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Pacanowski","year":"2001","journal-title":"Blood"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/aid.1992.8.199","article-title":"Interferons in the persistence, pathogenesis, and treatment of HIV infection.","volume":"8","author":"ML Francis","year":"1992","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nm1511","article-title":"Microbial translocation is a cause of systemic immune activation in chronic HIV infection.","volume":"12","author":"JM Brenchley","year":"2006","journal-title":"Nat Med"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1073\/pnas.0600363103","article-title":"Differential expression of IFN-alpha and TRAIL\/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.","volume":"103","author":"JP Herbeuval","year":"2006","journal-title":"Proc Natl Acad Sci U S 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Boasso","year":"2007","journal-title":"Blood"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1172\/JCI34823","article-title":"HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.","volume":"118","author":"O Manches","year":"2008","journal-title":"J Clin Invest"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1172\/JCI26032","article-title":"Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.","volume":"115","author":"AS Beignon","year":"2005","journal-title":"J Clin Invest"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1073\/pnas.0611353104","article-title":"HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.","volume":"104","author":"E Martinelli","year":"2007","journal-title":"Proc Natl Acad Sci U S 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