{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:30:25Z","timestamp":1742358625564,"version":"3.40.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"crossref","award":["AES, ICI20 \/ 00146"],"award-info":[{"award-number":["AES, ICI20 \/ 00146"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scholarships for Research Stay","award":["ISABIAL, Alicante, 2022"],"award-info":[{"award-number":["ISABIAL, Alicante, 2022"]}]},{"name":"Senior Grants","award":["Official College of Physicians of the Province of Alicante, COMA, 2002"],"award-info":[{"award-number":["Official College of Physicians of the Province of Alicante, COMA, 2002"]}]},{"name":"Spanish Ministry of Health","award":["2022 Communication Award during the VXIII National Spanish Pain Society Congress Valencia, Spain); the MORPHEO 2024-01 National Drug Plan Budget"],"award-info":[{"award-number":["2022 Communication Award during the VXIII National Spanish Pain Society Congress Valencia, Spain); the MORPHEO 2024-01 National Drug Plan Budget"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Existing evidence indicates sex-related differences in Prescription Opioid Use Disorder (OUD) in Chronic Non-Cancer Pain (CNCP). However to date, there is scant evidence for other socioeconomic factors in these differences. Our aim was to enquire about the influence of gender and drug copayment of OUD narratives by the text mining analysis. A prospective mixed-methods study was designed and performed at Pain Unit (PU) including 238 real world patients with CNCP divided in controls (n\u2009=\u2009206) and OUD cases (n\u2009=\u200932) due to DSM-5 diagnosis Variables related to pain, sleep, mental and health status were collected in together with sex and gender interaction, in pain status, along 30-45\u2009min face-to-face interviews. Sex differences were observed due to women\u2019s significantly older ages, with a stronger impact on mental health, and an even stronger one for the OUD women. Globally, OUD cases were more unemployed vs the CNCP controls, and on a significantly higher median opioid daily dose of 90 [100] mg\/day. Although OUD participants did more social activities, they tended to use less vocabulary to express themselves regardless of their sex, gender role or economic status. In contrast, the CNCP participants presented more differences driven by their incomes, with \u201climited\u201d being the most discriminating word for those on low income, followed by \u201cless\u201d and \u201chelp\u201d. Here, the most significant word of CNCP women was \u201chusband\u201d, followed by \u201ctasks\u201d. In contrast, gender reproductive roles shared similarities in both sexes, being one of the most discriminatory words \u201chelp\u201d. The data show that OUD patients seem to have a marked influence of OUD on poorer lexicon and simpler narrative, together with a significant impact of socioeconomic factors on the CNCP narratives. The conclusion suggests to extend the research to better understand the effect of sex, gender and socioeconomic status in CNCP especially on OUD women\u2019s health.<\/jats:p>","DOI":"10.1371\/journal.pone.0319574","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T17:22:37Z","timestamp":1742318557000},"page":"e0319574","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender 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