{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:46:30Z","timestamp":1775742390639,"version":"3.50.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1003802","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T20:51:14Z","timestamp":1386881474000},"page":"e1003802","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages"],"prefix":"10.1371","volume":"9","author":[{"given":"Migla","family":"Miskinyte","sequence":"first","affiliation":[]},{"given":"Ana","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Ricardo S.","family":"Ramiro","sequence":"additional","affiliation":[]},{"given":"Jorge A. Moura","family":"de Sousa","sequence":"additional","affiliation":[]},{"given":"Jerzy","family":"Kotlinowski","sequence":"additional","affiliation":[]},{"given":"Iris","family":"Caramalho","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Miguel P.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Gordo","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrg1088","article-title":"Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation","volume":"4","author":"SF Elena","year":"2003","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.1142284","article-title":"Adaptive mutations in bacteria: high rate and small effects","volume":"317","author":"L Perfeito","year":"2007","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1098\/rstb.2009.0290","article-title":"Beneficial mutations and the dynamics of adaptation in asexual populations","volume":"365","author":"PD Sniegowski","year":"2010","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1128\/JB.01035-07","article-title":"Reforming L forms: they need part of a wall after all?","volume":"189","author":"KD Young","year":"2007","journal-title":"J Bacteriol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/bies.201000071","article-title":"The phage-host arms race: shaping the evolution of microbes","volume":"33","author":"A Stern","year":"2011","journal-title":"Bioessays"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.tim.2005.05.009","article-title":"Off the hook\u2013how bacteria survive protozoan grazing","volume":"13","author":"C Matz","year":"2005","journal-title":"Trends Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nature08798","article-title":"Antagonistic coevolution accelerates molecular evolution","volume":"464","author":"S Paterson","year":"2010","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nature01164","article-title":"The role of parasites in sympatric and allopatric host diversification","volume":"420","author":"A Buckling","year":"2002","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nature05599","article-title":"The effects of competition and predation on diversification in a model adaptive radiation","volume":"446","author":"JR Meyer","year":"2007","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrmicro2298","article-title":"The population genetics of commensal Escherichia coli","volume":"8","author":"O Tenaillon","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1128\/JB.00710-10","article-title":"A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407","volume":"192","author":"LC Crossman","year":"2010","journal-title":"J Bacteriol"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Denamur E, Picard B. and Tenaillon O. (2010) Population Genetics of Pathogenic Escherichia coli. In: D. ARobinson DF, E. JFeil, editor. Bacterial Population Genetics in Infectious Disease Hoboken, NJUSA: John Wiley & Sons, Inc.","DOI":"10.1002\/9780470600122.ch14"},{"key":"ref13","first-page":"182","article-title":"Escherichia coli pyomyositis in an immunocompromised host","volume":"110","author":"U Sharma","year":"2011","journal-title":"WMJ"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E49","DOI":"10.1111\/tid.12046","article-title":"Fatal Escherichia coli skin and soft tissue infections in liver transplant recipients: report of three cases","volume":"15","author":"S Janny","year":"2012","journal-title":"Transpl Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/MD.0b013e31819dd0cf","article-title":"Recurrent Escherichia coli bloodstream infections: epidemiology and risk factors","volume":"88","author":"M Sanz-Garcia","year":"2009","journal-title":"Medicine (Baltimore)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"AW Thomas","year":"2013","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tree.2008.02.011","article-title":"Parasite immune evasion: a momentous molecular war","volume":"23","author":"P Schmid-Hempel","year":"2008","journal-title":"Trends Ecol Evol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1369-5274(02)00286-2","article-title":"A phagosome of one's own: a microbial guide to life in the macrophage","volume":"5","author":"AO Amer","year":"2002","journal-title":"Curr Opin Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev.micro.112408.134258","article-title":"Intracellular lifestyles and immune evasion strategies of uropathogenic Escherichia coli","volume":"64","author":"DA Hunstad","year":"2010","journal-title":"Annu Rev Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrmicro1384","article-title":"Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections","volume":"4","author":"RA Proctor","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/JCM.36.9.2530-2534.1998","article-title":"Chronic prosthetic hip infection caused by a small-colony variant of Escherichia coli","volume":"36","author":"A Roggenkamp","year":"1998","journal-title":"J Clin Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/MMBR.60.3.539-574.1996","article-title":"Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia","volume":"60","author":"JR Govan","year":"1996","journal-title":"Microbiol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.clinmicnews.2010.05.001","article-title":"Hypermucoviscous Phenotype Expressed by an Isolate of Uropathogenic Escherichia coli: an Overlooked and Underappreciated Virulence Factor","volume":"32","author":"EJ Bottone","year":"2010","journal-title":"Clin Microbiol Newslett"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.micro.59.050405.101230","article-title":"The Rcs phosphorelay: a complex signal transduction system","volume":"59","author":"N Majdalani","year":"2005","journal-title":"Annu Rev Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/j.1365-2958.1991.tb01906.x","article-title":"Regulation of capsular polysaccharide synthesis in Escherichia coli K12","volume":"5","author":"S Gottesman","year":"1991","journal-title":"Mol Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/j.1365-2958.2004.04213.x","article-title":"Repression of the RcsC-YojN-RcsB phosphorelay by the IgaA protein is a requisite for Salmonella virulence","volume":"53","author":"G Dominguez-Bernal","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biocel.2009.07.009","article-title":"Modulation of cellular function by polyamines","volume":"42","author":"K Igarashi","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1261\/rna.1592509","article-title":"Distinct functions of elongation factor G in ribosome recycling and translocation","volume":"15","author":"A Savelsbergh","year":"2009","journal-title":"RNA"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrmicro2319","article-title":"Antibiotic resistance and its cost: is it possible to reverse resistance?","volume":"8","author":"DI Andersson","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1128\/AAC.00871-08","article-title":"Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus","volume":"53","author":"J Lannergard","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1128\/JB.183.23.6943-6946.2001","article-title":"IS186 insertion at a hot spot in the lon promoter as a basis for lon protease deficiency of Escherichia coli B: identification of a consensus target sequence for IS186 transposition","volume":"183","author":"L saiSree","year":"2001","journal-title":"J Bacteriol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/jb.169.3.981-989.1987","article-title":"Capsule synthesis in Escherichia coli K-12 is regulated by proteolysis","volume":"169","author":"AS Torres-Cabassa","year":"1987","journal-title":"J Bacteriol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/AAC.01128-06","article-title":"Increased genome instability in Escherichia coli lon mutants: relation to emergence of multiple-antibiotic-resistant (Mar) mutants caused by insertion sequence elements and large tandem genomic amplifications","volume":"51","author":"H Nicoloff","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1073\/pnas.87.11.4048","article-title":"Role of instability in the cis action of the insertion sequence IS903 transposase","volume":"87","author":"KM Derbyshire","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1128\/JB.186.7.2091-2098.2004","article-title":"Protective role for H-NS protein in IS1 transposition","volume":"186","author":"C Rouquette","year":"2004","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1016\/S0021-9258(18)37843-8","article-title":"Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La","volume":"263","author":"DT Chin","year":"1988","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/JB.01519-08","article-title":"Regulation of igaA and the Rcs system by the MviA response regulator in Salmonella enterica","volume":"191","author":"CB Garcia-Calderon","year":"2009","journal-title":"J Bacteriol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0966-842X(99)01493-6","article-title":"Pathoadaptive mutations: gene loss and variation in bacterial pathogens","volume":"7","author":"EV Sokurenko","year":"1999","journal-title":"Trends Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1128\/jb.179.15.4706-4712.1997","article-title":"A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly","volume":"179","author":"C von Eiff","year":"1997","journal-title":"J Bacteriol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/IAI.66.1.280-288.1998","article-title":"Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge","volume":"66","author":"H Yu","year":"1998","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/jcm.7.5.474-478.1978","article-title":"Catalase-negative Escherichia coli isolated from blood","volume":"7","author":"H Funada","year":"1978","journal-title":"J Clin Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10096-005-0072-0","article-title":"First case of febrile bacteremia due to a wild type and small-colony variant of Escherichia coli","volume":"25","author":"D Tappe","year":"2006","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1128\/AAC.46.8.2498-2506.2002","article-title":"Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones","volume":"46","author":"XS Pan","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1128\/AAC.01395-07","article-title":"The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates","volume":"52","author":"S Besier","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/ismej.2011.174","article-title":"Co-evolution with lytic phage selects for the mucoid phenotype of Pseudomonas fluorescens SBW25","volume":"6","author":"PD Scanlan","year":"2012","journal-title":"ISME J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/AEM.69.1.170-176.2003","article-title":"Coevolution of bacteriophage PP01 and Escherichia coli O157:H7 in continuous culture","volume":"69","author":"K Mizoguchi","year":"2003","journal-title":"Appl Environ Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1286-4579(03)00049-2","article-title":"Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem","volume":"5","author":"TA Russo","year":"2003","journal-title":"Microbes Infect"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/gut.45.2.223","article-title":"Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity","volume":"45","author":"J MacFie","year":"1999","journal-title":"Gut"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1099\/mic.0.2007\/015891-0","article-title":"Instability of the Salmonella RcsCDB signalling system in the absence of the attenuator IgaA","volume":"154","author":"JF Mariscotti","year":"2008","journal-title":"Microbiology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1046\/j.1365-2958.2003.03815.x","article-title":"The RcsC sensor kinase is required for normal biofilm formation in Escherichia coli K-12 and controls the expression of a regulon in response to growth on a solid surface","volume":"50","author":"L Ferrieres","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.resmic.2005.11.005","article-title":"The role of the Rcs phosphorelay in Enterobacteriaceae","volume":"157","author":"YH Huang","year":"2006","journal-title":"Res Microbiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0076-6879(07)23016-2","article-title":"Genetic dissection of signaling through the Rcs phosphorelay","volume":"423","author":"N Majdalani","year":"2007","journal-title":"Methods Enzymol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1099\/mic.0.27913-0","article-title":"Escherichia coli tol and rcs genes participate in the complex network affecting curli synthesis","volume":"151","author":"A Vianney","year":"2005","journal-title":"Microbiology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1128\/JB.184.10.2850-2853.2002","article-title":"The RcsCB His-Asp phosphorelay system is essential to overcome chlorpromazine-induced stress in Escherichia coli","volume":"184","author":"A Conter","year":"2002","journal-title":"J Bacteriol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1365-2958.2006.05420.x","article-title":"The Rcs phosphorelay system is specific to enteric pathogens\/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice","volume":"62","author":"KD Erickson","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1128\/AAC.48.3.890-896.2004","article-title":"Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile","volume":"48","author":"N Kaldalu","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0378-1097(03)00616-5","article-title":"beta-Lactam induction of colanic acid gene expression in Escherichia coli","volume":"226","author":"FC Sailer","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/genetics\/162.4.1513","article-title":"Regulation of capsule synthesis and cell motility in Salmonella enterica by the essential gene igaA","volume":"162","author":"DA Cano","year":"2002","journal-title":"Genetics"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/AAC.01632-12","article-title":"Increased survival of antibiotic-resistant Escherichia coli inside macrophages","volume":"57","author":"M Miskinyte","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2958.2008.06126.x","article-title":"A multifaceted role for polyamines in bacterial pathogens","volume":"68","author":"P Shah","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.15739260","article-title":"The significance of responses of the genome to challenge","volume":"226","author":"B McClintock","year":"1984","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"R Medzhitov","year":"2012","journal-title":"Science"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1126\/science.1122469","article-title":"An equivalence principle for the incorporation of favorable mutations in asexual populations","volume":"311","author":"M Hegreness","year":"2006","journal-title":"Science"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2249.2002.01866.x","article-title":"CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7)","volume":"128","author":"P Utaisincharoen","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1128\/JVI.74.23.11067-11072.2000","article-title":"Estimating relative fitness in viral competition experiments","volume":"74","author":"AF Maree","year":"2000","journal-title":"J Virol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/IAI.69.9.5529-5537.2001","article-title":"Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death","volume":"69","author":"AL Glasser","year":"2001","journal-title":"Infect Immun"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Strober W (2001) Trypan blue exclusion test of cell viability. Curr Protoc Immunol Appendix 3: Appendix 3B.","DOI":"10.1002\/0471142735.ima03bs21"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jmb.2006.12.048","article-title":"Influence of tyrosine-kinase Wzc activity on colanic acid production in Escherichia coli K12 cells","volume":"367","author":"B Obadia","year":"2007","journal-title":"J Mol Biol"},{"key":"ref69","first-page":"Unit 2 4","article-title":"Preparation of genomic DNA from bacteria","volume":"Chapter 2","author":"K Wilson","year":"2001","journal-title":"Curr Protoc Mol Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/nature08480","article-title":"Genome evolution and adaptation in a long-term experiment with Escherichia coli","volume":"461","author":"JE Barrick","year":"2009","journal-title":"Nature"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1101\/gr.194201","article-title":"SSAHA: a fast search method for large DNA databases","volume":"11","author":"Z Ning","year":"2001","journal-title":"Genome Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/etc.5620150325","article-title":"Modeling dose response using generalized linear models","volume":"15","author":"DR Kerr","year":"1996","journal-title":"Environmental Toxicology and Chemistry"}],"container-title":["PLoS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1003802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T12:47:27Z","timestamp":1647694047000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1003802"}},"subtitle":[],"editor":[{"given":"Denise M.","family":"Monack","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,12,12]]},"references-count":72,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1003802","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718209833.793494517","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,12]]}}}