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Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1128\/JVI.74.1.505-512.2000","article-title":"Canine adenovirus vectors: an alternative for adenovirus mediated gene transfer","volume":"74","author":"EJ Kremer","year":"2000","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1128\/JVI.02321-10","article-title":"Functional genetic and biophysical analyses of membrane disruption by human adenovirus","volume":"85","author":"CL Moyer","year":"2011","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1128\/JVI.02257-14","article-title":"The amphipathic helix of adenovirus capsid protein VI contributes to penton release and postentry sorting","volume":"89","author":"R Martinez","year":"2015","journal-title":"J Virol"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1021\/acsnano.5b03020","article-title":"Fluorescence tracking of genome release during the mechanical unpacking of single viruses","volume":"9","author":"A Ortega-Esteban","year":"2015","journal-title":"ACS Nano"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.3390\/v6114536","article-title":"Structure, function and dynamics in adenovirus maturation","volume":"6","author":"WF Mangel","year":"2014","journal-title":"Viruses"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1128\/JVI.74.22.10639-10649.2000","article-title":"Canine adenovirus type 2 attachment and receptor, alternative receptors, and an RGD-independent pathway","volume":"74","author":"C Soudais","year":"2000","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.1300530","article-title":"Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation","volume":"191","author":"JJ Kaminski","year":"2013","journal-title":"J 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Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09337","article-title":"A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells","volume":"467","author":"N Manel","year":"2010","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/1743-422X-9-265","article-title":"Evaluation of nanoparticle tracking analysis for total virus particle determination","volume":"9","author":"P Kramberger","year":"2012","journal-title":"Virol J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1038\/srep05237","article-title":"Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry","volume":"4","author":"SE Headland","year":"2014","journal-title":"Sci Rep"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e1000442","DOI":"10.1371\/journal.ppat.1000442","article-title":"CAR-associated vesicular transport of an adenovirus in motor neuron axons","volume":"5","author":"S Salinas","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"JM Bergelson","year":"1997","journal-title":"Science"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/bs.ircmb.2015.10.006","article-title":"Membrane dynamics and signaling of coxsackievirus and adenovirus receptor","volume":"322","author":"F Loustalot","year":"2015","journal-title":"Int Rev Cell Mol 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levels of lysosomal proteolysis as compared to other human dendritic cell populations","volume":"5","author":"N McCurley","year":"2010","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1073\/pnas.1203912109","article-title":"Autonomous phagosomal degradation and antigen presentation in dendritic cells","volume":"109","author":"E Hoffmann","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"10366","DOI":"10.1128\/JVI.77.19.10366-10375.2003","article-title":"Identification of adenovirus (Ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative ad (Addl1520) for treatment of liver tumors","volume":"77","author":"SS Hong","year":"2003","journal-title":"J Virol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1128\/JVI.78.22.12320-12332.2004","article-title":"Postentry neutralization of adenovirus 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Wiethoff","year":"2015","journal-title":"Virology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1074\/jbc.M113.531855","article-title":"Autophagy induced by calcium phosphate precipitates targets damaged endosomes","volume":"289","author":"X Chen","year":"2014","journal-title":"J Biol Chem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1128\/JVI.01265-10","article-title":"Adenovirus membrane penetration activates the NLRP3 inflammasome","volume":"85","author":"U Barlan","year":"2011","journal-title":"J Virol"},{"key":"ref79","first-page":"1","article-title":"ATP release and purinergic signaling in NLRP3 inflammasome activation","volume":"3","author":"A Gombault","year":"2012","journal-title":"Front Immunol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e35812","DOI":"10.1371\/journal.pone.0035812","article-title":"Activation of P2X7 receptor by ATP plays an important role in regulating inflammatory responses during 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Med"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1182\/blood.V76.7.1392.1392","article-title":"Interleukin-4 (IL-4) Inhibits secretion of IL-lbeta, tumor necrosis factor-alpha, and IL-6 by human monocytes","volume":"76","author":"RJF Huijbens","year":"1990","journal-title":"Blood"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/icb.2014.125","article-title":"Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4","author":"I Hwang","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1\u00df in monocytes and macrophages","volume":"113","author":"M Netea","year":"2009","journal-title":"Blood"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.4049\/jimmunol.1100469","article-title":"Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response","volume":"187","author":"K Kis-Toth","year":"2011","journal-title":"J Immunol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1038\/ncomms8827","article-title":"Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC","volume":"6","author":"SR Morrone","year":"2015","journal-title":"Nat Commun"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/2193-1801-2-234","article-title":"Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5","volume":"2","author":"M Schulte","year":"2013","journal-title":"Springerplus"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.171.12.6329","article-title":"Cutting Edge: CIAS1\/Cryopyrin\/PYPAF1\/NALP3\/ CATERPILLER 1.1 is an inducible inflammatory mediator with NF-\u03baB suppressive properties","volume":"171","author":"W O\u2019Connor","year":"2003","journal-title":"J Immunol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"FG Bauernfeind","year":"2009","journal-title":"J Immunol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4049\/jimmunol.0900173","article-title":"TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation","volume":"183","author":"L Franchi","year":"2009","journal-title":"J Immunol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000353902","article-title":"HIV-1 induces the first signal to activate the NLRP3 inflammasome in monocyte-derived macrophages","volume":"57","author":"JC Hernandez","year":"2013","journal-title":"Intervirology"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.celrep.2013.12.014","article-title":"Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during Malaria","volume":"6","author":"P Kalantari","year":"2014","journal-title":"Cell Rep"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ni.2548","article-title":"Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21","volume":"14","author":"WA McEwan","year":"2013","journal-title":"Nat Immunol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"19985","DOI":"10.1073\/pnas.1014074107","article-title":"Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)","volume":"107","author":"DL Mallery","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jcv.2009.11.026","article-title":"Respiratory viruses, a common microbiological finding in neutropenic children with fever","volume":"47","author":"A Lindblom","year":"2010","journal-title":"J Clin Virol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/INF.0b013e318250084a","article-title":"Infectious etiologies of transient neutropenia in previously healthy children","volume":"31","author":"E Husain","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1158\/0008-5472.CAN-11-3368","article-title":"Gene immunotherapy of chronic lymphocytic leukemia: A phase I study of intranodally injected adenovirus expressing a chimeric CD154 molecule","volume":"72","author":"JE Castro","year":"2012","journal-title":"Cancer Res"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1182\/blood-2011-12-399931","article-title":"IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcgammaRIIa in human dendritic cells","volume":"120","author":"J Den Dunnen","year":"2012","journal-title":"Blood"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.4049\/jimmunol.1400628","article-title":"Immune complexes inhibit IL-1 secretion and inflammasome activation","volume":"193","author":"JR Janczy","year":"2014","journal-title":"J Immunol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature12940","article-title":"Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection","volume":"505","author":"G Doitsh","year":"2014","journal-title":"Nature"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ni1006-1029","article-title":"On regulation of phagosome maturation and antigen presentation","volume":"7","author":"JM Blander","year":"2006","journal-title":"Nat Immunol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1399-3046.2009.01263.x","article-title":"Different cytokine signatures in children with localized and invasive adenovirus infection after stem cell transplantation","volume":"14","author":"LM Haveman","year":"2010","journal-title":"Pediatr Transplant"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/ni.2919","article-title":"The NLRP3 inflammasome is released 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