273329","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adverse childhood experiences, bullying, inflammation and BMI in 10-year-old children: The biological embodiment"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-0519","authenticated-orcid":true,"given":"Sara","family":"Soares","sequence":"first","affiliation":[]},{"given":"Ana Cristina","family":"Santos","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Fraga","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"issue":"4","key":"pone.0273329.ref001","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. 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