{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:34:36Z","timestamp":1770503676327,"version":"3.49.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T00:00:00Z","timestamp":1274313600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1000916","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T19:05:58Z","timestamp":1274382358000},"page":"e1000916","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":83,"title":["VEGF Promotes Malaria-Associated Acute Lung Injury in Mice"],"prefix":"10.1371","volume":"6","author":[{"given":"Sabrina","family":"Epiphanio","sequence":"first","affiliation":[]},{"given":"Marta G.","family":"Campos","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Pamplona","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Carapau","sequence":"additional","affiliation":[]},{"given":"Ana C.","family":"Pena","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Ata\u00edde","sequence":"additional","affiliation":[]},{"given":"Carla A. A.","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"F\u00e9lix","sequence":"additional","affiliation":[]},{"given":"Artur","family":"Costa-Silva","sequence":"additional","affiliation":[]},{"given":"Claudio R. F.","family":"Marinho","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Maria M.","family":"Mota","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2010,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.pathol.2.010506.091913","article-title":"Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease.","volume":"2","author":"K Haldar","year":"2007","journal-title":"Annu Rev Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro1529","article-title":"The silent path to thousands of merozoites: the Plasmodium liver stage.","volume":"4","author":"M Prudencio","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref3","first-page":"179","article-title":"Acute lung injury and acute respiratory distress syndrome in malaria.","volume":"45","author":"A Mohan","year":"2008","journal-title":"J Vector Borne Dis"},{"key":"ref4","first-page":"47","article-title":"The relevance of host genes in malaria.","volume":"58","author":"M Prudencio","year":"2007","journal-title":"SEB Exp Biol Ser"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.biocel.2008.09.020","article-title":"Cerebral malaria and the hemolysis\/methemoglobin\/heme hypothesis: shedding new light on an old disease.","volume":"41","author":"A Pamplona","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406010581","article-title":"Insights into the immunopathogenesis of malaria using mouse models.","volume":"8","author":"TJ Lamb","year":"2006","journal-title":"Expert Rev Mol Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri1686","article-title":"Immunological processes in malaria pathogenesis.","volume":"5","author":"L Schofield","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1631\/jzus.2007.B0060","article-title":"Acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS): the mechanism, present strategies and future perspectives of therapies.","volume":"8","author":"SP Luh","year":"2007","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jcb.240470306","article-title":"Vascular permeability factor: a unique regulator of blood vessel function.","volume":"47","author":"DT Connolly","year":"1991","journal-title":"J Cell Biochem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1165\/ajrcmb.22.6.3779","article-title":"Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema.","volume":"22","author":"RJ Kaner","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1164\/ajrccm.164.9.2011071","article-title":"Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome.","volume":"164","author":"DR Thickett","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","first-page":"5421","article-title":"Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.","volume":"57","author":"B Barleon","year":"1997","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nm0398-336","article-title":"Vascular endothelial growth factor is essential for corpus luteum angiogenesis.","volume":"4","author":"N Ferrara","year":"1998","journal-title":"Nat Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8795","DOI":"10.1073\/pnas.95.15.8795","article-title":"Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate.","volume":"95","author":"CK Goldman","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1074\/jbc.271.13.7788","article-title":"The carboxyl-terminal domain (111\u2013165) of vascular endothelial growth factor is critical for its mitogenic potency.","volume":"271","author":"BA Keyt","year":"1996","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/CMR.17.3.509-539.2004","article-title":"Pathogenesis of malaria and clinically similar conditions.","volume":"17","author":"IA Clark","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2217\/17460913.2.4.361","article-title":"Severe malaria increases the list of heme oxygenase-1-protected diseases.","volume":"2","author":"A Pamplona","year":"2007","journal-title":"Future Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm1586","article-title":"Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.","volume":"13","author":"A Pamplona","year":"2007","journal-title":"Nat Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1513\/pats.200503-023AC","article-title":"Cytoprotection of heme oxygenase-1\/carbon monoxide in lung injury.","volume":"2","author":"Y Jin","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrg2126","article-title":"Genetic linkage and association analyses for trait mapping in Plasmodium falciparum.","volume":"8","author":"X Su","year":"2007","journal-title":"Nat Rev Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1128\/IAI.66.9.4080-4086.1998","article-title":"Acute Plasmodium chabaudi chabaudi malaria infection induces antibodies which bind to the surfaces of parasitized erythrocytes and promote their phagocytosis by macrophages in vitro.","volume":"66","author":"MM Mota","year":"1998","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1182\/blood-2006-09-018069","article-title":"Malarial anemia: of mice and men.","volume":"110","author":"AA Lamikanra","year":"2007","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1608","DOI":"10.1371\/journal.pone.0001608","article-title":"Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women.","volume":"3","author":"R Neres","year":"2008","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1086\/498579","article-title":"Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice.","volume":"193","author":"NF Delahaye","year":"2006","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0031182000074072","article-title":"Pathology of fatal and resolving Plasmodium berghei cerebral malaria in mice.","volume":"105 (Pt 2)","author":"AL Neill","year":"1992","journal-title":"Parasitology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2169\/internalmedicine.46.0401","article-title":"Noninvasive ventilation in Plasmodium vivax related ALI\/ARDS.","volume":"46","author":"R Agarwal","year":"2007","journal-title":"Intern Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00365540600904787","article-title":"P. vivax malaria complicated by shock and ARDS.","volume":"39","author":"S Kumar","year":"2007","journal-title":"Scand J Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1590\/S1413-86702005000500011","article-title":"Acute respiratory distress syndrome due to vivax malaria: case report and literature review.","volume":"9","author":"AV Lomar","year":"2005","journal-title":"Braz J Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.trstmh.2007.02.014","article-title":"Acute respiratory distress syndrome in Plasmodium vivax malaria: case report and review of the literature.","volume":"101","author":"L Price","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1086\/598667","article-title":"Acute pulmonary edema complicating ovale malaria.","volume":"29","author":"EY Lee","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ref31","first-page":"3004","article-title":"[P. falciparum and P. malariae malaria complicated by pulmonary edema with disseminated intravascular coagulation].","volume":"12","author":"F Lozano","year":"1983","journal-title":"Presse Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2165\/00151829-200605060-00007","article-title":"Pulmonary manifestations of malaria: recognition and management.","volume":"5","author":"WR Taylor","year":"2006","journal-title":"Treat Respir Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0272-5231(02)00004-7","article-title":"Malaria and the lung.","volume":"23","author":"WR Taylor","year":"2002","journal-title":"Clin Chest Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/00034983.1985.11811899","article-title":"Pulmonary damage associated with falciparum malaria: a report of ten cases.","volume":"79","author":"MF James","year":"1985","journal-title":"Ann Trop Med Parasitol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1164\/arrd.1972.106.1.23","article-title":"Pulmonary function studies in Plasmodium falciparum malaria.","volume":"106","author":"MJ Tong","year":"1972","journal-title":"Am Rev Respir Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e1000068","DOI":"10.1371\/journal.ppat.1000068","article-title":"Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.","volume":"4","author":"FE Lovegrove","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0002-9440(10)61744-0","article-title":"Role of CD40-CVD40L in mouse severe malaria.","volume":"159","author":"PF Piguet","year":"2001","journal-title":"Am J Pathol"},{"key":"ref38","first-page":"101","article-title":"Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.","volume":"7","author":"Y Shaked","year":"2005","journal-title":"Cancer Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-4894(83)90105-4","article-title":"Plasmodium berghei: a mouse model for the \u201csudden death\u201d and \u201cmalarial lung\u201d syndromes.","volume":"56","author":"ML Weiss","year":"1983","journal-title":"Exp Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.","volume":"219","author":"DR Senger","year":"1983","journal-title":"Science"},{"key":"ref41","first-page":"3364","article-title":"Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions.","volume":"5","author":"BK Zebrowski","year":"1999","journal-title":"Clin Cancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1465-9921-7-128","article-title":"Clinical implications for vascular endothelial growth factor in the lung: friend or foe?","volume":"7","author":"AI Papaioannou","year":"2006","journal-title":"Respir Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1099\/mic.0.2006\/002261-0","article-title":"Defect in early lung defence against Pseudomonas aeruginosa in DBA\/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naive macrophages.","volume":"153","author":"KR Wilson","year":"2007","journal-title":"Microbiology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.4049\/jimmunol.172.7.4618","article-title":"Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization.","volume":"172","author":"F Mor","year":"2004","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1475-2875-6-147","article-title":"Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children.","volume":"6","author":"HB Armah","year":"2007","journal-title":"Malar J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1475-2875-7-83","article-title":"Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India.","volume":"7","author":"V Jain","year":"2008","journal-title":"Malar J"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"17097","DOI":"10.1073\/pnas.0805782105","article-title":"Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria.","volume":"105","author":"TW Yeo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4269\/ajtmh.2010.09-0203","article-title":"Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria.","volume":"82","author":"T Furuta","journal-title":"Am J Trop Med Hyg"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e446","DOI":"10.1371\/journal.pmed.0030446","article-title":"Hypertension and maternal-fetal conflict during placental malaria.","volume":"3","author":"A Muehlenbachs","year":"2006","journal-title":"PLoS Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1164\/ajrccm.156.3.9606031","article-title":"Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.","volume":"156","author":"E Hamelmann","year":"1997","journal-title":"Am J Respir Crit Care Med"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1000916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T22:08:34Z","timestamp":1591308514000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1000916"}},"subtitle":[],"editor":[{"given":"Mary M.","family":"Stevenson","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2010,5,20]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1000916","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,20]]}}}