{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:48:30Z","timestamp":1775911710904,"version":"3.50.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04750\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00617\/2020"],"award-info":[{"award-number":["UIDP\/00617\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SGITR2023\/EPIUnit"],"award-info":[{"award-number":["SGITR2023\/EPIUnit"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["10.54499\/2021.01096.CEECIND\/CP1686\/CT0001"],"award-info":[{"award-number":["10.54499\/2021.01096.CEECIND\/CP1686\/CT0001"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Despite the potential effectiveness of bariatric surgery in promoting weight loss, a considerable proportion of patients still face the challenge of achieving optimal post-surgery outcomes. The timing of eating, in addition to the content of what is eaten, as well as chronotype and social jetlag (a marker of circadian misalignment), have been implicated in weight regulation. However, the current understanding of these chrono-related behaviours in individuals undergoing bariatric surgery is still scarce. Thus, this study aims to evaluate the role of chrono-nutrition, chronotype, and circadian misalignment in the weight-loss trajectory among individuals living with severe obesity who underwent bariatric surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The ChronoWise project is a prospective single-centre cohort study designed to follow patients experiencing bariatric surgery at the Santo Ant\u00f3nio Local Health Unit (ULSSA), Porto, Portugal. Participants will be recruited and evaluated at pre-surgery and followed-up over 3 and 6 months after surgery. The baseline evaluation will be conducted face-to-face during the hospital stay and by telephone or video call on the subsequent evaluations, following standard procedures. Data collection includes sociodemographics, food intake, chrono-nutrition behaviours, sleep time behaviour, sleep quality, screen time, physical activity and exercise behaviours, anthropometric measurements, and biochemical parameters. The \u2018Munich Chronotype Questionnaire\u2019 will be used to assess chronotype and social jet lag. Chrono-nutrition dimensions will be measured by the \u2018Chrononutrition Profile\u2014Questionnaire\u2019 in all evaluations. Weight and height will be self-reported and retrieved from medical registries. trajectories of weight-loss will be obtained.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>This study will add important evidence on the role of chrono-nutrition, chronotype and social jetlag profile in weight-loss outcomes after bariatric surgery. Identifying novel approaches to change the paradigm of post-surgical weight management towards a tailored treatment aligned with circadian rhythm may be useful to strengthen the existing treatments and improve patients\u2019 response to bariatric surgery.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0313096","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:34:38Z","timestamp":1731090878000},"page":"e0313096","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Weight loss in patients with severe obesity after bariatric surgery\u2013the potential role of the chrono-nutrition, chronotype and the circadian misalignment: A study protocol of the ChronoWise prospective cohort"],"prefix":"10.1371","volume":"19","author":[{"given":"Joana","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"V\u00e2nia","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-9841","authenticated-orcid":true,"given":"Maria Paula","family":"Santos","sequence":"additional","affiliation":[]},{"given":"C\u00e1tia","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Pichel","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-0140","authenticated-orcid":true,"given":"Sofia","family":"Vilela","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"pone.0313096.ref001","doi-asserted-by":"crossref","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","article-title":"A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on","volume":"133","author":"C Boutari","year":"2022","journal-title":"Metabolism"},{"issue":"10159","key":"pone.0313096.ref002","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"pone.0313096.ref003","volume-title":"WHO European regional obesity report 2022: World Health Organization","author":"World Health Organization","year":"2022"},{"issue":"1","key":"pone.0313096.ref004","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1186\/s12889-018-5480-z","article-title":"Prevalence of general and abdominal obesity in Portugal: comprehensive results from the National Food, nutrition and physical activity survey 2015\u20132016","volume":"18","author":"A Oliveira","year":"2018","journal-title":"BMC Public Health"},{"key":"pone.0313096.ref005","doi-asserted-by":"crossref","first-page":"104754","DOI":"10.1016\/j.compbiomed.2021.104754","article-title":"A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity","volume":"136","author":"M Safaei","year":"2021","journal-title":"Comput Biol Med"},{"issue":"2","key":"pone.0313096.ref006","article-title":"Obesity: Treatments, Conceptualizations, and Future Directions for a Growing Problem","volume":"11","author":"JS Baker","year":"2022","journal-title":"Biology (Basel)"},{"issue":"3","key":"pone.0313096.ref007","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/joim.12012","article-title":"Review of the key results from the Swedish Obese Subjects (SOS) trial\u2014a prospective controlled intervention study of bariatric surgery","volume":"273","author":"L. 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