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London: Taylor and Francis. pp.404\u2013414."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0014-5793(99)00519-0","article-title":"The vacuolar Ca<sup>2+<\/sup>\/H<sup>+<\/sup> exchanger Vcx1p\/Hum1p tightly controls cytosolic Ca<sup>2+<\/sup> levels in <italic>S. cerevisiae<\/italic>","volume":"451","author":"A Miseta","year":"1999","journal-title":"FEBS Lett"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1105\/tpc.007385","article-title":"The <italic>Arabidopsis cax1<\/italic> mutant exhibits impaired ion homeostasis, development, and hormonal responses and reveals interplay among vacuolar transporters","volume":"15","author":"NH Cheng","year":"2003","journal-title":"Plant Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(04)00449-0","article-title":"Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite","volume":"117","author":"O Billker","year":"2004","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1365-2958.2005.05014.x","article-title":"A calcium-dependent protein kinase regulates <italic>Plasmodium<\/italic> ookinete access to the midgut epithelial cell","volume":"59","author":"T Ishino","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1365-2958.2006.05189.x","article-title":"<italic>Plasmodium berghei<\/italic> calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion","volume":"60","author":"I Siden-Kiamos","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1017\/S0031182008004939","article-title":"Intracellular calcium levels in the <italic>Plasmodium berghei<\/italic> ookinete","volume":"135","author":"I Siden-Kiamos","year":"2008","journal-title":"Parasitology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"14085","DOI":"10.1074\/jbc.M107903200","article-title":"Inhibition of Ca<sup>2+<\/sup>\/calmodulin-dependent protein kinase blocks morphological differentiation of <italic>Plasmodium gallinaceum<\/italic> zygotes to ookinetes","volume":"277","author":"MA Silva-Neto","year":"2002","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1074\/jbc.M309084200","article-title":"The protein kinase SOS2 activates the <italic>Arabidopsis<\/italic> H<sup>+<\/sup>\/Ca<sup>2+<\/sup> antiporter CAX1 to integrate calcium transport and salt tolerance","volume":"279","author":"NH Cheng","year":"2004","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0166-6851(99)00010-9","article-title":"Characterization of protein Ser\/Thr phosphatases of the malaria parasite, <italic>Plasmodium falciparum<\/italic>: inhibition of the parasitic calcineurin by cyclophilin-cyclosporin complex","volume":"99","author":"S Dobson","year":"1999","journal-title":"Mol Biochem Parasitol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbiopara.2005.01.012","article-title":"<italic>Plasmodium falciparum<\/italic> calcineurin and its association with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin","volume":"141","author":"R Kumar","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e1000406","DOI":"10.1371\/journal.pmed.1000406","article-title":"A research agenda to underpin malaria eradication","volume":"8","author":"PL Alonso","year":"2011","journal-title":"PLoS Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2007.13","article-title":"High-efficiency yeast transformation using the LiAc\/SS carrier DNA\/PEG method","volume":"2","author":"RD Gietz","year":"2007","journal-title":"Nat Protoc"},{"key":"ref51","unstructured":"Collart MA, Oliviero S (2006) Preparation of yeast RNA by extraction with hot acidic phenol. 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